PAINT: Pathology-Aware Integrated Next-Scale Transformation for Virtual Immunohistochemistry

Virtual immunohistochemistry (IHC) aims to computationally synthesize molecular staining patterns from routine Hematoxylin and Eosin (H\&E) images, offering a cost-effective and tissue-efficient alternative to traditional physical staining. However, this task is particularly challenging: H\&E morphology provides ambiguous cues about protein expression, and similar tissue structures may correspond to distinct molecular states. Most existing methods focus on direct appearance synthesis to implicitly achieve cross-modal generation, often resulting in semantic inconsistencies due to insufficient structural priors. In this paper, we propose Pathology-Aware Integrated Next-Scale Transformation (PAINT), a visual autoregressive framework that reformulates the synthesis process as a structure-first conditional generation task. Unlike direct image translation, PAINT enforces a causal order by resolving molecular details conditioned on a global structural layout. Central to this approach is the introduction of a Spatial Structural Start Map (3S-Map), which grounds the autoregressive initialization in observed morphology, ensuring deterministic, spatially aligned synthesis. Experiments on the IHC4BC and MIST datasets demonstrate that PAINT outperforms state-of-the-art methods in structural fidelity and clinical downstream tasks, validating the potential of structure-guided autoregressive modeling.

Sim-to-Real Transfer via a Style-Identified Cycle Consistent Generative Adversarial Network: Zero-Shot Deployment on Robotic Manipulators through Visual Domain Adaptation

The sample efficiency challenge in Deep Reinforcement Learning (DRL) compromises its industrial adoption due to the high cost and time demands of real-world training. Virtual environments offer a cost-effective alternative for training DRL agents, but the transfer of learned policies to real setups is hindered by the sim-to-real gap. Achieving zero-shot transfer, where agents perform directly in real environments without additional tuning, is particularly desirable for its efficiency and practical value. This work proposes a novel domain adaptation approach relying on a Style-Identified Cycle Consistent Generative Adversarial Network (StyleID-CycleGAN or SICGAN), an original Cycle Consistent Generative Adversarial Network (CycleGAN) based model. SICGAN translates raw virtual observations into real-synthetic images, creating a hybrid domain for training DRL agents that combines virtual dynamics with real-like visual inputs. Following virtual training, the agent can be directly deployed, bypassing the need for real-world training. The pipeline is validated with two distinct industrial robots in the approaching phase of a pick-and-place operation. In virtual environments agents achieve success rates of 90 to 100\%, and real-world deployment confirms robust zero-shot transfer (i.e., without additional training in the physical environment) with accuracies above 95\% for most workspace regions. We use augmented reality targets to improve the evaluation process efficiency, and experimentally demonstrate that the agent successfully generalizes to real objects of varying colors and shapes, including LEGO\textsuperscript{\textregistered}~cubes and a mug. These results establish the proposed pipeline as an efficient, scalable solution to the sim-to-real problem.

ColorConceptBench: A Benchmark for Probabilistic Color-Concept Understanding in Text-to-Image Models

While text-to-image (T2I) models have advanced considerably, their capability to associate colors with implicit concepts remains underexplored. To address the gap, we introduce ColorConceptBench, a new human-annotated benchmark to systematically evaluate color-concept associations through the lens of probabilistic color distributions. ColorConceptBench moves beyond explicit color names or codes by probing how models translate 1,281 implicit color concepts using a foundation of 6,369 human annotations. Our evaluation of seven leading T2I models reveals that current models lack sensitivity to abstract semantics, and crucially, this limitation appears resistant to standard interventions (e.g., scaling and guidance). This demonstrates that achieving human-like color semantics requires more than larger models, but demands a fundamental shift in how models learn and represent implicit meaning.

SoS: Analysis of Surface over Semantics in Multilingual Text-To-Image Generation

Text-to-image (T2I) models are increasingly employed by users worldwide. However, prior research has pointed to the high sensitivity of T2I towards particular input languages - when faced with languages other than English (i.e., different surface forms of the same prompt), T2I models often produce culturally stereotypical depictions, prioritizing the surface over the prompt's semantics. Yet a comprehensive analysis of this behavior, which we dub Surface-over-Semantics (SoS), is missing. We present the first analysis of T2I models' SoS tendencies. To this end, we create a set of prompts covering 171 cultural identities, translated into 14 languages, and use it to prompt seven T2I models. To quantify SoS tendencies across models, languages, and cultures, we introduce a novel measure and analyze how the tendencies we identify manifest visually. We show that all but one model exhibit strong surface-level tendency in at least two languages, with this effect intensifying across the layers of T2I text encoders. Moreover, these surface tendencies frequently correlate with stereotypical visual depictions.

InstructTime++: Time Series Classification with Multimodal Language Modeling via Implicit Feature Enhancement

Most existing time series classification methods adopt a discriminative paradigm that maps input sequences directly to one-hot encoded class labels. While effective, this paradigm struggles to incorporate contextual features and fails to capture semantic relationships among classes. To address these limitations, we propose InstructTime, a novel framework that reformulates time series classification as a multimodal generative task. Specifically, continuous numerical sequences, contextual textual features, and task instructions are treated as multimodal inputs, while class labels are generated as textual outputs by tuned language models. To bridge the modality gap, InstructTime introduces a time series discretization module that converts continuous sequences into discrete temporal tokens, together with an alignment projection layer and a generative self-supervised pre-training strategy to enhance cross-modal representation alignment. Building upon this framework, we further propose InstructTime++, which extends InstructTime by incorporating implicit feature modeling to compensate for the limited inductive bias of language models. InstructTime++ leverages specialized toolkits to mine informative implicit patterns from raw time series and contextual inputs, including statistical feature extraction and vision-language-based image captioning, and translates them into textual descriptions for seamless integration. Extensive experiments on multiple benchmark datasets demonstrate the superior performance of InstructTime++.

Cross-Domain Object Detection Using Unsupervised Image Translation

Unsupervised domain adaptation for object detection addresses the adaption of detectors trained in a source domain to work accurately in an unseen target domain. Recently, methods approaching the alignment of the intermediate features proven to be promising, achieving state-of-the-art results. However, these methods are laborious to implement and hard to interpret. Although promising, there is still room for improvements to close the performance gap toward the upper-bound (when training with the target data). In this work, we propose a method to generate an artificial dataset in the target domain to train an object detector. We employed two unsupervised image translators (CycleGAN and an AdaIN-based model) using only annotated data from the source domain and non-annotated data from the target domain. Our key contributions are the proposal of a less complex yet more effective method that also has an improved interpretability. Results on real-world scenarios for autonomous driving show significant improvements, outperforming state-of-the-art methods in most cases, further closing the gap toward the upper-bound.

Sim2real Image Translation Enables Viewpoint-Robust Policies from Fixed-Camera Datasets

Vision-based policies for robot manipulation have achieved significant recent success, but are still brittle to distribution shifts such as camera viewpoint variations. Robot demonstration data is scarce and often lacks appropriate variation in camera viewpoints. Simulation offers a way to collect robot demonstrations at scale with comprehensive coverage of different viewpoints, but presents a visual sim2real challenge. To bridge this gap, we propose MANGO -- an unpaired image translation method with a novel segmentation-conditioned InfoNCE loss, a highly-regularized discriminator design, and a modified PatchNCE loss. We find that these elements are crucial for maintaining viewpoint consistency during sim2real translation. When training MANGO, we only require a small amount of fixed-camera data from the real world, but show that our method can generate diverse unseen viewpoints by translating simulated observations. In this domain, MANGO outperforms all other image translation methods we tested. Imitation-learning policies trained on data augmented by MANGO are able to achieve success rates as high as 60\% on views that the non-augmented policy fails completely on.

An efficient heuristic for geometric analysis of cell deformations

Sickle cell disease causes erythrocytes to become sickle-shaped, affecting their movement in the bloodstream and reducing oxygen delivery. It has a high global prevalence and places a significant burden on healthcare systems, especially in resource-limited regions. Automated classification of sickle cells in blood images is crucial, allowing the specialist to reduce the effort required and avoid errors when quantifying the deformed cells and assessing the severity of a crisis. Recent studies have proposed various erythrocyte representation and classification methods. Since classification depends solely on cell shape, a suitable approach models erythrocytes as closed planar curves in shape space. This approach employs elastic distances between shapes, which are invariant under rotations, translations, scaling, and reparameterizations, ensuring consistent distance measurements regardless of the curves' position, starting point, or traversal speed. While previous methods exploiting shape space distances had achieved high accuracy, we refined the model by considering the geometric characteristics of healthy and sickled erythrocytes. Our method proposes (1) to employ a fixed parameterization based on the major axis of each cell to compute distances and (2) to align each cell with two templates using this parameterization before computing distances. Aligning shapes to templates before distance computation, a concept successfully applied in areas such as molecular dynamics, and using a fixed parameterization, instead of minimizing distances across all possible parameterizations, simplifies calculations. This strategy achieves 96.03\% accuracy rate in both supervised classification and unsupervised clustering. Our method ensures efficient erythrocyte classification, maintaining or improving accuracy over shape space models while significantly reducing computational costs.

TranslateGemma Technical Report

We present TranslateGemma, a suite of open machine translation models based on the Gemma 3 foundation models. To enhance the inherent multilingual capabilities of Gemma 3 for the translation task, we employ a two-stage fine-tuning process. First, supervised fine-tuning is performed using a rich mixture of high-quality large-scale synthetic parallel data generated via state-of-the-art models and human-translated parallel data. This is followed by a reinforcement learning phase, where we optimize translation quality using an ensemble of reward models, including MetricX-QE and AutoMQM, targeting translation quality. We demonstrate the effectiveness of TranslateGemma with human evaluation on the WMT25 test set across 10 language pairs and with automatic evaluation on the WMT24++ benchmark across 55 language pairs. Automatic metrics show consistent and substantial gains over the baseline Gemma 3 models across all sizes. Notably, smaller TranslateGemma models often achieve performance comparable to larger baseline models, offering improved efficiency. We also show that TranslateGemma models retain strong multimodal capabilities, with enhanced performance on the Vistra image translation benchmark. The release of the open TranslateGemma models aims to provide the research community with powerful and adaptable tools for machine translation.

Press Start to Charge: Videogaming the Online Centralized Charging Scheduling Problem

We study the online centralized charging scheduling problem (OCCSP). In this problem, a central authority must decide, in real time, when to charge dynamically arriving electric vehicles (EVs), subject to capacity limits, with the objective of balancing load across a finite planning horizon. To solve the problem, we first gamify it; that is, we model it as a game where charging blocks are placed within temporal and capacity constraints on a grid. We design heuristic policies, train learning agents with expert demonstrations, and improve them using Dataset Aggregation (DAgger). From a theoretical standpoint, we show that gamification reduces model complexity and yields tighter generalization bounds than vector-based formulations. Experiments across multiple EV arrival patterns confirm that gamified learning enhances load balancing. In particular, the image-to-movement model trained with DAgger consistently outperforms heuristic baselines, vector-based approaches, and supervised learning agents, while also demonstrating robustness in sensitivity analyses. These operational gains translate into tangible economic value. In a real-world case study for the Greater Montréal Area (Québec, Canada) using utility cost data, the proposed methods lower system costs by tens of millions of dollars per year over the prevailing practice and show clear potential to delay costly grid upgrades.