Towards Fair Patient-Trial Matching via Patient-Criterion Level Fairness Constraint

Clinical trials are indispensable in developing new treatments, but they face obstacles in patient recruitment and retention, hindering the enrollment of necessary participants. To tackle these challenges, deep learning frameworks have been created to match patients to trials. These frameworks calculate the similarity between patients and clinical trial eligibility criteria, considering the discrepancy between inclusion and exclusion criteria. Recent studies have shown that these frameworks outperform earlier approaches. However, deep learning models may raise fairness issues in patient-trial matching when certain sensitive groups of individuals are underrepresented in clinical trials, leading to incomplete or inaccurate data and potential harm. To tackle the issue of fairness, this work proposes a fair patient-trial matching framework by generating a patient-criterion level fairness constraint. The proposed framework considers the inconsistency between the embedding of inclusion and exclusion criteria among patients of different sensitive groups. The experimental results on real-world patient-trial and patient-criterion matching tasks demonstrate that the proposed framework can successfully alleviate the predictions that tend to be biased.

Is Prompt All You Need? No. A Comprehensive and Broader View of Instruction Learning

Task semantics can be expressed by a set of input-to-output examples or a piece of textual instruction. Conventional machine learning approaches for natural language processing (NLP) mainly rely on the availability of large-scale sets of task-specific examples. Two issues arise: first, collecting task-specific labeled examples does not apply to scenarios where tasks may be too complicated or costly to annotate, or the system is required to handle a new task immediately; second, this is not user-friendly since end-users are probably more willing to provide task description rather than a set of examples before using the system. Therefore, the community is paying increasing interest in a new supervision-seeking paradigm for NLP: learning from task instructions. Despite its impressive progress, there are some common issues that the community struggles with. This survey paper tries to summarize the current research on instruction learning, particularly, by answering the following questions: (i) what is task instruction, and what instruction types exist? (ii) how to model instructions? (iii) what factors influence and explain the instructions' performance? (iv) what challenges remain in instruction learning? To our knowledge, this is the first comprehensive survey about textual instructions.

DDFM: Denoising Diffusion Model for Multi-Modality Image Fusion

Multi-modality image fusion aims to combine different modalities to produce fused images that retain the complementary features of each modality, such as functional highlights and texture details. To leverage strong generative priors and address challenges such as unstable training and lack of interpretability for GAN-based generative methods, we propose a novel fusion algorithm based on the denoising diffusion probabilistic model (DDPM). The fusion task is formulated as a conditional generation problem under the DDPM sampling framework, which is further divided into an unconditional generation subproblem and a maximum likelihood subproblem. The latter is modeled in a hierarchical Bayesian manner with latent variables and inferred by the expectation-maximization algorithm. By integrating the inference solution into the diffusion sampling iteration, our method can generate high-quality fused images with natural image generative priors and cross-modality information from source images. Note that all we required is an unconditional pre-trained generative model, and no fine-tuning is needed. Our extensive experiments indicate that our approach yields promising fusion results in infrared-visible image fusion and medical image fusion. The code will be released.

QVRF: A Quantization-error-aware Variable Rate Framework for Learned Image Compression

Learned image compression has exhibited promising compression performance, but variable bitrates over a wide range remain a challenge. State-of-the-art variable rate methods compromise the loss of model performance and require numerous additional parameters. In this paper, we present a Quantization-error-aware Variable Rate Framework (QVRF) that utilizes a univariate quantization regulator a to achieve wide-range variable rates within a single model. Specifically, QVRF defines a quantization regulator vector coupled with predefined Lagrange multipliers to control quantization error of all latent representation for discrete variable rates. Additionally, the reparameterization method makes QVRF compatible with a round quantizer. Exhaustive experiments demonstrate that existing fixed-rate VAE-based methods equipped with QVRF can achieve wide-range continuous variable rates within a single model without significant performance degradation. Furthermore, QVRF outperforms contemporary variable-rate methods in rate-distortion performance with minimal additional parameters.

Memory-adaptive Depth-wise Heterogenous Federated Learning

Federated learning is a promising paradigm that allows multiple clients to collaboratively train a model without sharing the local data. However, the presence of heterogeneous devices in federated learning, such as mobile phones and IoT devices with varying memory capabilities, would limit the scale and hence the performance of the model could be trained. The mainstream approaches to address memory limitations focus on width-slimming techniques, where different clients train subnetworks with reduced widths locally and then the server aggregates the subnetworks. The global model produced from these methods suffers from performance degradation due to the negative impact of the actions taken to handle the varying subnetwork widths in the aggregation phase. In this paper, we introduce a memory-adaptive depth-wise learning solution in FL called FeDepth, which adaptively decomposes the full model into blocks according to the memory budgets of each client and trains blocks sequentially to obtain a full inference model. Our method outperforms state-of-the-art approaches, achieving 5% and more than 10% improvements in top-1 accuracy on CIFAR-10 and CIFAR-100, respectively. We also demonstrate the effectiveness of depth-wise fine-tuning on ViT. Our findings highlight the importance of memory-aware techniques for federated learning with heterogeneous devices and the success of depth-wise training strategy in improving the global model's performance.

Securing Biomedical Images from Unauthorized Training with Anti-Learning Perturbation

The volume of open-source biomedical data has been essential to the development of various spheres of the healthcare community since more `free' data can provide individual researchers more chances to contribute. However, institutions often hesitate to share their data with the public due to the risk of data exploitation by unauthorized third parties for another commercial usage (e.g., training AI models). This phenomenon might hinder the development of the whole healthcare research community. To address this concern, we propose a novel approach termed `unlearnable biomedical image' for protecting biomedical data by injecting imperceptible but delusive noises into the data, making them unexploitable for AI models. We formulate the problem as a bi-level optimization and propose three kinds of anti-learning perturbation generation approaches to solve the problem. Our method is an important step toward encouraging more institutions to contribute their data for the long-term development of the research community.

Building Shortcuts between Distant Nodes with Biaffine Mapping for Graph Convolutional Networks

Multiple recent studies show a paradox in graph convolutional networks (GCNs), that is, shallow architectures limit the capability of learning information from high-order neighbors, while deep architectures suffer from over-smoothing or over-squashing. To enjoy the simplicity of shallow architectures and overcome their limits of neighborhood extension, in this work, we introduce Biaffine technique to improve the expressiveness of graph convolutional networks with a shallow architecture. The core design of our method is to learn direct dependency on long-distance neighbors for nodes, with which only one-hop message passing is capable of capturing rich information for node representation. Besides, we propose a multi-view contrastive learning method to exploit the representations learned from long-distance dependencies. Extensive experiments on nine graph benchmark datasets suggest that the shallow biaffine graph convolutional networks (BAGCN) significantly outperforms state-of-the-art GCNs (with deep or shallow architectures) on semi-supervised node classification. We further verify the effectiveness of biaffine design in node representation learning and the performance consistency on different sizes of training data.

A Comprehensive Survey on Pretrained Foundation Models: A History from BERT to ChatGPT

The Pretrained Foundation Models (PFMs) are regarded as the foundation for various downstream tasks with different data modalities. A pretrained foundation model, such as BERT, GPT-3, MAE, DALLE-E, and ChatGPT, is trained on large-scale data which provides a reasonable parameter initialization for a wide range of downstream applications. The idea of pretraining behind PFMs plays an important role in the application of large models. Different from previous methods that apply convolution and recurrent modules for feature extractions, the generative pre-training (GPT) method applies Transformer as the feature extractor and is trained on large datasets with an autoregressive paradigm. Similarly, the BERT apples transformers to train on large datasets as a contextual language model. Recently, the ChatGPT shows promising success on large language models, which applies an autoregressive language model with zero shot or few show prompting. With the extraordinary success of PFMs, AI has made waves in a variety of fields over the past few years. Considerable methods, datasets, and evaluation metrics have been proposed in the literature, the need is raising for an updated survey. This study provides a comprehensive review of recent research advancements, current and future challenges, and opportunities for PFMs in text, image, graph, as well as other data modalities. We first review the basic components and existing pretraining in natural language processing, computer vision, and graph learning. We then discuss other advanced PFMs for other data modalities and unified PFMs considering the data quality and quantity. Besides, we discuss relevant research about the fundamentals of the PFM, including model efficiency and compression, security, and privacy. Finally, we lay out key implications, future research directions, challenges, and open problems.

Fairly Predicting Graft Failure in Liver Transplant for Organ Assigning

Liver transplant is an essential therapy performed for severe liver diseases. The fact of scarce liver resources makes the organ assigning crucial. Model for End-stage Liver Disease (MELD) score is a widely adopted criterion when making organ distribution decisions. However, it ignores post-transplant outcomes and organ/donor features. These limitations motivate the emergence of machine learning (ML) models. Unfortunately, ML models could be unfair and trigger bias against certain groups of people. To tackle this problem, this work proposes a fair machine learning framework targeting graft failure prediction in liver transplant. Specifically, knowledge distillation is employed to handle dense and sparse features by combining the advantages of tree models and neural networks. A two-step debiasing method is tailored for this framework to enhance fairness. Experiments are conducted to analyze unfairness issues in existing models and demonstrate the superiority of our method in both prediction and fairness performance.

Event-Based Frame Interpolation with Ad-hoc Deblurring

The performance of video frame interpolation is inherently correlated with the ability to handle motion in the input scene. Even though previous works recognize the utility of asynchronous event information for this task, they ignore the fact that motion may or may not result in blur in the input video to be interpolated, depending on the length of the exposure time of the frames and the speed of the motion, and assume either that the input video is sharp, restricting themselves to frame interpolation, or that it is blurry, including an explicit, separate deblurring stage before interpolation in their pipeline. We instead propose a general method for event-based frame interpolation that performs deblurring ad-hoc and thus works both on sharp and blurry input videos. Our model consists in a bidirectional recurrent network that naturally incorporates the temporal dimension of interpolation and fuses information from the input frames and the events adaptively based on their temporal proximity. In addition, we introduce a novel real-world high-resolution dataset with events and color videos named HighREV, which provides a challenging evaluation setting for the examined task. Extensive experiments on the standard GoPro benchmark and on our dataset show that our network consistently outperforms previous state-of-the-art methods on frame interpolation, single image deblurring and the joint task of interpolation and deblurring. Our code and dataset will be made publicly available.