PPGL-Swarm: Integrated Multimodal Risk Stratification and Hereditary Syndrome Detection in Pheochromocytoma and Paraganglioma

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors, of which 15-25% develop metastatic disease with 5-year survival rates reported as low as 34%. PPGL may indicate hereditary syndromes requiring stricter, syndrome-specific treatment and surveillance, but clinicians often fail to recognize these associations in routine care. Clinical practice uses GAPP score for PPGL grading, but several limitations remain for PPGL diagnosis: (1) GAPP scoring demands a high workload for clinician because it requires the manual evaluation of six independent components; (2) key components such as cellularity and Ki-67 are often evaluated with subjective criteria; (3) several clinically relevant metastatic risk factors are not captured by GAPP, such as SDHB mutations, which have been associated with reported metastatic rates of 35-75%. Agent-driven diagnostic systems appear promising, but most lack traceable reasoning for decision-making and do not incorporate domain-specific knowledge such as PPGL genotype information. To address these limitations, we present PPGL-Swarm, an agentic PPGL diagnostic system that generates a comprehensive report, including automated GAPP scoring (with quantified cellularity and Ki-67), genotype risk alerts, and multimodal report with integrated evidence. The system provides an auditable reasoning trail by decomposing diagnosis into micro-tasks, each assigned to a specialized agent. The gene and table agents use knowledge enhancement to better interpret genotype and laboratory findings, and during training we use reinforcement learning to refine tool selection and task assignment.

KoopmanFlow: Spectrally Decoupled Generative Control Policy via Koopman Structural Bias

Generative Control Policies (GCPs) show immense promise in robotic manipulation but struggle to simultaneously model stable global motions and high-frequency local corrections. While modern architectures extract multi-scale spatial features, their underlying Probability Flow ODEs apply a uniform temporal integration schedule. Compressed to a single step for real-time Receding Horizon Control (RHC), uniform ODE solvers mathematically smooth over sparse, high-frequency transients entangled within low-frequency steady states. To decouple these dynamics without accumulating pipelined errors, we introduce KoopmanFlow, a parameter-efficient generative policy guided by a Koopman-inspired structural inductive bias. Operating in a unified multimodal latent space with visual context, KoopmanFlow bifurcates generation at the terminal stage. Because visual conditioning occurs before spectral decomposition, both branches are visually guided yet temporally specialized. A macroscopic branch anchors slow-varying trajectories via single-step Consistency Training, while a transient branch uses Flow Matching to isolate high-frequency residuals stimulated by sudden visual cues (e.g., contacts or occlusions). Guided by an explicit spectral prior and optimized via a novel asymmetric consistency objective, KoopmanFlow establishes a fused co-training mechanism. This allows the variant branch to absorb localized dynamics without multi-stage error accumulation. Extensive experiments show KoopmanFlow significantly outperforms state-of-the-art baselines in contact-rich tasks requiring agile disturbance rejection. By trading a surplus latency buffer for a richer structural prior, KoopmanFlow achieves superior control fidelity and parameter efficiency within real-time deployment limits.

SVLL: Staged Vision-Language Learning for Physically Grounded Embodied Task Planning

Embodied task planning demands vision-language models to generate action sequences that are both visually grounded and causally coherent over time. However, existing training paradigms face a critical trade-off: joint end-to-end training often leads to premature temporal binding, while standard reinforcement learning methods suffer from optimization instability. To bridge this gap, we present Staged Vision-Language Learning (SVLL), a unified three-stage framework for robust, physically-grounded embodied planning. In the first two stages, SVLL decouples spatial grounding from temporal reasoning, establishing robust visual dependency before introducing sequential action history. In the final stage, we identify a key limitation of standard Direct Preference Optimization (DPO), its purely relative nature -- optimizing only the preference gap between winning and losing trajectories while neglecting absolute likelihood constraints on optimal path, often yields unsafe or hallucinated behaviors. To address this, we further introduce Bias-DPO, a novel alignment objective that injects an inductive bias toward expert trajectories by explicitly maximizing likelihood on ground-truth actions while penalizing overconfident hallucinations. By anchoring the policy to the expert manifold and mitigating causal misalignment, SVLL, powered by Bias-DPO, ensures strict adherence to environmental affordances and effectively suppresses physically impossible shortcuts. Finally, extensive experiments on the interactive AI2-THOR benchmark and real-world robotic deployments demonstrate that SVLL outperforms both state-of-the-art open-source (e.g., Qwen2.5-VL-7B) and closed-source models (e.g., GPT-4o, Gemini-2.0-flash) in task success rate, while significantly reducing physical constraint violations.

VP-VAE: Rethinking Vector Quantization via Adaptive Vector Perturbation

Vector Quantized Variational Autoencoders (VQ-VAEs) are fundamental to modern generative modeling, yet they often suffer from training instability and "codebook collapse" due to the inherent coupling of representation learning and discrete codebook optimization. In this paper, we propose VP-VAE (Vector Perturbation VAE), a novel paradigm that decouples representation learning from discretization by eliminating the need for an explicit codebook during training. Our key insight is that, from the neural network's viewpoint, performing quantization primarily manifests as injecting a structured perturbation in latent space. Accordingly, VP-VAE replaces the non-differentiable quantizer with distribution-consistent and scale-adaptive latent perturbations generated via Metropolis--Hastings sampling. This design enables stable training without a codebook while making the model robust to inference-time quantization error. Moreover, under the assumption of approximately uniform latent variables, we derive FSP (Finite Scalar Perturbation), a lightweight variant of VP-VAE that provides a unified theoretical explanation and a practical improvement for FSQ-style fixed quantizers. Extensive experiments on image and audio benchmarks demonstrate that VP-VAE and FSP improve reconstruction fidelity and achieve substantially more balanced token usage, while avoiding the instability inherent to coupled codebook training.

Foundation Models for Medical Imaging: Status, Challenges, and Directions

Foundation models (FMs) are rapidly reshaping medical imaging, shifting the field from narrowly trained, task-specific networks toward large, general-purpose models that can be adapted across modalities, anatomies, and clinical tasks. In this review, we synthesize the emerging landscape of medical imaging FMs along three major axes: principles of FM design, applications of FMs, and forward-looking challenges and opportunities. Taken together, this review provides a technically grounded, clinically aware, and future-facing roadmap for developing FMs that are not only powerful and versatile but also trustworthy and ready for responsible translation into clinical practice.

WS-IMUBench: Can Weakly Supervised Methods from Audio, Image, and Video Be Adapted for IMU-based Temporal Action Localization?

IMU-based Human Activity Recognition (HAR) has enabled a wide range of ubiquitous computing applications, yet its dominant clip classification paradigm cannot capture the rich temporal structure of real-world behaviors. This motivates a shift toward IMU Temporal Action Localization (IMU-TAL), which predicts both action categories and their start/end times in continuous streams. However, current progress is strongly bottlenecked by the need for dense, frame-level boundary annotations, which are costly and difficult to scale. To address this bottleneck, we introduce WS-IMUBench, a systematic benchmark study of weakly supervised IMU-TAL (WS-IMU-TAL) under only sequence-level labels. Rather than proposing a new localization algorithm, we evaluate how well established weakly supervised localization paradigms from audio, image, and video transfer to IMU-TAL under only sequence-level labels. We benchmark seven representative weakly supervised methods on seven public IMU datasets, resulting in over 3,540 model training runs and 7,080 inference evaluations. Guided by three research questions on transferability, effectiveness, and insights, our findings show that (i) transfer is modality-dependent, with temporal-domain methods generally more stable than image-derived proposal-based approaches; (ii) weak supervision can be competitive on favorable datasets (e.g., with longer actions and higher-dimensional sensing); and (iii) dominant failure modes arise from short actions, temporal ambiguity, and proposal quality. Finally, we outline concrete directions for advancing WS-IMU-TAL (e.g., IMU-specific proposal generation, boundary-aware objectives, and stronger temporal reasoning). Beyond individual results, WS-IMUBench establishes a reproducible benchmarking template, datasets, protocols, and analyses, to accelerate community-wide progress toward scalable WS-IMU-TAL.

MobiDiary: Autoregressive Action Captioning with Wearable Devices and Wireless Signals

Human Activity Recognition (HAR) in smart homes is critical for health monitoring and assistive living. While vision-based systems are common, they face privacy concerns and environmental limitations (e.g., occlusion). In this work, we present MobiDiary, a framework that generates natural language descriptions of daily activities directly from heterogeneous physical signals (specifically IMU and Wi-Fi). Unlike conventional approaches that restrict outputs to pre-defined labels, MobiDiary produces expressive, human-readable summaries. To bridge the semantic gap between continuous, noisy physical signals and discrete linguistic descriptions, we propose a unified sensor encoder. Instead of relying on modality-specific engineering, we exploit the shared inductive biases of motion-induced signals--where both inertial and wireless data reflect underlying kinematic dynamics. Specifically, our encoder utilizes a patch-based mechanism to capture local temporal correlations and integrates heterogeneous placement embedding to unify spatial contexts across different sensors. These unified signal tokens are then fed into a Transformer-based decoder, which employs an autoregressive mechanism to generate coherent action descriptions word-by-word. We comprehensively evaluate our approach on multiple public benchmarks (XRF V2, UWash, and WiFiTAD). Experimental results demonstrate that MobiDiary effectively generalizes across modalities, achieving state-of-the-art performance on captioning metrics (e.g., BLEU@4, CIDEr, RMC) and outperforming specialized baselines in continuous action understanding.

SlideChain: Semantic Provenance for Lecture Understanding via Blockchain Registration

Modern vision--language models (VLMs) are increasingly used to interpret and generate educational content, yet their semantic outputs remain challenging to verify, reproduce, and audit over time. Inconsistencies across model families, inference settings, and computing environments undermine the reliability of AI-generated instructional material, particularly in high-stakes and quantitative STEM domains. This work introduces SlideChain, a blockchain-backed provenance framework designed to provide verifiable integrity for multimodal semantic extraction at scale. Using the SlideChain Slides Dataset-a curated corpus of 1,117 medical imaging lecture slides from a university course-we extract concepts and relational triples from four state-of-the-art VLMs and construct structured provenance records for every slide. SlideChain anchors cryptographic hashes of these records on a local EVM (Ethereum Virtual Machine)-compatible blockchain, providing tamper-evident auditability and persistent semantic baselines. Through the first systematic analysis of semantic disagreement, cross-model similarity, and lecture-level variability in multimodal educational content, we reveal pronounced cross-model discrepancies, including low concept overlap and near-zero agreement in relational triples on many slides. We further evaluate gas usage, throughput, and scalability under simulated deployment conditions, and demonstrate perfect tamper detection along with deterministic reproducibility across independent extraction runs. Together, these results show that SlideChain provides a practical and scalable step toward trustworthy, verifiable multimodal educational pipelines, supporting long-term auditability, reproducibility, and integrity for AI-assisted instructional systems.

ALIVE: An Avatar-Lecture Interactive Video Engine with Content-Aware Retrieval for Real-Time Interaction

Traditional lecture videos offer flexibility but lack mechanisms for real-time clarification, forcing learners to search externally when confusion arises. Recent advances in large language models and neural avatars provide new opportunities for interactive learning, yet existing systems typically lack lecture awareness, rely on cloud-based services, or fail to integrate retrieval and avatar-delivered explanations in a unified, privacy-preserving pipeline. We present ALIVE, an Avatar-Lecture Interactive Video Engine that transforms passive lecture viewing into a dynamic, real-time learning experience. ALIVE operates fully on local hardware and integrates (1) Avatar-delivered lecture generated through ASR transcription, LLM refinement, and neural talking-head synthesis; (2) A content-aware retrieval mechanism that combines semantic similarity with timestamp alignment to surface contextually relevant lecture segments; and (3) Real-time multimodal interaction, enabling students to pause the lecture, ask questions through text or voice, and receive grounded explanations either as text or as avatar-delivered responses. To maintain responsiveness, ALIVE employs lightweight embedding models, FAISS-based retrieval, and segmented avatar synthesis with progressive preloading. We demonstrate the system on a complete medical imaging course, evaluate its retrieval accuracy, latency characteristics, and user experience, and show that ALIVE provides accurate, content-aware, and engaging real-time support. ALIVE illustrates how multimodal AI-when combined with content-aware retrieval and local deployment-can significantly enhance the pedagogical value of recorded lectures, offering an extensible pathway toward next-generation interactive learning environments.

3One2: One-step Regression Plus One-step Diffusion for One-hot Modulation in Dual-path Video Snapshot Compressive Imaging

Video snapshot compressive imaging (SCI) captures dynamic scene sequences through a two-dimensional (2D) snapshot, fundamentally relying on optical modulation for hardware compression and the corresponding software reconstruction. While mainstream video SCI using random binary modulation has demonstrated success, it inevitably results in temporal aliasing during compression. One-hot modulation, activating only one sub-frame per pixel, provides a promising solution for achieving perfect temporal decoupling, thereby alleviating issues associated with aliasing. However, no algorithms currently exist to fully exploit this potential. To bridge this gap, we propose an algorithm specifically designed for one-hot masks. First, leveraging the decoupling properties of one-hot modulation, we transform the reconstruction task into a generative video inpainting problem and introduce a stochastic differential equation (SDE) of the forward process that aligns with the hardware compression process. Next, we identify limitations of the pure diffusion method for video SCI and propose a novel framework that combines one-step regression initialization with one-step diffusion refinement. Furthermore, to mitigate the spatial degradation caused by one-hot modulation, we implement a dual optical path at the hardware level, utilizing complementary information from another path to enhance the inpainted video. To our knowledge, this is the first work integrating diffusion into video SCI reconstruction. Experiments conducted on synthetic datasets and real scenes demonstrate the effectiveness of our method.