GASCADE: Grouped Summarization of Adverse Drug Event for Enhanced Cancer Pharmacovigilance

In the realm of cancer treatment, summarizing adverse drug events (ADEs) reported by patients using prescribed drugs is crucial for enhancing pharmacovigilance practices and improving drug-related decision-making. While the volume and complexity of pharmacovigilance data have increased, existing research in this field has predominantly focused on general diseases rather than specifically addressing cancer. This work introduces the task of grouped summarization of adverse drug events reported by multiple patients using the same drug for cancer treatment. To address the challenge of limited resources in cancer pharmacovigilance, we present the MultiLabeled Cancer Adverse Drug Reaction and Summarization (MCADRS) dataset. This dataset includes pharmacovigilance posts detailing patient concerns regarding drug efficacy and adverse effects, along with extracted labels for drug names, adverse drug events, severity, and adversity of reactions, as well as summaries of ADEs for each drug. Additionally, we propose the Grouping and Abstractive Summarization of Cancer Adverse Drug events (GASCADE) framework, a novel pipeline that combines the information extraction capabilities of Large Language Models (LLMs) with the summarization power of the encoder-decoder T5 model. Our work is the first to apply alignment techniques, including advanced algorithms like Direct Preference Optimization, to encoder-decoder models using synthetic datasets for summarization tasks. Through extensive experiments, we demonstrate the superior performance of GASCADE across various metrics, validated through both automated assessments and human evaluations. This multitasking approach enhances drug-related decision-making and fosters a deeper understanding of patient concerns, paving the way for advancements in personalized and responsive cancer care. The code and dataset used in this work are publicly available.

PipeSpec: Breaking Stage Dependencies in Hierarchical LLM Decoding

Speculative decoding accelerates large language model inference by using smaller draft models to generate candidate tokens for parallel verification. However, current approaches are limited by sequential stage dependencies that prevent full hardware utilization. We present PipeSpec, a framework that generalizes speculative decoding to $k$ models arranged in a hierarchical pipeline, enabling asynchronous execution with lightweight coordination for prediction verification and rollback. Our analytical model characterizes token generation rates across pipeline stages and proves guaranteed throughput improvements over traditional decoding for any non-zero acceptance rate. We further derive closed-form expressions for steady-state verification probabilities that explain the empirical benefits of pipeline depth. Experimental results show that PipeSpec achieves up to 2.54$\times$ speedup while outperforming state-of-the-art methods. We validate PipeSpec across text summarization and code generation tasks using LLaMA 2 and 3 models, demonstrating that pipeline efficiency increases with model depth, providing a scalable approach to accelerating LLM inference on multi-device systems.

Large Language Models are Qualified Benchmark Builders: Rebuilding Pre-Training Datasets for Advancing Code Intelligence Tasks

Pre-trained code models rely heavily on high-quality pre-training data, particularly human-written reference comments that bridge code and natural language. However, these comments often become outdated as software evolves, degrading model performance. Large language models (LLMs) excel at generating high-quality code comments. We investigate whether replacing human-written comments with LLM-generated ones improves pre-training datasets. Since standard metrics cannot assess reference comment quality, we propose two novel reference-free evaluation tasks: code-comment inconsistency detection and semantic code search. Results show that LLM-generated comments are more semantically consistent with code than human-written ones, as confirmed by manual evaluation. Leveraging this finding, we rebuild the CodeSearchNet dataset with LLM-generated comments and re-pre-train CodeT5. Evaluations demonstrate that models trained on LLM-enhanced data outperform those using original human comments in code summarization, generation, and translation tasks. This work validates rebuilding pre-training datasets with LLMs to advance code intelligence, challenging the traditional reliance on human reference comments.

Which Agent Causes Task Failures and When? On Automated Failure Attribution of LLM Multi-Agent Systems

Failure attribution in LLM multi-agent systems-identifying the agent and step responsible for task failures-provides crucial clues for systems debugging but remains underexplored and labor-intensive. In this paper, we propose and formulate a new research area: automated failure attribution for LLM multi-agent systems. To support this initiative, we introduce the Who&When dataset, comprising extensive failure logs from 127 LLM multi-agent systems with fine-grained annotations linking failures to specific agents and decisive error steps. Using the Who&When, we develop and evaluate three automated failure attribution methods, summarizing their corresponding pros and cons. The best method achieves 53.5% accuracy in identifying failure-responsible agents but only 14.2% in pinpointing failure steps, with some methods performing below random. Even SOTA reasoning models, such as OpenAI o1 and DeepSeek R1, fail to achieve practical usability. These results highlight the task's complexity and the need for further research in this area. Code and dataset are available at https://github.com/mingyin1/Agents_Failure_Attribution

Early Exit and Multi Stage Knowledge Distillation in VLMs for Video Summarization

We introduce DEEVISum (Distilled Early Exit Vision language model for Summarization), a lightweight, efficient, and scalable vision language model designed for segment wise video summarization. Leveraging multi modal prompts that combine textual and audio derived signals, DEEVISum incorporates Multi Stage Knowledge Distillation (MSKD) and Early Exit (EE) to strike a balance between performance and efficiency. MSKD offers a 1.33% absolute F1 improvement over baseline distillation (0.5%), while EE reduces inference time by approximately 21% with a 1.3 point drop in F1. Evaluated on the TVSum dataset, our best model PaLI Gemma2 3B + MSKD achieves an F1 score of 61.1, competing the performance of significantly larger models, all while maintaining a lower computational footprint. We publicly release our code and processed dataset to support further research.

Talk Before You Retrieve: Agent-Led Discussions for Better RAG in Medical QA

Medical question answering (QA) is a reasoning-intensive task that remains challenging for large language models (LLMs) due to hallucinations and outdated domain knowledge. Retrieval-Augmented Generation (RAG) provides a promising post-training solution by leveraging external knowledge. However, existing medical RAG systems suffer from two key limitations: (1) a lack of modeling for human-like reasoning behaviors during information retrieval, and (2) reliance on suboptimal medical corpora, which often results in the retrieval of irrelevant or noisy snippets. To overcome these challenges, we propose Discuss-RAG, a plug-and-play module designed to enhance the medical QA RAG system through collaborative agent-based reasoning. Our method introduces a summarizer agent that orchestrates a team of medical experts to emulate multi-turn brainstorming, thereby improving the relevance of retrieved content. Additionally, a decision-making agent evaluates the retrieved snippets before their final integration. Experimental results on four benchmark medical QA datasets show that Discuss-RAG consistently outperforms MedRAG, especially significantly improving answer accuracy by up to 16.67% on BioASQ and 12.20% on PubMedQA. The code is available at: https://github.com/LLM-VLM-GSL/Discuss-RAG.

Towards Leveraging Large Language Model Summaries for Topic Modeling in Source Code

Understanding source code is a topic of great interest in the software engineering community, since it can help programmers in various tasks such as software maintenance and reuse. Recent advances in large language models (LLMs) have demonstrated remarkable program comprehension capabilities, while transformer-based topic modeling techniques offer effective ways to extract semantic information from text. This paper proposes and explores a novel approach that combines these strengths to automatically identify meaningful topics in a corpus of Python programs. Our method consists in applying topic modeling on the descriptions obtained by asking an LLM to summarize the code. To assess the internal consistency of the extracted topics, we compare them against topics inferred from function names alone, and those derived from existing docstrings. Experimental results suggest that leveraging LLM-generated summaries provides interpretable and semantically rich representation of code structure. The promising results suggest that our approach can be fruitfully applied in various software engineering tasks such as automatic documentation and tagging, code search, software reorganization and knowledge discovery in large repositories.

TextTIGER: Text-based Intelligent Generation with Entity Prompt Refinement for Text-to-Image Generation

Generating images from prompts containing specific entities requires models to retain as much entity-specific knowledge as possible. However, fully memorizing such knowledge is impractical due to the vast number of entities and their continuous emergence. To address this, we propose Text-based Intelligent Generation with Entity prompt Refinement (TextTIGER), which augments knowledge on entities included in the prompts and then summarizes the augmented descriptions using Large Language Models (LLMs) to mitigate performance degradation from longer inputs. To evaluate our method, we introduce WiT-Cub (WiT with Captions and Uncomplicated Background-explanations), a dataset comprising captions, images, and an entity list. Experiments on four image generation models and five LLMs show that TextTIGER improves image generation performance in standard metrics (IS, FID, and CLIPScore) compared to caption-only prompts. Additionally, multiple annotators' evaluation confirms that the summarized descriptions are more informative, validating LLMs' ability to generate concise yet rich descriptions. These findings demonstrate that refining prompts with augmented and summarized entity-related descriptions enhances image generation capabilities. The code and dataset will be available upon acceptance.

Stealing Creator's Workflow: A Creator-Inspired Agentic Framework with Iterative Feedback Loop for Improved Scientific Short-form Generation

Generating engaging, accurate short-form videos from scientific papers is challenging due to content complexity and the gap between expert authors and readers. Existing end-to-end methods often suffer from factual inaccuracies and visual artifacts, limiting their utility for scientific dissemination. To address these issues, we propose SciTalk, a novel multi-LLM agentic framework, grounding videos in various sources, such as text, figures, visual styles, and avatars. Inspired by content creators' workflows, SciTalk uses specialized agents for content summarization, visual scene planning, and text and layout editing, and incorporates an iterative feedback mechanism where video agents simulate user roles to give feedback on generated videos from previous iterations and refine generation prompts. Experimental evaluations show that SciTalk outperforms simple prompting methods in generating scientifically accurate and engaging content over the refined loop of video generation. Although preliminary results are still not yet matching human creators' quality, our framework provides valuable insights into the challenges and benefits of feedback-driven video generation. Our code, data, and generated videos will be publicly available.

Bridge the Domains: Large Language Models Enhanced Cross-domain Sequential Recommendation

Cross-domain Sequential Recommendation (CDSR) aims to extract the preference from the user's historical interactions across various domains. Despite some progress in CDSR, two problems set the barrier for further advancements, i.e., overlap dilemma and transition complexity. The former means existing CDSR methods severely rely on users who own interactions on all domains to learn cross-domain item relationships, compromising the practicability. The latter refers to the difficulties in learning the complex transition patterns from the mixed behavior sequences. With powerful representation and reasoning abilities, Large Language Models (LLMs) are promising to address these two problems by bridging the items and capturing the user's preferences from a semantic view. Therefore, we propose an LLMs Enhanced Cross-domain Sequential Recommendation model (LLM4CDSR). To obtain the semantic item relationships, we first propose an LLM-based unified representation module to represent items. Then, a trainable adapter with contrastive regularization is designed to adapt the CDSR task. Besides, a hierarchical LLMs profiling module is designed to summarize user cross-domain preferences. Finally, these two modules are integrated into the proposed tri-thread framework to derive recommendations. We have conducted extensive experiments on three public cross-domain datasets, validating the effectiveness of LLM4CDSR. We have released the code online.