R-GenIMA: Integrating Neuroimaging and Genetics with Interpretable Multimodal AI for Alzheimer's Disease Progression

Early detection of Alzheimer's disease (AD) requires models capable of integrating macro-scale neuroanatomical alterations with micro-scale genetic susceptibility, yet existing multimodal approaches struggle to align these heterogeneous signals. We introduce R-GenIMA, an interpretable multimodal large language model that couples a novel ROI-wise vision transformer with genetic prompting to jointly model structural MRI and single nucleotide polymorphisms (SNPs) variations. By representing each anatomically parcellated brain region as a visual token and encoding SNP profiles as structured text, the framework enables cross-modal attention that links regional atrophy patterns to underlying genetic factors. Applied to the ADNI cohort, R-GenIMA achieves state-of-the-art performance in four-way classification across normal cognition (NC), subjective memory concerns (SMC), mild cognitive impairment (MCI), and AD. Beyond predictive accuracy, the model yields biologically meaningful explanations by identifying stage-specific brain regions and gene signatures, as well as coherent ROI-Gene association patterns across the disease continuum. Attention-based attribution revealed genes consistently enriched for established GWAS-supported AD risk loci, including APOE, BIN1, CLU, and RBFOX1. Stage-resolved neuroanatomical signatures identified shared vulnerability hubs across disease stages alongside stage-specific patterns: striatal involvement in subjective decline, frontotemporal engagement during prodromal impairment, and consolidated multimodal network disruption in AD. These results demonstrate that interpretable multimodal AI can synthesize imaging and genetics to reveal mechanistic insights, providing a foundation for clinically deployable tools that enable earlier risk stratification and inform precision therapeutic strategies in Alzheimer's disease.

Auxiliary Descriptive Knowledge for Few-Shot Adaptation of Vision-Language Model

Despite the impressive zero-shot capabilities of Vision-Language Models (VLMs), they often struggle in downstream tasks with distribution shifts from the pre-training data. Few-Shot Adaptation (FSA-VLM) has emerged as a key solution, typically using Parameter-Efficient Fine-Tuning (PEFT) to adapt models with minimal data. However, these PEFT methods are constrained by their reliance on fixed, handcrafted prompts, which are often insufficient to understand the semantics of classes. While some studies have proposed leveraging image-induced prompts to provide additional clues for classification, they introduce prohibitive computational overhead at inference. Therefore, we introduce Auxiliary Descriptive Knowledge (ADK), a novel framework that efficiently enriches text representations without compromising efficiency. ADK first leverages a Large Language Model to generate a rich set of descriptive prompts for each class offline. These pre-computed features are then deployed in two ways: (1) as Compositional Knowledge, an averaged representation that provides rich semantics, especially beneficial when class names are ambiguous or unfamiliar to the VLM; and (2) as Instance-Specific Knowledge, where a lightweight, non-parametric attention mechanism dynamically selects the most relevant descriptions for a given image. This approach provides two additional types of knowledge alongside the handcrafted prompt, thereby facilitating category distinction across various domains. Also, ADK acts as a parameter-free, plug-and-play component that enhances existing PEFT methods. Extensive experiments demonstrate that ADK consistently boosts the performance of multiple PEFT baselines, setting a new state-of-the-art across various scenarios.

OmniMER: Indonesian Multimodal Emotion Recognition via Auxiliary-Enhanced LLM Adaptation

Indonesian, spoken by over 200 million people, remains underserved in multimodal emotion recognition research despite its dominant presence on Southeast Asian social media platforms. We introduce IndoMER, the first multimodal emotion recognition benchmark for Indonesian, comprising 1,944 video segments from 203 speakers with temporally aligned text, audio, and visual annotations across seven emotion categories. The dataset exhibits realistic challenges including cross-modal inconsistency and long-tailed class distributions shaped by Indonesian cultural communication norms. To address these challenges, we propose OmniMER, a multimodal adaptation framework built upon Qwen2.5-Omni that enhances emotion recognition through three auxiliary modality-specific perception tasks: emotion keyword extraction for text, facial expression analysis for video, and prosody analysis for audio. These auxiliary tasks help the model identify emotion-relevant cues in each modality before fusion, reducing reliance on spurious correlations in low-resource settings. Experiments on IndoMER show that OmniMER achieves 0.582 Macro-F1 on sentiment classification and 0.454 on emotion recognition, outperforming the base model by 7.6 and 22.1 absolute points respectively. Cross-lingual evaluation on the Chinese CH-SIMS dataset further demonstrates the generalizability of the proposed framework. The dataset and code are publicly available. https://github.com/yanxm01/INDOMER

InstructNet: A Novel Approach for Multi-Label Instruction Classification through Advanced Deep Learning

People use search engines for various topics and items, from daily essentials to more aspirational and specialized objects. Therefore, search engines have taken over as peoples preferred resource. The How To prefix has become familiar and widely used in various search styles to find solutions to particular problems. This search allows people to find sequential instructions by providing detailed guidelines to accomplish specific tasks. Categorizing instructional text is also essential for task-oriented learning and creating knowledge bases. This study uses the How To articles to determine the multi-label instruction category. We have brought this work with a dataset comprising 11,121 observations from wikiHow, where each record has multiple categories. To find out the multi-label category meticulously, we employ some transformer-based deep neural architectures, such as Generalized Autoregressive Pretraining for Language Understanding (XLNet), Bidirectional Encoder Representation from Transformers (BERT), etc. In our multi-label instruction classification process, we have reckoned our proposed architectures using accuracy and macro f1-score as the performance metrics. This thorough evaluation showed us much about our strategys strengths and drawbacks. Specifically, our implementation of the XLNet architecture has demonstrated unprecedented performance, achieving an accuracy of 97.30% and micro and macro average scores of 89.02% and 93%, a noteworthy accomplishment in multi-label classification. This high level of accuracy and macro average score is a testament to the effectiveness of the XLNet architecture in our proposed InstructNet approach. By employing a multi-level strategy in our evaluation process, we have gained a more comprehensive knowledge of the effectiveness of our proposed architectures and identified areas for forthcoming improvement and refinement.

BrepLLM: Native Boundary Representation Understanding with Large Language Models

Current token-sequence-based Large Language Models (LLMs) are not well-suited for directly processing 3D Boundary Representation (Brep) models that contain complex geometric and topological information. We propose BrepLLM, the first framework that enables LLMs to parse and reason over raw Brep data, bridging the modality gap between structured 3D geometry and natural language. BrepLLM employs a two-stage training pipeline: Cross-modal Alignment Pre-training and Multi-stage LLM Fine-tuning. In the first stage, an adaptive UV sampling strategy converts Breps into graphs representation with geometric and topological information. We then design a hierarchical BrepEncoder to extract features from geometry (i.e., faces and edges) and topology, producing both a single global token and a sequence of node tokens. Then we align the global token with text embeddings from a frozen CLIP text encoder (ViT-L/14) via contrastive learning. In the second stage, we integrate the pretrained BrepEncoder into an LLM. We then align its sequence of node tokens using a three-stage progressive training strategy: (1) training an MLP-based semantic mapping from Brep representation to 2D with 2D-LLM priors. (2) performing fine-tuning of the LLM. (3) designing a Mixture-of-Query Experts (MQE) to enhance geometric diversity modeling. We also construct Brep2Text, a dataset comprising 269,444 Brep-text question-answer pairs. Experiments show that BrepLLM achieves state-of-the-art (SOTA) results on 3D object classification and captioning tasks.

SLIM: Semantic-based Low-bitrate Image compression for Machines by leveraging diffusion

In recent years, the demand of image compression models for machine vision has increased dramatically. However, the training frameworks of image compression still focus on the vision of human, maintaining the excessive perceptual details, thus have limitations in optimally reducing the bits per pixel in the case of performing machine vision tasks. In this paper, we propose Semantic-based Low-bitrate Image compression for Machines by leveraging diffusion, termed SLIM. This is a new effective training framework of image compression for machine vision, using a pretrained latent diffusion model.The compressor model of our method focuses only on the Region-of-Interest (RoI) areas for machine vision in the image latent, to compress it compactly. Then the pretrained Unet model enhances the decompressed latent, utilizing a RoI-focused text caption which containing semantic information of the image. Therefore, SLIM is able to focus on RoI areas of the image without any guide mask at the inference stage, achieving low bitrate when compressing. And SLIM is also able to enhance a decompressed latent by denoising steps, so the final reconstructed image from the enhanced latent can be optimized for the machine vision task while still containing perceptual details for human vision. Experimental results show that SLIM achieves a higher classification accuracy in the same bits per pixel condition, compared to conventional image compression models for machines.

Generalization Gaps in Political Fake News Detection: An Empirical Study on the LIAR Dataset

The proliferation of linguistically subtle political disinformation poses a significant challenge to automated fact-checking systems. Despite increasing emphasis on complex neural architectures, the empirical limits of text-only linguistic modeling remain underexplored. We present a systematic diagnostic evaluation of nine machine learning algorithms on the LIAR benchmark. By isolating lexical features (Bag-of-Words, TF-IDF) and semantic embeddings (GloVe), we uncover a hard "Performance Ceiling", with fine-grained classification not exceeding a Weighted F1-score of 0.32 across models. Crucially, a simple linear SVM (Accuracy: 0.624) matches the performance of pre-trained Transformers such as RoBERTa (Accuracy: 0.620), suggesting that model capacity is not the primary bottleneck. We further diagnose a massive "Generalization Gap" in tree-based ensembles, which achieve more than 99% training accuracy but collapse to approximately 25% on test data, indicating reliance on lexical memorization rather than semantic inference. Synthetic data augmentation via SMOTE yields no meaningful gains, confirming that the limitation is semantic (feature ambiguity) rather than distributional. These findings indicate that for political fact-checking, increasing model complexity without incorporating external knowledge yields diminishing returns.

PathFLIP: Fine-grained Language-Image Pretraining for Versatile Computational Pathology

While Vision-Language Models (VLMs) have achieved notable progress in computational pathology (CPath), the gigapixel scale and spatial heterogeneity of Whole Slide Images (WSIs) continue to pose challenges for multimodal understanding. Existing alignment methods struggle to capture fine-grained correspondences between textual descriptions and visual cues across thousands of patches from a slide, compromising their performance on downstream tasks. In this paper, we propose PathFLIP (Pathology Fine-grained Language-Image Pretraining), a novel framework for holistic WSI interpretation. PathFLIP decomposes slide-level captions into region-level subcaptions and generates text-conditioned region embeddings to facilitate precise visual-language grounding. By harnessing Large Language Models (LLMs), PathFLIP can seamlessly follow diverse clinical instructions and adapt to varied diagnostic contexts. Furthermore, it exhibits versatile capabilities across multiple paradigms, efficiently handling slide-level classification and retrieval, fine-grained lesion localization, and instruction following. Extensive experiments demonstrate that PathFLIP outperforms existing large-scale pathological VLMs on four representative benchmarks while requiring significantly less training data, paving the way for fine-grained, instruction-aware WSI interpretation in clinical practice.

Confidence-Credibility Aware Weighted Ensembles of Small LLMs Outperform Large LLMs in Emotion Detection

This paper introduces a confidence-weighted, credibility-aware ensemble framework for text-based emotion detection, inspired by Condorcet's Jury Theorem (CJT). Unlike conventional ensembles that often rely on homogeneous architectures, our approach combines architecturally diverse small transformer-based large language models (sLLMs) - BERT, RoBERTa, DistilBERT, DeBERTa, and ELECTRA, each fully fine-tuned for emotion classification. To preserve error diversity, we minimize parameter convergence while taking advantage of the unique biases of each model. A dual-weighted voting mechanism integrates both global credibility (validation F1 score) and local confidence (instance-level probability) to dynamically weight model contributions. Experiments on the DAIR-AI dataset demonstrate that our credibility-confidence ensemble achieves a macro F1 score of 93.5 percent, surpassing state-of-the-art benchmarks and significantly outperforming large-scale LLMs, including Falcon, Mistral, Qwen, and Phi, even after task-specific Low-Rank Adaptation (LoRA). With only 595M parameters in total, our small LLMs ensemble proves more parameter-efficient and robust than models up to 7B parameters, establishing that carefully designed ensembles of small, fine-tuned models can outperform much larger LLMs in specialized natural language processing (NLP) tasks such as emotion detection.

LLM-Assisted Abstract Screening with OLIVER: Evaluating Calibration and Single-Model vs. Actor-Critic Configurations in Literature Reviews

Introduction: Recent work suggests large language models (LLMs) can accelerate screening, but prior evaluations focus on earlier LLMs, standardized Cochrane reviews, single-model setups, and accuracy as the primary metric, leaving generalizability, configuration effects, and calibration largely unexamined. Methods: We developed OLIVER (Optimized LLM-based Inclusion and Vetting Engine for Reviews), an open-source pipeline for LLM-assisted abstract screening. We evaluated multiple contemporary LLMs across two non-Cochrane systematic reviews and performance was assessed at both the full-text screening and final inclusion stages using accuracy, AUC, and calibration metrics. We further tested an actor-critic screening framework combining two lightweight models under three aggregation rules. Results: Across individual models, performance varied widely. In the smaller Review 1 (821 abstracts, 63 final includes), several models achieved high sensitivity for final includes but at the cost of substantial false positives and poor calibration. In the larger Review 2 (7741 abstracts, 71 final includes), most models were highly specific but struggled to recover true includes, with prompt design influencing recall. Calibration was consistently weak across single-model configurations despite high overall accuracy. Actor-critic screening improved discrimination and markedly reduced calibration error in both reviews, yielding higher AUCs. Discussion: LLMs may eventually accelerate abstract screening, but single-model performance is highly sensitive to review characteristics, prompting, and calibration is limited. An actor-critic framework improves classification quality and confidence reliability while remaining computationally efficient, enabling large-scale screening at low cost.