MimicIK: Real-Time Generative Inverse Kinematics from Teleoperation with FK Consistency

Inverse kinematics (IK) remains a critical bottleneck for real-time robot manipulation. Classical numerical solvers achieve high geometric precision but often suffer from discontinuous branch switching and unstable behavior near kinematic singularities during closed-loop deployment. Meanwhile, learned IK approaches frequently struggle to balance spatial accuracy, motion smoothness, and real-time efficiency, particularly when trained on noisy human teleoperation data. We present \textbf{MimicIK}, a real-time generative inverse kinematics framework that learns smooth and robust joint-space motion priors from teleoperation demonstrations through conditional flow matching. Given the current joint configuration and a target end-effector pose, MimicIK predicts continuous delta-joint commands using an efficient two-step iterative refinement process based on a Minimal Iterative Policy (MIP) backbone. To enforce physical consistency, we further introduce an FK consistency loss, a differentiable forward-kinematics regularization that penalizes task-space deviations from the target pose during training. We evaluate MimicIK on a real-world 6-DOF robot dataset containing 8,848 teleoperation demonstrations. MimicIK achieves a mean position error of 4.65 mm, a 10 mm success rate of 92.01\%, and a trajectory spike rate of only 7.99\%. Compared with a UNet diffusion baseline, our method improves both spatial accuracy and motion smoothness while reducing inference latency from 21.66 ms to 6.74 ms. Furthermore, unlike deterministic MLP baselines that catastrophically diverge under out-of-distribution deployment, MimicIK remains stable near singular configurations and enables robust 20 Hz real-time control on deployment hardware.

Learning Directional Semantic Transitions for Longitudinal Chest X-ray Analysis

Chest X-ray (CXR) interpretation often requires longitudinal comparison to assess disease progression. Existing approaches typically rely on temporal feature fusion or inter-study discrepancy modeling, yet remain limited in capturing subtle progression semantics and overlook the inherently directional nature of disease trajectories. In this paper, we propose ProTrans, a novel vision-language pretraining framework that formulates disease progression as a directional semantic transition between paired CXR studies. ProTrans leverages radiology reports to anchor individual CXR representations within interpretable disease states, and introduces a learnable progression feature map to explicitly encode semantic shifts between states, aligned with report-derived progression descriptions. To enforce direction-aware perception, ProTrans incorporates a reversed temporal modeling process and imposes bidirectional reconstruction consistency across states and transitions, thereby disentangling directional semantics and promoting coherent trajectory modeling. Extensive experiments on longitudinal downstream tasks, including disease progression classification and progression captioning, demonstrate that ProTrans consistently outperforms existing methods, establishing a unified pretraining framework for longitudinal CXR understanding. https://github.com/RPIDIAL/ProTrans

Acting While Understanding: Asynchronous Semantic-Action Decoupling for Real-Time Vision-Language-Action Models

Vision-Language-Action models (VLAs) have demonstrated strong task understanding and generalization in robotic manipulation, yet the high computational cost of full-model inference limits their deployment in low-latency, high-frequency closed-loop control. We propose an asynchronous semantic-action decoupling framework that separates semantic understanding from action generation along the internal semantic-action interface of existing VLAs, without redesigning the vision-language backbone or introducing an external planner. A low-frequency understanding module asynchronously updates reusable semantic conditions, while a high-frequency action module continuously outputs control actions without repeatedly invoking the full model. To mitigate the temporal mismatch between stale semantics and the current execution state, we further introduce historical action conditioning and time-misalignment training, which provide short-horizon execution context and improve feedback control robustness under stale semantic conditions. Experiments on LIBERO with $π_{0.5}$ and UniVLA, together with real-robot deployment using UniVLA, show that the proposed framework achieves up to 35.6 Hz server-side action-module inference throughput and offers a low-intrusion path to high-frequency closed-loop control without running full VLA inference at control rate.

Elastic Queries Reinforcement Learning: Self-Aware Policy Execution for VLA Models

Vision-language-action (VLA) models are powerful action generators for robot manipulation, but they are typically executed with fixed inference and replanning schedules. This rigidity ignores the uneven difficulty of robot control: contact-rich or uncertain states may need more computation and fresher feedback, while easier states can often be handled with fewer inference steps and longer open-loop execution. We propose Elastic Queries Reinforcement Learning (EQRL), a framework that makes each VLA policy query elastic. A lightweight latent-schedule adaptor jointly selects the latent input, denoising budget, and action chunk length, without fine-tuning the underlying VLA model. To make scheduling difficulty-aware, EQRL trains a critic over the joint latent-schedule action and derives a state difficulty signal from critic ensemble disagreement. This signal guides compute toward difficult states, while a learned residual allows task-driven correction. We formulate variable chunk execution as query-level macro-action RL with chunk-dependent discounting and an amortized number-of-function-evaluations (NFE) budget. Across simulation and real-robot manipulation, EQRL reduces amortized inference cost while preserving or improving task success.

HypothesisMed: Inference-Time Answer Fusion and Structured Hypothesis-Space Reporting for Biomedical Question Answering

Biomedical question answering with large language models is commonly evaluated using answer accuracy, but answer accuracy alone does not indicate whether a model can produce parseable outputs, follow structured reliability instructions, recognize weak answer spaces, or avoid confident incorrect commitments. This paper presents HypothesisMed, an inference-time reliability pipeline for biomedical multiple-choice question answering. It combines direct, chain-of-thought, HypothesisMed-v3 prompting, and answer fusion. The final answer is selected by fusion, while HypothesisMed-v3 supplies SPACE labels and confidence information. SPACE labels mark the answer space as VALID, INCOMPLETE, or CONTRADICTED. We evaluate Qwen2.5-7B, Phi-4-mini, DeepSeek-R1-32B, and BioMistral-7B on MedQA, MedMCQA, and PubMedQA using 1,000 examples per dataset. The pipeline improves weighted accuracy over each model's best direct or chain-of-thought baseline while increasing parse and SPACE coverage. We also scale evaluation to Qwen2.5-7B and Phi-4-mini using 10,183 examples per model. Fusion improves Phi-4-mini accuracy from 0.4296 to 0.5192, while Qwen2.5-7B chain-of-thought remains slightly higher in answer accuracy. However, Qwen2.5-7B fusion achieves complete parse and SPACE coverage with much lower false commitment. A 12,000-example SPACE stress test shows answer-space diagnosis remains difficult, with SPACE accuracy of 0.3074 for Qwen2.5-7B and 0.4168 for Phi-4-mini. These results show that answer accuracy, parseability, structured reliability reporting, calibration behavior, and false-commitment behavior are separable capabilities. The main contribution is not a universal state-of-the-art claim, but a reproducible inference-time framework for evaluating biomedical question answering models as auditable workflow components under structured reliability constraints.

Gemma 4, Phi-4, and Qwen3: Accuracy-Efficiency Tradeoffs in Dense and MoE Reasoning Language Models

Mixture-of-experts (MoE) language models are often expected to offer better quality-efficiency tradeoffs than dense models because only a subset of parameters is activated per token, but the practical value of that advantage depends on end-to-end behavior under realistic inference constraints. We present a controlled empirical benchmark of seven recent reasoning-oriented instruction-tuned models spanning dense and MoE designs, namely Gemma-4-E2B, Gemma-4-E4B, Gemma-4-26B-A4B, Phi-4-mini-reasoning, Phi-4-reasoning, Qwen3-8B, and Qwen3-30B-A3B, evaluated on four benchmarks -- ARC-Challenge, GSM8K, Math Level 1-3, and TruthfulQA MC1 -- under three prompting strategies: zero-shot, chain-of-thought, and few-shot chain-of-thought. The study covers 8,400 total model-dataset-prompt evaluations and records accuracy, latency, peak GPU memory usage (VRAM), and an approximate floating-point operations (FLOPs)-per-token proxy. Across the weighted multi-task summary, Gemma-4-E4B with few-shot chain-of-thought achieved the best overall result, reaching weighted accuracy 0.675 with mean VRAM 14.9 GB, while Gemma-4-26B-A4B was close in accuracy at 0.663 but substantially more memory intensive at 48.1 GB. At the task level, Gemma models dominated ARC and Math, Phi models were strongest on TruthfulQA, and GSM8K showed the largest prompt sensitivity, including a sharp drop for Phi-4-reasoning from 0.67 under chain-of-thought to 0.11 under few-shot chain-of-thought. These results show that sparse activation alone does not guarantee the best practical operating point: observed accuracy-efficiency tradeoffs depend jointly on architecture, prompting protocol, and task composition. We release a reproducible benchmark pipeline, aggregated results, and paired statistical analyses to support deployment-oriented evaluation of reasoning LLMs under real resource constraints.

MRI-to-CT synthesis using drifting models

Accurate MRI-to-CT synthesis could enable MR-only pelvic workflows by providing CT-like images with bone details while avoiding additional ionizing radiation. In this work, we investigate recently proposed drifting models for synthesizing pelvis CT images from MRI and benchmark them against convolutional neural networks (UNet, VAE), a generative adversarial network (WGAN-GP), a physics-inspired probabilistic model (PPFM), and diffusion-based methods (FastDDPM, DDIM, DDPM). Experiments are performed on two complementary datasets: Gold Atlas Male Pelvis and the SynthRAD2023 pelvis subset. Image fidelity and structural consistency are evaluated with SSIM, PSNR, and RMSE, complemented by qualitative assessment of anatomically critical regions such as cortical bone and pelvic soft-tissue interfaces. Across both datasets, the proposed drifting model achieves high SSIM and PSNR and low RMSE, surpassing strong diffusion baselines and conventional CNN-, VAE-, GAN-, and PPFM-based methods. Visual inspection shows sharper cortical bone edges, improved depiction of sacral and femoral head geometry, and reduced artifacts or over-smoothing, particularly at bone-air-soft tissue boundaries. Moreover, the drifting model attains these gains with one-step inference and inference times on the order of milliseconds, yielding a more favorable accuracy-efficiency trade-off than iterative diffusion sampling while remaining competitive in image quality. These findings suggest that drifting models are a promising direction for fast, high-quality pelvic synthetic CT generation from MRI and warrant further investigation for downstream applications such as MRI-only radiotherapy planning and PET/MR attenuation correction.

PPGL-Swarm: Integrated Multimodal Risk Stratification and Hereditary Syndrome Detection in Pheochromocytoma and Paraganglioma

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors, of which 15-25% develop metastatic disease with 5-year survival rates reported as low as 34%. PPGL may indicate hereditary syndromes requiring stricter, syndrome-specific treatment and surveillance, but clinicians often fail to recognize these associations in routine care. Clinical practice uses GAPP score for PPGL grading, but several limitations remain for PPGL diagnosis: (1) GAPP scoring demands a high workload for clinician because it requires the manual evaluation of six independent components; (2) key components such as cellularity and Ki-67 are often evaluated with subjective criteria; (3) several clinically relevant metastatic risk factors are not captured by GAPP, such as SDHB mutations, which have been associated with reported metastatic rates of 35-75%. Agent-driven diagnostic systems appear promising, but most lack traceable reasoning for decision-making and do not incorporate domain-specific knowledge such as PPGL genotype information. To address these limitations, we present PPGL-Swarm, an agentic PPGL diagnostic system that generates a comprehensive report, including automated GAPP scoring (with quantified cellularity and Ki-67), genotype risk alerts, and multimodal report with integrated evidence. The system provides an auditable reasoning trail by decomposing diagnosis into micro-tasks, each assigned to a specialized agent. The gene and table agents use knowledge enhancement to better interpret genotype and laboratory findings, and during training we use reinforcement learning to refine tool selection and task assignment.

KoopmanFlow: Spectrally Decoupled Generative Control Policy via Koopman Structural Bias

Generative Control Policies (GCPs) show immense promise in robotic manipulation but struggle to simultaneously model stable global motions and high-frequency local corrections. While modern architectures extract multi-scale spatial features, their underlying Probability Flow ODEs apply a uniform temporal integration schedule. Compressed to a single step for real-time Receding Horizon Control (RHC), uniform ODE solvers mathematically smooth over sparse, high-frequency transients entangled within low-frequency steady states. To decouple these dynamics without accumulating pipelined errors, we introduce KoopmanFlow, a parameter-efficient generative policy guided by a Koopman-inspired structural inductive bias. Operating in a unified multimodal latent space with visual context, KoopmanFlow bifurcates generation at the terminal stage. Because visual conditioning occurs before spectral decomposition, both branches are visually guided yet temporally specialized. A macroscopic branch anchors slow-varying trajectories via single-step Consistency Training, while a transient branch uses Flow Matching to isolate high-frequency residuals stimulated by sudden visual cues (e.g., contacts or occlusions). Guided by an explicit spectral prior and optimized via a novel asymmetric consistency objective, KoopmanFlow establishes a fused co-training mechanism. This allows the variant branch to absorb localized dynamics without multi-stage error accumulation. Extensive experiments show KoopmanFlow significantly outperforms state-of-the-art baselines in contact-rich tasks requiring agile disturbance rejection. By trading a surplus latency buffer for a richer structural prior, KoopmanFlow achieves superior control fidelity and parameter efficiency within real-time deployment limits.

SVLL: Staged Vision-Language Learning for Physically Grounded Embodied Task Planning

Embodied task planning demands vision-language models to generate action sequences that are both visually grounded and causally coherent over time. However, existing training paradigms face a critical trade-off: joint end-to-end training often leads to premature temporal binding, while standard reinforcement learning methods suffer from optimization instability. To bridge this gap, we present Staged Vision-Language Learning (SVLL), a unified three-stage framework for robust, physically-grounded embodied planning. In the first two stages, SVLL decouples spatial grounding from temporal reasoning, establishing robust visual dependency before introducing sequential action history. In the final stage, we identify a key limitation of standard Direct Preference Optimization (DPO), its purely relative nature -- optimizing only the preference gap between winning and losing trajectories while neglecting absolute likelihood constraints on optimal path, often yields unsafe or hallucinated behaviors. To address this, we further introduce Bias-DPO, a novel alignment objective that injects an inductive bias toward expert trajectories by explicitly maximizing likelihood on ground-truth actions while penalizing overconfident hallucinations. By anchoring the policy to the expert manifold and mitigating causal misalignment, SVLL, powered by Bias-DPO, ensures strict adherence to environmental affordances and effectively suppresses physically impossible shortcuts. Finally, extensive experiments on the interactive AI2-THOR benchmark and real-world robotic deployments demonstrate that SVLL outperforms both state-of-the-art open-source (e.g., Qwen2.5-VL-7B) and closed-source models (e.g., GPT-4o, Gemini-2.0-flash) in task success rate, while significantly reducing physical constraint violations.