Multi-Agent Intelligence for Multidisciplinary Decision-Making in Gastrointestinal Oncology

Multimodal clinical reasoning in the field of gastrointestinal (GI) oncology necessitates the integrated interpretation of endoscopic imagery, radiological data, and biochemical markers. Despite the evident potential exhibited by Multimodal Large Language Models (MLLMs), they frequently encounter challenges such as context dilution and hallucination when confronted with intricate, heterogeneous medical histories. In order to address these limitations, a hierarchical Multi-Agent Framework is proposed, which emulates the collaborative workflow of a human Multidisciplinary Team (MDT). The system attained a composite expert evaluation score of 4.60/5.00, thereby demonstrating a substantial improvement over the monolithic baseline. It is noteworthy that the agent-based architecture yielded the most substantial enhancements in reasoning logic and medical accuracy. The findings indicate that mimetic, agent-based collaboration provides a scalable, interpretable, and clinically robust paradigm for automated decision support in oncology.

AIonopedia: an LLM agent orchestrating multimodal learning for ionic liquid discovery

The discovery of novel Ionic Liquids (ILs) is hindered by critical challenges in property prediction, including limited data, poor model accuracy, and fragmented workflows. Leveraging the power of Large Language Models (LLMs), we introduce AIonopedia, to the best of our knowledge, the first LLM agent for IL discovery. Powered by an LLM-augmented multimodal domain foundation model for ILs, AIonopedia enables accurate property predictions and incorporates a hierarchical search architecture for molecular screening and design. Trained and evaluated on a newly curated and comprehensive IL dataset, our model delivers superior performance. Complementing these results, evaluations on literature-reported systems indicate that the agent can perform effective IL modification. Moving beyond offline tests, the practical efficacy was further confirmed through real-world wet-lab validation, in which the agent demonstrated exceptional generalization capabilities on challenging out-of-distribution tasks, underscoring its ability to accelerate real-world IL discovery.

Safe and Non-Conservative Contingency Planning for Autonomous Vehicles via Online Learning-Based Reachable Set Barriers

Autonomous vehicles must navigate dynamically uncertain environments while balancing the safety and driving efficiency. This challenge is exacerbated by the unpredictable nature of surrounding human-driven vehicles (HVs) and perception inaccuracies, which require planners to adapt to evolving uncertainties while maintaining safe trajectories. Overly conservative planners degrade driving efficiency, while deterministic approaches may encounter serious issues and risks of failure when faced with sudden and unexpected maneuvers. To address these issues, we propose a real-time contingency trajectory optimization framework in this paper. By employing event-triggered online learning of HV control-intent sets, our method dynamically quantifies multi-modal HV uncertainties and refines the forward reachable set (FRS) incrementally. Crucially, we enforce invariant safety through FRS-based barrier constraints that ensure safety without reliance on accurate trajectory prediction of HVs. These constraints are embedded in contingency trajectory optimization and solved efficiently through consensus alternative direction method of multipliers (ADMM). The system continuously adapts to the uncertainties in HV behaviors, preserving feasibility and safety without resorting to excessive conservatism. High-fidelity simulations on highway and urban scenarios, as well as a series of real-world experiments demonstrate significant improvements in driving efficiency and passenger comfort while maintaining safety under uncertainty. The project page is available at https://pathetiue.github.io/frscp.github.io/.

M-MRE: Extending the Mutual Reinforcement Effect to Multimodal Information Extraction

Mutual Reinforcement Effect (MRE) is an emerging subfield at the intersection of information extraction and model interpretability. MRE aims to leverage the mutual understanding between tasks of different granularities, enhancing the performance of both coarse-grained and fine-grained tasks through joint modeling. While MRE has been explored and validated in the textual domain, its applicability to visual and multimodal domains remains unexplored. In this work, we extend MRE to the multimodal information extraction domain for the first time. Specifically, we introduce a new task: Multimodal Mutual Reinforcement Effect (M-MRE), and construct a corresponding dataset to support this task. To address the challenges posed by M-MRE, we further propose a Prompt Format Adapter (PFA) that is fully compatible with various Large Vision-Language Models (LVLMs). Experimental results demonstrate that MRE can also be observed in the M-MRE task, a multimodal text-image understanding scenario. This provides strong evidence that MRE facilitates mutual gains across three interrelated tasks, confirming its generalizability beyond the textual domain.

Occlusion-Aware Consistent Model Predictive Control for Robot Navigation in Occluded Obstacle-Dense Environments

Ensuring safety and motion consistency for robot navigation in occluded, obstacle-dense environments is a critical challenge. In this context, this study presents an occlusion-aware Consistent Model Predictive Control (CMPC) strategy. To account for the occluded obstacles, it incorporates adjustable risk regions that represent their potential future locations. Subsequently, dynamic risk boundary constraints are developed online to ensure safety. The CMPC then constructs multiple locally optimal trajectory branches (each tailored to different risk regions) to balance between exploitation and exploration. A shared consensus trunk is generated to ensure smooth transitions between branches without significant velocity fluctuations, further preserving motion consistency. To facilitate high computational efficiency and ensure coordination across local trajectories, we use the alternating direction method of multipliers (ADMM) to decompose the CMPC into manageable sub-problems for parallel solving. The proposed strategy is validated through simulation and real-world experiments on an Ackermann-steering robot platform. The results demonstrate the effectiveness of the proposed CMPC strategy through comparisons with baseline approaches in occluded, obstacle-dense environments.

Occlusion-Aware Contingency Safety-Critical Planning for Autonomous Vehicles

Ensuring safe driving while maintaining travel efficiency for autonomous vehicles in dynamic and occluded environments is a critical challenge. This paper proposes an occlusion-aware contingency safety-critical planning approach for real-time autonomous driving in such environments. Leveraging reachability analysis for risk assessment, forward reachable sets of occluded phantom vehicles are computed to quantify dynamic velocity boundaries. These velocity boundaries are incorporated into a biconvex nonlinear programming (NLP) formulation, enabling simultaneous optimization of exploration and fallback trajectories within a receding horizon planning framework. To facilitate real-time optimization and ensure coordination between trajectories, we employ the consensus alternating direction method of multipliers (ADMM) to decompose the biconvex NLP problem into low-dimensional convex subproblems. The effectiveness of the proposed approach is validated through simulation studies and real-world experiments in occluded intersections. Experimental results demonstrate enhanced safety and improved travel efficiency, enabling real-time safe trajectory generation in dynamic occluded intersections under varying obstacle conditions. A video showcasing the experimental results is available at https://youtu.be/CHayG7NChqM.

Bilevel Multi-Armed Bandit-Based Hierarchical Reinforcement Learning for Interaction-Aware Self-Driving at Unsignalized Intersections

In this work, we present BiM-ACPPO, a bilevel multi-armed bandit-based hierarchical reinforcement learning framework for interaction-aware decision-making and planning at unsignalized intersections. Essentially, it proactively takes the uncertainties associated with surrounding vehicles (SVs) into consideration, which encompass those stemming from the driver's intention, interactive behaviors, and the varying number of SVs. Intermediate decision variables are introduced to enable the high-level RL policy to provide an interaction-aware reference, for guiding low-level model predictive control (MPC) and further enhancing the generalization ability of the proposed framework. By leveraging the structured nature of self-driving at unsignalized intersections, the training problem of the RL policy is modeled as a bilevel curriculum learning task, which is addressed by the proposed Exp3.S-based BiMAB algorithm. It is noteworthy that the training curricula are dynamically adjusted, thereby facilitating the sample efficiency of the RL training process. Comparative experiments are conducted in the high-fidelity CARLA simulator, and the results indicate that our approach achieves superior performance compared to all baseline methods. Furthermore, experimental results in two new urban driving scenarios clearly demonstrate the commendable generalization performance of the proposed method.

LearningFlow: Automated Policy Learning Workflow for Urban Driving with Large Language Models

Recent advancements in reinforcement learning (RL) demonstrate the significant potential in autonomous driving. Despite this promise, challenges such as the manual design of reward functions and low sample efficiency in complex environments continue to impede the development of safe and effective driving policies. To tackle these issues, we introduce LearningFlow, an innovative automated policy learning workflow tailored to urban driving. This framework leverages the collaboration of multiple large language model (LLM) agents throughout the RL training process. LearningFlow includes a curriculum sequence generation process and a reward generation process, which work in tandem to guide the RL policy by generating tailored training curricula and reward functions. Particularly, each process is supported by an analysis agent that evaluates training progress and provides critical insights to the generation agent. Through the collaborative efforts of these LLM agents, LearningFlow automates policy learning across a series of complex driving tasks, and it significantly reduces the reliance on manual reward function design while enhancing sample efficiency. Comprehensive experiments are conducted in the high-fidelity CARLA simulator, along with comparisons with other existing methods, to demonstrate the efficacy of our proposed approach. The results demonstrate that LearningFlow excels in generating rewards and curricula. It also achieves superior performance and robust generalization across various driving tasks, as well as commendable adaptation to different RL algorithms.

Synergizing Decision Making and Trajectory Planning Using Two-Stage Optimization for Autonomous Vehicles

This paper introduces a local planner that synergizes the decision making and trajectory planning modules towards autonomous driving. The decision making and trajectory planning tasks are jointly formulated as a nonlinear programming problem with an integrated objective function. However, integrating the discrete decision variables into the continuous trajectory optimization leads to a mixed-integer programming (MIP) problem with inherent nonlinearity and nonconvexity. To address the challenge in solving the problem, the original problem is decomposed into two sub-stages, and a two-stage optimization (TSO) based approach is presented to ensure the coherence in outcomes for the two stages. The optimization problem in the first stage determines the optimal decision sequence that acts as an informed initialization. With the outputs from the first stage, the second stage necessitates the use of a high-fidelity vehicle model and strict enforcement of the collision avoidance constraints as part of the trajectory planning problem. We evaluate the effectiveness of our proposed planner across diverse multi-lane scenarios. The results demonstrate that the proposed planner simultaneously generates a sequence of optimal decisions and the corresponding trajectory that significantly improves driving performance in terms of driving safety and traveling efficiency as compared to alternative methods. Additionally, we implement the closed-loop simulation in CARLA, and the results showcase the effectiveness of the proposed planner to adapt to changing driving situations with high computational efficiency.

Safe and Real-Time Consistent Planning for Autonomous Vehicles in Partially Observed Environments via Parallel Consensus Optimization

Ensuring safety and driving consistency is a significant challenge for autonomous vehicles operating in partially observed environments. This work introduces a consistent parallel trajectory optimization (CPTO) approach to enable safe and consistent driving in dense obstacle environments with perception uncertainties. Utilizing discrete-time barrier function theory, we develop a consensus safety barrier module that ensures reliable safety coverage within the spatiotemporal trajectory space across potential obstacle configurations. Following this, a bi-convex parallel trajectory optimization problem is derived that facilitates decomposition into a series of low-dimensional quadratic programming problems to accelerate computation. By leveraging the consensus alternating direction method of multipliers (ADMM) for parallel optimization, each generated candidate trajectory corresponds to a possible environment configuration while sharing a common consensus trajectory segment. This ensures driving safety and consistency when executing the consensus trajectory segment for the ego vehicle in real time. We validate our CPTO framework through extensive comparisons with state-of-the-art baselines across multiple driving tasks in partially observable environments. Our results demonstrate improved safety and consistency using both synthetic and real-world traffic datasets.