Automatic Detection of Alzheimer's Disease with Multi-Modal Fusion of Clinical MRI Scans

The aging population of the U.S. drives the prevalence of Alzheimer's disease. Brookmeyer et al. forecasts approximately 15 million Americans will have either clinical AD or mild cognitive impairment by 2060. In response to this urgent call, methods for early detection of Alzheimer's disease have been developed for prevention and pre-treatment. Notably, literature on the application of deep learning in the automatic detection of the disease has been proliferating. This study builds upon previous literature and maintains a focus on leveraging multi-modal information to enhance automatic detection. We aim to predict the stage of the disease - Cognitively Normal (CN), Mildly Cognitive Impairment (MCI), and Alzheimer's Disease (AD), based on two different types of brain MRI scans. We design an AlexNet-based deep learning model that learns the synergy of complementary information from both T1 and FLAIR MRI scans.

Gentopia: A Collaborative Platform for Tool-Augmented LLMs

Augmented Language Models (ALMs) empower large language models with the ability to use tools, transforming them into intelligent agents for real-world interactions. However, most existing frameworks for ALMs, to varying degrees, are deficient in the following critical features: flexible customization, collaborative democratization, and holistic evaluation. We present gentopia, an ALM framework enabling flexible customization of agents through simple configurations, seamlessly integrating various language models, task formats, prompting modules, and plugins into a unified paradigm. Furthermore, we establish gentpool, a public platform enabling the registration and sharing of user-customized agents. Agents registered in gentpool are composable such that they can be assembled together for agent collaboration, advancing the democratization of artificial intelligence. To ensure high-quality agents, gentbench, an integral component of gentpool, is designed to thoroughly evaluate user-customized agents across diverse aspects such as safety, robustness, efficiency, etc. We release gentopia on Github and will continuously move forward.