Text as Partial Constraint: Core-Residual Alignment for Robust Vision-Language Learning

Vision-language alignment powers open-vocabulary recognition, retrieval, and LVLM grounding, yet natural captions are often underspecified, making similarity brittle and overly confident under paraphrase and omitted details. We aim to learn representations whose matching is stable across caption views and whose confidence reflects how strongly text constrains an image. We propose Text as Partial Constraint (TPC), a core-residual alignment framework that treats multi-view captions as incomplete supervision. It distills a consensus semantic core as the alignment target, learns a single-view core predictor for standard inference with one query, and explicitly discourages vision-language similarity from depending on the orthogonal unsaid residual. An uncertainty-aware contrastive objective further softens alignment when caption views disagree, reducing overconfident updates under weak language constraints. Across zero-shot recognition and adversarial robustness, TPC achieves 81.42/64.05 Top-1 clean/robust accuracy on ImageNet and 76.19/52.03 on an Avg-14 transfer suite, while improving LVLM transfer with 85.16 POPE F1 and 59.57 OKVQA accuracy under an LLaVA-1.5-7B stack. These results suggest that modeling text as a partial constraint is a practical and principled route to more reliable vision-language representations under underspecified language supervision.

Knowledge-augmented Agentic AI for Mental Health Medication Information Seeking

Patients increasingly seek medication information online, yet safety knowledge for psychiatric drugs is split between regulatory adverse-event records, which are authoritative but abstract, and patient narratives, which are experience-near but unvalidated. Integrating them without conflating evidence and anecdote is especially consequential in psychiatry, where poorly contextualised information can amplify fear, nocebo responses, and non-adherence. Here we develop a provenance-aware, knowledge-graph-based multi-agent framework unifying 466,525 Reddit posts, 60,782 WebMD reviews, and twenty years of U.S. FDA Adverse Event Reporting System records for nine antidepressants. A large-language-model entity-recognition pipeline benchmarked against physician annotations reached highest F1 scores of 0.969 for medications and 0.973 for conditions. The two community platforms were far more concordant with each other (overlap up to a Jaccard similarity of 0.905) than with regulatory reports, indicating that patient-generated data form a partly independent safety signal. For sertraline, many adverse events appeared in community sources hundreds of days before the corresponding FDA date. A Neo4j knowledge graph grounded in ATC-N, ICD-10, and MedDRA vocabularies preserves provenance, keeping every claim traceable and regulatory facts distinct from patient experience. These results establish source-aware integration as a route to more auditable psychiatric medication information, with usefulness and patient benefit to be tested prospectively.

Attention-Spectrum Regularization for Replay-Free Continual Multimodal LLMs

Multimodal large language models (MLLMs) are increasingly required to adapt to non-stationary streams of visual domains, question types, and user instructions, yet continual fine-tuning often causes severe forgetting of previously acquired multimodal skills. Existing continual vision-language methods mainly preserve outputs, replay data or pseudo-data, regularize embedding geometry, or allocate task-specific parameters, but they provide limited control over how internal cross-modal attention patterns supporting old skills drift during adaptation. We propose Attention-Spectrum Regularization (ASR), a replay-free continual learning framework that preserves skill-conditioned structures of cross-modal attention. ASR treats cross-attention maps as two-dimensional signals, summarizes their scale and directional properties into compact spectral statistics, and stores only skill-wise prototype distributions instead of replaying past image-question pairs, generated pseudo-examples, or old-stage teacher snapshots. In later stages, a phase-invariant spectral regularizer constrains harmful drift of these prototypes while allowing instance-level attention to adapt to new tasks. We provide theoretical analysis showing that skill-conditioned spectral drift controls forgetting under a spectral sufficiency assumption, and that Fourier power spectra are stable to spatial translations and bounded perturbations. Experiments on continual VQA and multimodal instruction-tuning benchmarks, including VQA v2, VQACL, CLT-VQA, CoIN, and UCIT, show that ASR consistently improves final performance and reduces forgetting over strong replay-, regularization-, and adapter-based baselines. Preserving skill-level attention structure is an effective and lightweight mechanism for continual MLLMs. Code is available at https://github.com/Creative-zcx/attention-spectrum-replay

LiteOdyssey: A Lightweight Reasoning AI Agent for Interpretable Rare-Disease Diagnosis

Most medical AI systems improve by scaling additional machinery: more fine-tuning data, more agents, and/or larger retrieval databases. In rare-disease diagnosis, however, such scaling can produce systems that are difficult to deploy, audit, and maintain. We asked whether state-of-the-art diagnostic performance could instead be achieved by extending the reasoning chain of a single AI agent: guiding it with a diagnostic policy, developed through human-AI collaboration and augmenting with freely available biomedical tools. We introduce LiteOdyssey, a lightweight rare-disease diagnostic framework that guides reasoning language model through a clinical genetics workflow. This framework was developed through Policy Iteration with Human Feedback (PIHF) and uses dynamic access to public biomedical tools. On two challenging benchmarks that provide only patient clinical features, LiteOdyssey achieved state-of-the-art performance, with an overall disease Recall@1 of 59.3% over the combined 1,243 cases of LIRICAL (n = 370) and the PhenoPacket Store (n = 873). Both benchmarks have a high proportion of ultra-rare disease (a prevalence below 1 in 1,000,000, with ultra-rare shares of approximately 45% and 52.8%, respectively). On the more difficult PhenoPacket subset, where causal diseases were not mapped to Orphanet in our rarity-mapping pipeline, LiteOdyssey achieved 60.7% Recall@1, compared with 10.7% for the same baseline model (GPT-5.4) without tools. This performance was achieved without fine-tuning, multi-agent ensembles, or a large case-retrieval database. Gains were also observed in the following: on cases never seen during development, on a private cohort of real-world rare disease patients, and on a smaller open-weights model. LiteOdyssey suggests a path toward rare-disease AI systems that are accurate, easier to deploy, and more transparent for physician review.

The Latent Space: Foundation, Evolution, Mechanism, Ability, and Outlook

Latent space is rapidly emerging as a native substrate for language-based models. While modern systems are still commonly understood through explicit token-level generation, an increasing body of work shows that many critical internal processes are more naturally carried out in continuous latent space than in human-readable verbal traces. This shift is driven by the structural limitations of explicit-space computation, including linguistic redundancy, discretization bottlenecks, sequential inefficiency, and semantic loss. This survey aims to provide a unified and up-to-date landscape of latent space in language-based models. We organize the survey into five sequential perspectives: Foundation, Evolution, Mechanism, Ability, and Outlook. We begin by delineating the scope of latent space, distinguishing it from explicit or verbal space and from the latent spaces commonly studied in generative visual models. We then trace the field's evolution from early exploratory efforts to the current large-scale expansion. To organize the technical landscape, we examine existing work through the complementary lenses of mechanism and ability. From the perspective of Mechanism, we identify four major lines of development: Architecture, Representation, Computation, and Optimization. From the perspective of Ability, we show how latent space supports a broad capability spectrum spanning Reasoning, Planning, Modeling, Perception, Memory, Collaboration, and Embodiment. Beyond consolidation, we discuss the key open challenges, and outline promising directions for future research. We hope this survey serves not only as a reference for existing work, but also as a foundation for understanding latent space as a general computational and systems paradigm for next-generation intelligence.

CoT2-Meta: Budgeted Metacognitive Control for Test-Time Reasoning

Recent test-time reasoning methods improve performance by generating more candidate chains or searching over larger reasoning trees, but they typically lack explicit control over when to expand, what to prune, how to repair, and when to abstain. We introduce CoT2-Meta, a training-free metacognitive reasoning framework that combines object-level chain-of-thought generation with meta-level control over partial reasoning trajectories. The framework integrates four components: strategy-conditioned thought generation, tree-structured search, an online process oracle for step-level reasoning evaluation, and a meta-controller that allocates computation through expansion, pruning, repair, stopping, and fallback decisions. Under matched inference budgets, CoT2-Meta consistently outperforms strong single-path, sampling-based, and search-based baselines, including ReST-MCTS. On the default backbone, it achieves 92.8 EM on MATH, 90.4 accuracy on GPQA, 98.65 EM on GSM8K, 75.8 accuracy on BBEH, 85.6 accuracy on MMMU-Pro, and 48.8 accuracy on HLE, with gains over the strongest non-CoT2-Meta baseline of +3.6, +5.2, +1.15, +2.0, +4.3, and +4.3 points, respectively. Beyond these core results, the framework remains effective across a broader 15-benchmark suite spanning knowledge and QA, multi-hop reasoning, coding, and out-of-distribution evaluation. Additional analyses show better compute scaling, improved calibration, stronger selective prediction, targeted repair behavior, and consistent gains across backbone families. These results suggest that explicit metacognitive control is a practical design principle for reliable and compute-efficient test-time reasoning systems.

MME-CoF-Pro: Evaluating Reasoning Coherence in Video Generative Models with Text and Visual Hints

Video generative models show emerging reasoning behaviors. It is essential to ensure that generated events remain causally consistent across frames for reliable deployment, a property we define as reasoning coherence. To bridge the gap in literature for missing reasoning coherence evaluation, we propose MME-CoF-Pro, a comprehensive video reasoning benchmark to assess reasoning coherence in video models. Specifically, MME-CoF-Pro contains 303 samples across 16 categories, ranging from visual logical to scientific reasoning. It introduces Reasoning Score as evaluation metric for assessing process-level necessary intermediate reasoning steps, and includes three evaluation settings, (a) no hint (b) text hint and (c) visual hint, enabling a controlled investigation into the underlying mechanisms of reasoning hint guidance. Evaluation results in 7 open and closed-source video models reveals insights including: (1) Video generative models exhibit weak reasoning coherence, decoupled from generation quality. (2) Text hints boost apparent correctness but often cause inconsistency and hallucinated reasoning (3) Visual hints benefit structured perceptual tasks but struggle with fine-grained perception. Website: https://video-reasoning-coherence.github.io/

ODAR: Principled Adaptive Routing for LLM Reasoning via Active Inference

The paradigm of large language model (LLM) reasoning is shifting from parameter scaling to test-time compute scaling, yet many existing approaches still rely on uniform brute-force sampling (for example, fixed best-of-N or self-consistency) that is costly, hard to attribute, and can trigger overthinking with diminishing returns. We propose ODAR-Expert, an adaptive routing framework that optimizes the accuracy-efficiency trade-off via principled resource allocation. ODAR uses a difficulty estimator grounded in amortized active inference to dynamically route queries between a heuristic Fast Agent and a deliberative Slow Agent. We further introduce a free-energy-principled, risk-sensitive fusion mechanism that selects answers by minimizing a variational free energy objective, balancing log-likelihood with epistemic uncertainty (varentropy) as a principled alternative to ad hoc voting over heterogeneous candidates. Extensive evaluation across 23 benchmarks shows strong and consistent gains, including 98.2% accuracy on MATH and 54.8% on Humanity's Last Exam (HLE), while improving the compute-accuracy frontier under compute-matched settings. We also validate reproducibility on a fully open-source stack (Llama 4 + DeepSeek), where ODAR surpasses homogeneous sampling strategies while reducing computational costs by 82%. Overall, our results suggest that thinking-optimal scaling requires adaptive resource allocation with free-energy-based decision-making rather than simply increasing test-time compute.

Crowdsourcing-Based Knowledge Graph Construction for Drug Side Effects Using Large Language Models with an Application on Semaglutide

Social media is a rich source of real-world data that captures valuable patient experience information for pharmacovigilance. However, mining data from unstructured and noisy social media content remains a challenging task. We present a systematic framework that leverages large language models (LLMs) to extract medication side effects from social media and organize them into a knowledge graph (KG). We apply this framework to semaglutide for weight loss using data from Reddit. Using the constructed knowledge graph, we perform comprehensive analyses to investigate reported side effects across different semaglutide brands over time. These findings are further validated through comparison with adverse events reported in the FAERS database, providing important patient-centered insights into semaglutide's side effects that complement its safety profile and current knowledge base of semaglutide for both healthcare professionals and patients. Our work demonstrates the feasibility of using LLMs to transform social media data into structured KGs for pharmacovigilance.

Patients Speak, AI Listens: LLM-based Analysis of Online Reviews Uncovers Key Drivers for Urgent Care Satisfaction

Investigating the public experience of urgent care facilities is essential for promoting community healthcare development. Traditional survey methods often fall short due to limited scope, time, and spatial coverage. Crowdsourcing through online reviews or social media offers a valuable approach to gaining such insights. With recent advancements in large language models (LLMs), extracting nuanced perceptions from reviews has become feasible. This study collects Google Maps reviews across the DMV and Florida areas and conducts prompt engineering with the GPT model to analyze the aspect-based sentiment of urgent care. We first analyze the geospatial patterns of various aspects, including interpersonal factors, operational efficiency, technical quality, finances, and facilities. Next, we determine Census Block Group(CBG)-level characteristics underpinning differences in public perception, including population density, median income, GINI Index, rent-to-income ratio, household below poverty rate, no insurance rate, and unemployment rate. Our results show that interpersonal factors and operational efficiency emerge as the strongest determinants of patient satisfaction in urgent care, while technical quality, finances, and facilities show no significant independent effects when adjusted for in multivariate models. Among socioeconomic and demographic factors, only population density demonstrates a significant but modest association with patient ratings, while the remaining factors exhibit no significant correlations. Overall, this study highlights the potential of crowdsourcing to uncover the key factors that matter to residents and provide valuable insights for stakeholders to improve public satisfaction with urgent care.