OUCopula: Bi-Channel Multi-Label Copula-Enhanced Adapter-Based CNN for Myopia Screening Based on OU-UWF Images

Myopia screening using cutting-edge ultra-widefield (UWF) fundus imaging is potentially significant for ophthalmic outcomes. Current multidisciplinary research between ophthalmology and deep learning (DL) concentrates primarily on disease classification and diagnosis using single-eye images, largely ignoring joint modeling and prediction for Oculus Uterque (OU, both eyes). Inspired by the complex relationships between OU and the high correlation between the (continuous) outcome labels (Spherical Equivalent and Axial Length), we propose a framework of copula-enhanced adapter convolutional neural network (CNN) learning with OU UWF fundus images (OUCopula) for joint prediction of multiple clinical scores. We design a novel bi-channel multi-label CNN that can (1) take bi-channel image inputs subject to both high correlation and heterogeneity (by sharing the same backbone network and employing adapters to parameterize the channel-wise discrepancy), and (2) incorporate correlation information between continuous output labels (using a copula). Solid experiments show that OUCopula achieves satisfactory performance in myopia score prediction compared to backbone models. Moreover, OUCopula can far exceed the performance of models constructed for single-eye inputs. Importantly, our study also hints at the potential extension of the bi-channel model to a multi-channel paradigm and the generalizability of OUCopula across various backbone CNNs.

CeCNN: Copula-enhanced convolutional neural networks in joint prediction of refraction error and axial length based on ultra-widefield fundus images

Ultra-widefield (UWF) fundus images are replacing traditional fundus images in screening, detection, prediction, and treatment of complications related to myopia because their much broader visual range is advantageous for highly myopic eyes. Spherical equivalent (SE) is extensively used as the main myopia outcome measure, and axial length (AL) has drawn increasing interest as an important ocular component for assessing myopia. Cutting-edge studies show that SE and AL are strongly correlated. Using the joint information from SE and AL is potentially better than using either separately. In the deep learning community, though there is research on multiple-response tasks with a 3D image biomarker, dependence among responses is only sporadically taken into consideration. Inspired by the spirit that information extracted from the data by statistical methods can improve the prediction accuracy of deep learning models, we formulate a class of multivariate response regression models with a higher-order tensor biomarker, for the bivariate tasks of regression-classification and regression-regression. Specifically, we propose a copula-enhanced convolutional neural network (CeCNN) framework that incorporates the dependence between responses through a Gaussian copula (with parameters estimated from a warm-up CNN) and uses the induced copula-likelihood loss with the backbone CNNs. We establish the statistical framework and algorithms for the aforementioned two bivariate tasks. We show that the CeCNN has better prediction accuracy after adding the dependency information to the backbone models. The modeling and the proposed CeCNN algorithm are applicable beyond the UWF scenario and can be effective with other backbones beyond ResNet and LeNet.

Human-robot Matching and Routing for Multi-robot Tour Guiding under Time Uncertainty

This work presents a framework for multi-robot tour guidance in a partially known environment with uncertainty, such as a museum. A simultaneous matching and routing problem (SMRP) is formulated to match the humans with robot guides according to their requested places of interest (POIs) and generate the routes for the robots according to uncertain time estimation. A large neighborhood search algorithm is developed to efficiently find sub-optimal low-cost solutions for the SMRP. The scalability and optimality of the multi-robot planner are evaluated computationally. The largest case tested involves 50 robots, 250 humans, and 50 POIs. A photo-realistic multi-robot simulation was developed to verify the tour guiding performance in an uncertain indoor environment.

AdvMIL: Adversarial Multiple Instance Learning for the Survival Analysis on Whole-Slide Images

The survival analysis on histological whole-slide images (WSIs) is one of the most important means to estimate patient prognosis. Although many weakly-supervised deep learning models have been developed for gigapixel WSIs, their potential is generally restricted by classical survival analysis rules and fully-supervision requirements. As a result, these models provide patients only with a completely-certain point estimation of time-to-event, and they could only learn from the well-annotated WSI data currently at a small scale. To tackle these problems, we propose a novel adversarial multiple instance learning (AdvMIL) framework. This framework is based on adversarial time-to-event modeling, and it integrates the multiple instance learning (MIL) that is much necessary for WSI representation learning. It is a plug-and-play one, so that most existing WSI-based models with embedding-level MIL networks can be easily upgraded by applying this framework, gaining the improved ability of survival distribution estimation and semi-supervised learning. Our extensive experiments show that AdvMIL could not only bring performance improvement to mainstream WSI models at a relatively low computational cost, but also enable these models to learn from unlabeled data with semi-supervised learning. Our AdvMIL framework could promote the research of time-to-event modeling in computational pathology with its novel paradigm of adversarial MIL.

Learning Task Requirements and Agent Capabilities for Multi-agent Task Allocation

This paper presents a learning framework to estimate an agent capability and task requirement model for multi-agent task allocation. With a set of team configurations and the corresponding task performances as the training data, linear task constraints can be learned to be embedded in many existing optimization-based task allocation frameworks. Comprehensive computational evaluations are conducted to test the scalability and prediction accuracy of the learning framework with a limited number of team configurations and performance pairs. A ROS and Gazebo-based simulation environment is developed to validate the proposed requirements learning and task allocation framework in practical multi-agent exploration and manipulation tasks. Results show that the learning process for scenarios with 40 tasks and 6 types of agents uses around 12 seconds, ending up with prediction errors in the range of 0.5-2%.

Dual-Stream Transformer with Cross-Attention on Whole-Slide Image Pyramids for Cancer Prognosis

The cancer prognosis on gigapixel Whole-Slide Images (WSIs) has always been a challenging task. Most existing approaches focus solely on single-resolution images. The multi-resolution schemes, utilizing image pyramids to enhance WSI visual representations, have not yet been paid enough attention to. In order to explore a multi-resolution solution for improving cancer prognosis accuracy, this paper proposes a dual-stream architecture to model WSIs by an image pyramid strategy. This architecture consists of two sub-streams: one for low-resolution WSIs, and the other especially for high-resolution ones. Compared to other approaches, our scheme has three highlights: (i) there exists a one-to-one relation between stream and resolution; (ii) a square pooling layer is added to align the patches from two resolution streams, largely reducing computation cost and enabling a natural stream feature fusion; (iii) a cross-attention-based method is proposed to pool high-resolution patches spatially under the guidance of low-resolution ones. We validate our scheme on three publicly-available datasets with a total number of 3,101 WSIs from 1,911 patients. Experimental results verify that (i) hierarchical dual-stream representation is more effective than single-stream ones for cancer prognosis, gaining an average C-Index rise of 5.0% and 1.8% on a single low-resolution and high-resolution stream, respectively; (ii) our dual-stream scheme could outperform current state-of-the-art ones, by an average C-Index improvement of 5.1%; (iii) the cancer diseases with observable survival differences could have different preferences for model complexity. Our scheme could serve as an alternative tool for further facilitating WSI prognosis research.

Simultaneous Human-robot Matching and Routing for Multi-robot Tour Guiding under Time Uncertainty

This work presents a framework for multi-robot tour guidance in a partially known environment with uncertainty, such as a museum. In the proposed centralized multi-robot planner, a simultaneous matching and routing problem (SMRP) is formulated to match the humans with robot guides according to their selected places of interest (POIs) and generate the routes and schedules for the robots according to uncertain spatial and time estimation. A large neighborhood search algorithm is developed to efficiently find sub-optimal low-cost solutions for the SMRP. The scalability and optimality of the multi-robot planner are evaluated computationally under different numbers of humans, robots, and POIs. The largest case tested involves 50 robots, 250 humans, and 50 POIs. Then, a photo-realistic multi-robot simulation platform was developed based on Habitat-AI to verify the tour guiding performance in an uncertain indoor environment. Results demonstrate that the proposed centralized tour planner is scalable, makes a smooth trade-off in the plans under different environmental constraints, and can lead to robust performance with inaccurate uncertainty estimations (within a certain margin).

Robust Task Scheduling for Heterogeneous Robot Teams under Capability Uncertainty

This paper develops a stochastic programming framework for multi-agent systems where task decomposition, assignment, and scheduling problems are simultaneously optimized. Due to their inherent flexibility and robustness, multi-agent systems are applied in a growing range of real-world problems that involve heterogeneous tasks and uncertain information. Most previous works assume a unique way to decompose a task into roles that can later be assigned to the agents. This assumption is not valid for a complex task where the roles can vary and multiple decomposition structures exist. Meanwhile, it is unclear how uncertainties in task requirements and agent capabilities can be systematically quantified and optimized under a multi-agent system setting. A representation for complex tasks is proposed to avoid the non-convex task decomposition enumeration: agent capabilities are represented as a vector of random distributions, and task requirements are verified by a generalizable binary function. The conditional value at risk (CVaR) is chosen as a metric in the objective function to generate robust plans. An efficient algorithm is described to solve the model, and the whole framework is evaluated in two different practical test cases: capture-the-flag and robotic service coordination during a pandemic (e.g., COVID-19). Results demonstrate that the framework is scalable, generalizable, and provides low-cost plans that ensure a high probability of success.

Robust localization for planar moving robot in changing environment: A perspective on density of correspondence and depth

Visual localization for planar moving robot is important to various indoor service robotic applications. To handle the textureless areas and frequent human activities in indoor environments, a novel robust visual localization algorithm which leverages dense correspondence and sparse depth for planar moving robot is proposed. The key component is a minimal solution which computes the absolute camera pose with one 3D-2D correspondence and one 2D-2D correspondence. The advantages are obvious in two aspects. First, the robustness is enhanced as the sample set for pose estimation is maximal by utilizing all correspondences with or without depth. Second, no extra effort for dense map construction is required to exploit dense correspondences for handling textureless and repetitive texture scenes. That is meaningful as building a dense map is computational expensive especially in large scale. Moreover, a probabilistic analysis among different solutions is presented and an automatic solution selection mechanism is designed to maximize the success rate by selecting appropriate solutions in different environmental characteristics. Finally, a complete visual localization pipeline considering situations from the perspective of correspondence and depth density is summarized and validated on both simulation and public real-world indoor localization dataset. The code is released on github.