An AI-native experimental laboratory for autonomous biomolecular engineering

Autonomous scientific research, capable of independently conducting complex experiments and serving non-specialists, represents a long-held aspiration. Achieving it requires a fundamental paradigm shift driven by artificial intelligence (AI). While autonomous experimental systems are emerging, they remain confined to areas featuring singular objectives and well-defined, simple experimental workflows, such as chemical synthesis and catalysis. We present an AI-native autonomous laboratory, targeting highly complex scientific experiments for applications like autonomous biomolecular engineering. This system autonomously manages instrumentation, formulates experiment-specific procedures and optimization heuristics, and concurrently serves multiple user requests. Founded on a co-design philosophy of models, experiments, and instruments, the platform supports the co-evolution of AI models and the automation system. This establishes an end-to-end, multi-user autonomous laboratory that handles complex, multi-objective experiments across diverse instrumentation. Our autonomous laboratory supports fundamental nucleic acid functions-including synthesis, transcription, amplification, and sequencing. It also enables applications in fields such as disease diagnostics, drug development, and information storage. Without human intervention, it autonomously optimizes experimental performance to match state-of-the-art results achieved by human scientists. In multi-user scenarios, the platform significantly improves instrument utilization and experimental efficiency. This platform paves the way for advanced biomaterials research to overcome dependencies on experts and resource barriers, establishing a blueprint for science-as-a-service at scale.

Learning Comprehensive Motion Representation for Action Recognition

For action recognition learning, 2D CNN-based methods are efficient but may yield redundant features due to applying the same 2D convolution kernel to each frame. Recent efforts attempt to capture motion information by establishing inter-frame connections while still suffering the limited temporal receptive field or high latency. Moreover, the feature enhancement is often only performed by channel or space dimension in action recognition. To address these issues, we first devise a Channel-wise Motion Enhancement (CME) module to adaptively emphasize the channels related to dynamic information with a channel-wise gate vector. The channel gates generated by CME incorporate the information from all the other frames in the video. We further propose a Spatial-wise Motion Enhancement (SME) module to focus on the regions with the critical target in motion, according to the point-to-point similarity between adjacent feature maps. The intuition is that the change of background is typically slower than the motion area. Both CME and SME have clear physical meaning in capturing action clues. By integrating the two modules into the off-the-shelf 2D network, we finally obtain a Comprehensive Motion Representation (CMR) learning method for action recognition, which achieves competitive performance on Something-Something V1 & V2 and Kinetics-400. On the temporal reasoning datasets Something-Something V1 and V2, our method outperforms the current state-of-the-art by 2.3% and 1.9% when using 16 frames as input, respectively.