Monocular Marker-free Patient-to-Image Intraoperative Registration for Cochlear Implant Surgery

This paper presents a novel method for monocular patient-to-image intraoperative registration, specifically designed to operate without any external hardware tracking equipment or fiducial point markers. Leveraging a synthetic microscopy surgical scene dataset with a wide range of transformations, our approach directly maps preoperative CT scans to 2D intraoperative surgical frames through a lightweight neural network for real-time cochlear implant surgery guidance via a zero-shot learning approach. Unlike traditional methods, our framework seamlessly integrates with monocular surgical microscopes, making it highly practical for clinical use without additional hardware dependencies and requirements. Our method estimates camera poses, which include a rotation matrix and a translation vector, by learning from the synthetic dataset, enabling accurate and efficient intraoperative registration. The proposed framework was evaluated on nine clinical cases using a patient-specific and cross-patient validation strategy. Our results suggest that our approach achieves clinically relevant accuracy in predicting 6D camera poses for registering 3D preoperative CT scans to 2D surgical scenes with an angular error within 10 degrees in most cases, while also addressing limitations of traditional methods, such as reliance on external tracking systems or fiducial markers.

Weakly-supervised Mamba-Based Mastoidectomy Shape Prediction for Cochlear Implant Surgery Using 3D T-Distribution Loss

Cochlear implant surgery is a treatment for individuals with severe hearing loss. It involves inserting an array of electrodes inside the cochlea to electrically stimulate the auditory nerve and restore hearing sensation. A crucial step in this procedure is mastoidectomy, a surgical intervention that removes part of the mastoid region of the temporal bone, providing a critical pathway to the cochlea for electrode placement. Accurate prediction of the mastoidectomy region from preoperative imaging assists presurgical planning, reduces surgical risks, and improves surgical outcomes. In previous work, a self-supervised network was introduced to predict the mastoidectomy region using only preoperative CT scans. While promising, the method suffered from suboptimal robustness, limiting its practical application. To address this limitation, we propose a novel weakly-supervised Mamba-based framework to predict accurate mastoidectomy regions directly from preoperative CT scans. Our approach utilizes a 3D T-Distribution loss function inspired by the Student-t distribution, which effectively handles the complex geometric variability inherent in mastoidectomy shapes. Weak supervision is achieved using the segmentation results from the prior self-supervised network to eliminate the need for manual data cleaning or labeling throughout the training process. The proposed method is extensively evaluated against state-of-the-art approaches, demonstrating superior performance in predicting accurate and clinically relevant mastoidectomy regions. Our findings highlight the robustness and efficiency of the weakly-supervised learning framework with the proposed novel 3D T-Distribution loss.

Vision6D: 3D-to-2D Interactive Visualization and Annotation Tool for 6D Pose Estimation

Accurate 6D pose estimation has gained more attention over the years for robotics-assisted tasks that require precise interaction with physical objects. This paper presents an interactive 3D-to-2D visualization and annotation tool to support the 6D pose estimation research community. To the best of our knowledge, the proposed work is the first tool that allows users to visualize and manipulate 3D objects interactively on a 2D real-world scene, along with a comprehensive user study. This system supports robust 6D camera pose annotation by providing both visual cues and spatial relationships to determine object position and orientation in various environments. The annotation feature in Vision6D is particularly helpful in scenarios where the transformation matrix between the camera and world objects is unknown, as it enables accurate annotation of these objects' poses using only the camera intrinsic matrix. This capability serves as a foundational step in developing and training advanced pose estimation models across various domains. We evaluate Vision6D's effectiveness by utilizing widely-used open-source pose estimation datasets Linemod and HANDAL through comparisons between the default ground-truth camera poses with manual annotations. A user study was performed to show that Vision6D generates accurate pose annotations via visual cues in an intuitive 3D user interface. This approach aims to bridge the gap between 2D scene projections and 3D scenes, offering an effective way for researchers and developers to solve 6D pose annotation related problems. The software is open-source and publicly available at https://github.com/InteractiveGL/vision6D.

LLMs as Educational Analysts: Transforming Multimodal Data Traces into Actionable Reading Assessment Reports

Reading assessments are essential for enhancing students' comprehension, yet many EdTech applications focus mainly on outcome-based metrics, providing limited insights into student behavior and cognition. This study investigates the use of multimodal data sources -- including eye-tracking data, learning outcomes, assessment content, and teaching standards -- to derive meaningful reading insights. We employ unsupervised learning techniques to identify distinct reading behavior patterns, and then a large language model (LLM) synthesizes the derived information into actionable reports for educators, streamlining the interpretation process. LLM experts and human educators evaluate these reports for clarity, accuracy, relevance, and pedagogical usefulness. Our findings indicate that LLMs can effectively function as educational analysts, turning diverse data into teacher-friendly insights that are well-received by educators. While promising for automating insight generation, human oversight remains crucial to ensure reliability and fairness. This research advances human-centered AI in education, connecting data-driven analytics with practical classroom applications.

SSDD-GAN: Single-Step Denoising Diffusion GAN for Cochlear Implant Surgical Scene Completion

Recent deep learning-based image completion methods, including both inpainting and outpainting, have demonstrated promising results in restoring corrupted images by effectively filling various missing regions. Among these, Generative Adversarial Networks (GANs) and Denoising Diffusion Probabilistic Models (DDPMs) have been employed as key generative image completion approaches, excelling in the field of generating high-quality restorations with reduced artifacts and improved fine details. In previous work, we developed a method aimed at synthesizing views from novel microscope positions for mastoidectomy surgeries; however, that approach did not have the ability to restore the surrounding surgical scene environment. In this paper, we propose an efficient method to complete the surgical scene of the synthetic postmastoidectomy dataset. Our approach leverages self-supervised learning on real surgical datasets to train a Single-Step Denoising Diffusion-GAN (SSDD-GAN), combining the advantages of diffusion models with the adversarial optimization of GANs for improved Structural Similarity results of 6%. The trained model is then directly applied to the synthetic postmastoidectomy dataset using a zero-shot approach, enabling the generation of realistic and complete surgical scenes without the need for explicit ground-truth labels from the synthetic postmastoidectomy dataset. This method addresses key limitations in previous work, offering a novel pathway for full surgical microscopy scene completion and enhancing the usability of the synthetic postmastoidectomy dataset in surgical preoperative planning and intraoperative navigation.

Beyond Instructed Tasks: Recognizing In-the-Wild Reading Behaviors in the Classroom Using Eye Tracking

Understanding reader behaviors such as skimming, deep reading, and scanning is essential for improving educational instruction. While prior eye-tracking studies have trained models to recognize reading behaviors, they often rely on instructed reading tasks, which can alter natural behaviors and limit the applicability of these findings to in-the-wild settings. Additionally, there is a lack of clear definitions for reading behavior archetypes in the literature. We conducted a classroom study to address these issues by collecting instructed and in-the-wild reading data. We developed a mixed-method framework, including a human-driven theoretical model, statistical analyses, and an AI classifier, to differentiate reading behaviors based on their velocity, density, and sequentiality. Our lightweight 2D CNN achieved an F1 score of 0.8 for behavior recognition, providing a robust approach for understanding in-the-wild reading. This work advances our ability to provide detailed behavioral insights to educators, supporting more targeted and effective assessment and instruction.

LUCY: Linguistic Understanding and Control Yielding Early Stage of Her

The film Her features Samantha, a sophisticated AI audio agent who is capable of understanding both linguistic and paralinguistic information in human speech and delivering real-time responses that are natural, informative and sensitive to emotional subtleties. Moving one step toward more sophisticated audio agent from recent advancement in end-to-end (E2E) speech systems, we propose LUCY, a E2E speech model that (1) senses and responds to user's emotion, (2) deliver responses in a succinct and natural style, and (3) use external tool to answer real-time inquiries. Experiment results show that LUCY is better at emotion control than peer models, generating emotional responses based on linguistic emotional instructions and responding to paralinguistic emotional cues. Lucy is also able to generate responses in a more natural style, as judged by external language models, without sacrificing much performance on general question answering. Finally, LUCY can leverage function calls to answer questions that are out of its knowledge scope.

FreeCodec: A disentangled neural speech codec with fewer tokens

Neural speech codecs have gained great attention for their outstanding reconstruction with discrete token representations. It is a crucial component in generative tasks such as speech coding and large language models (LLM). However, most works based on residual vector quantization perform worse with fewer tokens due to low coding efficiency for modeling complex coupled information. In this paper, we propose a neural speech codec named FreeCodec which employs a more effective encoding framework by decomposing intrinsic properties of speech into different components: 1) a global vector is extracted as the timbre information, 2) a prosody encoder with a long stride level is used to model the prosody information, 3) the content information is from a content encoder. Using different training strategies, FreeCodec achieves state-of-the-art performance in reconstruction and disentanglement scenarios. Results from subjective and objective experiments demonstrate that our framework outperforms existing methods.

Surgical Depth Anything: Depth Estimation for Surgical Scenes using Foundation Models

Monocular depth estimation is crucial for tracking and reconstruction algorithms, particularly in the context of surgical videos. However, the inherent challenges in directly obtaining ground truth depth maps during surgery render supervised learning approaches impractical. While many self-supervised methods based on Structure from Motion (SfM) have shown promising results, they rely heavily on high-quality camera motion and require optimization on a per-patient basis. These limitations can be mitigated by leveraging the current state-of-the-art foundational model for depth estimation, Depth Anything. However, when directly applied to surgical scenes, Depth Anything struggles with issues such as blurring, bleeding, and reflections, resulting in suboptimal performance. This paper presents a fine-tuning of the Depth Anything model specifically for the surgical domain, aiming to deliver more accurate pixel-wise depth maps tailored to the unique requirements and challenges of surgical environments. Our fine-tuning approach significantly improves the model's performance in surgical scenes, reducing errors related to blurring and reflections, and achieving a more reliable and precise depth estimation.

Mastoidectomy Multi-View Synthesis from a Single Microscopy Image

Cochlear Implant (CI) procedures involve performing an invasive mastoidectomy to insert an electrode array into the cochlea. In this paper, we introduce a novel pipeline that is capable of generating synthetic multi-view videos from a single CI microscope image. In our approach, we use a patient's pre-operative CT scan to predict the post-mastoidectomy surface using a method designed for this purpose. We manually align the surface with a selected microscope frame to obtain an accurate initial pose of the reconstructed CT mesh relative to the microscope. We then perform UV projection to transfer the colors from the frame to surface textures. Novel views of the textured surface can be used to generate a large dataset of synthetic frames with ground truth poses. We evaluated the quality of synthetic views rendered using Pytorch3D and PyVista. We found both rendering engines lead to similarly high-quality synthetic novel-view frames compared to ground truth with a structural similarity index for both methods averaging about 0.86. A large dataset of novel views with known poses is critical for ongoing training of a method to automatically estimate microscope pose for 2D to 3D registration with the pre-operative CT to facilitate augmented reality surgery. This dataset will empower various downstream tasks, such as integrating Augmented Reality (AR) in the OR, tracking surgical tools, and supporting other video analysis studies.