Nucleus-aware Self-supervised Pretraining Using Unpaired Image-to-image Translation for Histopathology Images

Self-supervised pretraining attempts to enhance model performance by obtaining effective features from unlabeled data, and has demonstrated its effectiveness in the field of histopathology images. Despite its success, few works concentrate on the extraction of nucleus-level information, which is essential for pathologic analysis. In this work, we propose a novel nucleus-aware self-supervised pretraining framework for histopathology images. The framework aims to capture the nuclear morphology and distribution information through unpaired image-to-image translation between histopathology images and pseudo mask images. The generation process is modulated by both conditional and stochastic style representations, ensuring the reality and diversity of the generated histopathology images for pretraining. Further, an instance segmentation guided strategy is employed to capture instance-level information. The experiments on 7 datasets show that the proposed pretraining method outperforms supervised ones on Kather classification, multiple instance learning, and 5 dense-prediction tasks with the transfer learning protocol, and yields superior results than other self-supervised approaches on 8 semi-supervised tasks. Our project is publicly available at https://github.com/zhiyuns/UNITPathSSL.

Object-Aware Distillation Pyramid for Open-Vocabulary Object Detection

Open-vocabulary object detection aims to provide object detectors trained on a fixed set of object categories with the generalizability to detect objects described by arbitrary text queries. Previous methods adopt knowledge distillation to extract knowledge from Pretrained Vision-and-Language Models (PVLMs) and transfer it to detectors. However, due to the non-adaptive proposal cropping and single-level feature mimicking processes, they suffer from information destruction during knowledge extraction and inefficient knowledge transfer. To remedy these limitations, we propose an Object-Aware Distillation Pyramid (OADP) framework, including an Object-Aware Knowledge Extraction (OAKE) module and a Distillation Pyramid (DP) mechanism. When extracting object knowledge from PVLMs, the former adaptively transforms object proposals and adopts object-aware mask attention to obtain precise and complete knowledge of objects. The latter introduces global and block distillation for more comprehensive knowledge transfer to compensate for the missing relation information in object distillation. Extensive experiments show that our method achieves significant improvement compared to current methods. Especially on the MS-COCO dataset, our OADP framework reaches $35.6$ mAP$^{\text{N}}_{50}$, surpassing the current state-of-the-art method by $3.3$ mAP$^{\text{N}}_{50}$. Code is released at https://github.com/LutingWang/OADP.

Transfer learning to decode brain states reflecting the relationship between cognitive tasks

Transfer learning improves the performance of the target task by leveraging the data of a specific source task: the closer the relationship between the source and the target tasks, the greater the performance improvement by transfer learning. In neuroscience, the relationship between cognitive tasks is usually represented by similarity of activated brain regions or neural representation. However, no study has linked transfer learning and neuroscience to reveal the relationship between cognitive tasks. In this study, we propose a transfer learning framework to reflect the relationship between cognitive tasks, and compare the task relations reflected by transfer learning and by the overlaps of brain regions (e.g., neurosynth). Our results of transfer learning create cognitive taskonomy to reflect the relationship between cognitive tasks which is well in line with the task relations derived from neurosynth. Transfer learning performs better in task decoding with fMRI data if the source and target cognitive tasks activate similar brain regions. Our study uncovers the relationship of multiple cognitive tasks and provides guidance for source task selection in transfer learning for neural decoding based on small-sample data.