Bridging MRI and PET physiology: Untangling complementarity through orthogonal representations

Multimodal imaging analysis often relies on joint latent representations, yet these approaches rarely define what information is shared versus modality-specific. Clarifying this distinction is clinically relevant, as it delineates the irreducible contribution of each modality and informs rational acquisition strategies. We propose a subspace decomposition framework that reframes multimodal fusion as a problem of orthogonal subspace separation rather than translation. We decompose Prostate-Specific Membrane Antigen (PSMA) PET uptake into an MRI-explainable physiological envelope and an orthogonal residual reflecting signal components not expressible within the MRI feature manifold. Using multiparametric MRI, we train an intensity-based, non-spatial implicit neural representation (INR) to map MRI feature vectors to PET uptake. We introduce a projection-based regularization using singular value decomposition to penalize residual components lying within the span of the MRI feature manifold. This enforces mathematical orthogonality between tissue-level physiological properties (structure, diffusion, perfusion) and intracellular PSMA expression. Tested on 13 prostate cancer patients, the model demonstrates that residual components spanned by MRI features are absorbed into the learned envelope, while the orthogonal residual is largest in tumour regions. This indicates that PSMA PET contains signal components not recoverable from MRI-derived physiological descriptors. The resulting decomposition provides a structured characterization of modality complementarity grounded in representation geometry rather than image translation.

Distilling Photon-Counting CT into Routine Chest CT through Clinically Validated Degradation Modeling

Photon-counting CT (PCCT) provides superior image quality with higher spatial resolution and lower noise compared to conventional energy-integrating CT (EICT), but its limited clinical availability restricts large-scale research and clinical deployment. To bridge this gap, we propose SUMI, a simulated degradation-to-enhancement method that learns to reverse realistic acquisition artifacts in low-quality EICT by leveraging high-quality PCCT as reference. Our central insight is to explicitly model realistic acquisition degradations, transforming PCCT into clinically plausible lower-quality counterparts and learning to invert this process. The simulated degradations were validated for clinical realism by board-certified radiologists, enabling faithful supervision without requiring paired acquisitions at scale. As outcomes of this technical contribution, we: (1) train a latent diffusion model on 1,046 PCCTs, using an autoencoder first pre-trained on both these PCCTs and 405,379 EICTs from 145 hospitals to extract general CT latent features that we release for reuse in other generative medical imaging tasks; (2) construct a large-scale dataset of over 17,316 publicly available EICTs enhanced to PCCT-like quality, with radiologist-validated voxel-wise annotations of airway trees, arteries, veins, lungs, and lobes; and (3) demonstrate substantial improvements: across external data, SUMI outperforms state-of-the-art image translation methods by 15% in SSIM and 20% in PSNR, improves radiologist-rated clinical utility in reader studies, and enhances downstream top-ranking lesion detection performance, increasing sensitivity by up to 15% and F1 score by up to 10%. Our results suggest that emerging imaging advances can be systematically distilled into routine EICT using limited high-quality scans as reference.

Three Modalities, Two Design Probes, One Prototype, and No Vision: Experience-Based Co-Design of a Multi-modal 3D Data Visualization Tool

Three-dimensional (3D) data visualizations, such as surface plots, are vital in STEM fields from biomedical imaging to spectroscopy, yet remain largely inaccessible to blind and low-vision (BLV) people. To address this gap, we conducted an Experience-Based Co-Design with BLV co-designers with expertise in non-visual data representations to create an accessible, multi-modal, web-native visualization tool. Using a multi-phase methodology, our team of five BLV and one non-BLV researcher(s) participated in two iterative sessions, comparing a low-fidelity tactile probe with a high-fidelity digital prototype. This process produced a prototype with empirically grounded features, including reference sonification, stereo and volumetric audio, and configurable buffer aggregation, which our co-designers validated as improving analytic accuracy and learnability. In this study, we target core analytic tasks essential for non-visual 3D data exploration: orientation, landmark and peak finding, comparing local maxima versus global trends, gradient tracing, and identifying occluded or partially hidden features. Our work offers accessibility researchers and developers a co-design protocol for translating tactile knowledge to digital interfaces, concrete design guidance for future systems, and opportunities to extend accessible 3D visualization into embodied data environments.

AfriVoices-KE: A Multilingual Speech Dataset for Kenyan Languages

AfriVoices-KE is a large-scale multilingual speech dataset comprising approximately 3,000 hours of audio across five Kenyan languages: Dholuo, Kikuyu, Kalenjin, Maasai, and Somali. The dataset includes 750 hours of scripted speech and 2,250 hours of spontaneous speech, collected from 4,777 native speakers across diverse regions and demographics. This work addresses the critical underrepresentation of African languages in speech technology by providing a high-quality, linguistically diverse resource. Data collection followed a dual methodology: scripted recordings drew from compiled text corpora, translations, and domain-specific generated sentences spanning eleven domains relevant to the Kenyan context, while unscripted speech was elicited through textual and image prompts to capture natural linguistic variation and dialectal nuances. A customized mobile application enabled contributors to record using smartphones. Quality assurance operated at multiple layers, encompassing automated signal-to-noise ratio validation prior to recording and human review for content accuracy. Though the project encountered challenges common to low-resource settings, including unreliable infrastructure, device compatibility issues, and community trust barriers, these were mitigated through local mobilizers, stakeholder partnerships, and adaptive training protocols. AfriVoices-KE provides a foundational resource for developing inclusive automatic speech recognition and text-to-speech systems, while advancing the digital preservation of Kenya's linguistic heritage.

Lighting-grounded Video Generation with Renderer-based Agent Reasoning

Diffusion models have achieved remarkable progress in video generation, but their controllability remains a major limitation. Key scene factors such as layout, lighting, and camera trajectory are often entangled or only weakly modeled, restricting their applicability in domains like filmmaking and virtual production where explicit scene control is essential. We present LiVER, a diffusion-based framework for scene-controllable video generation. To achieve this, we introduce a novel framework that conditions video synthesis on explicit 3D scene properties, supported by a new large-scale dataset with dense annotations of object layout, lighting, and camera parameters. Our method disentangles these properties by rendering control signals from a unified 3D representation. We propose a lightweight conditioning module and a progressive training strategy to integrate these signals into a foundational video diffusion model, ensuring stable convergence and high fidelity. Our framework enables a wide range of applications, including image-to-video and video-to-video synthesis where the underlying 3D scene is fully editable. To further enhance usability, we develop a scene agent that automatically translates high-level user instructions into the required 3D control signals. Experiments show that LiVER achieves state-of-the-art photorealism and temporal consistency while enabling precise, disentangled control over scene factors, setting a new standard for controllable video generation.

A Systematic Framework for Tabular Data Disentanglement

Tabular data, widely used in various applications such as industrial control systems, finance, and supply chain, often contains complex interrelationships among its attributes. Data disentanglement seeks to transform such data into latent variables with reduced interdependencies, facilitating more effective and efficient processing. Despite the extensive studies on data disentanglement over image, text, or audio data, tabular data disentanglement may require further investigation due to the more intricate attribute interactions typically found in tabular data. Moreover, due to the highly complex interrelationships, direct translation from other data domains results in suboptimal data disentanglement. Existing tabular data disentanglement methods, such as factor analysis, CT-GAN, and VAE face limitations including scalability issues, mode collapse, and poor extrapolation. In this paper, we propose the use of a framework to provide a systematic view on tabular data disentanglement that modularizes the process into four core components: data extraction, data modeling, model analysis, and latent representation extrapolation. We believe this work provides a deeper understanding of tabular data disentanglement and existing methods, and lays the foundation for potential future research in developing robust, efficient, and scalable data disentanglement techniques. Finally, we demonstrate the framework's applicability through a case study on synthetic tabular data generation, showcasing its potential in the particular downstream task of data synthesis.

A Mixture of Experts Foundation Model for Scanning Electron Microscopy Image Analysis

Scanning Electron Microscopy (SEM) is indispensable in modern materials science, enabling high-resolution imaging across a wide range of structural, chemical, and functional investigations. However, SEM imaging remains constrained by task-specific models and labor-intensive acquisition processes that limit its scalability across diverse applications. Here, we introduce the first foundation model for SEM images, pretrained on a large corpus of multi-instrument, multi-condition scientific micrographs, enabling generalization across diverse material systems and imaging conditions. Leveraging a self-supervised transformer architecture, our model learns rich and transferable representations that can be fine-tuned or adapted to a wide range of downstream tasks. As a compelling demonstration, we focus on defocus-to-focus image translation-an essential yet underexplored challenge in automated microscopy pipelines. Our method not only restores focused detail from defocused inputs without paired supervision but also outperforms state-of-the-art techniques across multiple evaluation metrics. This work lays the groundwork for a new class of adaptable SEM models, accelerating materials discovery by bridging foundational representation learning with real-world imaging needs.

Vision-Language Model-Guided Deep Unrolling Enables Personalized, Fast MRI

Magnetic Resonance Imaging (MRI) is a cornerstone in medicine and healthcare but suffers from long acquisition times. Traditional accelerated MRI methods optimize for generic image quality, lacking adaptability for specific clinical tasks. To address this, we introduce PASS (Personalized, Anomaly-aware Sampling and reconStruction), an intelligent MRI framework that leverages a Vision-Language Model (VLM) to guide a deep unrolling network for task-oriented, fast imaging. PASS dynamically personalizes the imaging pipeline through three core contributions: (1) a deep unrolled reconstruction network derived from a physics-based MRI model; (2) a sampling module that generates patient-specific $k$-space trajectories; and (3) an anomaly-aware prior, extracted from a pretrained VLM, which steers both sampling and reconstruction toward clinically relevant regions. By integrating the high-level clinical reasoning of a VLM with an interpretable, physics-aware network, PASS achieves superior image quality across diverse anatomies, contrasts, anomalies, and acceleration factors. This enhancement directly translates to improvements in downstream diagnostic tasks, including fine-grained anomaly detection, localization, and diagnosis.

Structural Evaluation Metrics for SVG Generation via Leave-One-Out Analysis

Scalable Vector Graphics (SVG) represent visual content as structured, editable code. Each element (path, shape, or text node) can be individually inspected, transformed, or removed. This structural editability is a main motivation for SVG generation, yet prevailing evaluation protocols primarily reduce the output to a single similarity score against a reference image or input texts, measuring how faithfully the result reproduces an image or follows the instructions, but not how well it preserves the structural properties that make SVG valuable. In particular, existing metrics cannot determine which generated elements contribute positively to overall visual quality, how visual concepts map to specific parts of the code, or whether the generated output supports meaningful downstream editing. We introduce element-level leave-one-out (LOO) analysis, inspired by the classic jackknife estimator. The procedure renders the SVG with and without each element, measures the resulting visual change, and derives a suite of structural quality metrics. Despite its simplicity, the jackknife's capacity to decompose an aggregate statistic into per-sample contributions translates directly to this setting. From a single mechanism, we obtain: (1) quality scores per element through LOO scoring that enable zero-shot artifact detection; (2) concept-element attribution that maps each element to the visual concept it serves; and (3) four structural metrics, purity, coverage, compactness, and locality, that quantify SVG modularity from complementary perspectives. We validate these metrics on over 19,000 edits (5 types) across 5 generation systems and 3 complexity tiers.

HistDiT: A Structure-Aware Latent Conditional Diffusion Model for High-Fidelity Virtual Staining in Histopathology

Immunohistochemistry (IHC) is essential for assessing specific immune biomarkers like Human Epidermal growth-factor Receptor 2 (HER2) in breast cancer. However, the traditional protocols of obtaining IHC stains are resource-intensive, time-consuming, and prone to structural damages. Virtual staining has emerged as a scalable alternative, but it faces significant challenges in preserving fine-grained cellular structures while accurately translating biochemical expressions. Current state-of-the-art methods still rely on Generative Adversarial Networks (GANs) or standard convolutional U-Net diffusion models that often struggle with "structure and staining trade-offs". The generated samples are either structurally relevant but blurry, or texturally realistic but have artifacts that compromise their diagnostic use. In this paper, we introduce HistDiT, a novel latent conditional Diffusion Transformer (DiT) architecture that establishes a new benchmark for visual fidelity in virtual histological staining. The novelty introduced in this work is, a) the Dual-Stream Conditioning strategy that explicitly maintains a balance between spatial constraints via VAE-encoded latents and semantic phenotype guidance via UNI embeddings; b) the multi-objective loss function that contributes to sharper images with clear morphological structure; and c) the use of the Structural Correlation Metric (SCM) to focus on the core morphological structure for precise assessment of sample quality. Consequently, our model outperforms existing baselines, as demonstrated through rigorous quantitative and qualitative evaluations.