Radiomics-Integrated Deep Learning with Hierarchical Loss for Osteosarcoma Histology Classification

Osteosarcoma (OS) is an aggressive primary bone malignancy. Accurate histopathological assessment of viable versus non-viable tumor regions after neoadjuvant chemotherapy is critical for prognosis and treatment planning, yet manual evaluation remains labor-intensive, subjective, and prone to inter-observer variability. Recent advances in digital pathology have enabled automated necrosis quantification. Evaluating on test data, independently sampled on patient-level, revealed that the deep learning model performance dropped significantly from the tile-level generalization ability reported in previous studies. First, this work proposes the use of radiomic features as additional input in model training. We show that, despite that they are derived from the images, such a multimodal input effectively improved the classification performance, in addition to its added benefits in interpretability. Second, this work proposes to optimize two binary classification tasks with hierarchical classes (i.e. tumor-vs-non-tumor and viable-vs-non-viable), as opposed to the alternative ``flat'' three-class classification task (i.e. non-tumor, non-viable tumor, viable tumor), thereby enabling a hierarchical loss. We show that such a hierarchical loss, with trainable weightings between the two tasks, the per-class performance can be improved significantly. Using the TCIA OS Tumor Assessment dataset, we experimentally demonstrate the benefits from each of the proposed new approaches and their combination, setting a what we consider new state-of-the-art performance on this open dataset for this application. Code and trained models: https://github.com/YaxiiC/RadiomicsOS.git.

Interpretability and Individuality in Knee MRI: Patient-Specific Radiomic Fingerprint with Reconstructed Healthy Personas

For automated assessment of knee MRI scans, both accuracy and interpretability are essential for clinical use and adoption. Traditional radiomics rely on predefined features chosen at the population level; while more interpretable, they are often too restrictive to capture patient-specific variability and can underperform end-to-end deep learning (DL). To address this, we propose two complementary strategies that bring individuality and interpretability: radiomic fingerprints and healthy personas. First, a radiomic fingerprint is a dynamically constructed, patient-specific feature set derived from MRI. Instead of applying a uniform population-level signature, our model predicts feature relevance from a pool of candidate features and selects only those most predictive for each patient, while maintaining feature-level interpretability. This fingerprint can be viewed as a latent-variable model of feature usage, where an image-conditioned predictor estimates usage probabilities and a transparent logistic regression with global coefficients performs classification. Second, a healthy persona synthesises a pathology-free baseline for each patient using a diffusion model trained to reconstruct healthy knee MRIs. Comparing features extracted from pathological images against their personas highlights deviations from normal anatomy, enabling intuitive, case-specific explanations of disease manifestations. We systematically compare fingerprints, personas, and their combination across three clinical tasks. Experimental results show that both approaches yield performance comparable to or surpassing state-of-the-art DL models, while supporting interpretability at multiple levels. Case studies further illustrate how these perspectives facilitate human-explainable biomarker discovery and pathology localisation.

All Changes May Have Invariant Principles: Improving Ever-Shifting Harmful Meme Detection via Design Concept Reproduction

Harmful memes are ever-shifting in the Internet communities, which are difficult to analyze due to their type-shifting and temporal-evolving nature. Although these memes are shifting, we find that different memes may share invariant principles, i.e., the underlying design concept of malicious users, which can help us analyze why these memes are harmful. In this paper, we propose RepMD, an ever-shifting harmful meme detection method based on the design concept reproduction. We first refer to the attack tree to define the Design Concept Graph (DCG), which describes steps that people may take to design a harmful meme. Then, we derive the DCG from historical memes with design step reproduction and graph pruning. Finally, we use DCG to guide the Multimodal Large Language Model (MLLM) to detect harmful memes. The evaluation results show that RepMD achieves the highest accuracy with 81.1% and has slight accuracy decreases when generalized to type-shifting and temporal-evolving memes. Human evaluation shows that RepMD can improve the efficiency of human discovery on harmful memes, with 15$\sim$30 seconds per meme.

Iterative Inference-time Scaling with Adaptive Frequency Steering for Image Super-Resolution

Diffusion models have become a leading paradigm for image super-resolution (SR), but existing methods struggle to guarantee both the high-frequency perceptual quality and the low-frequency structural fidelity of generated images. Although inference-time scaling can theoretically improve this trade-off by allocating more computation, existing strategies remain suboptimal: reward-driven particle optimization often causes perceptual over-smoothing, while optimal-path search tends to lose structural consistency. To overcome these difficulties, we propose Iterative Diffusion Inference-Time Scaling with Adaptive Frequency Steering (IAFS), a training-free framework that jointly leverages iterative refinement and frequency-aware particle fusion. IAFS addresses the challenge of balancing perceptual quality and structural fidelity by progressively refining the generated image through iterative correction of structural deviations. Simultaneously, it ensures effective frequency fusion by adaptively integrating high-frequency perceptual cues with low-frequency structural information, allowing for a more accurate and balanced reconstruction across different image details. Extensive experiments across multiple diffusion-based SR models show that IAFS effectively resolves the perception-fidelity conflict, yielding consistently improved perceptual detail and structural accuracy, and outperforming existing inference-time scaling methods.

FinPercep-RM: A Fine-grained Reward Model and Co-evolutionary Curriculum for RL-based Real-world Super-Resolution

Reinforcement Learning with Human Feedback (RLHF) has proven effective in image generation field guided by reward models to align human preferences. Motivated by this, adapting RLHF for Image Super-Resolution (ISR) tasks has shown promise in optimizing perceptual quality with Image Quality Assessment (IQA) model as reward models. However, the traditional IQA model usually output a single global score, which are exceptionally insensitive to local and fine-grained distortions. This insensitivity allows ISR models to produce perceptually undesirable artifacts that yield spurious high scores, misaligning optimization objectives with perceptual quality and results in reward hacking. To address this, we propose a Fine-grained Perceptual Reward Model (FinPercep-RM) based on an Encoder-Decoder architecture. While providing a global quality score, it also generates a Perceptual Degradation Map that spatially localizes and quantifies local defects. We specifically introduce the FGR-30k dataset to train this model, consisting of diverse and subtle distortions from real-world super-resolution models. Despite the success of the FinPercep-RM model, its complexity introduces significant challenges in generator policy learning, leading to training instability. To address this, we propose a Co-evolutionary Curriculum Learning (CCL) mechanism, where both the reward model and the ISR model undergo synchronized curricula. The reward model progressively increases in complexity, while the ISR model starts with a simpler global reward for rapid convergence, gradually transitioning to the more complex model outputs. This easy-to-hard strategy enables stable training while suppressing reward hacking. Experiments validates the effectiveness of our method across ISR models in both global quality and local realism on RLHF methods.

VideoScaffold: Elastic-Scale Visual Hierarchies for Streaming Video Understanding in MLLMs

Understanding long videos with multimodal large language models (MLLMs) remains challenging due to the heavy redundancy across frames and the need for temporally coherent representations. Existing static strategies, such as sparse sampling, frame compression, and clustering, are optimized for offline settings and often produce fragmented or over-compressed outputs when applied to continuous video streams. We present VideoScaffold, a dynamic representation framework designed for streaming video understanding. It adaptively adjusts event granularity according to video duration while preserving fine-grained visual semantics. VideoScaffold introduces two key components: Elastic-Scale Event Segmentation (EES), which performs prediction-guided segmentation to dynamically refine event boundaries, and Hierarchical Event Consolidation (HEC), which progressively aggregates semantically related segments into multi-level abstractions. Working in concert, EES and HEC enable VideoScaffold to transition smoothly from fine-grained frame understanding to abstract event reasoning as the video stream unfolds. Extensive experiments across both offline and streaming video understanding benchmarks demonstrate that VideoScaffold achieves state-of-the-art performance. The framework is modular and plug-and-play, seamlessly extending existing image-based MLLMs to continuous video comprehension. The code is available at https://github.com/zheng980629/VideoScaffold.

SketchAssist: A Practical Assistant for Semantic Edits and Precise Local Redrawing

Sketch editing is central to digital illustration, yet existing image editing systems struggle to preserve the sparse, style-sensitive structure of line art while supporting both high-level semantic changes and precise local redrawing. We present SketchAssist, an interactive sketch drawing assistant that accelerates creation by unifying instruction-guided global edits with line-guided region redrawing, while keeping unrelated regions and overall composition intact. To enable this assistant at scale, we introduce a controllable data generation pipeline that (i) constructs attribute-addition sequences from attribute-free base sketches, (ii) forms multi-step edit chains via cross-sequence sampling, and (iii) expands stylistic coverage with a style-preserving attribute-removal model applied to diverse sketches. Building on this data, SketchAssist employs a unified sketch editing framework with minimal changes to DiT-based editors. We repurpose the RGB channels to encode the inputs, enabling seamless switching between instruction-guided edits and line-guided redrawing within a single input interface. To further specialize behavior across modes, we integrate a task-guided mixture-of-experts into LoRA layers, routing by text and visual cues to improve semantic controllability, structural fidelity, and style preservation. Extensive experiments show state-of-the-art results on both tasks, with superior instruction adherence and style/structure preservation compared to recent baselines. Together, our dataset and SketchAssist provide a practical, controllable assistant for sketch creation and revision.

A Roadmap for Applying Graph Neural Networks to Numerical Data: Insights from Cementitious Materials

Machine learning (ML) has been increasingly applied in concrete research to optimize performance and mixture design. However, one major challenge in applying ML to cementitious materials is the limited size and diversity of available databases. A promising solution is the development of multi-modal databases that integrate both numerical and graphical data. Conventional ML frameworks in cement research are typically restricted to a single data modality. Graph neural network (GNN) represents a new generation of neural architectures capable of learning from data structured as graphs, capturing relationships through irregular or topology-dependent connections rather than fixed spatial coordinates. While GNN is inherently designed for graphical data, they can be adapted to extract correlations from numerical datasets and potentially embed physical laws directly into their architecture, enabling explainable and physics-informed predictions. This work is among the first few studies to implement GNNs to design concrete, with a particular emphasis on establishing a clear and reproducible pathway for converting tabular data into graph representations using the k-nearest neighbor (K-NN) approach. Model hyperparameters and feature selection are systematically optimized to enhance prediction performance. The GNN shows performance comparable to the benchmark random forest, which has been demonstrated by many studies to yield reliable predictions for cementitious materials. Overall, this study provides a foundational roadmap for transitioning from traditional ML to advanced AI architectures. The proposed framework establishes a strong foundation for future multi-modal and physics-informed GNN models capable of capturing complex material behaviors and accelerating the design and optimization of cementitious materials.

Fast-ARDiff: An Entropy-informed Acceleration Framework for Continuous Space Autoregressive Generation

Autoregressive(AR)-diffusion hybrid paradigms combine AR's structured modeling with diffusion's photorealistic synthesis, yet suffer from high latency due to sequential AR generation and iterative denoising. In this work, we tackle this bottleneck and propose a unified AR-diffusion framework Fast-ARDiff that jointly optimizes both components, accelerating AR speculative decoding while simultaneously facilitating faster diffusion decoding. Specifically: (1) The entropy-informed speculative strategy encourages draft model to produce higher-entropy representations aligned with target model's entropy characteristics, mitigating entropy mismatch and high rejection rates caused by draft overconfidence. (2) For diffusion decoding, rather than treating it as an independent module, we integrate it into the same end-to-end framework using a dynamic scheduler that prioritizes AR optimization to guide the diffusion part in further steps. The diffusion part is optimized through a joint distillation framework combining trajectory and distribution matching, ensuring stable training and high-quality synthesis with extremely few steps. During inference, shallow feature entropy from AR module is used to pre-filter low-entropy drafts, avoiding redundant computation and improving latency. Fast-ARDiff achieves state-of-the-art acceleration across diverse models: on ImageNet 256$\times$256, TransDiff attains 4.3$\times$ lossless speedup, and NextStep-1 achieves 3$\times$ acceleration on text-conditioned generation. Code will be available at https://github.com/aSleepyTree/Fast-ARDiff.

Revisiting Multimodal Positional Encoding in Vision-Language Models

Multimodal position encoding is essential for vision-language models, yet there has been little systematic investigation into multimodal position encoding. We conduct a comprehensive analysis of multimodal Rotary Positional Embedding (RoPE) by examining its two core components: position design and frequency allocation. Through extensive experiments, we identify three key guidelines: positional coherence, full frequency utilization, and preservation of textual priors-ensuring unambiguous layout, rich representation, and faithful transfer from the pre-trained LLM. Based on these insights, we propose Multi-Head RoPE (MHRoPE) and MRoPE-Interleave (MRoPE-I), two simple and plug-and-play variants that require no architectural changes. Our methods consistently outperform existing approaches across diverse benchmarks, with significant improvements in both general and fine-grained multimodal understanding. Code will be avaliable at https://github.com/JJJYmmm/Multimodal-RoPEs.