Image-based Quantification of Postural Deviations on Patients with Cervical Dystonia: A Machine Learning Approach Using Synthetic Training Data

Cervical dystonia (CD) is the most common form of dystonia, yet current assessment relies on subjective clinical rating scales, such as the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), which requires expertise, is subjective and faces low inter-rater reliability some items of the score. To address the lack of established objective tools for monitoring disease severity and treatment response, this study validates an automated image-based head pose and shift estimation system for patients with CD. We developed an assessment tool that combines a pretrained head-pose estimation algorithm for rotational symptoms with a deep learning model trained exclusively on ~16,000 synthetic avatar images to evaluate rare translational symptoms, specifically lateral shift. This synthetic data approach overcomes the scarcity of clinical training examples. The system's performance was validated in a multicenter study by comparing its predicted scores against the consensus ratings of 20 clinical experts using a dataset of 100 real patient images and 100 labeled synthetic avatars. The automated system demonstrated strong agreement with expert clinical ratings for rotational symptoms, achieving high correlations for torticollis (r=0.91), laterocollis (r=0.81), and anteroretrocollis (r=0.78). For lateral shift, the tool achieved a moderate correlation (r=0.55) with clinical ratings and demonstrated higher accuracy than human raters in controlled benchmark tests on avatars. By leveraging synthetic training data to bridge the clinical data gap, this model successfully generalizes to real-world patients, providing a validated, objective tool for CD postural assessment that can enable standardized clinical decision-making and trial evaluation.

SD-FSMIS: Adapting Stable Diffusion for Few-Shot Medical Image Segmentation

Few-Shot Medical Image Segmentation (FSMIS) aims to segment novel object classes in medical images using only minimal annotated examples, addressing the critical challenges of data scarcity and domain shifts prevalent in medical imaging. While Diffusion Models (DM) excel in visual tasks, their potential for FSMIS remains largely unexplored. We propose that the rich visual priors learned by large-scale DMs offer a powerful foundation for a more robust and data-efficient segmentation approach. In this paper, we introduce SD-FSMIS, a novel framework designed to effectively adapt the powerful pre-trained Stable Diffusion (SD) model for the FSMIS task. Our approach repurposes its conditional generative architecture by introducing two key components: a Support-Query Interaction (SQI) and a Visual-to-Textual Condition Translator (VTCT). Specifically, SQI provides a straightforward yet powerful means of adapting SD to the FSMIS paradigm. The VTCT module translates visual cues from the support set into an implicit textual embedding that guides the diffusion model, enabling precise conditioning of the generation process. Extensive experiments demonstrate that SD-FSMIS achieves competitive results compared to state-of-the-art methods in standard settings. Surprisingly, it also demonstrated excellent generalization ability in more challenging cross-domain scenarios. These findings highlight the immense potential of adapting large-scale generative models to advance data-efficient and robust medical image segmentation.

Structured Observation Language for Efficient and Generalizable Vision-Language Navigation

Vision-Language Navigation (VLN) requires an embodied agent to navigate complex environments by following natural language instructions, which typically demands tight fusion of visual and language modalities. Existing VLN methods often convert raw images into visual tokens or implicit features, requiring large-scale visual pre-training and suffering from poor generalization under environmental variations (e.g., lighting, texture). To address these issues, we propose SOL-Nav (Structured Observation Language for Navigation), a novel framework that translates egocentric visual observations into compact structured language descriptions for efficient and generalizable navigation. Specifically, we divide RGB-D images into a N*N grid, extract representative semantic, color, and depth information for each grid cell to form structured text, and concatenate this with the language instruction as pure language input to a pre-trained language model (PLM). Experimental results on standard VLN benchmarks (R2R, RxR) and real-world deployments demonstrate that SOL-Nav significantly reduces the model size and training data dependency, fully leverages the reasoning and representation capabilities of PLMs, and achieves strong generalization to unseen environments.

M2H-MX: Multi-Task Dense Visual Perception for Real-Time Monocular Spatial Understanding

Monocular cameras are attractive for robotic perception due to their low cost and ease of deployment, yet achieving reliable real-time spatial understanding from a single image stream remains challenging. While recent multi-task dense prediction models have improved per-pixel depth and semantic estimation, translating these advances into stable monocular mapping systems is still non-trivial. This paper presents M2H-MX, a real-time multi-task perception model for monocular spatial understanding. The model preserves multi-scale feature representations while introducing register-gated global context and controlled cross-task interaction in a lightweight decoder, enabling depth and semantic predictions to reinforce each other under strict latency constraints. Its outputs integrate directly into an unmodified monocular SLAM pipeline through a compact perception-to-mapping interface. We evaluate both dense prediction accuracy and in-the-loop system performance. On NYUDv2, M2H-MX-L achieves state-of-the-art results, improving semantic mIoU by 6.6% and reducing depth RMSE by 9.4% over representative multi-task baselines. When deployed in a real-time monocular mapping system on ScanNet, M2H-MX reduces average trajectory error by 60.7% compared to a strong monocular SLAM baseline while producing cleaner metric-semantic maps. These results demonstrate that modern multi-task dense prediction can be reliably deployed for real-time monocular spatial perception in robotic systems.

MEDIC-AD: Towards Medical Vision-Language Model's Clinical Intelligence

Lesion detection, symptom tracking, and visual explainability are central to real-world medical image analysis, yet current medical Vision-Language Models (VLMs) still lack mechanisms that translate their broad knowledge into clinically actionable outputs. To bridge this gap, we present MEDIC-AD, a clinically oriented VLM that strengthens these three capabilities through a stage-wise framework. First, learnable anomaly-aware tokens (<Ano>) encourage the model to focus on abnormal regions and build more discriminative lesion centered representations. Second, inter image difference tokens (<Diff>) explicitly encode temporal changes between studies, allowing the model to distinguish worsening, improvement, and stability in disease burden. Finally, a dedicated explainability stage trains the model to generate heatmaps that highlight lesion-related regions, offering clear visual evidence that is consistent with the model's reasoning. Through our staged design, MEDIC-AD steadily boosts performance across anomaly detection, symptom tracking, and anomaly segmentation, achieving state-of-the-art results compared with both closed source and medical-specialized baselines. Evaluations on real longitudinal clinical data collected from real hospital workflows further show that MEDIC-AD delivers stable predictions and clinically faithful explanations in practical patient-monitoring and decision-support workflows

Enhancing behavioral nudges with large language model-based iterative personalization: A field experiment on electricity and hot-water conservation

Nudging is widely used to promote behavioral change, but its effectiveness is often limited when recipients must repeatedly translate feedback into workable next steps under changing circumstances. Large language models (LLMs) may help reduce part of this cognitive work by generating personalized guidance and updating it iteratively across intervention rounds. We developed an LLM agent for iterative personalization and tested it in a three-arm randomized experiment among 233 university residents in China, using daily electricity and shower hot-water conservation as objectively measured cases differing in friction. LLM-personalized nudges (T2) produced the largest conservation effects, while image-enhanced conventional nudges (T1) and text-based conventional nudges (C) showed similar outcomes (omnibus p = 0.009). Relative to C, T2 reduced electricity consumption by 0.56 kWh per room-day (p = 0.014), corresponding to an 18.3 percentage-point higher adjusted saving rate. This advantage emerged within the first two intervention rounds, alongside iterative updating of personalized guidance, and persisted thereafter. Hot-water outcomes followed the same direction but were smaller, less precisely estimated, and attenuated over time, consistent with stronger friction in this domain. LLM-personalized nudges emphasized prospective and context-specific guidance and were associated with higher participant engagement. This study provides field evidence that LLM-based iterative personalization can enhance behavioral nudging, with behavioral friction as a potential boundary condition. Larger trials and extension to more behaviors are warranted.

IMTBench: A Multi-Scenario Cross-Modal Collaborative Evaluation Benchmark for In-Image Machine Translation

End-to-end In-Image Machine Translation (IIMT) aims to convert text embedded within an image into a target language while preserving the original visual context, layout, and rendering style. However, existing IIMT benchmarks are largely synthetic and thus fail to reflect real-world complexity, while current evaluation protocols focus on single-modality metrics and overlook cross-modal faithfulness between rendered text and model outputs. To address these shortcomings, we present In-image Machine Translation Benchmark (IMTBench), a new benchmark of 2,500 image translation samples covering four practical scenarios and nine languages. IMTBench supports multi-aspect evaluation, including translation quality, background preservation, overall image quality, and a cross-modal alignment score that measures consistency between the translated text produced by the model and the text rendered in the translated image. We benchmark strong commercial cascade systems, and both closed- and open-source unified multi-modal models, and observe large performance gaps across scenarios and languages, especially on natural scenes and resource-limited languages, highlighting substantial headroom for end-to-end image text translation. We hope IMTBench establishes a standardized benchmark to accelerate progress in this emerging task.

A Reasoning-Enabled Vision-Language Foundation Model for Chest X-ray Interpretation

Chest X-rays (CXRs) are among the most frequently performed imaging examinations worldwide, yet rising imaging volumes increase radiologist workload and the risk of diagnostic errors. Although artificial intelligence (AI) systems have shown promise for CXR interpretation, most generate only final predictions, without making explicit how visual evidence is translated into radiographic findings and diagnostic predictions. We present CheXOne, a reasoning-enabled vision-language model for CXR interpretation. CheXOne jointly generates diagnostic predictions and explicit, clinically grounded reasoning traces that connect visual evidence, radiographic findings, and these predictions. The model is trained on 14.7 million instruction and reasoning samples curated from 30 public datasets spanning 36 CXR interpretation tasks, using a two-stage framework that combines instruction tuning with reinforcement learning to improve reasoning quality. We evaluate CheXOne in zero-shot settings across visual question answering, report generation, visual grounding and reasoning assessment, covering 17 evaluation settings. CheXOne outperforms existing medical and general-domain foundation models and achieves strong performance on independent public benchmarks. A clinical reader study demonstrates that CheXOne-drafted reports are comparable to or better than resident-written reports in 55% of cases, while effectively addressing clinical indications and enhancing both report writing and CXR interpretation efficiency. Further analyses involving radiologists reveal that the generated reasoning traces show high clinical factuality and provide causal support for the final predictions, offering a plausible explanation for the performance gains. These results suggest that explicit reasoning can improve model performance, interpretability and clinical utility in AI-assisted CXR interpretation.

TuLaBM: Tumor-Biased Latent Bridge Matching for Contrast-Enhanced MRI Synthesis

Contrast-enhanced magnetic resonance imaging (CE-MRI) plays a crucial role in brain tumor assessment; however, its acquisition requires gadolinium-based contrast agents (GBCAs), which increase costs and raise safety concerns. Consequently, synthesizing CE-MRI from non-contrast MRI (NC-MRI) has emerged as a promising alternative. Early Generative Adversarial Network (GAN)-based approaches suffered from instability and mode collapse, while diffusion models, despite impressive synthesis quality, remain computationally expensive and often fail to faithfully reproduce critical tumor contrast patterns. To address these limitations, we propose Tumor-Biased Latent Bridge Matching (TuLaBM), which formulates NC-to-CE MRI translation as Brownian bridge transport between source and target distributions in a learned latent space, enabling efficient training and inference. To enhance tumor-region fidelity, we introduce a Tumor-Biased Attention Mechanism (TuBAM) that amplifies tumor-relevant latent features during bridge evolution, along with a boundary-aware loss that constrains tumor interfaces to improve margin sharpness. While bridge matching has been explored for medical image translation in pixel space, our latent formulation substantially reduces computational cost and inference time. Experiments on BraTS2023-GLI (BraSyn) and Cleveland Clinic (in-house) liver MRI dataset show that TuLaBM consistently outperforms state-of-the-art baselines on both whole-image and tumor-region metrics, generalizes effectively to unseen liver MRI data in zero-shot and fine-tuned settings, and achieves inference times under 0.097 seconds per image.

HyPER-GAN: Hybrid Patch-Based Image-to-Image Translation for Real-Time Photorealism Enhancement

Generative models are widely employed to enhance the photorealism of synthetic data for training computer vision algorithms. However, they often introduce visual artifacts that degrade the accuracy of these algorithms and require high computational resources, limiting their applicability in real-time training or evaluation scenarios. In this paper, we propose Hybrid Patch Enhanced Realism Generative Adversarial Network (HyPER-GAN), a lightweight image-to-image translation method based on a U-Net-style generator designed for real-time inference. The model is trained using paired synthetic and photorealism-enhanced images, complemented by a hybrid training strategy that incorporates matched patches from real-world data to improve visual realism and semantic consistency. Experimental results demonstrate that HyPER-GAN outperforms state-of-the-art paired image-to-image translation methods in terms of inference latency, visual realism, and semantic robustness. Moreover, it is illustrated that the proposed hybrid training strategy indeed improves visual quality and semantic consistency compared to training the model solely with paired synthetic and photorealism-enhanced images. Code and pretrained models are publicly available for download at: https://github.com/stefanos50/HyPER-GAN