Segmentation-before-Staining Improves Structural Fidelity in Virtual IHC-to-Multiplex IF Translation

Multiplex immunofluorescence (mIF) enables simultaneous single-cell quantification of multiple biomarkers within intact tissue architecture, yet its high reagent cost, multi-round staining protocols, and need for specialized imaging platforms limit routine clinical adoption. Virtual staining can synthesize mIF channels from widely available brightfield immunohistochemistry (IHC), but current translators optimize pixel-level fidelity without explicitly constraining nuclear morphology. In pathology, this gap is clinically consequential: subtle distortions in nuclei count, shape, or spatial arrangement propagate directly to quantification endpoints such as the Ki67 proliferation index, where errors of a few percent can shift treatment-relevant risk categories. This work introduces a supervision-free, architecture-agnostic conditioning strategy that injects a continuous cell probability map from a pretrained nuclei segmentation foundation model as an explicit input prior, together with a variance-preserving regularization term that matches local intensity statistics to maintain cell-level heterogeneity in synthesized fluorescence channels. The soft prior retains gradient-level boundary information lost by binary thresholding, providing a richer conditioning signal without task-specific tuning. Controlled experiments across Pix2Pix with U-Net and ResNet generators, deterministic regression U-Net, and conditional diffusion on two independent datasets demonstrate consistent improvements in nuclei count fidelity and perceptual quality, as the sole modifications. Code will be made publicly available upon acceptance.

EgoForge: Goal-Directed Egocentric World Simulator

Generative world models have shown promise for simulating dynamic environments, yet egocentric video remains challenging due to rapid viewpoint changes, frequent hand-object interactions, and goal-directed procedures whose evolution depends on latent human intent. Existing approaches either focus on hand-centric instructional synthesis with limited scene evolution, perform static view translation without modeling action dynamics, or rely on dense supervision, such as camera trajectories, long video prefixes, synchronized multicamera capture, etc. In this work, we introduce EgoForge, an egocentric goal-directed world simulator that generates coherent, first-person video rollouts from minimal static inputs: a single egocentric image, a high-level instruction, and an optional auxiliary exocentric view. To improve intent alignment and temporal consistency, we propose VideoDiffusionNFT, a trajectory-level reward-guided refinement that optimizes goal completion, temporal causality, scene consistency, and perceptual fidelity during diffusion sampling. Extensive experiments show EgoForge achieves consistent gains in semantic alignment, geometric stability, and motion fidelity over strong baselines, and robust performance in real-world smart-glasses experiments.

R&D: Balancing Reliability and Diversity in Synthetic Data Augmentation for Semantic Segmentation

Collecting and annotating datasets for pixel-level semantic segmentation tasks are highly labor-intensive. Data augmentation provides a viable solution by enhancing model generalization without additional real-world data collection. Traditional augmentation techniques, such as translation, scaling, and color transformations, create geometric variations but fail to generate new structures. While generative models have been employed to extend semantic information of datasets, they often struggle to maintain consistency between the original and generated images, particularly for pixel-level tasks. In this work, we propose a novel synthetic data augmentation pipeline that integrates controllable diffusion models. Our approach balances diversity and reliability data, effectively bridging the gap between synthetic and real data. We utilize class-aware prompting and visual prior blending to improve image quality further, ensuring precise alignment with segmentation labels. By evaluating benchmark datasets such as PASCAL VOC and BDD100K, we demonstrate that our method significantly enhances semantic segmentation performance, especially in data-scarce scenarios, while improving model robustness in real-world applications. Our code is available at \href{https://github.com/chequanghuy/Enhanced-Generative-Data-Augmentation-for-Semantic-Segmentation-via-Stronger-Guidance}{https://github.com/chequanghuy/Enhanced-Generative-Data-Augmentation-for-Semantic-Segmentation-via-Stronger-Guidance}.

A Systematic Benchmark of GAN Architectures for MRI-to-CT Synthesis

The translation from Magnetic resonance imaging (MRI) to Computed tomography (CT) has been proposed as an effective solution to facilitate MRI-only clinical workflows while limiting exposure to ionizing radiation. Although numerous Generative Adversarial Network (GAN) architectures have been proposed for MRI-to-CT translation, systematic and fair comparisons across heterogeneous models remain limited. We present a comprehensive benchmark of ten GAN architectures evaluated on the SynthRAD2025 dataset across three anatomical districts (abdomen, thorax, head-and-neck). All models were trained under a unified validation protocol with identical preprocessing and optimization settings. Performance was assessed using complementary metrics capturing voxel-wise accuracy, structural fidelity, perceptual quality, and distribution-level realism, alongside an analysis of computational complexity. Supervised Paired models consistently outperformed Unpaired approaches, confirming the importance of voxel-wise supervision. Pix2Pix achieved the most balanced performance across districts while maintaining a favorable quality-to-complexity trade-off. Multi-district training improved structural robustness, whereas intra-district training maximized voxel-wise fidelity. This benchmark provides quantitative and computational guidance for model selection in MRI-only radiotherapy workflows and establishes a reproducible framework for future comparative studies. To ensure the reproducibility of our experiments we make our code public, together with the overall results, at the following link:https://github.com/arco-group/MRI_TO_CT.git

Universal Skeleton Understanding via Differentiable Rendering and MLLMs

Multimodal large language models (MLLMs) exhibit strong visual-language reasoning, yet remain confined to their native modalities and cannot directly process structured, non-visual data such as human skeletons. Existing methods either compress skeleton dynamics into lossy feature vectors for text alignment, or quantize motion into discrete tokens that generalize poorly across heterogeneous skeleton formats. We present SkeletonLLM, which achieves universal skeleton understanding by translating arbitrary skeleton sequences into the MLLM's native visual modality. At its core is DrAction, a differentiable, format-agnostic renderer that converts skeletal kinematics into compact image sequences. Because the pipeline is end-to-end differentiable, MLLM gradients can directly guide the rendering to produce task-informative visual tokens. To further enhance reasoning capabilities, we introduce a cooperative training strategy: Causal Reasoning Distillation transfers structured, step-by-step reasoning from a teacher model, while Discriminative Finetuning sharpens decision boundaries between confusable actions. SkeletonLLM demonstrates strong generalization on diverse tasks including recognition, captioning, reasoning, and cross-format transfer -- suggesting a viable path for applying MLLMs to non-native modalities. Code will be released upon acceptance.

When Minor Edits Matter: LLM-Driven Prompt Attack for Medical VLM Robustness in Ultrasound

Ultrasound is widely used in clinical practice due to its portability, cost-effectiveness, safety, and real-time imaging capabilities. However, image acquisition and interpretation remain highly operator dependent, motivating the development of robust AI-assisted analysis methods. Vision-language models (VLMs) have recently demonstrated strong multimodal reasoning capabilities and competitive performance in medical image analysis, including ultrasound. However, emerging evidence highlights significant concerns about their trustworthiness. In particular, adversarial robustness is critical because Med-VLMs operate via natural-language instructions, rendering prompt formulation a realistic and practically exploitable point of vulnerability. Small variations (typos, shorthand, underspecified requests, or ambiguous wording) can meaningfully shift model outputs. We propose a scalable adversarial evaluation framework that leverages a large language model (LLM) to generate clinically plausible adversarial prompt variants via "humanized" rewrites and minimal edits that mimic routine clinical communication. Using ultrasound multiple-choice question answering benchmarks, we systematically assess the vulnerability of SOTA Med-VLMs to these attacks, examine how attacker LLM capacity influences attack success, analyze the relationship between attack success and model confidence, and identify consistent failure patterns across models. Our results highlight realistic robustness gaps that must be addressed for safe clinical translation. Code will be released publicly following the review process.

WeEdit: A Dataset, Benchmark and Glyph-Guided Framework for Text-centric Image Editing

Instruction-based image editing aims to modify specific content within existing images according to user-provided instructions while preserving non-target regions. Beyond traditional object- and style-centric manipulation, text-centric image editing focuses on modifying, translating, or rearranging textual elements embedded within images. However, existing leading models often struggle to execute complex text editing precisely, frequently producing blurry or hallucinated characters. We attribute these failures primarily to the lack of specialized training paradigms tailored for text-centric editing, as well as the absence of large-scale datasets and standardized benchmarks necessary for a closed-loop training and evaluation system. To address these limitations, we present WeEdit, a systematic solution encompassing a scalable data construction pipeline, two benchmarks, and a tailored two-stage training strategy. Specifically, we propose a novel HTML-based automatic editing pipeline, which generates 330K training pairs covering diverse editing operations and 15 languages, accompanied by standardized bilingual and multilingual benchmarks for comprehensive evaluation. On the algorithmic side, we employ glyph-guided supervised fine-tuning to inject explicit spatial and content priors, followed by a multi-objective reinforcement learning stage to align generation with instruction adherence, text clarity, and background preservation. Extensive experiments demonstrate that WeEdit outperforms previous open-source models by a clear margin across diverse editing operations.

SA-CycleGAN-2.5D: Self-Attention CycleGAN with Tri-Planar Context for Multi-Site MRI Harmonization

Multi-site neuroimaging analysis is fundamentally confounded by scanner-induced covariate shifts, where the marginal distribution of voxel intensities $P(\mathbf{x})$ varies non-linearly across acquisition protocols while the conditional anatomy $P(\mathbf{y}|\mathbf{x})$ remains constant. This is particularly detrimental to radiomic reproducibility, where acquisition variance often exceeds biological pathology variance. Existing statistical harmonization methods (e.g., ComBat) operate in feature space, precluding spatial downstream tasks, while standard deep learning approaches are theoretically bounded by local effective receptive fields (ERF), failing to model the global intensity correlations characteristic of field-strength bias. We propose SA-CycleGAN-2.5D, a domain adaptation framework motivated by the $HΔH$-divergence bound of Ben-David et al., integrating three architectural innovations: (1) A 2.5D tri-planar manifold injection preserving through-plane gradients $\nabla_z$ at $O(HW)$ complexity; (2) A U-ResNet generator with dense voxel-to-voxel self-attention, surpassing the $O(\sqrt{L})$ receptive field limit of CNNs to model global scanner field biases; and (3) A spectrally-normalized discriminator constraining the Lipschitz constant ($K_D \le 1$) for stable adversarial optimization. Evaluated on 654 glioma patients across two institutional domains (BraTS and UPenn-GBM), our method reduces Maximum Mean Discrepancy (MMD) by 99.1% ($1.729 \to 0.015$) and degrades domain classifier accuracy to near-chance (59.7%). Ablation confirms that global attention is statistically essential (Cohen's $d = 1.32$, $p < 0.001$) for the harder heterogeneous-to-homogeneous translation direction. By bridging 2D efficiency and 3D consistency, our framework yields voxel-level harmonized images that preserve tumor pathophysiology, enabling reproducible multi-center radiomic analysis.

CodePercept: Code-Grounded Visual STEM Perception for MLLMs

When MLLMs fail at Science, Technology, Engineering, and Mathematics (STEM) visual reasoning, a fundamental question arises: is it due to perceptual deficiencies or reasoning limitations? Through systematic scaling analysis that independently scales perception and reasoning components, we uncover a critical insight: scaling perception consistently outperforms scaling reasoning. This reveals perception as the true lever limiting current STEM visual reasoning. Motivated by this insight, our work focuses on systematically enhancing the perception capabilities of MLLMs by establishing code as a powerful perceptual medium--executable code provides precise semantics that naturally align with the structured nature of STEM visuals. Specifically, we construct ICC-1M, a large-scale dataset comprising 1M Image-Caption-Code triplets that materializes this code-as-perception paradigm through two complementary approaches: (1) Code-Grounded Caption Generation treats executable code as ground truth for image captions, eliminating the hallucinations inherent in existing knowledge distillation methods; (2) STEM Image-to-Code Translation prompts models to generate reconstruction code, mitigating the ambiguity of natural language for perception enhancement. To validate this paradigm, we further introduce STEM2Code-Eval, a novel benchmark that directly evaluates visual perception in STEM domains. Unlike existing work relying on problem-solving accuracy as a proxy that only measures problem-relevant understanding, our benchmark requires comprehensive visual comprehension through executable code generation for image reconstruction, providing deterministic and verifiable assessment. Code is available at https://github.com/TongkunGuan/Qwen-CodePercept.

UNet-AF: An alias-free UNet for image restoration

The simplicity and effectiveness of the UNet architecture makes it ubiquitous in image restoration, image segmentation, and diffusion models. They are often assumed to be equivariant to translations, yet they traditionally consist of layers that are known to be prone to aliasing, which hinders their equivariance in practice. To overcome this limitation, we propose a new alias-free UNet designed from a careful selection of state-of-the-art translation-equivariant layers. We evaluate the proposed equivariant architecture against non-equivariant baselines on image restoration tasks and observe competitive performance with a significant increase in measured equivariance. Through extensive ablation studies, we also demonstrate that each change is crucial for its empirical equivariance. Our implementation is available at https://github.com/jscanvic/UNet-AF