Research on Disease Prediction Model Construction Based on Computer AI deep Learning Technology

The prediction of disease risk factors can screen vulnerable groups for effective prevention and treatment, so as to reduce their morbidity and mortality. Machine learning has a great demand for high-quality labeling information, and labeling noise in medical big data poses a great challenge to efficient disease risk warning methods. Therefore, this project intends to study the robust learning algorithm and apply it to the early warning of infectious disease risk. A dynamic truncated loss model is proposed, which combines the traditional mutual entropy implicit weight feature with the mean variation feature. It is robust to label noise. A lower bound on training loss is constructed, and a method based on sampling rate is proposed to reduce the gradient of suspected samples to reduce the influence of noise on training results. The effectiveness of this method under different types of noise was verified by using a stroke screening data set as an example. This method enables robust learning of data containing label noise.

Application of Computer Deep Learning Model in Diagnosis of Pulmonary Nodules

The 3D simulation model of the lung was established by using the reconstruction method. A computer aided pulmonary nodule detection model was constructed. The process iterates over the images to refine the lung nodule recognition model based on neural networks. It is integrated with 3D virtual modeling technology to improve the interactivity of the system, so as to achieve intelligent recognition of lung nodules. A 3D RCNN (Region-based Convolutional Neural Network) was utilized for feature extraction and nodule identification. The LUNA16 large sample database was used as the research dataset. FROC (Free-response Receiver Operating Characteristic) analysis was applied to evaluate the model, calculating sensitivity at various false positive rates to derive the average FROC. Compared with conventional diagnostic methods, the recognition rate was significantly improved. This technique facilitates the detection of pulmonary abnormalities at an initial phase, which holds immense value for the prompt diagnosis of lung malignancies.

LoRA Dropout as a Sparsity Regularizer for Overfitting Control

Parameter-efficient fine-tuning methods, represented by LoRA, play an essential role in adapting large-scale pre-trained models to downstream tasks. However, fine-tuning LoRA-series models also faces the risk of overfitting on the training dataset, and yet there's still a lack of theoretical guidance and practical mechanism to control overfitting on LoRA-based PEFT methods. In this paper, we propose a LoRA Dropout mechanism for the LoRA-based methods by introducing random noises to the learnable low-rank matrices and increasing parameter sparsity. We then demonstrate the theoretical mechanism of our LoRA Dropout mechanism from the perspective of sparsity regularization by providing a generalization error bound under this framework. Theoretical results show that appropriate sparsity would help tighten the gap between empirical and generalization risks and thereby control overfitting. Furthermore, based on the LoRA Dropout framework, we introduce a test-time ensemble strategy and provide theoretical evidence demonstrating that the ensemble method can further compress the error bound, and lead to better performance during inference time. Extensive experiments on various NLP tasks provide practical validations of the effectiveness of our LoRA Dropout framework in improving model accuracy and calibration.

Parameter Efficient Quasi-Orthogonal Fine-Tuning via Givens Rotation

With the increasingly powerful performances and enormous scales of Pretrained Language Models (PLMs), promoting parameter efficiency in fine-tuning has become a crucial need for effective and efficient adaptation to various downstream tasks. One representative line of fine-tuning methods is Orthogonal Fine-tuning (OFT), which rigorously preserves the angular distances within the parameter space to preserve the pretrained knowledge. Despite the empirical effectiveness, OFT still suffers low parameter efficiency at $\mathcal{O}(d^2)$ and limited capability of downstream adaptation. Inspired by Givens rotation, in this paper, we proposed quasi-Givens Orthogonal Fine-Tuning (qGOFT) to address the problems. We first use $\mathcal{O}(d)$ Givens rotations to accomplish arbitrary orthogonal transformation in $SO(d)$ with provable equivalence, reducing parameter complexity from $\mathcal{O}(d^2)$ to $\mathcal{O}(d)$. Then we introduce flexible norm and relative angular adjustments under soft orthogonality regularization to enhance the adaptation capability of downstream semantic deviations. Extensive experiments on various tasks and PLMs validate the effectiveness of our methods.

AMLNet: Adversarial Mutual Learning Neural Network for Non-AutoRegressive Multi-Horizon Time Series Forecasting

Multi-horizon time series forecasting, crucial across diverse domains, demands high accuracy and speed. While AutoRegressive (AR) models excel in short-term predictions, they suffer speed and error issues as the horizon extends. Non-AutoRegressive (NAR) models suit long-term predictions but struggle with interdependence, yielding unrealistic results. We introduce AMLNet, an innovative NAR model that achieves realistic forecasts through an online Knowledge Distillation (KD) approach. AMLNet harnesses the strengths of both AR and NAR models by training a deep AR decoder and a deep NAR decoder in a collaborative manner, serving as ensemble teachers that impart knowledge to a shallower NAR decoder. This knowledge transfer is facilitated through two key mechanisms: 1) outcome-driven KD, which dynamically weights the contribution of KD losses from the teacher models, enabling the shallow NAR decoder to incorporate the ensemble's diversity; and 2) hint-driven KD, which employs adversarial training to extract valuable insights from the model's hidden states for distillation. Extensive experimentation showcases AMLNet's superiority over conventional AR and NAR models, thereby presenting a promising avenue for multi-horizon time series forecasting that enhances accuracy and expedites computation.

ProNet: Progressive Neural Network for Multi-Horizon Time Series Forecasting

In this paper, we introduce ProNet, an novel deep learning approach designed for multi-horizon time series forecasting, adaptively blending autoregressive (AR) and non-autoregressive (NAR) strategies. Our method involves dividing the forecasting horizon into segments, predicting the most crucial steps in each segment non-autoregressively, and the remaining steps autoregressively. The segmentation process relies on latent variables, which effectively capture the significance of individual time steps through variational inference. In comparison to AR models, ProNet showcases remarkable advantages, requiring fewer AR iterations, resulting in faster prediction speed, and mitigating error accumulation. On the other hand, when compared to NAR models, ProNet takes into account the interdependency of predictions in the output space, leading to improved forecasting accuracy. Our comprehensive evaluation, encompassing four large datasets, and an ablation study, demonstrate the effectiveness of ProNet, highlighting its superior performance in terms of accuracy and prediction speed, outperforming state-of-the-art AR and NAR forecasting models.

A Boundary Offset Prediction Network for Named Entity Recognition

Named entity recognition (NER) is a fundamental task in natural language processing that aims to identify and classify named entities in text. However, span-based methods for NER typically assign entity types to text spans, resulting in an imbalanced sample space and neglecting the connections between non-entity and entity spans. To address these issues, we propose a novel approach for NER, named the Boundary Offset Prediction Network (BOPN), which predicts the boundary offsets between candidate spans and their nearest entity spans. By leveraging the guiding semantics of boundary offsets, BOPN establishes connections between non-entity and entity spans, enabling non-entity spans to function as additional positive samples for entity detection. Furthermore, our method integrates entity type and span representations to generate type-aware boundary offsets instead of using entity types as detection targets. We conduct experiments on eight widely-used NER datasets, and the results demonstrate that our proposed BOPN outperforms previous state-of-the-art methods.

Learning to Correct Noisy Labels for Fine-Grained Entity Typing via Co-Prediction Prompt Tuning

Fine-grained entity typing (FET) is an essential task in natural language processing that aims to assign semantic types to entities in text. However, FET poses a major challenge known as the noise labeling problem, whereby current methods rely on estimating noise distribution to identify noisy labels but are confused by diverse noise distribution deviation. To address this limitation, we introduce Co-Prediction Prompt Tuning for noise correction in FET, which leverages multiple prediction results to identify and correct noisy labels. Specifically, we integrate prediction results to recall labeled labels and utilize a differentiated margin to identify inaccurate labels. Moreover, we design an optimization objective concerning divergent co-predictions during fine-tuning, ensuring that the model captures sufficient information and maintains robustness in noise identification. Experimental results on three widely-used FET datasets demonstrate that our noise correction approach significantly enhances the quality of various types of training samples, including those annotated using distant supervision, ChatGPT, and crowdsourcing.

Graph Interpolation via Fast Fused-Gromovization

Graph data augmentation has proven to be effective in enhancing the generalizability and robustness of graph neural networks (GNNs) for graph-level classifications. However, existing methods mainly focus on augmenting the graph signal space and the graph structure space independently, overlooking their joint interaction. This paper addresses this limitation by formulating the problem as an optimal transport problem that aims to find an optimal strategy for matching nodes between graphs considering the interactions between graph structures and signals. To tackle this problem, we propose a novel graph mixup algorithm dubbed FGWMixup, which leverages the Fused Gromov-Wasserstein (FGW) metric space to identify a "midpoint" of the source graphs. To improve the scalability of our approach, we introduce a relaxed FGW solver that accelerates FGWMixup by enhancing the convergence rate from $\mathcal{O}(t^{-1})$ to $\mathcal{O}(t^{-2})$. Extensive experiments conducted on five datasets, utilizing both classic (MPNNs) and advanced (Graphormers) GNN backbones, demonstrate the effectiveness of FGWMixup in improving the generalizability and robustness of GNNs.

Recurrent Neural Network-coupled SPAD TCSPC System for Real-time Fluorescence Lifetime Imaging

Fluorescence lifetime imaging (FLI) has been receiving increased attention in recent years as a powerful imaging technique in biological and medical research. However, existing FLI systems often suffer from a tradeoff between processing speed, accuracy, and robustness. In this paper, we propose a SPAD TCSPC system coupled to a recurrent neural network (RNN) for FLI that accurately estimates on the fly fluorescence lifetime directly from raw timestamps instead of histograms, which drastically reduces the data transfer rate and hardware resource utilization. We train two variants of the RNN on a synthetic dataset and compare the results to those obtained using the center-of-mass method (CMM) and least squares fitting (LS fitting) methods. The results demonstrate that two RNN variants, gated recurrent unit (GRU) and long short-term memory (LSTM), are comparable to CMM and LS fitting in terms of accuracy and outperform CMM and LS fitting by a large margin in the presence of background noise. We also look at the Cramer-Rao lower bound and detailed analysis showed that the RNN models are close to the theoretical optima. The analysis of experimental data shows that our model, which is purely trained on synthetic datasets, works well on real-world data. We build a FLI microscope setup for evaluation based on Piccolo, a 32$\times$32 SPAD sensor developed in our lab. Four quantized GRU cores, capable of processing up to 4 million photons per second, are deployed on a Xilinx Kintex-7 FPGA. Powered by the GRU, the FLI setup can retrieve real-time fluorescence lifetime images at up to 10 frames per second. The proposed FLI system is promising for many important biomedical applications, ranging from biological imaging of fast-moving cells to fluorescence-assisted diagnosis and surgery.