United Minds or Isolated Agents? Exploring Coordination of LLMs under Cognitive Load Theory

Large Language Models (LLMs) exhibit a notable performance ceiling on complex, multi-faceted tasks, as they often fail to integrate diverse information or adhere to multiple constraints. We posit that such limitation arises when the demands of a task exceed the LLM's effective cognitive load capacity. This interpretation draws a strong analogy to Cognitive Load Theory (CLT) in cognitive science, which explains similar performance boundaries in the human mind, and is further supported by emerging evidence that reveals LLMs have bounded working memory characteristics. Building upon this CLT-grounded understanding, we introduce CoThinker, a novel LLM-based multi-agent framework designed to mitigate cognitive overload and enhance collaborative problem-solving abilities. CoThinker operationalizes CLT principles by distributing intrinsic cognitive load through agent specialization and managing transactional load via structured communication and a collective working memory. We empirically validate CoThinker on complex problem-solving tasks and fabricated high cognitive load scenarios, demonstrating improvements over existing multi-agent baselines in solution quality and efficiency. Our analysis reveals characteristic interaction patterns, providing insights into the emergence of collective cognition and effective load management, thus offering a principled approach to overcoming LLM performance ceilings.

RTime-QA: A Benchmark for Atomic Temporal Event Understanding in Large Multi-modal Models

Understanding accurate atomic temporal event is essential for video comprehension. However, current video-language benchmarks often fall short to evaluate Large Multi-modal Models' (LMMs) temporal event understanding capabilities, as they can be effectively addressed using image-language models. In this paper, we introduce RTime-QA, a novel benchmark specifically designed to assess the atomic temporal event understanding ability of LMMs. RTime-QA comprises 822 high-quality, carefully-curated video-text questions, each meticulously annotated by human experts. Each question features a video depicting an atomic temporal event, paired with both correct answers and temporal negative descriptions, specifically designed to evaluate temporal understanding. To advance LMMs' temporal event understanding ability, we further introduce RTime-IT, a 14k instruction-tuning dataset that employs a similar annotation process as RTime-QA. Extensive experimental analysis demonstrates that RTime-QA presents a significant challenge for LMMs: the state-of-the-art model Qwen2-VL achieves only 34.6 on strict-ACC metric, substantially lagging behind human performance. Furthermore, our experiments reveal that RTime-IT effectively enhance LMMs' capacity in temporal understanding. By fine-tuning on RTime-IT, our Qwen2-VL achieves 65.9 on RTime-QA.

Adams Bashforth Moulton Solver for Inversion and Editing in Rectified Flow

Rectified flow models have achieved remarkable performance in image and video generation tasks. However, existing numerical solvers face a trade-off between fast sampling and high-accuracy solutions, limiting their effectiveness in downstream applications such as reconstruction and editing. To address this challenge, we propose leveraging the Adams-Bashforth-Moulton (ABM) predictor-corrector method to enhance the accuracy of ODE solving in rectified flow models. Specifically, we introduce ABM-Solver, which integrates a multi step predictor corrector approach to reduce local truncation errors and employs Adaptive Step Size Adjustment to improve sampling speed. Furthermore, to effectively preserve non edited regions while facilitating semantic modifications, we introduce a Mask Guided Feature Injection module. We estimate self-similarity to generate a spatial mask that differentiates preserved regions from those available for editing. Extensive experiments on multiple high-resolution image datasets validate that ABM-Solver significantly improves inversion precision and editing quality, outperforming existing solvers without requiring additional training or optimization.

Multi-Class Segmentation of Aortic Branches and Zones in Computed Tomography Angiography: The AortaSeg24 Challenge

Multi-class segmentation of the aorta in computed tomography angiography (CTA) scans is essential for diagnosing and planning complex endovascular treatments for patients with aortic dissections. However, existing methods reduce aortic segmentation to a binary problem, limiting their ability to measure diameters across different branches and zones. Furthermore, no open-source dataset is currently available to support the development of multi-class aortic segmentation methods. To address this gap, we organized the AortaSeg24 MICCAI Challenge, introducing the first dataset of 100 CTA volumes annotated for 23 clinically relevant aortic branches and zones. This dataset was designed to facilitate both model development and validation. The challenge attracted 121 teams worldwide, with participants leveraging state-of-the-art frameworks such as nnU-Net and exploring novel techniques, including cascaded models, data augmentation strategies, and custom loss functions. We evaluated the submitted algorithms using the Dice Similarity Coefficient (DSC) and Normalized Surface Distance (NSD), highlighting the approaches adopted by the top five performing teams. This paper presents the challenge design, dataset details, evaluation metrics, and an in-depth analysis of the top-performing algorithms. The annotated dataset, evaluation code, and implementations of the leading methods are publicly available to support further research. All resources can be accessed at https://aortaseg24.grand-challenge.org.

Enhancing Cluster Resilience: LLM-agent Based Autonomous Intelligent Cluster Diagnosis System and Evaluation Framework

Recent advancements in Large Language Models (LLMs) and related technologies such as Retrieval-Augmented Generation (RAG) and Diagram of Thought (DoT) have enabled the creation of autonomous intelligent systems capable of performing cluster diagnostics and troubleshooting. By integrating these technologies with self-play methodologies, we have developed an LLM-agent system designed to autonomously diagnose and resolve issues within AI clusters. Our innovations include a knowledge base tailored for cluster diagnostics, enhanced LLM algorithms, practical deployment strategies for agents, and a benchmark specifically designed for evaluating LLM capabilities in this domain. Through extensive experimentation across multiple dimensions, we have demonstrated the superiority of our system in addressing the challenges faced in cluster diagnostics, particularly in detecting and rectifying performance issues more efficiently and accurately than traditional methods.

Identifying Influential nodes in Brain Networks via Self-Supervised Graph-Transformer

Studying influential nodes (I-nodes) in brain networks is of great significance in the field of brain imaging. Most existing studies consider brain connectivity hubs as I-nodes. However, this approach relies heavily on prior knowledge from graph theory, which may overlook the intrinsic characteristics of the brain network, especially when its architecture is not fully understood. In contrast, self-supervised deep learning can learn meaningful representations directly from the data. This approach enables the exploration of I-nodes for brain networks, which is also lacking in current studies. This paper proposes a Self-Supervised Graph Reconstruction framework based on Graph-Transformer (SSGR-GT) to identify I-nodes, which has three main characteristics. First, as a self-supervised model, SSGR-GT extracts the importance of brain nodes to the reconstruction. Second, SSGR-GT uses Graph-Transformer, which is well-suited for extracting features from brain graphs, combining both local and global characteristics. Third, multimodal analysis of I-nodes uses graph-based fusion technology, combining functional and structural brain information. The I-nodes we obtained are distributed in critical areas such as the superior frontal lobe, lateral parietal lobe, and lateral occipital lobe, with a total of 56 identified across different experiments. These I-nodes are involved in more brain networks than other regions, have longer fiber connections, and occupy more central positions in structural connectivity. They also exhibit strong connectivity and high node efficiency in both functional and structural networks. Furthermore, there is a significant overlap between the I-nodes and both the structural and functional rich-club. These findings enhance our understanding of the I-nodes within the brain network, and provide new insights for future research in further understanding the brain working mechanisms.

Gradient Diffusion: A Perturbation-Resilient Gradient Leakage Attack

Recent years have witnessed the vulnerability of Federated Learning (FL) against gradient leakage attacks, where the private training data can be recovered from the exchanged gradients, making gradient protection a critical issue for the FL training process. Existing solutions often resort to perturbation-based mechanisms, such as differential privacy, where each participating client injects a specific amount of noise into local gradients before aggregating to the server, and the global distribution variation finally conceals the gradient privacy. However, perturbation is not always the panacea for gradient protection since the robustness heavily relies on the injected noise. This intuition raises an interesting question: \textit{is it possible to deactivate existing protection mechanisms by removing the perturbation inside the gradients?} In this paper, we present the answer: \textit{yes} and propose the Perturbation-resilient Gradient Leakage Attack (PGLA), the first attempt to recover the perturbed gradients, without additional access to the original model structure or third-party data. Specifically, we leverage the inherent diffusion property of gradient perturbation protection and construct a novel diffusion-based denoising model to implement PGLA. Our insight is that capturing the disturbance level of perturbation during the diffusion reverse process can release the gradient denoising capability, which promotes the diffusion model to generate approximate gradients as the original clean version through adaptive sampling steps. Extensive experiments demonstrate that PGLA effectively recovers the protected gradients and exposes the FL training process to the threat of gradient leakage, achieving the best quality in gradient denoising and data recovery compared to existing models. We hope to arouse public attention on PGLA and its defense.

ZeroDDI: A Zero-Shot Drug-Drug Interaction Event Prediction Method with Semantic Enhanced Learning and Dual-Modal Uniform Alignment

Drug-drug interactions (DDIs) can result in various pharmacological changes, which can be categorized into different classes known as DDI events (DDIEs). In recent years, previously unobserved/unseen DDIEs have been emerging, posing a new classification task when unseen classes have no labelled instances in the training stage, which is formulated as a zero-shot DDIE prediction (ZS-DDIE) task. However, existing computational methods are not directly applicable to ZS-DDIE, which has two primary challenges: obtaining suitable DDIE representations and handling the class imbalance issue. To overcome these challenges, we propose a novel method named ZeroDDI for the ZS-DDIE task. Specifically, we design a biological semantic enhanced DDIE representation learning module, which emphasizes the key biological semantics and distills discriminative molecular substructure-related semantics for DDIE representation learning. Furthermore, we propose a dual-modal uniform alignment strategy to distribute drug pair representations and DDIE semantic representations uniformly in a unit sphere and align the matched ones, which can mitigate the issue of class imbalance. Extensive experiments showed that ZeroDDI surpasses the baselines and indicate that it is a promising tool for detecting unseen DDIEs. Our code has been released in https://github.com/wzy-Sarah/ZeroDDI.

Advancing Generalized Transfer Attack with Initialization Derived Bilevel Optimization and Dynamic Sequence Truncation

Transfer attacks generate significant interest for real-world black-box applications by crafting transferable adversarial examples through surrogate models. Whereas, existing works essentially directly optimize the single-level objective w.r.t. the surrogate model, which always leads to poor interpretability of attack mechanism and limited generalization performance over unknown victim models. In this work, we propose the \textbf{B}il\textbf{E}vel \textbf{T}ransfer \textbf{A}ttac\textbf{K} (BETAK) framework by establishing an initialization derived bilevel optimization paradigm, which explicitly reformulates the nested constraint relationship between the Upper-Level (UL) pseudo-victim attacker and the Lower-Level (LL) surrogate attacker. Algorithmically, we introduce the Hyper Gradient Response (HGR) estimation as an effective feedback for the transferability over pseudo-victim attackers, and propose the Dynamic Sequence Truncation (DST) technique to dynamically adjust the back-propagation path for HGR and reduce computational overhead simultaneously. Meanwhile, we conduct detailed algorithmic analysis and provide convergence guarantee to support non-convexity of the LL surrogate attacker. Extensive evaluations demonstrate substantial improvement of BETAK (e.g., $\mathbf{53.41}$\% increase of attack success rates against IncRes-v$2_{ens}$) against different victims and defense methods in targeted and untargeted attack scenarios. The source code is available at https://github.com/callous-youth/BETAK.

Chem-FINESE: Validating Fine-Grained Few-shot Entity Extraction through Text Reconstruction

Fine-grained few-shot entity extraction in the chemical domain faces two unique challenges. First, compared with entity extraction tasks in the general domain, sentences from chemical papers usually contain more entities. Moreover, entity extraction models usually have difficulty extracting entities of long-tailed types. In this paper, we propose Chem-FINESE, a novel sequence-to-sequence (seq2seq) based few-shot entity extraction approach, to address these two challenges. Our Chem-FINESE has two components: a seq2seq entity extractor to extract named entities from the input sentence and a seq2seq self-validation module to reconstruct the original input sentence from extracted entities. Inspired by the fact that a good entity extraction system needs to extract entities faithfully, our new self-validation module leverages entity extraction results to reconstruct the original input sentence. Besides, we design a new contrastive loss to reduce excessive copying during the extraction process. Finally, we release ChemNER+, a new fine-grained chemical entity extraction dataset that is annotated by domain experts with the ChemNER schema. Experiments in few-shot settings with both ChemNER+ and CHEMET datasets show that our newly proposed framework has contributed up to 8.26% and 6.84% absolute F1-score gains respectively.