Dose-aware Diffusion Model for 3D Ultra Low-dose PET Imaging

As PET imaging is accompanied by substantial radiation exposure and cancer risk, reducing radiation dose in PET scans is an important topic. Recently, diffusion models have emerged as the new state-of-the-art generative model to generate high-quality samples and have demonstrated strong potential for various tasks in medical imaging. However, it is difficult to extend diffusion models for 3D image reconstructions due to the memory burden. Directly stacking 2D slices together to create 3D image volumes would results in severe inconsistencies between slices. Previous works tried to either applying a penalty term along the z-axis to remove inconsistencies or reconstructing the 3D image volumes with 2 pre-trained perpendicular 2D diffusion models. Nonetheless, these previous methods failed to produce satisfactory results in challenging cases for PET image denoising. In addition to administered dose, the noise-levels in PET images are affected by several other factors in clinical settings, such as scan time, patient size, and weight, etc. Therefore, a method to simultaneously denoise PET images with different noise-levels is needed. Here, we proposed a dose-aware diffusion model for 3D low-dose PET imaging (DDPET) to address these challenges. The proposed DDPET method was tested on 295 patients from three different medical institutions globally with different low-dose levels. These patient data were acquired on three different commercial PET scanners, including Siemens Vision Quadra, Siemens mCT, and United Imaging Healthcare uExplorere. The proposed method demonstrated superior performance over previously proposed diffusion models for 3D imaging problems as well as models proposed for noise-aware medical image denoising. Code is available at: xxx.

A Lifetime Extended Energy Management Strategy for Fuel Cell Hybrid Electric Vehicles via Self-Learning Fuzzy Reinforcement Learning

Modeling difficulty, time-varying model, and uncertain external inputs are the main challenges for energy management of fuel cell hybrid electric vehicles. In the paper, a fuzzy reinforcement learning-based energy management strategy for fuel cell hybrid electric vehicles is proposed to reduce fuel consumption, maintain the batteries' long-term operation, and extend the lifetime of the fuel cells system. Fuzzy Q-learning is a model-free reinforcement learning that can learn itself by interacting with the environment, so there is no need for modeling the fuel cells system. In addition, frequent startup of the fuel cells will reduce the remaining useful life of the fuel cells system. The proposed method suppresses frequent fuel cells startup by considering the penalty for the times of fuel cell startups in the reward of reinforcement learning. Moreover, applying fuzzy logic to approximate the value function in Q-Learning can solve continuous state and action space problems. Finally, a python-based training and testing platform verify the effectiveness and self-learning improvement of the proposed method under conditions of initial state change, model change and driving condition change.

Multi-scale temporal-frequency attention for music source separation

In recent years, deep neural networks (DNNs) based approaches have achieved the start-of-the-art performance for music source separation (MSS). Although previous methods have addressed the large receptive field modeling using various methods, the temporal and frequency correlations of the music spectrogram with repeated patterns have not been explicitly explored for the MSS task. In this paper, a temporal-frequency attention module is proposed to model the spectrogram correlations along both temporal and frequency dimensions. Moreover, a multi-scale attention is proposed to effectively capture the correlations for music signal. The experimental results on MUSDB18 dataset show that the proposed method outperforms the existing state-of-the-art systems with 9.51 dB signal-to-distortion ratio (SDR) on separating the vocal stems, which is the primary practical application of MSS.

A two-step backward compatible fullband speech enhancement system

Speech enhancement methods based on deep learning have surpassed traditional methods. While many of these new approaches are operating on the wideband (16kHz) sample rate, a new fullband (48kHz) speech enhancement system is proposed in this paper. Compared to the existing fullband systems that utilizes perceptually motivated features to train the fullband speech enhancement using a single network structure, the proposed system is a two-step system ensuring good fullband speech enhancement quality while backward compatible to the existing wideband systems.

Subsampling Bias and The Best-Discrepancy Systematic Cross Validation

Statistical machine learning models should be evaluated and validated before putting to work. Conventional k-fold Monte Carlo Cross-Validation (MCCV) procedure uses a pseudo-random sequence to partition instances into k subsets, which usually causes subsampling bias, inflates generalization errors and jeopardizes the reliability and effectiveness of cross-validation. Based on ordered systematic sampling theory in statistics and low-discrepancy sequence theory in number theory, we propose a new k-fold cross-validation procedure by replacing a pseudo-random sequence with a best-discrepancy sequence, which ensures low subsampling bias and leads to more precise Expected-Prediction-Error estimates. Experiments with 156 benchmark datasets and three classifiers (logistic regression, decision tree and naive bayes) show that in general, our cross-validation procedure can extrude subsampling bias in the MCCV by lowering the EPE around 7.18% and the variances around 26.73%. In comparison, the stratified MCCV can reduce the EPE and variances of the MCCV around 1.58% and 11.85% respectively. The Leave-One-Out (LOO) can lower the EPE around 2.50% but its variances are much higher than the any other CV procedure. The computational time of our cross-validation procedure is just 8.64% of the MCCV, 8.67% of the stratified MCCV and 16.72% of the LOO. Experiments also show that our approach is more beneficial for datasets characterized by relatively small size and large aspect ratio. This makes our approach particularly pertinent when solving bioscience classification problems. Our proposed systematic subsampling technique could be generalized to other machine learning algorithms that involve random subsampling mechanism.