SoDaCam: Software-defined Cameras via Single-Photon Imaging

Reinterpretable cameras are defined by their post-processing capabilities that exceed traditional imaging. We present "SoDaCam" that provides reinterpretable cameras at the granularity of photons, from photon-cubes acquired by single-photon devices. Photon-cubes represent the spatio-temporal detections of photons as a sequence of binary frames, at frame-rates as high as 100 kHz. We show that simple transformations of the photon-cube, or photon-cube projections, provide the functionality of numerous imaging systems including: exposure bracketing, flutter shutter cameras, video compressive systems, event cameras, and even cameras that move during exposure. Our photon-cube projections offer the flexibility of being software-defined constructs that are only limited by what is computable, and shot-noise. We exploit this flexibility to provide new capabilities for the emulated cameras. As an added benefit, our projections provide camera-dependent compression of photon-cubes, which we demonstrate using an implementation of our projections on a novel compute architecture that is designed for single-photon imaging.

Recurrent Neural Network-coupled SPAD TCSPC System for Real-time Fluorescence Lifetime Imaging

Fluorescence lifetime imaging (FLI) has been receiving increased attention in recent years as a powerful imaging technique in biological and medical research. However, existing FLI systems often suffer from a tradeoff between processing speed, accuracy, and robustness. In this paper, we propose a SPAD TCSPC system coupled to a recurrent neural network (RNN) for FLI that accurately estimates on the fly fluorescence lifetime directly from raw timestamps instead of histograms, which drastically reduces the data transfer rate and hardware resource utilization. We train two variants of the RNN on a synthetic dataset and compare the results to those obtained using the center-of-mass method (CMM) and least squares fitting (LS fitting) methods. The results demonstrate that two RNN variants, gated recurrent unit (GRU) and long short-term memory (LSTM), are comparable to CMM and LS fitting in terms of accuracy and outperform CMM and LS fitting by a large margin in the presence of background noise. We also look at the Cramer-Rao lower bound and detailed analysis showed that the RNN models are close to the theoretical optima. The analysis of experimental data shows that our model, which is purely trained on synthetic datasets, works well on real-world data. We build a FLI microscope setup for evaluation based on Piccolo, a 32$\times$32 SPAD sensor developed in our lab. Four quantized GRU cores, capable of processing up to 4 million photons per second, are deployed on a Xilinx Kintex-7 FPGA. Powered by the GRU, the FLI setup can retrieve real-time fluorescence lifetime images at up to 10 frames per second. The proposed FLI system is promising for many important biomedical applications, ranging from biological imaging of fast-moving cells to fluorescence-assisted diagnosis and surgery.

On-chip fully reconfigurable Artificial Neural Network in 16 nm FinFET for Positron Emission Tomography

Smarty is a fully-reconfigurable on-chip feed-forward artificial neural network (ANN) with ten integrated time-to-digital converters (TDCs) designed in a 16 nm FinFET CMOS technology node. The integration of TDCs together with an ANN aims to reduce system complexity and minimize data throughput requirements in positron emission tomography (PET) applications. The TDCs have an average LSB of 53.5 ps. The ANN is fully reconfigurable, the user being able to change its topology as desired within a set of constraints. The chip can execute 363 MOPS with a maximum power consumption of 1.9 mW, for an efficiency of 190 GOPS/W. The system performance was tested in a coincidence measurement setup interfacing Smarty with two groups of five 4 mm x 4 mm analog silicon photomultipliers (A-SiPMs) used as inputs for the TDCs. The ANN successfully distinguished between six different positions of a radioactive source placed between the two photodetector arrays by solely using the TDC timestamps.

Quanta Burst Photography

Single-photon avalanche diodes (SPADs) are an emerging sensor technology capable of detecting individual incident photons, and capturing their time-of-arrival with high timing precision. While these sensors were limited to single-pixel or low-resolution devices in the past, recently, large (up to 1 MPixel) SPAD arrays have been developed. These single-photon cameras (SPCs) are capable of capturing high-speed sequences of binary single-photon images with no read noise. We present quanta burst photography, a computational photography technique that leverages SPCs as passive imaging devices for photography in challenging conditions, including ultra low-light and fast motion. Inspired by recent success of conventional burst photography, we design algorithms that align and merge binary sequences captured by SPCs into intensity images with minimal motion blur and artifacts, high signal-to-noise ratio (SNR), and high dynamic range. We theoretically analyze the SNR and dynamic range of quanta burst photography, and identify the imaging regimes where it provides significant benefits. We demonstrate, via a recently developed SPAD array, that the proposed method is able to generate high-quality images for scenes with challenging lighting, complex geometries, high dynamic range and moving objects. With the ongoing development of SPAD arrays, we envision quanta burst photography finding applications in both consumer and scientific photography.

A `Little Bit' Too Much? High Speed Imaging from Sparse Photon Counts

Recent advances in photographic sensing technologies have made it possible to achieve light detection in terms of a single photon. Photon counting sensors are being increasingly used in many diverse applications. We address the problem of jointly recovering spatial and temporal scene radiance from very few photon counts. Our ConvNet-based scheme effectively combines spatial and temporal information present in measurements to reduce noise. We demonstrate that using our method one can acquire videos at a high frame rate and still achieve good quality signal-to-noise ratio. Experiments show that the proposed scheme performs quite well in different challenging scenarios while the existing denoising schemes are unable to handle them.