The FM Agent

Large language models (LLMs) are catalyzing the development of autonomous AI research agents for scientific and engineering discovery. We present FM Agent, a novel and general-purpose multi-agent framework that leverages a synergistic combination of LLM-based reasoning and large-scale evolutionary search to address complex real-world challenges. The core of FM Agent integrates several key innovations: 1) a cold-start initialization phase incorporating expert guidance, 2) a novel evolutionary sampling strategy for iterative optimization, 3) domain-specific evaluators that combine correctness, effectiveness, and LLM-supervised feedback, and 4) a distributed, asynchronous execution infrastructure built on Ray. Demonstrating broad applicability, our system has been evaluated across diverse domains, including operations research, machine learning, GPU kernel optimization, and classical mathematical problems. FM Agent reaches state-of-the-art results autonomously, without human interpretation or tuning -- 1976.3 on ALE-Bench (+5.2\%), 43.56\% on MLE-Bench (+4.0pp), up to 20x speedups on KernelBench, and establishes new state-of-the-art(SOTA) results on several classical mathematical problems. Beyond academic benchmarks, FM Agent shows considerable promise for both large-scale enterprise R\&D workflows and fundamental scientific research, where it can accelerate innovation, automate complex discovery processes, and deliver substantial engineering and scientific advances with broader societal impact.

Strategic priorities for transformative progress in advancing biology with proteomics and artificial intelligence

Artificial intelligence (AI) is transforming scientific research, including proteomics. Advances in mass spectrometry (MS)-based proteomics data quality, diversity, and scale, combined with groundbreaking AI techniques, are unlocking new challenges and opportunities in biological discovery. Here, we highlight key areas where AI is driving innovation, from data analysis to new biological insights. These include developing an AI-friendly ecosystem for proteomics data generation, sharing, and analysis; improving peptide and protein identification and quantification; characterizing protein-protein interactions and protein complexes; advancing spatial and perturbation proteomics; integrating multi-omics data; and ultimately enabling AI-empowered virtual cells.

MacLight: Multi-scene Aggregation Convolutional Learning for Traffic Signal Control

Reinforcement learning methods have proposed promising traffic signal control policy that can be trained on large road networks. Current SOTA methods model road networks as topological graph structures, incorporate graph attention into deep Q-learning, and merge local and global embeddings to improve policy. However, graph-based methods are difficult to parallelize, resulting in huge time overhead. Moreover, none of the current peer studies have deployed dynamic traffic systems for experiments, which is far from the actual situation. In this context, we propose Multi-Scene Aggregation Convolutional Learning for traffic signal control (MacLight), which offers faster training speeds and more stable performance. Our approach consists of two main components. The first is the global representation, where we utilize variational autoencoders to compactly compress and extract the global representation. The second component employs the proximal policy optimization algorithm as the backbone, allowing value evaluation to consider both local features and global embedding representations. This backbone model significantly reduces time overhead and ensures stability in policy updates. We validated our method across multiple traffic scenarios under both static and dynamic traffic systems. Experimental results demonstrate that, compared to general and domian SOTA methods, our approach achieves superior stability, optimized convergence levels and the highest time efficiency. The code is under https://github.com/Aegis1863/MacLight.