Unsupervised risk factor identification across cancer types and data modalities via explainable artificial intelligence

Risk stratification is a key tool in clinical decision-making, yet current approaches often fail to translate sophisticated survival analysis into actionable clinical criteria. We present a novel method for unsupervised machine learning that directly optimizes for survival heterogeneity across patient clusters through a differentiable adaptation of the multivariate logrank statistic. Unlike most existing methods that rely on proxy metrics, our approach represents novel methodology for training any neural network architecture on any data modality to identify prognostically distinct patient groups. We thoroughly evaluate the method in simulation experiments and demonstrate its utility in practice by applying it to two distinct cancer types: analyzing laboratory parameters from multiple myeloma patients and computed tomography images from non-small cell lung cancer patients, identifying prognostically distinct patient subgroups with significantly different survival outcomes in both cases. Post-hoc explainability analyses uncover clinically meaningful features determining the group assignments which align well with established risk factors and thus lend strong weight to the methods utility. This pan-cancer, model-agnostic approach represents a valuable advancement in clinical risk stratification, enabling the discovery of novel prognostic signatures across diverse data types while providing interpretable results that promise to complement treatment personalization and clinical decision-making in oncology and beyond.

Generalist Models in Medical Image Segmentation: A Survey and Performance Comparison with Task-Specific Approaches

Following the successful paradigm shift of large language models, leveraging pre-training on a massive corpus of data and fine-tuning on different downstream tasks, generalist models have made their foray into computer vision. The introduction of Segment Anything Model (SAM) set a milestone on segmentation of natural images, inspiring the design of a multitude of architectures for medical image segmentation. In this survey we offer a comprehensive and in-depth investigation on generalist models for medical image segmentation. We start with an introduction on the fundamentals concepts underpinning their development. Then, we provide a taxonomy on the different declinations of SAM in terms of zero-shot, few-shot, fine-tuning, adapters, on the recent SAM 2, on other innovative models trained on images alone, and others trained on both text and images. We thoroughly analyze their performances at the level of both primary research and best-in-literature, followed by a rigorous comparison with the state-of-the-art task-specific models. We emphasize the need to address challenges in terms of compliance with regulatory frameworks, privacy and security laws, budget, and trustworthy artificial intelligence (AI). Finally, we share our perspective on future directions concerning synthetic data, early fusion, lessons learnt from generalist models in natural language processing, agentic AI and physical AI, and clinical translation.

Adaptive Spatial Augmentation for Semi-supervised Semantic Segmentation

In semi-supervised semantic segmentation (SSSS), data augmentation plays a crucial role in the weak-to-strong consistency regularization framework, as it enhances diversity and improves model generalization. Recent strong augmentation methods have primarily focused on intensity-based perturbations, which have minimal impact on the semantic masks. In contrast, spatial augmentations like translation and rotation have long been acknowledged for their effectiveness in supervised semantic segmentation tasks, but they are often ignored in SSSS. In this work, we demonstrate that spatial augmentation can also contribute to model training in SSSS, despite generating inconsistent masks between the weak and strong augmentations. Furthermore, recognizing the variability among images, we propose an adaptive augmentation strategy that dynamically adjusts the augmentation for each instance based on entropy. Extensive experiments show that our proposed Adaptive Spatial Augmentation (\textbf{ASAug}) can be integrated as a pluggable module, consistently improving the performance of existing methods and achieving state-of-the-art results on benchmark datasets such as PASCAL VOC 2012, Cityscapes, and COCO.

DragNeXt: Rethinking Drag-Based Image Editing

Drag-Based Image Editing (DBIE), which allows users to manipulate images by directly dragging objects within them, has recently attracted much attention from the community. However, it faces two key challenges: (\emph{\textcolor{magenta}{i}}) point-based drag is often highly ambiguous and difficult to align with users' intentions; (\emph{\textcolor{magenta}{ii}}) current DBIE methods primarily rely on alternating between motion supervision and point tracking, which is not only cumbersome but also fails to produce high-quality results. These limitations motivate us to explore DBIE from a new perspective -- redefining it as deformation, rotation, and translation of user-specified handle regions. Thereby, by requiring users to explicitly specify both drag areas and types, we can effectively address the ambiguity issue. Furthermore, we propose a simple-yet-effective editing framework, dubbed \textcolor{SkyBlue}{\textbf{DragNeXt}}. It unifies DBIE as a Latent Region Optimization (LRO) problem and solves it through Progressive Backward Self-Intervention (PBSI), simplifying the overall procedure of DBIE while further enhancing quality by fully leveraging region-level structure information and progressive guidance from intermediate drag states. We validate \textcolor{SkyBlue}{\textbf{DragNeXt}} on our NextBench, and extensive experiments demonstrate that our proposed method can significantly outperform existing approaches. Code will be released on github.

ATI: Any Trajectory Instruction for Controllable Video Generation

We propose a unified framework for motion control in video generation that seamlessly integrates camera movement, object-level translation, and fine-grained local motion using trajectory-based inputs. In contrast to prior methods that address these motion types through separate modules or task-specific designs, our approach offers a cohesive solution by projecting user-defined trajectories into the latent space of pre-trained image-to-video generation models via a lightweight motion injector. Users can specify keypoints and their motion paths to control localized deformations, entire object motion, virtual camera dynamics, or combinations of these. The injected trajectory signals guide the generative process to produce temporally consistent and semantically aligned motion sequences. Our framework demonstrates superior performance across multiple video motion control tasks, including stylized motion effects (e.g., motion brushes), dynamic viewpoint changes, and precise local motion manipulation. Experiments show that our method provides significantly better controllability and visual quality compared to prior approaches and commercial solutions, while remaining broadly compatible with various state-of-the-art video generation backbones. Project page: https://anytraj.github.io/.

Multimodal Spatial Language Maps for Robot Navigation and Manipulation

Grounding language to a navigating agent's observations can leverage pretrained multimodal foundation models to match perceptions to object or event descriptions. However, previous approaches remain disconnected from environment mapping, lack the spatial precision of geometric maps, or neglect additional modality information beyond vision. To address this, we propose multimodal spatial language maps as a spatial map representation that fuses pretrained multimodal features with a 3D reconstruction of the environment. We build these maps autonomously using standard exploration. We present two instances of our maps, which are visual-language maps (VLMaps) and their extension to audio-visual-language maps (AVLMaps) obtained by adding audio information. When combined with large language models (LLMs), VLMaps can (i) translate natural language commands into open-vocabulary spatial goals (e.g., "in between the sofa and TV") directly localized in the map, and (ii) be shared across different robot embodiments to generate tailored obstacle maps on demand. Building upon the capabilities above, AVLMaps extend VLMaps by introducing a unified 3D spatial representation integrating audio, visual, and language cues through the fusion of features from pretrained multimodal foundation models. This enables robots to ground multimodal goal queries (e.g., text, images, or audio snippets) to spatial locations for navigation. Additionally, the incorporation of diverse sensory inputs significantly enhances goal disambiguation in ambiguous environments. Experiments in simulation and real-world settings demonstrate that our multimodal spatial language maps enable zero-shot spatial and multimodal goal navigation and improve recall by 50% in ambiguous scenarios. These capabilities extend to mobile robots and tabletop manipulators, supporting navigation and interaction guided by visual, audio, and spatial cues.

Design and Evaluation of Deep Learning-Based Dual-Spectrum Image Fusion Methods

Visible images offer rich texture details, while infrared images emphasize salient targets. Fusing these complementary modalities enhances scene understanding, particularly for advanced vision tasks under challenging conditions. Recently, deep learning-based fusion methods have gained attention, but current evaluations primarily rely on general-purpose metrics without standardized benchmarks or downstream task performance. Additionally, the lack of well-developed dual-spectrum datasets and fair algorithm comparisons hinders progress. To address these gaps, we construct a high-quality dual-spectrum dataset captured in campus environments, comprising 1,369 well-aligned visible-infrared image pairs across four representative scenarios: daytime, nighttime, smoke occlusion, and underpasses. We also propose a comprehensive and fair evaluation framework that integrates fusion speed, general metrics, and object detection performance using the lang-segment-anything model to ensure fairness in downstream evaluation. Extensive experiments benchmark several state-of-the-art fusion algorithms under this framework. Results demonstrate that fusion models optimized for downstream tasks achieve superior performance in target detection, especially in low-light and occluded scenes. Notably, some algorithms that perform well on general metrics do not translate to strong downstream performance, highlighting limitations of current evaluation practices and validating the necessity of our proposed framework. The main contributions of this work are: (1)a campus-oriented dual-spectrum dataset with diverse and challenging scenes; (2) a task-aware, comprehensive evaluation framework; and (3) thorough comparative analysis of leading fusion methods across multiple datasets, offering insights for future development.

Subspecialty-Specific Foundation Model for Intelligent Gastrointestinal Pathology

Gastrointestinal (GI) diseases represent a clinically significant burden, necessitating precise diagnostic approaches to optimize patient outcomes. Conventional histopathological diagnosis, heavily reliant on the subjective interpretation of pathologists, suffers from limited reproducibility and diagnostic variability. To overcome these limitations and address the lack of pathology-specific foundation models for GI diseases, we develop Digepath, a specialized foundation model for GI pathology. Our framework introduces a dual-phase iterative optimization strategy combining pretraining with fine-screening, specifically designed to address the detection of sparsely distributed lesion areas in whole-slide images. Digepath is pretrained on more than 353 million image patches from over 200,000 hematoxylin and eosin-stained slides of GI diseases. It attains state-of-the-art performance on 33 out of 34 tasks related to GI pathology, including pathological diagnosis, molecular prediction, gene mutation prediction, and prognosis evaluation, particularly in diagnostically ambiguous cases and resolution-agnostic tissue classification.We further translate the intelligent screening module for early GI cancer and achieve near-perfect 99.6% sensitivity across 9 independent medical institutions nationwide. The outstanding performance of Digepath highlights its potential to bridge critical gaps in histopathological practice. This work not only advances AI-driven precision pathology for GI diseases but also establishes a transferable paradigm for other pathology subspecialties.

A Culturally-diverse Multilingual Multimodal Video Benchmark & Model

Large multimodal models (LMMs) have recently gained attention due to their effectiveness to understand and generate descriptions of visual content. Most existing LMMs are in English language. While few recent works explore multilingual image LMMs, to the best of our knowledge, moving beyond the English language for cultural and linguistic inclusivity is yet to be investigated in the context of video LMMs. In pursuit of more inclusive video LMMs, we introduce a multilingual Video LMM benchmark, named ViMUL-Bench, to evaluate Video LMMs across 14 languages, including both low- and high-resource languages: English, Chinese, Spanish, French, German, Hindi, Arabic, Russian, Bengali, Urdu, Sinhala, Tamil, Swedish, and Japanese. Our ViMUL-Bench is designed to rigorously test video LMMs across 15 categories including eight culturally diverse categories, ranging from lifestyles and festivals to foods and rituals and from local landmarks to prominent cultural personalities. ViMUL-Bench comprises both open-ended (short and long-form) and multiple-choice questions spanning various video durations (short, medium, and long) with 8k samples that are manually verified by native language speakers. In addition, we also introduce a machine translated multilingual video training set comprising 1.2 million samples and develop a simple multilingual video LMM, named ViMUL, that is shown to provide a better tradeoff between high-and low-resource languages for video understanding. We hope our ViMUL-Bench and multilingual video LMM along with a large-scale multilingual video training set will help ease future research in developing cultural and linguistic inclusive multilingual video LMMs. Our proposed benchmark, video LMM and training data will be publicly released at https://mbzuai-oryx.github.io/ViMUL/.

AquaMonitor: A multimodal multi-view image sequence dataset for real-life aquatic invertebrate biodiversity monitoring

This paper presents the AquaMonitor dataset, the first large computer vision dataset of aquatic invertebrates collected during routine environmental monitoring. While several large species identification datasets exist, they are rarely collected using standardized collection protocols, and none focus on aquatic invertebrates, which are particularly laborious to collect. For AquaMonitor, we imaged all specimens from two years of monitoring whenever imaging was possible given practical limitations. The dataset enables the evaluation of automated identification methods for real-life monitoring purposes using a realistically challenging and unbiased setup. The dataset has 2.7M images from 43,189 specimens, DNA sequences for 1358 specimens, and dry mass and size measurements for 1494 specimens, making it also one of the largest biological multi-view and multimodal datasets to date. We define three benchmark tasks and provide strong baselines for these: 1) Monitoring benchmark, reflecting real-life deployment challenges such as open-set recognition, distribution shift, and extreme class imbalance, 2) Classification benchmark, which follows a standard fine-grained visual categorization setup, and 3) Few-shot benchmark, which targets classes with only few training examples from very fine-grained categories. Advancements on the Monitoring benchmark can directly translate to improvement of aquatic biodiversity monitoring, which is an important component of regular legislative water quality assessment in many countries.