Image-to-image translation is the process of converting an image from one domain to another using deep learning techniques.
We study the online centralized charging scheduling problem (OCCSP). In this problem, a central authority must decide, in real time, when to charge dynamically arriving electric vehicles (EVs), subject to capacity limits, with the objective of balancing load across a finite planning horizon. To solve the problem, we first gamify it; that is, we model it as a game where charging blocks are placed within temporal and capacity constraints on a grid. We design heuristic policies, train learning agents with expert demonstrations, and improve them using Dataset Aggregation (DAgger). From a theoretical standpoint, we show that gamification reduces model complexity and yields tighter generalization bounds than vector-based formulations. Experiments across multiple EV arrival patterns confirm that gamified learning enhances load balancing. In particular, the image-to-movement model trained with DAgger consistently outperforms heuristic baselines, vector-based approaches, and supervised learning agents, while also demonstrating robustness in sensitivity analyses. These operational gains translate into tangible economic value. In a real-world case study for the Greater Montréal Area (Québec, Canada) using utility cost data, the proposed methods lower system costs by tens of millions of dollars per year over the prevailing practice and show clear potential to delay costly grid upgrades.
Attention mechanisms represent a fundamental paradigm shift in neural network architectures, enabling models to selectively focus on relevant portions of input sequences through learned weighting functions. This monograph provides a comprehensive and rigorous mathematical treatment of attention mechanisms, encompassing their theoretical foundations, computational properties, and practical implementations in contemporary deep learning systems. Applications in natural language processing, computer vision, and multimodal learning demonstrate the versatility of attention mechanisms. We examine language modeling with autoregressive transformers, bidirectional encoders for representation learning, sequence-to-sequence translation, Vision Transformers for image classification, and cross-modal attention for vision-language tasks. Empirical analysis reveals training characteristics, scaling laws that relate performance to model size and computation, attention pattern visualizations, and performance benchmarks across standard datasets. We discuss the interpretability of learned attention patterns and their relationship to linguistic and visual structures. The monograph concludes with a critical examination of current limitations, including computational scalability, data efficiency, systematic generalization, and interpretability challenges.
Glaucoma is a top cause of irreversible blindness globally, making early detection and longitudinal follow-up pivotal to preventing permanent vision loss. Current screening and progression assessment, however, rely on single tests or loosely linked examinations, introducing subjectivity and fragmented care. Limited access to high-quality imaging tools and specialist expertise further compromises consistency and equity in real-world use. To address these gaps, we developed Fair-Eye Net, a fair, reliable multimodal AI system closing the clinical loop from glaucoma screening to follow-up and risk alerting. It integrates fundus photos, OCT structural metrics, VF functional indices, and demographic factors via a dual-stream heterogeneous fusion architecture, with an uncertainty-aware hierarchical gating strategy for selective prediction and safe referral. A fairness constraint reduces missed diagnoses in disadvantaged subgroups. Experimental results show it achieved an AUC of 0.912 (96.7% specificity), cut racial false-negativity disparity by 73.4% (12.31% to 3.28%), maintained stable cross-domain performance, and enabled 3-12 months of early risk alerts (92% sensitivity, 88% specificity). Unlike post hoc fairness adjustments, Fair-Eye Net optimizes fairness as a primary goal with clinical reliability via multitask learning, offering a reproducible path for clinical translation and large-scale deployment to advance global eye health equity.
Multimodal models excel in English, supported by abundant image-text and audio-text data, but performance drops sharply for other languages due to limited multilingual multimodal resources. Existing solutions rely heavily on machine translation, while advances in multilingual text modeling remain underutilized. We introduce METAL, a lightweight alignment method that learns only a few linear layers using English text alone to map multilingual text embeddings into a multimodal space. Despite its simplicity, METAL matches baseline performance in English (94.9 percent Recall at 10) and achieves strong zero-shot transfer (89.5 percent Recall at 10 averaged across 11 languages, 10 unseen) on XTD text-to-image retrieval. Qualitative t-SNE visualizations show that multilingual embeddings align tightly with multimodal representations, while weight analysis reveals that the transformation reshapes embedding geometry rather than performing trivial rotations. Beyond image-text retrieval, METAL generalizes to audio-text retrieval and cross-lingual text-to-image generation. We release code and checkpoints at https://github.com/m2m-codebase/M2M , as well as multilingual evaluation datasets including MSCOCO Multilingual 30K (https://huggingface.co/datasets/piyushsinghpasi/mscoco-multilingual-30k ), AudioCaps Multilingual (https://huggingface.co/datasets/piyushsinghpasi/audiocaps-multilingual ), and Clotho Multilingual (https://huggingface.co/datasets/piyushsinghpasi/clotho-multilingual ), to facilitate further research.
Scalable and maintainable map representations are fundamental to enabling large-scale visual navigation and facilitating the deployment of robots in real-world environments. While collaborative localization across multi-session mapping enhances efficiency, traditional structure-based methods struggle with high maintenance costs and fail in feature-less environments or under significant viewpoint changes typical of crowd-sourced data. To address this, we propose OPENNAVMAP, a lightweight, structure-free topometric system leveraging 3D geometric foundation models for on-demand reconstruction. Our method unifies dynamic programming-based sequence matching, geometric verification, and confidence-calibrated optimization to robust, coarse-to-fine submap alignment without requiring pre-built 3D models. Evaluations on the Map-Free benchmark demonstrate superior accuracy over structure-from-motion and regression baselines, achieving an average translation error of 0.62m. Furthermore, the system maintains global consistency across 15km of multi-session data with an absolute trajectory error below 3m for map merging. Finally, we validate practical utility through 12 successful autonomous image-goal navigation tasks on simulated and physical robots. Code and datasets will be publicly available in https://rpl-cs-ucl.github.io/OpenNavMap_page.
We present HAQAGen, a unified generative model for resolution-invariant NIR-to-RGB colorization that balances chromatic realism with structural fidelity. The proposed model introduces (i) a combined loss term aligning the global color statistics through differentiable histogram matching, perceptual image quality measure, and feature based similarity to preserve texture information, (ii) local hue-saturation priors injected via Spatially Adaptive Denormalization (SPADE) to stabilize chromatic reconstruction, and (iii) texture-aware supervision within a Mamba backbone to preserve fine details. We introduce an adaptive-resolution inference engine that further enables high-resolution translation without sacrificing quality. Our proposed NIR-to-RGB translation model simultaneously enforces global color statistics and local chromatic consistency, while scaling to native resolutions without compromising texture fidelity or generalization. Extensive evaluations on FANVID, OMSIV, VCIP2020, and RGB2NIR using different evaluation metrics demonstrate consistent improvements over state-of-the-art baseline methods. HAQAGen produces images with sharper textures, natural colors, attaining significant gains as per perceptual metrics. These results position HAQAGen as a scalable and effective solution for NIR-to-RGB translation across diverse imaging scenarios. Project Page: https://rajeev-dw9.github.io/HAQAGen/
Cardiovascular disease arises from interactions between inherited risk, molecular programmes, and tissue-scale remodelling that are observed clinically through imaging. Health systems now routinely generate large volumes of cardiac MRI, CT and echocardiography together with bulk, single-cell and spatial transcriptomics, yet these data are still analysed in separate pipelines. This review examines joint representations that link cardiac imaging phenotypes to transcriptomic and spatially resolved molecular states. An imaging-anchored perspective is adopted in which echocardiography, cardiac MRI and CT define a spatial phenotype of the heart, and bulk, single-cell and spatial transcriptomics provide cell-type- and location-specific molecular context. The biological and technical characteristics of these modalities are first summarised, and representation-learning strategies for each are outlined. Multimodal fusion approaches are reviewed, with emphasis on handling missing data, limited sample size, and batch effects. Finally, integrative pipelines for radiogenomics, spatial molecular alignment, and image-based prediction of gene expression are discussed, together with common failure modes, practical considerations, and open challenges. Spatial multiomics of human myocardium and atherosclerotic plaque, single-cell and spatial foundation models, and multimodal medical foundation models are collectively bringing imaging-anchored multiomics closer to large-scale cardiovascular translation.
Vision-Language-Action (VLA) models have emerged as essential generalist robot policies for diverse manipulation tasks, conventionally relying on directly translating multimodal inputs into actions via Vision-Language Model (VLM) embeddings. Recent advancements have introduced explicit intermediary reasoning, such as sub-task prediction (language) or goal image synthesis (vision), to guide action generation. However, these intermediate reasoning are often indirect and inherently limited in their capacity to convey the full, granular information required for precise action execution. Instead, we posit that the most effective form of reasoning is one that deliberates directly in the action space. We introduce Action Chain-of-Thought (ACoT), a paradigm where the reasoning process itself is formulated as a structured sequence of coarse action intents that guide the final policy. In this paper, we propose ACoT-VLA, a novel architecture that materializes the ACoT paradigm. Specifically, we introduce two complementary components: an Explicit Action Reasoner (EAR) and Implicit Action Reasoner (IAR). The former proposes coarse reference trajectories as explicit action-level reasoning steps, while the latter extracts latent action priors from internal representations of multimodal input, co-forming an ACoT that conditions the downstream action head to enable grounded policy learning. Extensive experiments in real-world and simulation environments demonstrate the superiority of our proposed method, which achieves 98.5%, 84.1%, and 47.4% on LIBERO, LIBERO-Plus and VLABench, respectively.
Sickle cell disease causes erythrocytes to become sickle-shaped, affecting their movement in the bloodstream and reducing oxygen delivery. It has a high global prevalence and places a significant burden on healthcare systems, especially in resource-limited regions. Automated classification of sickle cells in blood images is crucial, allowing the specialist to reduce the effort required and avoid errors when quantifying the deformed cells and assessing the severity of a crisis. Recent studies have proposed various erythrocyte representation and classification methods. Since classification depends solely on cell shape, a suitable approach models erythrocytes as closed planar curves in shape space. This approach employs elastic distances between shapes, which are invariant under rotations, translations, scaling, and reparameterizations, ensuring consistent distance measurements regardless of the curves' position, starting point, or traversal speed. While previous methods exploiting shape space distances had achieved high accuracy, we refined the model by considering the geometric characteristics of healthy and sickled erythrocytes. Our method proposes (1) to employ a fixed parameterization based on the major axis of each cell to compute distances and (2) to align each cell with two templates using this parameterization before computing distances. Aligning shapes to templates before distance computation, a concept successfully applied in areas such as molecular dynamics, and using a fixed parameterization, instead of minimizing distances across all possible parameterizations, simplifies calculations. This strategy achieves 96.03\% accuracy rate in both supervised classification and unsupervised clustering. Our method ensures efficient erythrocyte classification, maintaining or improving accuracy over shape space models while significantly reducing computational costs.
Supervised convolutional neural networks (CNNs) are widely used to solve imaging inverse problems, achieving state-of-the-art performance in numerous applications. However, despite their empirical success, these methods are poorly understood from a theoretical perspective and often treated as black boxes. To bridge this gap, we analyze trained neural networks through the lens of the Minimum Mean Square Error (MMSE) estimator, incorporating functional constraints that capture two fundamental inductive biases of CNNs: translation equivariance and locality via finite receptive fields. Under the empirical training distribution, we derive an analytic, interpretable, and tractable formula for this constrained variant, termed Local-Equivariant MMSE (LE-MMSE). Through extensive numerical experiments across various inverse problems (denoising, inpainting, deconvolution), datasets (FFHQ, CIFAR-10, FashionMNIST), and architectures (U-Net, ResNet, PatchMLP), we demonstrate that our theory matches the neural networks outputs (PSNR $\gtrsim25$dB). Furthermore, we provide insights into the differences between \emph{physics-aware} and \emph{physics-agnostic} estimators, the impact of high-density regions in the training (patch) distribution, and the influence of other factors (dataset size, patch size, etc).