GRLoc: Geometric Representation Regression for Visual Localization

Absolute Pose Regression (APR) has emerged as a compelling paradigm for visual localization. However, APR models typically operate as black boxes, directly regressing a 6-DoF pose from a query image, which can lead to memorizing training views rather than understanding 3D scene geometry. In this work, we propose a geometrically-grounded alternative. Inspired by novel view synthesis, which renders images from intermediate geometric representations, we reformulate APR as its inverse that regresses the underlying 3D representations directly from the image, and we name this paradigm Geometric Representation Regression (GRR). Our model explicitly predicts two disentangled geometric representations in the world coordinate system: (1) a ray bundle's directions to estimate camera rotation, and (2) a corresponding pointmap to estimate camera translation. The final 6-DoF camera pose is then recovered from these geometric components using a differentiable deterministic solver. This disentangled approach, which separates the learned visual-to-geometry mapping from the final pose calculation, introduces a strong geometric prior into the network. We find that the explicit decoupling of rotation and translation predictions measurably boosts performance. We demonstrate state-of-the-art performance on 7-Scenes and Cambridge Landmarks datasets, validating that modeling the inverse rendering process is a more robust path toward generalizable absolute pose estimation.

Enabling Fast and Accurate Neutral Atom Readout through Image Denoising

Neutral atom quantum computers hold promise for scaling up to hundreds of thousands of qubits, but their progress is constrained by slow qubit readout. Measuring qubits currently takes milliseconds-much longer than the underlying quantum gate operations-making readout the primary bottleneck in deploying quantum error correction. Because each round of QEC depends on measurement, long readout times increase cycle duration and slow down program execution. Reducing the readout duration speeds up cycles and reduces decoherence errors that accumulate while qubits idle, but it also lowers the number of collected photons, making measurements noisier and more error-prone. This tradeoff leaves neutral atom systems stuck between slow but accurate readout and fast but unreliable readout. We show that image denoising can resolve this tension. Our framework, GANDALF, uses explicit denoising using image translation to reconstruct clear signals from short, low-photon measurements, enabling reliable classification at up to 1.6x shorter readout times. Combined with lightweight classifiers and a pipelined readout design, our approach both reduces logical error rate by up to 35x and overall QEC cycle time up to 1.77x compared to state-of-the-art CNN-based readout for Cesium (Cs) Neutral Atom arrays.

From Retinal Pixels to Patients: Evolution of Deep Learning Research in Diabetic Retinopathy Screening

Diabetic Retinopathy (DR) remains a leading cause of preventable blindness, with early detection critical for reducing vision loss worldwide. Over the past decade, deep learning has transformed DR screening, progressing from early convolutional neural networks trained on private datasets to advanced pipelines addressing class imbalance, label scarcity, domain shift, and interpretability. This survey provides the first systematic synthesis of DR research spanning 2016-2025, consolidating results from 50+ studies and over 20 datasets. We critically examine methodological advances, including self- and semi-supervised learning, domain generalization, federated training, and hybrid neuro-symbolic models, alongside evaluation protocols, reporting standards, and reproducibility challenges. Benchmark tables contextualize performance across datasets, while discussion highlights open gaps in multi-center validation and clinical trust. By linking technical progress with translational barriers, this work outlines a practical agenda for reproducible, privacy-preserving, and clinically deployable DR AI. Beyond DR, many of the surveyed innovations extend broadly to medical imaging at scale.

Alias-Free ViT: Fractional Shift Invariance via Linear Attention

Transformers have emerged as a competitive alternative to convnets in vision tasks, yet they lack the architectural inductive bias of convnets, which may hinder their potential performance. Specifically, Vision Transformers (ViTs) are not translation-invariant and are more sensitive to minor image translations than standard convnets. Previous studies have shown, however, that convnets are also not perfectly shift-invariant, due to aliasing in downsampling and nonlinear layers. Consequently, anti-aliasing approaches have been proposed to certify convnets' translation robustness. Building on this line of work, we propose an Alias-Free ViT, which combines two main components. First, it uses alias-free downsampling and nonlinearities. Second, it uses linear cross-covariance attention that is shift-equivariant to both integer and fractional translations, enabling a shift-invariant global representation. Our model maintains competitive performance in image classification and outperforms similar-sized models in terms of robustness to adversarial translations.

LINGUAL: Language-INtegrated GUidance in Active Learning for Medical Image Segmentation

Although active learning (AL) in segmentation tasks enables experts to annotate selected regions of interest (ROIs) instead of entire images, it remains highly challenging, labor-intensive, and cognitively demanding due to the blurry and ambiguous boundaries commonly observed in medical images. Also, in conventional AL, annotation effort is a function of the ROI- larger regions make the task cognitively easier but incur higher annotation costs, whereas smaller regions demand finer precision and more attention from the expert. In this context, language guidance provides an effective alternative, requiring minimal expert effort while bypassing the cognitively demanding task of precise boundary delineation in segmentation. Towards this goal, we introduce LINGUAL: a framework that receives natural language instructions from an expert, translates them into executable programs through in-context learning, and automatically performs the corresponding sequence of sub-tasks without any human intervention. We demonstrate the effectiveness of LINGUAL in active domain adaptation (ADA) achieving comparable or superior performance to AL baselines while reducing estimated annotation time by approximately 80%.

Towards High-Consistency Embodied World Model with Multi-View Trajectory Videos

Embodied world models aim to predict and interact with the physical world through visual observations and actions. However, existing models struggle to accurately translate low-level actions (e.g., joint positions) into precise robotic movements in predicted frames, leading to inconsistencies with real-world physical interactions. To address these limitations, we propose MTV-World, an embodied world model that introduces Multi-view Trajectory-Video control for precise visuomotor prediction. Specifically, instead of directly using low-level actions for control, we employ trajectory videos obtained through camera intrinsic and extrinsic parameters and Cartesian-space transformation as control signals. However, projecting 3D raw actions onto 2D images inevitably causes a loss of spatial information, making a single view insufficient for accurate interaction modeling. To overcome this, we introduce a multi-view framework that compensates for spatial information loss and ensures high-consistency with physical world. MTV-World forecasts future frames based on multi-view trajectory videos as input and conditioning on an initial frame per view. Furthermore, to systematically evaluate both robotic motion precision and object interaction accuracy, we develop an auto-evaluation pipeline leveraging multimodal large models and referring video object segmentation models. To measure spatial consistency, we formulate it as an object location matching problem and adopt the Jaccard Index as the evaluation metric. Extensive experiments demonstrate that MTV-World achieves precise control execution and accurate physical interaction modeling in complex dual-arm scenarios.

A Multi-domain Image Translative Diffusion StyleGAN for Iris Presentation Attack Detection

An iris biometric system can be compromised by presentation attacks (PAs) where artifacts such as artificial eyes, printed eye images, or cosmetic contact lenses are presented to the system. To counteract this, several presentation attack detection (PAD) methods have been developed. However, there is a scarcity of datasets for training and evaluating iris PAD techniques due to the implicit difficulties in constructing and imaging PAs. To address this, we introduce the Multi-domain Image Translative Diffusion StyleGAN (MID-StyleGAN), a new framework for generating synthetic ocular images that captures the PA and bonafide characteristics in multiple domains such as bonafide, printed eyes and cosmetic contact lens. MID-StyleGAN combines the strengths of diffusion models and generative adversarial networks (GANs) to produce realistic and diverse synthetic data. Our approach utilizes a multi-domain architecture that enables the translation between bonafide ocular images and different PA domains. The model employs an adaptive loss function tailored for ocular data to maintain domain consistency. Extensive experiments demonstrate that MID-StyleGAN outperforms existing methods in generating high-quality synthetic ocular images. The generated data was used to significantly enhance the performance of PAD systems, providing a scalable solution to the data scarcity problem in iris and ocular biometrics. For example, on the LivDet2020 dataset, the true detect rate at 1% false detect rate improved from 93.41% to 98.72%, showcasing the impact of the proposed method.

MeCaMIL: Causality-Aware Multiple Instance Learning for Fair and Interpretable Whole Slide Image Diagnosis

Multiple instance learning (MIL) has emerged as the dominant paradigm for whole slide image (WSI) analysis in computational pathology, achieving strong diagnostic performance through patch-level feature aggregation. However, existing MIL methods face critical limitations: (1) they rely on attention mechanisms that lack causal interpretability, and (2) they fail to integrate patient demographics (age, gender, race), leading to fairness concerns across diverse populations. These shortcomings hinder clinical translation, where algorithmic bias can exacerbate health disparities. We introduce \textbf{MeCaMIL}, a causality-aware MIL framework that explicitly models demographic confounders through structured causal graphs. Unlike prior approaches treating demographics as auxiliary features, MeCaMIL employs principled causal inference -- leveraging do-calculus and collider structures -- to disentangle disease-relevant signals from spurious demographic correlations. Extensive evaluation on three benchmarks demonstrates state-of-the-art performance across CAMELYON16 (ACC/AUC/F1: 0.939/0.983/0.946), TCGA-Lung (0.935/0.979/0.931), and TCGA-Multi (0.977/0.993/0.970, five cancer types). Critically, MeCaMIL achieves superior fairness -- demographic disparity variance drops by over 65% relative reduction on average across attributes, with notable improvements for underserved populations. The framework generalizes to survival prediction (mean C-index: 0.653, +0.017 over best baseline across five cancer types). Ablation studies confirm causal graph structure is essential -- alternative designs yield 0.048 lower accuracy and 4.2x times worse fairness. These results establish MeCaMIL as a principled framework for fair, interpretable, and clinically actionable AI in digital pathology. Code will be released upon acceptance.

nnMIL: A generalizable multiple instance learning framework for computational pathology

Computational pathology holds substantial promise for improving diagnosis and guiding treatment decisions. Recent pathology foundation models enable the extraction of rich patch-level representations from large-scale whole-slide images (WSIs), but current approaches for aggregating these features into slide-level predictions remain constrained by design limitations that hinder generalizability and reliability. Here, we developed nnMIL, a simple yet broadly applicable multiple-instance learning framework that connects patch-level foundation models to robust slide-level clinical inference. nnMIL introduces random sampling at both the patch and feature levels, enabling large-batch optimization, task-aware sampling strategies, and efficient and scalable training across datasets and model architectures. A lightweight aggregator performs sliding-window inference to generate ensemble slide-level predictions and supports principled uncertainty estimation. Across 40,000 WSIs encompassing 35 clinical tasks and four pathology foundation models, nnMIL consistently outperformed existing MIL methods for disease diagnosis, histologic subtyping, molecular biomarker detection, and pan- cancer prognosis prediction. It further demonstrated strong cross-model generalization, reliable uncertainty quantification, and robust survival stratification in multiple external cohorts. In conclusion, nnMIL offers a practical and generalizable solution for translating pathology foundation models into clinically meaningful predictions, advancing the development and deployment of reliable AI systems in real-world settings.

Segment Any Tumour: An Uncertainty-Aware Vision Foundation Model for Whole-Body Analysis

Prompt-driven vision foundation models, such as the Segment Anything Model, have recently demonstrated remarkable adaptability in computer vision. However, their direct application to medical imaging remains challenging due to heterogeneous tissue structures, imaging artefacts, and low-contrast boundaries, particularly in tumours and cancer primaries leading to suboptimal segmentation in ambiguous or overlapping lesion regions. Here, we present Segment Any Tumour 3D (SAT3D), a lightweight volumetric foundation model designed to enable robust and generalisable tumour segmentation across diverse medical imaging modalities. SAT3D integrates a shifted-window vision transformer for hierarchical volumetric representation with an uncertainty-aware training pipeline that explicitly incorporates uncertainty estimates as prompts to guide reliable boundary prediction in low-contrast regions. Adversarial learning further enhances model performance for the ambiguous pathological regions. We benchmark SAT3D against three recent vision foundation models and nnUNet across 11 publicly available datasets, encompassing 3,884 tumour and cancer cases for training and 694 cases for in-distribution evaluation. Trained on 17,075 3D volume-mask pairs across multiple modalities and cancer primaries, SAT3D demonstrates strong generalisation and robustness. To facilitate practical use and clinical translation, we developed a 3D Slicer plugin that enables interactive, prompt-driven segmentation and visualisation using the trained SAT3D model. Extensive experiments highlight its effectiveness in improving segmentation accuracy under challenging and out-of-distribution scenarios, underscoring its potential as a scalable foundation model for medical image analysis.