HeMeNet: Heterogeneous Multichannel Equivariant Network for Protein Multitask Learning

Understanding and leveraging the 3D structures of proteins is central to a variety of biological and drug discovery tasks. While deep learning has been applied successfully for structure-based protein function prediction tasks, current methods usually employ distinct training for each task. However, each of the tasks is of small size, and such a single-task strategy hinders the models' performance and generalization ability. As some labeled 3D protein datasets are biologically related, combining multi-source datasets for larger-scale multi-task learning is one way to overcome this problem. In this paper, we propose a neural network model to address multiple tasks jointly upon the input of 3D protein structures. In particular, we first construct a standard structure-based multi-task benchmark called Protein-MT, consisting of 6 biologically relevant tasks, including affinity prediction and property prediction, integrated from 4 public datasets. Then, we develop a novel graph neural network for multi-task learning, dubbed Heterogeneous Multichannel Equivariant Network (HeMeNet), which is E(3) equivariant and able to capture heterogeneous relationships between different atoms. Besides, HeMeNet can achieve task-specific learning via the task-aware readout mechanism. Extensive evaluations on our benchmark verify the effectiveness of multi-task learning, and our model generally surpasses state-of-the-art models.

TELEClass: Taxonomy Enrichment and LLM-Enhanced Hierarchical Text Classification with Minimal Supervision

Hierarchical text classification aims to categorize each document into a set of classes in a label taxonomy. Most earlier works focus on fully or semi-supervised methods that require a large amount of human annotated data which is costly and time-consuming to acquire. To alleviate human efforts, in this paper, we work on hierarchical text classification with the minimal amount of supervision: using the sole class name of each node as the only supervision. Recently, large language models (LLM) show competitive performance on various tasks through zero-shot prompting, but this method performs poorly in the hierarchical setting, because it is ineffective to include the large and structured label space in a prompt. On the other hand, previous weakly-supervised hierarchical text classification methods only utilize the raw taxonomy skeleton and ignore the rich information hidden in the text corpus that can serve as additional class-indicative features. To tackle the above challenges, we propose TELEClass, Taxonomy Enrichment and LLM-Enhanced weakly-supervised hierarchical text classification, which (1) automatically enriches the label taxonomy with class-indicative topical terms mined from the corpus to facilitate classifier training and (2) utilizes LLMs for both data annotation and creation tailored for the hierarchical label space. Experiments show that TELEClass can outperform previous weakly-supervised hierarchical text classification methods and LLM-based zero-shot prompting methods on two public datasets.

LiPO: Listwise Preference Optimization through Learning-to-Rank

Aligning language models (LMs) with curated human feedback is critical to control their behaviors in real-world applications. Several recent policy optimization methods, such as DPO and SLiC, serve as promising alternatives to the traditional Reinforcement Learning from Human Feedback (RLHF) approach. In practice, human feedback often comes in a format of a ranked list over multiple responses to amortize the cost of reading prompt. Multiple responses can also be ranked by reward models or AI feedback. There lacks such a study on directly fitting upon a list of responses. In this work, we formulate the LM alignment as a listwise ranking problem and describe the Listwise Preference Optimization (LiPO) framework, where the policy can potentially learn more effectively from a ranked list of plausible responses given the prompt. This view draws an explicit connection to Learning-to-Rank (LTR), where most existing preference optimization work can be mapped to existing ranking objectives, especially pairwise ones. Following this connection, we provide an examination of ranking objectives that are not well studied for LM alignment withDPO and SLiC as special cases when list size is two. In particular, we highlight a specific method, LiPO-{\lambda}, which leverages a state-of-the-art listwise ranking objective and weights each preference pair in a more advanced manner. We show that LiPO-{\lambda} can outperform DPO and SLiC by a clear margin on two preference alignment tasks.

On What Basis? Predicting Text Preference Via Structured Comparative Reasoning

Comparative reasoning plays a crucial role in text preference prediction; however, large language models (LLMs) often demonstrate inconsistencies in their reasoning. While approaches like Chain-of-Thought improve accuracy in many other settings, they struggle to consistently distinguish the similarities and differences of complex texts. We introduce SC, a prompting approach that predicts text preferences by generating structured intermediate comparisons. SC begins by proposing aspects of comparison, followed by generating textual comparisons under each aspect. We select consistent comparisons with a pairwise consistency comparator that ensures each aspect's comparisons clearly distinguish differences between texts, significantly reducing hallucination and improving consistency. Our comprehensive evaluations across various NLP tasks, including summarization, retrieval, and automatic rating, demonstrate that SC equips LLMs to achieve state-of-the-art performance in text preference prediction.

Explanation-aware Soft Ensemble Empowers Large Language Model In-context Learning

Large language models (LLMs) have shown remarkable capabilities in various natural language understanding tasks. With only a few demonstration examples, these LLMs can quickly adapt to target tasks without expensive gradient updates. Common strategies to boost such 'in-context' learning ability are to ensemble multiple model decoded results and require the model to generate an explanation along with the prediction. However, these models often treat different class predictions equally and neglect the potential discrepancy between the explanations and predictions. To fully unleash the power of explanations, we propose EASE, an Explanation-Aware Soft Ensemble framework to empower in-context learning with LLMs. We design two techniques, explanation-guided ensemble, and soft probability aggregation, to mitigate the effect of unreliable explanations and improve the consistency between explanations and final predictions. Experiments on seven natural language understanding tasks and four varying-size LLMs demonstrate the effectiveness of our proposed framework.

Bridging the Gap: Fine-to-Coarse Sketch Interpolation Network for High-Quality Animation Sketch Inbetweening

The 2D animation workflow is typically initiated with the creation of keyframes using sketch-based drawing. Subsequent inbetweens (i.e., intermediate sketch frames) are crafted through manual interpolation for smooth animations, which is a labor-intensive process. Thus, the prospect of automatic animation sketch interpolation has become highly appealing. However, existing video interpolation methods are generally hindered by two key issues for sketch inbetweening: 1) limited texture and colour details in sketches, and 2) exaggerated alterations between two sketch keyframes. To overcome these issues, we propose a novel deep learning method, namely Fine-to-Coarse Sketch Interpolation Network (FC-SIN). This approach incorporates multi-level guidance that formulates region-level correspondence, sketch-level correspondence and pixel-level dynamics. A multi-stream U-Transformer is then devised to characterize sketch inbewteening patterns using these multi-level guides through the integration of both self-attention and cross-attention mechanisms. Additionally, to facilitate future research on animation sketch inbetweening, we constructed a large-scale dataset - STD-12K, comprising 30 sketch animation series in diverse artistic styles. Comprehensive experiments on this dataset convincingly show that our proposed FC-SIN surpasses the state-of-the-art interpolation methods. Our code and dataset will be publicly available.

Large Language Models are Effective Text Rankers with Pairwise Ranking Prompting

Ranking documents using Large Language Models (LLMs) by directly feeding the query and candidate documents into the prompt is an interesting and practical problem. However, there has been limited success so far, as researchers have found it difficult to outperform fine-tuned baseline rankers on benchmark datasets. We analyze pointwise and listwise ranking prompts used by existing methods and argue that off-the-shelf LLMs do not fully understand these ranking formulations, possibly due to the nature of how LLMs are trained. In this paper, we propose to significantly reduce the burden on LLMs by using a new technique called Pairwise Ranking Prompting (PRP). Our results are the first in the literature to achieve state-of-the-art ranking performance on standard benchmarks using moderate-sized open-sourced LLMs. On TREC-DL2020, PRP based on the Flan-UL2 model with 20B parameters outperforms the previous best approach in the literature, which is based on the blackbox commercial GPT-4 that has 50x (estimated) model size, by over 5% at NDCG@1. On TREC-DL2019, PRP is only inferior to the GPT-4 solution on the NDCG@5 and NDCG@10 metrics, while outperforming other existing solutions, such as InstructGPT which has 175B parameters, by over 10% for nearly all ranking metrics. Furthermore, we propose several variants of PRP to improve efficiency and show that it is possible to achieve competitive results even with linear complexity. We also discuss other benefits of PRP, such as supporting both generation and scoring LLM APIs, as well as being insensitive to input ordering.

Large Language Model as Attributed Training Data Generator: A Tale of Diversity and Bias

Large language models (LLMs) have been recently leveraged as training data generators for various natural language processing (NLP) tasks. While previous research has explored different approaches to training models using generated data, they generally rely on simple class-conditional prompts, which may limit the diversity of the generated data and inherit systematic biases of LLM. Thus, we investigate training data generation with diversely attributed prompts (e.g., specifying attributes like length and style), which have the potential to yield diverse and attributed generated data. Our investigation focuses on datasets with high cardinality and diverse domains, wherein we demonstrate that attributed prompts outperform simple class-conditional prompts in terms of the resulting model's performance. Additionally, we present a comprehensive empirical study on data generation encompassing vital aspects like bias, diversity, and efficiency, and highlight three key observations: firstly, synthetic datasets generated by simple prompts exhibit significant biases, such as regional bias; secondly, attribute diversity plays a pivotal role in enhancing model performance; lastly, attributed prompts achieve the performance of simple class-conditional prompts while utilizing only 5\% of the querying cost of ChatGPT associated with the latter. We release the generated dataset and used prompts to facilitate future research. The data and code will be available on \url{https://github.com/yueyu1030/AttrPrompt}.

Local Boosting for Weakly-Supervised Learning

Boosting is a commonly used technique to enhance the performance of a set of base models by combining them into a strong ensemble model. Though widely adopted, boosting is typically used in supervised learning where the data is labeled accurately. However, in weakly supervised learning, where most of the data is labeled through weak and noisy sources, it remains nontrivial to design effective boosting approaches. In this work, we show that the standard implementation of the convex combination of base learners can hardly work due to the presence of noisy labels. Instead, we propose $\textit{LocalBoost}$, a novel framework for weakly-supervised boosting. LocalBoost iteratively boosts the ensemble model from two dimensions, i.e., intra-source and inter-source. The intra-source boosting introduces locality to the base learners and enables each base learner to focus on a particular feature regime by training new base learners on granularity-varying error regions. For the inter-source boosting, we leverage a conditional function to indicate the weak source where the sample is more likely to appear. To account for the weak labels, we further design an estimate-then-modify approach to compute the model weights. Experiments on seven datasets show that our method significantly outperforms vanilla boosting methods and other weakly-supervised methods.

ReGen: Zero-Shot Text Classification via Training Data Generation with Progressive Dense Retrieval

With the development of large language models (LLMs), zero-shot learning has attracted much attention for various NLP tasks. Different from prior works that generate training data with billion-scale natural language generation (NLG) models, we propose a retrieval-enhanced framework to create training data from a general-domain unlabeled corpus. To realize this, we first conduct contrastive pretraining to learn an unsupervised dense retriever for extracting the most relevant documents using class-descriptive verbalizers. We then further propose two simple strategies, namely Verbalizer Augmentation with Demonstrations and Self-consistency Guided Filtering to improve the topic coverage of the dataset while removing noisy examples. Experiments on nine datasets demonstrate that REGEN achieves 4.3% gain over the strongest baselines and saves around 70% of the time compared to baselines using large NLG models. Besides, REGEN can be naturally integrated with recently proposed large language models to boost performance.