Foundation Model for Advancing Healthcare: Challenges, Opportunities, and Future Directions

Foundation model, which is pre-trained on broad data and is able to adapt to a wide range of tasks, is advancing healthcare. It promotes the development of healthcare artificial intelligence (AI) models, breaking the contradiction between limited AI models and diverse healthcare practices. Much more widespread healthcare scenarios will benefit from the development of a healthcare foundation model (HFM), improving their advanced intelligent healthcare services. Despite the impending widespread deployment of HFMs, there is currently a lack of clear understanding about how they work in the healthcare field, their current challenges, and where they are headed in the future. To answer these questions, a comprehensive and deep survey of the challenges, opportunities, and future directions of HFMs is presented in this survey. It first conducted a comprehensive overview of the HFM including the methods, data, and applications for a quick grasp of the current progress. Then, it made an in-depth exploration of the challenges present in data, algorithms, and computing infrastructures for constructing and widespread application of foundation models in healthcare. This survey also identifies emerging and promising directions in this field for future development. We believe that this survey will enhance the community's comprehension of the current progress of HFM and serve as a valuable source of guidance for future development in this field. The latest HFM papers and related resources are maintained on our website: https://github.com/YutingHe-list/Awesome-Foundation-Models-for-Advancing-Healthcare.

Medical Image Debiasing by Learning Adaptive Agreement from a Biased Council

Deep learning could be prone to learning shortcuts raised by dataset bias and result in inaccurate, unreliable, and unfair models, which impedes its adoption in real-world clinical applications. Despite its significance, there is a dearth of research in the medical image classification domain to address dataset bias. Furthermore, the bias labels are often agnostic, as identifying biases can be laborious and depend on post-hoc interpretation. This paper proposes learning Adaptive Agreement from a Biased Council (Ada-ABC), a debiasing framework that does not rely on explicit bias labels to tackle dataset bias in medical images. Ada-ABC develops a biased council consisting of multiple classifiers optimized with generalized cross entropy loss to learn the dataset bias. A debiasing model is then simultaneously trained under the guidance of the biased council. Specifically, the debiasing model is required to learn adaptive agreement with the biased council by agreeing on the correctly predicted samples and disagreeing on the wrongly predicted samples by the biased council. In this way, the debiasing model could learn the target attribute on the samples without spurious correlations while also avoiding ignoring the rich information in samples with spurious correlations. We theoretically demonstrated that the debiasing model could learn the target features when the biased model successfully captures dataset bias. Moreover, to our best knowledge, we constructed the first medical debiasing benchmark from four datasets containing seven different bias scenarios. Our extensive experiments practically showed that our proposed Ada-ABC outperformed competitive approaches, verifying its effectiveness in mitigating dataset bias for medical image classification. The codes and organized benchmark datasets will be made publicly available.

MHSnet: Multi-head and Spatial Attention Network with False-Positive Reduction for Pulmonary Nodules Detection

The mortality of lung cancer has ranked high among cancers for many years. Early detection of lung cancer is critical for disease prevention, cure, and mortality rate reduction. However, existing detection methods on pulmonary nodules introduce an excessive number of false positive proposals in order to achieve high sensitivity, which is not practical in clinical situations. In this paper, we propose the multi-head detection and spatial squeeze-and-attention network, MHSnet, to detect pulmonary nodules, in order to aid doctors in the early diagnosis of lung cancers. Specifically, we first introduce multi-head detectors and skip connections to customize for the variety of nodules in sizes, shapes and types and capture multi-scale features. Then, we implement a spatial attention module to enable the network to focus on different regions differently inspired by how experienced clinicians screen CT images, which results in fewer false positive proposals. Lastly, we present a lightweight but effective false positive reduction module with the Linear Regression model to cut down the number of false positive proposals, without any constraints on the front network. Extensive experimental results compared with the state-of-the-art models have shown the superiority of the MHSnet in terms of the average FROC, sensitivity and especially false discovery rate (2.98% and 2.18% improvement in terms of average FROC and sensitivity, 5.62% and 28.33% decrease in terms of false discovery rate and average candidates per scan). The false positive reduction module significantly decreases the average number of candidates generated per scan by 68.11% and the false discovery rate by 13.48%, which is promising to reduce distracted proposals for the downstream tasks based on the detection results.

A Coarse-to-fine Morphological Approach With Knowledge-based Rules and Self-adapting Correction for Lung Nodules Segmentation

The segmentation module which precisely outlines the nodules is a crucial step in a computer-aided diagnosis(CAD) system. The most challenging part of such a module is how to achieve high accuracy of the segmentation, especially for the juxtapleural, non-solid and small nodules. In this research, we present a coarse-to-fine methodology that greatly improves the thresholding method performance with a novel self-adapting correction algorithm and effectively removes noisy pixels with well-defined knowledge-based principles. Compared with recent strong morphological baselines, our algorithm, by combining dataset features, achieves state-of-the-art performance on both the public LIDC-IDRI dataset (DSC 0.699) and our private LC015 dataset (DSC 0.760) which closely approaches the SOTA deep learning-based models' performances. Furthermore, unlike most available morphological methods that can only segment the isolated and well-circumscribed nodules accurately, the precision of our method is totally independent of the nodule type or diameter, proving its applicability and generality.

How Pandemic Spread in News: Text Analysis Using Topic Model

Researches about COVID-19 has increased largely, no matter in the biology field or the others. This research conducted a text analysis using LDA topic model. We firstly scraped totally 1127 articles and 5563 comments on SCMP covering COVID-19 from Jan 20 to May 19, then we trained the LDA model and tuned parameters based on the Cv coherence as the model evaluation method. With the optimal model, dominant topics, representative documents of each topic and the inconsistence between articles and comments are analyzed. 3 possible improvements are discussed at last.