Abstract:Generative Control Policies (GCPs) show immense promise in robotic manipulation but struggle to simultaneously model stable global motions and high-frequency local corrections. While modern architectures extract multi-scale spatial features, their underlying Probability Flow ODEs apply a uniform temporal integration schedule. Compressed to a single step for real-time Receding Horizon Control (RHC), uniform ODE solvers mathematically smooth over sparse, high-frequency transients entangled within low-frequency steady states. To decouple these dynamics without accumulating pipelined errors, we introduce KoopmanFlow, a parameter-efficient generative policy guided by a Koopman-inspired structural inductive bias. Operating in a unified multimodal latent space with visual context, KoopmanFlow bifurcates generation at the terminal stage. Because visual conditioning occurs before spectral decomposition, both branches are visually guided yet temporally specialized. A macroscopic branch anchors slow-varying trajectories via single-step Consistency Training, while a transient branch uses Flow Matching to isolate high-frequency residuals stimulated by sudden visual cues (e.g., contacts or occlusions). Guided by an explicit spectral prior and optimized via a novel asymmetric consistency objective, KoopmanFlow establishes a fused co-training mechanism. This allows the variant branch to absorb localized dynamics without multi-stage error accumulation. Extensive experiments show KoopmanFlow significantly outperforms state-of-the-art baselines in contact-rich tasks requiring agile disturbance rejection. By trading a surplus latency buffer for a richer structural prior, KoopmanFlow achieves superior control fidelity and parameter efficiency within real-time deployment limits.
Abstract:Embodied task planning demands vision-language models to generate action sequences that are both visually grounded and causally coherent over time. However, existing training paradigms face a critical trade-off: joint end-to-end training often leads to premature temporal binding, while standard reinforcement learning methods suffer from optimization instability. To bridge this gap, we present Staged Vision-Language Learning (SVLL), a unified three-stage framework for robust, physically-grounded embodied planning. In the first two stages, SVLL decouples spatial grounding from temporal reasoning, establishing robust visual dependency before introducing sequential action history. In the final stage, we identify a key limitation of standard Direct Preference Optimization (DPO), its purely relative nature -- optimizing only the preference gap between winning and losing trajectories while neglecting absolute likelihood constraints on optimal path, often yields unsafe or hallucinated behaviors. To address this, we further introduce Bias-DPO, a novel alignment objective that injects an inductive bias toward expert trajectories by explicitly maximizing likelihood on ground-truth actions while penalizing overconfident hallucinations. By anchoring the policy to the expert manifold and mitigating causal misalignment, SVLL, powered by Bias-DPO, ensures strict adherence to environmental affordances and effectively suppresses physically impossible shortcuts. Finally, extensive experiments on the interactive AI2-THOR benchmark and real-world robotic deployments demonstrate that SVLL outperforms both state-of-the-art open-source (e.g., Qwen2.5-VL-7B) and closed-source models (e.g., GPT-4o, Gemini-2.0-flash) in task success rate, while significantly reducing physical constraint violations.
Abstract:G protein-coupled receptors (GPCRs) govern diverse physiological processes and are central to modern pharmacology. Yet discovering GPCR modulators remains challenging because receptor activation often arises from complex allosteric effects rather than direct binding affinity, and conventional assays are slow, costly, and not optimized for capturing these dynamics. Here we present GPCR-Filter, a deep learning framework specifically developed for GPCR modulator discovery. We assembled a high-quality dataset of over 90,000 experimentally validated GPCR-ligand pairs, providing a robust foundation for training and evaluation. GPCR-Filter integrates the ESM-3 protein language model for high-fidelity GPCR sequence representations with graph neural networks that encode ligand structures, coupled through an attention-based fusion mechanism that learns receptor-ligand functional relationships. Across multiple evaluation settings, GPCR-Filter consistently outperforms state-of-the-art compound-protein interaction models and exhibits strong generalization to unseen receptors and ligands. Notably, the model successfully identified micromolar-level agonists of the 5-HT\textsubscript{1A} receptor with distinct chemical frameworks. These results establish GPCR-Filter as a scalable and effective computational approach for GPCR modulator discovery, advancing AI-assisted drug development for complex signaling systems.




Abstract:AI-generated videos have achieved near-perfect visual realism (e.g., Sora), urgently necessitating reliable detection mechanisms. However, detecting such videos faces significant challenges in modeling high-dimensional spatiotemporal dynamics and identifying subtle anomalies that violate physical laws. In this paper, we propose a physics-driven AI-generated video detection paradigm based on probability flow conservation principles. Specifically, we propose a statistic called Normalized Spatiotemporal Gradient (NSG), which quantifies the ratio of spatial probability gradients to temporal density changes, explicitly capturing deviations from natural video dynamics. Leveraging pre-trained diffusion models, we develop an NSG estimator through spatial gradients approximation and motion-aware temporal modeling without complex motion decomposition while preserving physical constraints. Building on this, we propose an NSG-based video detection method (NSG-VD) that computes the Maximum Mean Discrepancy (MMD) between NSG features of the test and real videos as a detection metric. Last, we derive an upper bound of NSG feature distances between real and generated videos, proving that generated videos exhibit amplified discrepancies due to distributional shifts. Extensive experiments confirm that NSG-VD outperforms state-of-the-art baselines by 16.00% in Recall and 10.75% in F1-Score, validating the superior performance of NSG-VD. The source code is available at https://github.com/ZSHsh98/NSG-VD.




Abstract:Mixed-Integer Linear Programming (MILP) is fundamental to solving complex decision-making problems. The proliferation of MILP instance generation methods, driven by machine learning's demand for diverse optimization datasets and the limitations of static benchmarks, has significantly outpaced standardized evaluation techniques. Consequently, assessing the fidelity and utility of synthetic MILP instances remains a critical, multifaceted challenge. This paper introduces a comprehensive benchmark framework designed for the systematic and objective evaluation of MILP instance generation methods. Our framework provides a unified and extensible methodology, assessing instance quality across crucial dimensions: mathematical validity, structural similarity, computational hardness, and utility in downstream machine learning tasks. A key innovation is its in-depth analysis of solver-internal features -- particularly by comparing distributions of key solver outputs including root node gap, heuristic success rates, and cut plane usage -- leveraging the solver's dynamic solution behavior as an `expert assessment' to reveal nuanced computational resemblances. By offering a structured approach with clearly defined solver-independent and solver-dependent metrics, our benchmark aims to facilitate robust comparisons among diverse generation techniques, spur the development of higher-quality instance generators, and ultimately enhance the reliability of research reliant on synthetic MILP data. The framework's effectiveness in systematically comparing the fidelity of instance sets is demonstrated using contemporary generative models.
Abstract:Recent advances in audio-driven talking head generation have achieved impressive results in lip synchronization and emotional expression. However, they largely overlook the crucial task of facial attribute editing. This capability is crucial for achieving deep personalization and expanding the range of practical applications, including user-tailored digital avatars, engaging online education content, and brand-specific digital customer service. In these key domains, the flexible adjustment of visual attributes-such as hairstyle, accessories, and subtle facial features is essential for aligning with user preferences, reflecting diverse brand identities, and adapting to varying contextual demands. In this paper, we present FaceEditTalker, a unified framework that enables controllable facial attribute manipulation while generating high-quality, audio-synchronized talking head videos. Our method consists of two key components: an image feature space editing module, which extracts semantic and detail features and allows flexible control over attributes like expression, hairstyle, and accessories; and an audio-driven video generation module, which fuses these edited features with audio-guided facial landmarks to drive a diffusion-based generator. This design ensures temporal coherence, visual fidelity, and identity preservation across frames. Extensive experiments on public datasets demonstrate that our method outperforms state-of-the-art approaches in lip-sync accuracy, video quality, and attribute controllability. Project page: https://peterfanfan.github.io/FaceEditTalker/
Abstract:Music-to-dance generation represents a challenging yet pivotal task at the intersection of choreography, virtual reality, and creative content generation. Despite its significance, existing methods face substantial limitation in achieving choreographic consistency. To address the challenge, we propose MatchDance, a novel framework for music-to-dance generation that constructs a latent representation to enhance choreographic consistency. MatchDance employs a two-stage design: (1) a Kinematic-Dynamic-based Quantization Stage (KDQS), which encodes dance motions into a latent representation by Finite Scalar Quantization (FSQ) with kinematic-dynamic constraints and reconstructs them with high fidelity, and (2) a Hybrid Music-to-Dance Generation Stage(HMDGS), which uses a Mamba-Transformer hybrid architecture to map music into the latent representation, followed by the KDQS decoder to generate 3D dance motions. Additionally, a music-dance retrieval framework and comprehensive metrics are introduced for evaluation. Extensive experiments on the FineDance dataset demonstrate state-of-the-art performance. Code will be released upon acceptance.
Abstract:Motion retargeting seeks to faithfully replicate the spatio-temporal motion characteristics of a source character onto a target character with a different body shape. Apart from motion semantics preservation, ensuring geometric plausibility and maintaining temporal consistency are also crucial for effective motion retargeting. However, many existing methods prioritize either geometric plausibility or temporal consistency. Neglecting geometric plausibility results in interpenetration while neglecting temporal consistency leads to motion jitter. In this paper, we propose a novel sequence-to-sequence model for seamless Spatial-Temporal aware motion Retargeting (STaR), with penetration and consistency constraints. STaR consists of two modules: (1) a spatial module that incorporates dense shape representation and a novel limb penetration constraint to ensure geometric plausibility while preserving motion semantics, and (2) a temporal module that utilizes a temporal transformer and a novel temporal consistency constraint to predict the entire motion sequence at once while enforcing multi-level trajectory smoothness. The seamless combination of the two modules helps us achieve a good balance between the semantic, geometric, and temporal targets. Extensive experiments on the Mixamo and ScanRet datasets demonstrate that our method produces plausible and coherent motions while significantly reducing interpenetration rates compared with other approaches.




Abstract:Existing 3D Gaussian Splatting (3DGS) methods for hand rendering rely on rigid skeletal motion with an oversimplified non-rigid motion model, which fails to capture fine geometric and appearance details. Additionally, they perform densification based solely on per-point gradients and process poses independently, ignoring spatial and temporal correlations. These limitations lead to geometric detail loss, temporal instability, and inefficient point distribution. To address these issues, we propose HandSplat, a novel Gaussian Splatting-based framework that enhances both fidelity and stability for hand rendering. To improve fidelity, we extend standard 3DGS attributes with implicit geometry and appearance embeddings for finer non-rigid motion modeling while preserving the static hand characteristic modeled by original 3DGS attributes. Additionally, we introduce a local gradient-aware densification strategy that dynamically refines Gaussian density in high-variation regions. To improve stability, we incorporate pose-conditioned attribute regularization to encourage attribute consistency across similar poses, mitigating temporal artifacts. Extensive experiments on InterHand2.6M demonstrate that HandSplat surpasses existing methods in fidelity and stability while achieving real-time performance. We will release the code and pre-trained models upon acceptance.




Abstract:Deep neural networks (DNNs) are vulnerable to adversarial samples crafted by adding imperceptible perturbations to clean data, potentially leading to incorrect and dangerous predictions. Adversarial purification has been an effective means to improve DNNs robustness by removing these perturbations before feeding the data into the model. However, it faces significant challenges in preserving key structural and semantic information of data, as the imperceptible nature of adversarial perturbations makes it hard to avoid over-correcting, which can destroy important information and degrade model performance. In this paper, we break away from traditional adversarial purification methods by focusing on the clean data manifold. To this end, we reveal that samples generated by a well-trained generative model are close to clean ones but far from adversarial ones. Leveraging this insight, we propose Consistency Model-based Adversarial Purification (CMAP), which optimizes vectors within the latent space of a pre-trained consistency model to generate samples for restoring clean data. Specifically, 1) we propose a \textit{Perceptual consistency restoration} mechanism by minimizing the discrepancy between generated samples and input samples in both pixel and perceptual spaces. 2) To maintain the optimized latent vectors within the valid data manifold, we introduce a \textit{Latent distribution consistency constraint} strategy to align generated samples with the clean data distribution. 3) We also apply a \textit{Latent vector consistency prediction} scheme via an ensemble approach to enhance prediction reliability. CMAP fundamentally addresses adversarial perturbations at their source, providing a robust purification. Extensive experiments on CIFAR-10 and ImageNet-100 show that our CMAP significantly enhances robustness against strong adversarial attacks while preserving high natural accuracy.