RAVE: Residual Vector Embedding for CLIP-Guided Backlit Image Enhancement

In this paper we propose a novel modification of Contrastive Language-Image Pre-Training (CLIP) guidance for the task of unsupervised backlit image enhancement. Our work builds on the state-of-the-art CLIP-LIT approach, which learns a prompt pair by constraining the text-image similarity between a prompt (negative/positive sample) and a corresponding image (backlit image/well-lit image) in the CLIP embedding space. Learned prompts then guide an image enhancement network. Based on the CLIP-LIT framework, we propose two novel methods for CLIP guidance. First, we show that instead of tuning prompts in the space of text embeddings, it is possible to directly tune their embeddings in the latent space without any loss in quality. This accelerates training and potentially enables the use of additional encoders that do not have a text encoder. Second, we propose a novel approach that does not require any prompt tuning. Instead, based on CLIP embeddings of backlit and well-lit images from training data, we compute the residual vector in the embedding space as a simple difference between the mean embeddings of the well-lit and backlit images. This vector then guides the enhancement network during training, pushing a backlit image towards the space of well-lit images. This approach further dramatically reduces training time, stabilizes training and produces high quality enhanced images without artifacts, both in supervised and unsupervised training regimes. Additionally, we show that residual vectors can be interpreted, revealing biases in training data, and thereby enabling potential bias correction.

RoGUENeRF: A Robust Geometry-Consistent Universal Enhancer for NeRF

Recent advances in neural rendering have enabled highly photorealistic 3D scene reconstruction and novel view synthesis. Despite this progress, current state-of-the-art methods struggle to reconstruct high frequency detail, due to factors such as a low-frequency bias of radiance fields and inaccurate camera calibration. One approach to mitigate this issue is to enhance images post-rendering. 2D enhancers can be pre-trained to recover some detail but are agnostic to scene geometry and do not easily generalize to new distributions of image degradation. Conversely, existing 3D enhancers are able to transfer detail from nearby training images in a generalizable manner, but suffer from inaccurate camera calibration and can propagate errors from the geometry into rendered images. We propose a neural rendering enhancer, RoGUENeRF, which exploits the best of both paradigms. Our method is pre-trained to learn a general enhancer while also leveraging information from nearby training images via robust 3D alignment and geometry-aware fusion. Our approach restores high-frequency textures while maintaining geometric consistency and is also robust to inaccurate camera calibration. We show that RoGUENeRF substantially enhances the rendering quality of a wide range of neural rendering baselines, e.g. improving the PSNR of MipNeRF360 by 0.63dB and Nerfacto by 1.34dB on the real world 360v2 dataset.

MOAB: Multi-Modal Outer Arithmetic Block For Fusion Of Histopathological Images And Genetic Data For Brain Tumor Grading

Brain tumors are an abnormal growth of cells in the brain. They can be classified into distinct grades based on their growth. Often grading is performed based on a histological image and is one of the most significant predictors of a patients prognosis, the higher the grade, the more aggressive the tumor. Correct diagnosis of a tumor grade remains challenging. Though histopathological grading has been shown to be prognostic, results are subject to interobserver variability, even among experienced pathologists. Recently, the World Health Organization reported that advances in molecular genetics have led to improvements in tumor classification. This paper seeks to integrate histological images and genetic data for improved computer-aided diagnosis. We propose a novel Multi-modal Outer Arithmetic Block (MOAB) based on arithmetic operations to combine latent representations of the different modalities for predicting the tumor grade (Grade \rom{2}, \rom{3} and \rom{4}). Extensive experiments evaluate the effectiveness of our approach. By applying MOAB to The Cancer Genome Atlas (TCGA) glioma dataset, we show that it can improve separation between similar classes (Grade \rom{2} and \rom{3}) and outperform prior state-of-the-art grade classification techniques.

FOAA: Flattened Outer Arithmetic Attention For Multimodal Tumor Classification

Fusion of multimodal healthcare data holds great promise to provide a holistic view of a patient's health, taking advantage of the complementarity of different modalities while leveraging their correlation. This paper proposes a simple and effective approach, inspired by attention, to fuse discriminative features from different modalities. We propose a novel attention mechanism, called Flattened Outer Arithmetic Attention (FOAA), which relies on outer arithmetic operators (addition, subtraction, product, and division) to compute attention scores from keys, queries and values derived from flattened embeddings of each modality. We demonstrate how FOAA can be implemented for self-attention and cross-attention, providing a reusable component in neural network architectures. We evaluate FOAA on two datasets for multimodal tumor classification and achieve state-of-the-art results, and we demonstrate that features enriched by FOAA are superior to those derived from other fusion approaches. The code is publicly available at \href{https://github.com/omniaalwazzan/FOAA}{https://github.com/omniaalwazzan/FOAA}

Crop and Couple: cardiac image segmentation using interlinked specialist networks

Diagnosis of cardiovascular disease using automated methods often relies on the critical task of cardiac image segmentation. We propose a novel strategy that performs segmentation using specialist networks that focus on a single anatomy (left ventricle, right ventricle, or myocardium). Given an input long-axis cardiac MR image, our method performs a ternary segmentation in the first stage to identify these anatomical regions, followed by cropping the original image to focus subsequent processing on the anatomical regions. The specialist networks are coupled through an attention mechanism that performs cross-attention to interlink features from different anatomies, serving as a soft relative shape prior. Central to our approach is an additive attention block (E-2A block), which is used throughout our architecture thanks to its efficiency.

Multi-Stain Self-Attention Graph Multiple Instance Learning Pipeline for Histopathology Whole Slide Images

Whole Slide Images (WSIs) present a challenging computer vision task due to their gigapixel size and presence of numerous artefacts. Yet they are a valuable resource for patient diagnosis and stratification, often representing the gold standard for diagnostic tasks. Real-world clinical datasets tend to come as sets of heterogeneous WSIs with labels present at the patient-level, with poor to no annotations. Weakly supervised attention-based multiple instance learning approaches have been developed in recent years to address these challenges, but can fail to resolve both long and short-range dependencies. Here we propose an end-to-end multi-stain self-attention graph (MUSTANG) multiple instance learning pipeline, which is designed to solve a weakly-supervised gigapixel multi-image classification task, where the label is assigned at the patient-level, but no slide-level labels or region annotations are available. The pipeline uses a self-attention based approach by restricting the operations to a highly sparse k-Nearest Neighbour Graph of embedded WSI patches based on the Euclidean distance. We show this approach achieves a state-of-the-art F1-score/AUC of 0.89/0.92, outperforming the widely used CLAM model. Our approach is highly modular and can easily be modified to suit different clinical datasets, as it only requires a patient-level label without annotations and accepts WSI sets of different sizes, as the graphs can be of varying sizes and structures. The source code can be found at https://github.com/AmayaGS/MUSTANG.

Automated segmentation of rheumatoid arthritis immunohistochemistry stained synovial tissue

Rheumatoid Arthritis (RA) is a chronic, autoimmune disease which primarily affects the joint's synovial tissue. It is a highly heterogeneous disease, with wide cellular and molecular variability observed in synovial tissues. Over the last two decades, the methods available for their study have advanced considerably. In particular, Immunohistochemistry stains are well suited to highlighting the functional organisation of samples. Yet, analysis of IHC-stained synovial tissue samples is still overwhelmingly done manually and semi-quantitatively by expert pathologists. This is because in addition to the fragmented nature of IHC stained synovial tissue, there exist wide variations in intensity and colour, strong clinical centre batch effect, as well as the presence of many undesirable artefacts present in gigapixel Whole Slide Images (WSIs), such as water droplets, pen annotation, folded tissue, blurriness, etc. There is therefore a strong need for a robust, repeatable automated tissue segmentation algorithm which can cope with this variability and provide support to imaging pipelines. We train a UNET on a hand-curated, heterogeneous real-world multi-centre clinical dataset R4RA, which contains multiple types of IHC staining. The model obtains a DICE score of 0.865 and successfully segments different types of IHC staining, as well as dealing with variance in colours, intensity and common WSIs artefacts from the different clinical centres. It can be used as the first step in an automated image analysis pipeline for synovial tissue samples stained with IHC, increasing speed, reproducibility and robustness.

Graph Neural Networks in Vision-Language Image Understanding: A Survey

2D image understanding is a complex problem within Computer Vision, but it holds the key to providing human level scene comprehension. It goes further than identifying the objects in an image, and instead it attempts to understand the scene. Solutions to this problem form the underpinning of a range of tasks, including image captioning, Visual Question Answering (VQA), and image retrieval. Graphs provide a natural way to represent the relational arrangement between objects in an image, and thus in recent years Graph Neural Networks (GNNs) have become a standard component of many 2D image understanding pipelines, becoming a core architectural component especially in the VQA group of tasks. In this survey, we review this rapidly evolving field and we provide a taxonomy of graph types used in 2D image understanding approaches, a comprehensive list of the GNN models used in this domain, and a roadmap of future potential developments. To the best of our knowledge, this is the first comprehensive survey that covers image captioning, visual question answering, and image retrieval techniques that focus on using GNNs as the main part of their architecture.

Vector Quantized Semantic Communication System

Although analog semantic communication systems have received considerable attention in the literature, there is less work on digital semantic communication systems. In this paper, we develop a deep learning (DL)-enabled vector quantized (VQ) semantic communication system for image transmission, named VQ-DeepSC. Specifically, we propose a convolutional neural network (CNN)-based transceiver to extract multi-scale semantic features of images and introduce multi-scale semantic embedding spaces to perform semantic feature quantization, rendering the data compatible with digital communication systems. Furthermore, we employ adversarial training to improve the quality of received images by introducing a PatchGAN discriminator. Experimental results demonstrate that the proposed VQ-DeepSC outperforms traditional image transmission methods in terms of SSIM.

FlexHDR: Modelling Alignment and Exposure Uncertainties for Flexible HDR Imaging

High dynamic range (HDR) imaging is of fundamental importance in modern digital photography pipelines and used to produce a high-quality photograph with well exposed regions despite varying illumination across the image. This is typically achieved by merging multiple low dynamic range (LDR) images taken at different exposures. However, over-exposed regions and misalignment errors due to poorly compensated motion result in artefacts such as ghosting. In this paper, we present a new HDR imaging technique that specifically models alignment and exposure uncertainties to produce high quality HDR results. We introduce a strategy that learns to jointly align and assess the alignment and exposure reliability using an HDR-aware, uncertainty-driven attention map that robustly merges the frames into a single high quality HDR image. Further, we introduce a progressive, multi-stage image fusion approach that can flexibly merge any number of LDR images in a permutation-invariant manner. Experimental results show our method can produce better quality HDR images with up to 0.8dB PSNR improvement to the state-of-the-art, and subjective improvements in terms of better detail, colours, and fewer artefacts.