SHALA-LLM: Smartly Handling Ambiguous Labels in Aligning LLMs

Many human-centered tasks, including natural language inference (NLI) and emotion recognition (ER), have multiple plausible interpretations, leading to label ambiguity and challenging disagreements across human annotators. As LLMs are increasingly deployed in real-world settings, faithfully modeling such ambiguity is essential to identify contested inputs, preserve variability in ambiguous cases, and capture the full distribution of human judgments. Yet, existing LLM alignment approaches have predominantly assumed a single correct label, excluding annotator disagreement during optimization. Instead of treating this ambiguity as noise, we show how to treat it as information that improves model behavior through a new algorithm called SMARTLY HANDLING AMBIGUOUS LABELS IN ALIGNING LLMS (SHALA-LLM). This reinforcement learning framework provides a new way for LLMs to learn directly from annotator distributions while dynamically prioritizing highly ambiguous samples during optimization. Experiments on ambiguity-sensitive NLI and ER benchmarks, including ChaosNLI, GoEmotions, and MSP-Podcast, demonstrate that SHALA-LLM improves agreement with annotator label distributions, e.g. on ChaosNLI, it reduces Jensen-Shannon Distance by up to 62.1%. At the same time, SHALA-LLM improves F1 by up to 16.7%, showing that modeling annotator disagreement can also strengthen classification performance.

DECADE: A Temporally-Consistent Unsupervised Diffusion Model for Enhanced Rb-82 Dynamic Cardiac PET Image Denoising

Rb-82 dynamic cardiac PET imaging is widely used for the clinical diagnosis of coronary artery disease (CAD), but its short half-life results in high noise levels that degrade dynamic frame quality and parametric imaging. The lack of paired clean-noisy training data, rapid tracer kinetics, and frame-dependent noise variations further limit the effectiveness of existing deep learning denoising methods. We propose DECADE (A Temporally-Consistent Unsupervised Diffusion model for Enhanced Rb-82 CArdiac PET DEnoising), an unsupervised diffusion framework that generalizes across early- to late-phase dynamic frames. DECADE incorporates temporal consistency during both training and iterative sampling, using noisy frames as guidance to preserve quantitative accuracy. The method was trained and evaluated on datasets acquired from Siemens Vision 450 and Siemens Biograph Vision Quadra scanners. On the Vision 450 dataset, DECADE consistently produced high-quality dynamic and parametric images with reduced noise while preserving myocardial blood flow (MBF) and myocardial flow reserve (MFR). On the Quadra dataset, using 15%-count images as input and full-count images as reference, DECADE outperformed UNet-based and other diffusion models in image quality and K1/MBF quantification. The proposed framework enables effective unsupervised denoising of Rb-82 dynamic cardiac PET without paired training data, supporting clearer visualization while maintaining quantitative integrity.