BRIGHT: A Collaborative Generalist-Specialist Foundation Model for Breast Pathology

Generalist pathology foundation models (PFMs), pretrained on large-scale multi-organ datasets, have demonstrated remarkable predictive capabilities across diverse clinical applications. However, their proficiency on the full spectrum of clinically essential tasks within a specific organ system remains an open question due to the lack of large-scale validation cohorts for a single organ as well as the absence of a tailored training paradigm that can effectively translate broad histomorphological knowledge into the organ-specific expertise required for specialist-level interpretation. In this study, we propose BRIGHT, the first PFM specifically designed for breast pathology, trained on approximately 210 million histopathology tiles from over 51,000 breast whole-slide images derived from a cohort of over 40,000 patients across 19 hospitals. BRIGHT employs a collaborative generalist-specialist framework to capture both universal and organ-specific features. To comprehensively evaluate the performance of PFMs on breast oncology, we curate the largest multi-institutional cohorts to date for downstream task development and evaluation, comprising over 25,000 WSIs across 10 hospitals. The validation cohorts cover the full spectrum of breast pathology across 24 distinct clinical tasks spanning diagnosis, biomarker prediction, treatment response and survival prediction. Extensive experiments demonstrate that BRIGHT outperforms three leading generalist PFMs, achieving state-of-the-art (SOTA) performance in 21 of 24 internal validation tasks and in 5 of 10 external validation tasks with excellent heatmap interpretability. By evaluating on large-scale validation cohorts, this study not only demonstrates BRIGHT's clinical utility in breast oncology but also validates a collaborative generalist-specialist paradigm, providing a scalable template for developing PFMs on a specific organ system.

MR-Compass: Inertial Navigation-Driven Motion Correction for Brain MRI

Inertial sensors can track object kinematics, however, unbounded drift from integrating noisy signals makes them impractical for MRI motion correction at millimeter resolution and minute-long scans. We introduce MR-Compass, which exploits the MRI system's static magnetic and gravitational fields to estimate 3-DOF orientation at 2 kHz directly, without integration, eliminating random-walk. The remaining 3-DOF translation is recovered via phase correlation from the MRI data. We experimentally validate the efficacy of the method retrospectively using a 3D radial koosh-ball sequence and prospectively using 2D EPI fMRI during large volunteer motions. MR-Compass followed by phase-correlation achieved a mean accuracy of 0.6$^o$ and 0.4 pixels across all experiments. Image quality improved when motion correction was applied in all volunteer scans for both retrospective and prospective correction cases. MR-Compass was effective in measuring head motion in the MRI scanner with high accuracy at unprecedented sample rates, and enabled both retrospective and prospective reconstruction to improve image quality by aligning the k-space data appropriately and by reducing the motion related artifacts.

RAFM: Retrieval-Augmented Flow Matching for Unpaired CBCT-to-CT Translation

Cone-beam CT (CBCT) is routinely acquired in radiotherapy but suffers from severe artifacts and unreliable Hounsfield Unit (HU) values, limiting its direct use for dose calculation. Synthetic CT (sCT) generation from CBCT is therefore an important task, yet paired CBCT--CT data are often unavailable or unreliable due to temporal gaps, anatomical variation, and registration errors. In this work, we introduce rectified flow (RF) into unpaired CBCT-to-CT translation in medical imaging. Although RF is theoretically compatible with unpaired learning through distribution-level coupling and deterministic transport, its practical effectiveness under small medical datasets and limited batch sizes remains underexplored. Direct application with random or batch-local pseudo pairing can produce unstable supervision due to semantically mismatched endpoint samples. To address this challenge, we propose Retrieval-Augmented Flow Matching (RAFM), which adapts RF to the medical setting by constructing retrieval-guided pseudo pairs using a frozen DINOv3 encoder and a global CT memory bank. This strategy improves empirical coupling quality and stabilizes unpaired flow-based training. Experiments on SynthRAD2023 under a strict subject-level true-unpaired protocol show that RAFM outperforms existing methods across FID, MAE, SSIM, PSNR, and SegScore. The code is available at https://github.com/HiLab-git/RAFM.git.

Rate-Distortion Signatures of Generalization and Information Trade-offs

Generalization to novel visual conditions remains a central challenge for both human and machine vision, yet standard robustness metrics offer limited insight into how systems trade accuracy for robustness. We introduce a rate-distortion-theoretic framework that treats stimulus-response behavior as an effective communication channel, derives rate-distortion (RD) frontiers from confusion matrices, and summarizes each system with two interpretable geometric signatures - slope ($β$) and curvature ($κ$) - which capture the marginal cost and abruptness of accuracy-robustness trade-offs. Applying this framework to human psychophysics and 18 deep vision models under controlled image perturbations, we compare generalization geometry across model architectures and training regimes. We find that both biological and artificial systems follow a common lossy-compression principle but occupy systematically different regions of RD space. In particular, humans exhibit smoother, more flexible trade-offs, whereas modern deep networks operate in steeper and more brittle regimes even at matched accuracy. Across training regimes, robustness training induces systematic but dissociable shifts in beta/kappa, revealing cases where improved robustness or accuracy does not translate into more human-like generalization geometry. These results demonstrate that RD geometry provides a compact, model-agnostic lens for comparing generalization behavior across systems beyond standard accuracy-based metrics.

OpenRad: a Curated Repository of Open-access AI models for Radiology

The rapid developments in artificial intelligence (AI) research in radiology have produced numerous models that are scattered across various platforms and sources, limiting discoverability, reproducibility and clinical translation. Herein, OpenRad was created, a curated, standardized, open-access repository that aggregates radiology AI models and providing details such as the availability of pretrained weights and interactive applications. Retrospective analysis of peer reviewed literature and preprints indexed in PubMed, arXiv and Scopus was performed until Dec 2025 (n = 5239 records). Model records were generated using a locally hosted LLM (gpt-oss:120b), based on the RSNA AI Roadmap JSON schema, and manually verified by ten expert reviewers. Stability of LLM outputs was assessed on 225 randomly selected papers using text similarity metrics. A total of 1694 articles were included after review. Included models span all imaging modalities (CT, MRI, X-ray, US) and radiology subspecialties. Automated extraction demonstrated high stability for structured fields (Levenshtein ratio > 90%), with 78.5% of record edits being characterized as minor during expert review. Statistical analysis of the repository revealed CNN and transformer architectures as dominant, while MRI was the most commonly used modality (in 621 neuroradiology AI models). Research output was mostly concentrated in China and the United States. The OpenRad web interface enables model discovery via keyword search and filters for modality, subspecialty, intended use, verification status and demo availability, alongside live statistics. The community can contribute new models through a dedicated portal. OpenRad contains approx. 1700 open access, curated radiology AI models with standardized metadata, supplemented with analysis of code repositories, thereby creating a comprehensive, searchable resource for the radiology community.

Global-Local Dual Perception for MLLMs in High-Resolution Text-Rich Image Translation

Text Image Machine Translation (TIMT) aims to translate text embedded in images in the source-language into target-language, requiring synergistic integration of visual perception and linguistic understanding. Existing TIMT methods, whether cascaded pipelines or end-to-end multimodal large language models (MLLMs),struggle with high-resolution text-rich images due to cluttered layouts, diverse fonts, and non-textual distractions, resulting in text omission, semantic drift, and contextual inconsistency. To address these challenges, we propose GLoTran, a global-local dual visual perception framework for MLLM-based TIMT. GLoTran integrates a low-resolution global image with multi-scale region-level text image slices under an instruction-guided alignment strategy, conditioning MLLMs to maintain scene-level contextual consistency while faithfully capturing fine-grained textual details. Moreover, to realize this dual-perception paradigm, we construct GLoD, a large-scale text-rich TIMT dataset comprising 510K high-resolution global-local image-text pairs covering diverse real-world scenarios. Extensive experiments demonstrate that GLoTran substantially improves translation completeness and accuracy over state-of-the-art MLLMs, offering a new paradigm for fine-grained TIMT under high-resolution and text-rich conditions.

Structure-to-Image: Zero-Shot Depth Estimation in Colonoscopy via High-Fidelity Sim-to-Real Adaptation

Monocular depth estimation (MDE) for colonoscopy is hampered by the domain gap between simulated and real-world images. Existing image-to-image translation methods, which use depth as a posterior constraint, often produce structural distortions and specular highlights by failing to balance realism with structure consistency. To address this, we propose a Structure-to-Image paradigm that transforms the depth map from a passive constraint into an active generative foundation. We are the first to introduce phase congruency to colonoscopic domain adaptation and design a cross-level structure constraint to co-optimize geometric structures and fine-grained details like vascular textures. In zero-shot evaluations conducted on a publicly available phantom dataset, the MDE model that was fine-tuned on our generated data achieved a maximum reduction of 44.18% in RMSE compared to competing methods. Our code is available at https://github.com/YyangJJuan/PC-S2I.git.

Provable Subspace Identification of Nonlinear Multi-view CCA

We investigate the identifiability of nonlinear Canonical Correlation Analysis (CCA) in a multi-view setup, where each view is generated by an unknown nonlinear map applied to a linear mixture of shared latents and view-private noise. Rather than attempting exact unmixing, a problem proven to be ill-posed, we instead reframe multi-view CCA as a basis-invariant subspace identification problem. We prove that, under suitable latent priors and spectral separation conditions, multi-view CCA recovers the pairwise correlated signal subspaces up to view-wise orthogonal ambiguity. For $N \geq 3$ views, the objective provably isolates the jointly correlated subspaces shared across all views while eliminating view-private variations. We further establish finite-sample consistency guarantees by translating the concentration of empirical cross-covariances into explicit subspace error bounds via spectral perturbation theory. Experiments on synthetic and rendered image datasets validate our theoretical findings and confirm the necessity of the assumed conditions.

TherA: Thermal-Aware Visual-Language Prompting for Controllable RGB-to-Thermal Infrared Translation

Despite the inherent advantages of thermal infrared(TIR) imaging, large-scale data collection and annotation remain a major bottleneck for TIR-based perception. A practical alternative is to synthesize pseudo TIR data via image translation; however, most RGB-to-TIR approaches heavily rely on RGB-centric priors that overlook thermal physics, yielding implausible heat distributions. In this paper, we introduce TherA, a controllable RGB-to-TIR translation framework that produces diverse and thermally plausible images at both scene and object level. TherA couples TherA-VLM with a latent-diffusion-based translator. Given a single RGB image and a user-prompted condition pair, TherA-VLM yields a thermal-aware embedding that encodes scene, object, material, and heat-emission context reflecting the input scene-condition pair. Conditioning the diffusion model on this embedding enables realistic TIR synthesis and fine-grained control across time of day, weather, and object state. Compared to other baselines, TherA achieves state-of-the-art translation performance, demonstrating improved zero-shot translation performance up to 33% increase averaged across all metrics.

FlowFixer: Towards Detail-Preserving Subject-Driven Generation

We present FlowFixer, a refinement framework for subject-driven generation (SDG) that restores fine details lost during generation caused by changes in scale and perspective of a subject. FlowFixer proposes direct image-to-image translation from visual references, avoiding ambiguities in language prompts. To enable image-to-image training, we introduce a one-step denoising scheme to generate self-supervised training data, which automatically removes high-frequency details while preserving global structure, effectively simulating real-world SDG errors. We further propose a keypoint matching-based metric to properly assess fidelity in details beyond semantic similarities usually measured by CLIP or DINO. Experimental results demonstrate that FlowFixer outperforms state-of-the-art SDG methods in both qualitative and quantitative evaluations, setting a new benchmark for high-fidelity subject-driven generation.