Hunyuan-TurboS: Advancing Large Language Models through Mamba-Transformer Synergy and Adaptive Chain-of-Thought

As Large Language Models (LLMs) rapidly advance, we introduce Hunyuan-TurboS, a novel large hybrid Transformer-Mamba Mixture of Experts (MoE) model. It synergistically combines Mamba's long-sequence processing efficiency with Transformer's superior contextual understanding. Hunyuan-TurboS features an adaptive long-short chain-of-thought (CoT) mechanism, dynamically switching between rapid responses for simple queries and deep "thinking" modes for complex problems, optimizing computational resources. Architecturally, this 56B activated (560B total) parameter model employs 128 layers (Mamba2, Attention, FFN) with an innovative AMF/MF block pattern. Faster Mamba2 ensures linear complexity, Grouped-Query Attention minimizes KV cache, and FFNs use an MoE structure. Pre-trained on 16T high-quality tokens, it supports a 256K context length and is the first industry-deployed large-scale Mamba model. Our comprehensive post-training strategy enhances capabilities via Supervised Fine-Tuning (3M instructions), a novel Adaptive Long-short CoT Fusion method, Multi-round Deliberation Learning for iterative improvement, and a two-stage Large-scale Reinforcement Learning process targeting STEM and general instruction-following. Evaluations show strong performance: overall top 7 rank on LMSYS Chatbot Arena with a score of 1356, outperforming leading models like Gemini-2.0-Flash-001 (1352) and o4-mini-2025-04-16 (1345). TurboS also achieves an average of 77.9% across 23 automated benchmarks. Hunyuan-TurboS balances high performance and efficiency, offering substantial capabilities at lower inference costs than many reasoning models, establishing a new paradigm for efficient large-scale pre-trained models.

EpiLLM: Unlocking the Potential of Large Language Models in Epidemic Forecasting

Advanced epidemic forecasting is critical for enabling precision containment strategies, highlighting its strategic importance for public health security. While recent advances in Large Language Models (LLMs) have demonstrated effectiveness as foundation models for domain-specific tasks, their potential for epidemic forecasting remains largely unexplored. In this paper, we introduce EpiLLM, a novel LLM-based framework tailored for spatio-temporal epidemic forecasting. Considering the key factors in real-world epidemic transmission: infection cases and human mobility, we introduce a dual-branch architecture to achieve fine-grained token-level alignment between such complex epidemic patterns and language tokens for LLM adaptation. To unleash the multi-step forecasting and generalization potential of LLM architectures, we propose an autoregressive modeling paradigm that reformulates the epidemic forecasting task into next-token prediction. To further enhance LLM perception of epidemics, we introduce spatio-temporal prompt learning techniques, which strengthen forecasting capabilities from a data-driven perspective. Extensive experiments show that EpiLLM significantly outperforms existing baselines on real-world COVID-19 datasets and exhibits scaling behavior characteristic of LLMs.

D2SA: Dual-Stage Distribution and Slice Adaptation for Efficient Test-Time Adaptation in MRI Reconstruction

Variations in Magnetic resonance imaging (MRI) scanners and acquisition protocols cause distribution shifts that degrade reconstruction performance on unseen data. Test-time adaptation (TTA) offers a promising solution to address this discrepancies. However, previous single-shot TTA approaches are inefficient due to repeated training and suboptimal distributional models. Self-supervised learning methods are also limited by scarce date scenarios. To address these challenges, we propose a novel Dual-Stage Distribution and Slice Adaptation (D2SA) via MRI implicit neural representation (MR-INR) to improve MRI reconstruction performance and efficiency, which features two stages. In the first stage, an MR-INR branch performs patient-wise distribution adaptation by learning shared representations across slices and modelling patient-specific shifts with mean and variance adjustments. In the second stage, single-slice adaptation refines the output from frozen convolutional layers with a learnable anisotropic diffusion module, preventing over-smoothing and reducing computation. Experiments across four MRI distribution shifts demonstrate that our method can integrate well with various self-supervised learning (SSL) framework, improving performance and accelerating convergence under diverse conditions.

AutoCas: Autoregressive Cascade Predictor in Social Networks via Large Language Models

Popularity prediction in information cascades plays a crucial role in social computing, with broad applications in viral marketing, misinformation control, and content recommendation. However, information propagation mechanisms, user behavior, and temporal activity patterns exhibit significant diversity, necessitating a foundational model capable of adapting to such variations. At the same time, the amount of available cascade data remains relatively limited compared to the vast datasets used for training large language models (LLMs). Recent studies have demonstrated the feasibility of leveraging LLMs for time-series prediction by exploiting commonalities across different time-series domains. Building on this insight, we introduce the Autoregressive Information Cascade Predictor (AutoCas), an LLM-enhanced model designed specifically for cascade popularity prediction. Unlike natural language sequences, cascade data is characterized by complex local topologies, diffusion contexts, and evolving dynamics, requiring specialized adaptations for effective LLM integration. To address these challenges, we first tokenize cascade data to align it with sequence modeling principles. Next, we reformulate cascade diffusion as an autoregressive modeling task to fully harness the architectural strengths of LLMs. Beyond conventional approaches, we further introduce prompt learning to enhance the synergy between LLMs and cascade prediction. Extensive experiments demonstrate that AutoCas significantly outperforms baseline models in cascade popularity prediction while exhibiting scaling behavior inherited from LLMs. Code is available at this repository: https://anonymous.4open.science/r/AutoCas-85C6

Strategic priorities for transformative progress in advancing biology with proteomics and artificial intelligence

Artificial intelligence (AI) is transforming scientific research, including proteomics. Advances in mass spectrometry (MS)-based proteomics data quality, diversity, and scale, combined with groundbreaking AI techniques, are unlocking new challenges and opportunities in biological discovery. Here, we highlight key areas where AI is driving innovation, from data analysis to new biological insights. These include developing an AI-friendly ecosystem for proteomics data generation, sharing, and analysis; improving peptide and protein identification and quantification; characterizing protein-protein interactions and protein complexes; advancing spatial and perturbation proteomics; integrating multi-omics data; and ultimately enabling AI-empowered virtual cells.

Scaling Autonomous Agents via Automatic Reward Modeling And Planning

Large language models (LLMs) have demonstrated remarkable capabilities across a range of text-generation tasks. However, LLMs still struggle with problems requiring multi-step decision-making and environmental feedback, such as online shopping, scientific reasoning, and mathematical problem-solving. Unlike pure text data, collecting large-scale decision-making data is challenging. Moreover, many powerful LLMs are only accessible through APIs, which hinders their fine-tuning for agent tasks due to cost and complexity. To address LLM agents' limitations, we propose a framework that can automatically learn a reward model from the environment without human annotations. This model can be used to evaluate the action trajectories of LLM agents and provide heuristics for task planning. Specifically, our approach involves employing one LLM-based agent to navigate an environment randomly, generating diverse action trajectories. Subsequently, a separate LLM is leveraged to assign a task intent and synthesize a negative response alongside the correct response for each trajectory. These triplets (task intent, positive response, and negative response) are then utilized as training data to optimize a reward model capable of scoring action trajectories. The effectiveness and generalizability of our framework are demonstrated through evaluations conducted on different agent benchmarks. In conclusion, our proposed framework represents a significant advancement in enhancing LLM agents' decision-making capabilities. By automating the learning of reward models, we overcome the challenges of data scarcity and API limitations, potentially revolutionizing the application of LLMs in complex and interactive environments. This research paves the way for more sophisticated AI agents capable of tackling a wide range of real-world problems requiring multi-step decision-making.

Exemplar-condensed Federated Class-incremental Learning

We propose Exemplar-Condensed federated class-incremental learning (ECoral) to distil the training characteristics of real images from streaming data into informative rehearsal exemplars. The proposed method eliminates the limitations of exemplar selection in replay-based approaches for mitigating catastrophic forgetting in federated continual learning (FCL). The limitations particularly related to the heterogeneity of information density of each summarized data. Our approach maintains the consistency of training gradients and the relationship to past tasks for the summarized exemplars to represent the streaming data compared to the original images effectively. Additionally, our approach reduces the information-level heterogeneity of the summarized data by inter-client sharing of the disentanglement generative model. Extensive experiments show that our ECoral outperforms several state-of-the-art methods and can be seamlessly integrated with many existing approaches to enhance performance.

LLM4AD: A Platform for Algorithm Design with Large Language Model

We introduce LLM4AD, a unified Python platform for algorithm design (AD) with large language models (LLMs). LLM4AD is a generic framework with modularized blocks for search methods, algorithm design tasks, and LLM interface. The platform integrates numerous key methods and supports a wide range of algorithm design tasks across various domains including optimization, machine learning, and scientific discovery. We have also designed a unified evaluation sandbox to ensure a secure and robust assessment of algorithms. Additionally, we have compiled a comprehensive suite of support resources, including tutorials, examples, a user manual, online resources, and a dedicated graphical user interface (GUI) to enhance the usage of LLM4AD. We believe this platform will serve as a valuable tool for fostering future development in the merging research direction of LLM-assisted algorithm design.

AIArena: A Blockchain-Based Decentralized AI Training Platform

The rapid advancement of AI has underscored critical challenges in its development and implementation, largely due to centralized control by a few major corporations. This concentration of power intensifies biases within AI models, resulting from inadequate governance and oversight mechanisms. Additionally, it limits public involvement and heightens concerns about the integrity of model generation. Such monopolistic control over data and AI outputs threatens both innovation and fair data usage, as users inadvertently contribute data that primarily benefits these corporations. In this work, we propose AIArena, a blockchain-based decentralized AI training platform designed to democratize AI development and alignment through on-chain incentive mechanisms. AIArena fosters an open and collaborative environment where participants can contribute models and computing resources. Its on-chain consensus mechanism ensures fair rewards for participants based on their contributions. We instantiate and implement AIArena on the public Base blockchain Sepolia testnet, and the evaluation results demonstrate the feasibility of AIArena in real-world applications.

A Universal Degradation-based Bridging Technique for Domain Adaptive Semantic Segmentation

Semantic segmentation often suffers from significant performance degradation when the trained network is applied to a different domain. To address this issue, unsupervised domain adaptation (UDA) has been extensively studied. Existing methods introduce the domain bridging techniques to mitigate substantial domain gap, which construct intermediate domains to facilitate the gradual transfer of knowledge across different domains. However, these strategies often require dataset-specific designs and may generate unnatural intermediate distributions that lead to semantic shift. In this paper, we propose DiDA, a universal degradation-based bridging technique formalized as a diffusion forward process. DiDA consists of two key modules: (1) Degradation-based Intermediate Domain Construction, which creates continuous intermediate domains through simple image degradation operations to encourage learning domain-invariant features as domain differences gradually diminish; (2) Semantic Shift Compensation, which leverages a diffusion encoder to encode and compensate for semantic shift information with degraded time-steps, preserving discriminative representations in the intermediate domains. As a plug-and-play solution, DiDA supports various degradation operations and seamlessly integrates with existing UDA methods. Extensive experiments on prevalent synthetic-to-real semantic segmentation benchmarks demonstrate that DiDA consistently improves performance across different settings and achieves new state-of-the-art results when combined with existing methods.