Investigating a Policy-Based Formulation for Endoscopic Camera Pose Recovery

In endoscopic surgery, surgeons continuously locate the endoscopic view relative to the anatomy by interpreting the evolving visual appearance of the intraoperative scene in the context of their prior knowledge. Vision-based navigation systems seek to replicate this capability by recovering camera pose directly from endoscopic video, but most approaches do not embody the same principles of reasoning about new frames that makes surgeons successful. Instead, they remain grounded in feature matching and geometric optimization over keyframes, an approach that has been shown to degrade under the challenging conditions of endoscopic imaging like low texture and rapid illumination changes. Here, we pursue an alternative approach and investigate a policy-based formulation of endoscopic camera pose recovery that seeks to imitate experts in estimating trajectories conditioned on the previous camera state. Our approach directly predicts short-horizon relative motions without maintaining an explicit geometric representation at inference time. It thus addresses, by design, some of the notorious challenges of geometry-based approaches, such as brittle correspondence matching, instability in texture-sparse regions, and limited pose coverage due to reconstruction failure. We evaluate the proposed formulation on cadaveric sinus endoscopy. Under oracle state conditioning, we compare short-horizon motion prediction quality to geometric baselines achieving lowest mean translation error and competitive rotational accuracy. We analyze robustness by grouping prediction windows according to texture richness and illumination change indicating reduced sensitivity to low-texture conditions. These findings suggest that a learned motion policy offers a viable alternative formulation for endoscopic camera pose recovery.

R&D: Balancing Reliability and Diversity in Synthetic Data Augmentation for Semantic Segmentation

Collecting and annotating datasets for pixel-level semantic segmentation tasks are highly labor-intensive. Data augmentation provides a viable solution by enhancing model generalization without additional real-world data collection. Traditional augmentation techniques, such as translation, scaling, and color transformations, create geometric variations but fail to generate new structures. While generative models have been employed to extend semantic information of datasets, they often struggle to maintain consistency between the original and generated images, particularly for pixel-level tasks. In this work, we propose a novel synthetic data augmentation pipeline that integrates controllable diffusion models. Our approach balances diversity and reliability data, effectively bridging the gap between synthetic and real data. We utilize class-aware prompting and visual prior blending to improve image quality further, ensuring precise alignment with segmentation labels. By evaluating benchmark datasets such as PASCAL VOC and BDD100K, we demonstrate that our method significantly enhances semantic segmentation performance, especially in data-scarce scenarios, while improving model robustness in real-world applications. Our code is available at \href{https://github.com/chequanghuy/Enhanced-Generative-Data-Augmentation-for-Semantic-Segmentation-via-Stronger-Guidance}{https://github.com/chequanghuy/Enhanced-Generative-Data-Augmentation-for-Semantic-Segmentation-via-Stronger-Guidance}.

Do VLMs Need Vision Transformers? Evaluating State Space Models as Vision Encoders

Large vision--language models (VLMs) often use a frozen vision backbone, whose image features are mapped into a large language model through a lightweight connector. While transformer-based encoders are the standard visual backbone, we ask whether state space model (SSM) vision backbones can be a strong alternative. We systematically evaluate SSM vision backbones for VLMs in a controlled setting. Under matched ImageNet-1K initialization, the SSM backbone achieves the strongest overall performance across both VQA and grounding/localization. We further adapt both SSM and ViT-family backbones with detection or segmentation training and find that dense-task tuning generally improves performance across families; after this adaptation, the SSM backbone remains competitive while operating at a substantially smaller model scale. We further observe that (i) higher ImageNet accuracy or larger backbones do not reliably translate into better VLM performance, and (ii) some visual backbones are unstable in localization. Based on these findings, we propose stabilization strategies that improve robustness for both backbone families and highlight SSM backbones as a strong alternative to transformer-based vision encoders in VLMs.

AU Codes, Language, and Synthesis: Translating Anatomy to Text for Facial Behavior Synthesis

Facial behavior synthesis remains a critical yet underexplored challenge. While text-to-face models have made progress, they often rely on coarse emotion categories, which lack the nuance needed to capture the full spectrum of human nonverbal communication. Action Units (AUs) provide a more precise and anatomically grounded alternative. However, current AU-based approaches typically encode AUs as one-hot vectors, modeling compound expressions as simple linear combinations of individual AUs. This linearity becomes problematic when handling conflicting AUs--defined as those which activate the same facial muscle with opposing actions. Such cases lead to anatomically implausible artifacts and unnatural motion superpositions. To address this, we propose a novel method that represents facial behavior through natural language descriptions of AUs. This approach preserves the expressiveness of the AU framework while enabling explicit modeling of complex and conflicting AUs. It also unlocks the potential of modern text-to-image models for high-fidelity facial synthesis. Supporting this direction, we introduce BP4D-AUText, the first large-scale text-image paired dataset for complex facial behavior. It is synthesized by applying a rule-based Dynamic AU Text Processor to the BP4D and BP4D+ datasets. We further propose VQ-AUFace, a generative model that leverages facial structural priors to synthesize realistic and diverse facial behaviors from text. Extensive quantitative experiments and user studies demonstrate that our approach significantly outperforms existing methods. It excels in generating facial expressions that are anatomically plausible, behaviorally rich, and perceptually convincing, particularly under challenging conditions involving conflicting AUs.

Universal Skeleton Understanding via Differentiable Rendering and MLLMs

Multimodal large language models (MLLMs) exhibit strong visual-language reasoning, yet remain confined to their native modalities and cannot directly process structured, non-visual data such as human skeletons. Existing methods either compress skeleton dynamics into lossy feature vectors for text alignment, or quantize motion into discrete tokens that generalize poorly across heterogeneous skeleton formats. We present SkeletonLLM, which achieves universal skeleton understanding by translating arbitrary skeleton sequences into the MLLM's native visual modality. At its core is DrAction, a differentiable, format-agnostic renderer that converts skeletal kinematics into compact image sequences. Because the pipeline is end-to-end differentiable, MLLM gradients can directly guide the rendering to produce task-informative visual tokens. To further enhance reasoning capabilities, we introduce a cooperative training strategy: Causal Reasoning Distillation transfers structured, step-by-step reasoning from a teacher model, while Discriminative Finetuning sharpens decision boundaries between confusable actions. SkeletonLLM demonstrates strong generalization on diverse tasks including recognition, captioning, reasoning, and cross-format transfer -- suggesting a viable path for applying MLLMs to non-native modalities. Code will be released upon acceptance.

Interpretable Cross-Domain Few-Shot Learning with Rectified Target-Domain Local Alignment

Cross-Domain Few-Shot Learning (CDFSL) adapts models trained with large-scale general data (source domain) to downstream target domains with only scarce training data, where the research on vision-language models (e.g., CLIP) is still in the early stages. Typical downstream domains, such as medical diagnosis, require fine-grained visual cues for interpretable recognition, but we find that current fine-tuned CLIP models can hardly focus on these cues, albeit they can roughly focus on important regions in source domains. Although current works have demonstrated CLIP's shortcomings in capturing local subtle patterns, in this paper, we find that the domain gap and scarce training data further exacerbate such shortcomings, much more than that of holistic patterns, which we call the local misalignment problem in CLIP-based CDFSL. To address this problem, due to the lack of supervision in aligning local visual features and text semantics, we turn to self-supervision information. Inspired by the translation task, we propose the CC-CDFSL method with cycle consistency, which translates local visual features into text features and then translates them back into visual features (and vice versa), and constrains the original features close to the translated back features. To reduce the noise imported by richer information in the visual modality, we further propose a Semantic Anchor mechanism, which first augments visual features to provide a larger corpus for the text-to-image mapping, and then shrinks the image features to filter out irrelevant image-to-text mapping. Extensive experiments on various benchmarks, backbones, and fine-tuning methods show we can (1) effectively improve the local vision-language alignment, (2) enhance the interpretability of learned patterns and model decisions by visualizing patches, and (3) achieve state-of-the-art performance.

Segmentation-before-Staining Improves Structural Fidelity in Virtual IHC-to-Multiplex IF Translation

Multiplex immunofluorescence (mIF) enables simultaneous single-cell quantification of multiple biomarkers within intact tissue architecture, yet its high reagent cost, multi-round staining protocols, and need for specialized imaging platforms limit routine clinical adoption. Virtual staining can synthesize mIF channels from widely available brightfield immunohistochemistry (IHC), but current translators optimize pixel-level fidelity without explicitly constraining nuclear morphology. In pathology, this gap is clinically consequential: subtle distortions in nuclei count, shape, or spatial arrangement propagate directly to quantification endpoints such as the Ki67 proliferation index, where errors of a few percent can shift treatment-relevant risk categories. This work introduces a supervision-free, architecture-agnostic conditioning strategy that injects a continuous cell probability map from a pretrained nuclei segmentation foundation model as an explicit input prior, together with a variance-preserving regularization term that matches local intensity statistics to maintain cell-level heterogeneity in synthesized fluorescence channels. The soft prior retains gradient-level boundary information lost by binary thresholding, providing a richer conditioning signal without task-specific tuning. Controlled experiments across Pix2Pix with U-Net and ResNet generators, deterministic regression U-Net, and conditional diffusion on two independent datasets demonstrate consistent improvements in nuclei count fidelity and perceptual quality, as the sole modifications. Code will be made publicly available upon acceptance.

LoGSAM: Parameter-Efficient Cross-Modal Grounding for MRI Segmentation

Precise localization and delineation of brain tumors using Magnetic Resonance Imaging (MRI) are essential for planning therapy and guiding surgical decisions. However, most existing approaches rely on task-specific supervised models and are constrained by the limited availability of annotated data. To address this, we propose LoGSAM, a parameter-efficient, detection-driven framework that transforms radiologist dictation into text prompts for foundation-model-based localization and segmentation. Radiologist speech is first transcribed and translated using a pretrained Whisper ASR model, followed by negation-aware clinical NLP to extract tumor-specific textual prompts. These prompts guide text-conditioned tumor localization via a LoRA-adapted vision-language detection model, Grounding DINO (GDINO). The LoRA adaptation updates using 5% of the model parameters, thereby enabling computationally efficient domain adaptation while preserving pretrained cross-modal knowledge. The predicted bounding boxes are used as prompts for MedSAM to generate pixel-level tumor masks without any additional fine-tuning. Conditioning the frozen MedSAM on LoGSAM-derived priors yields a state-of-the-art dice score of 80.32% on BRISC 2025. In addition, we evaluate the full pipeline using German dictations from a board-certified radiologist on 12 unseen MRI scans, achieving 91.7% case-level accuracy. These results highlight the feasibility of constructing a modular, speech-to-segmentation pipeline by intelligently leveraging pretrained foundation models with minimal parameter updates.

Oscillating Dispersion for Maximal Light-throughput Spectral Imaging

Existing computational spectral imaging systems typically rely on coded aperture and beam splitters that block a substantial fraction of incident light, degrading reconstruction quality under light-starved conditions. To address this limitation, we develop the Oscillating Dispersion Imaging Spectrometer (ODIS), which for the first time achieves near-full light throughput by axially translating a disperser between the conjugate image plane and a defocused position, sequentially capturing a panchromatic (PAN) image and a dispersed measurement along a single optical path. We further propose a PAN-guided Dispersion-Aware Deep Unfolding Network (PDAUN) that recovers high-fidelity spectral information from maskless dispersion under PAN structural guidance. Its data-fidelity step derives an FFT-Woodbury preconditioned solver by exploiting the cyclic-convolution property of the ODIS forward model, while a Dispersion-Aware Deformable Convolution module (DADC) corrects sub-pixel spectral misalignment using PAN features. Experiments show state-of-the-art performance on standard benchmarks, and cross-system comparisons confirm that ODIS yields decisive gains under low illumination. High-fidelity reconstruction is validated on a physical prototype.

SA-CycleGAN-2.5D: Self-Attention CycleGAN with Tri-Planar Context for Multi-Site MRI Harmonization

Multi-site neuroimaging analysis is fundamentally confounded by scanner-induced covariate shifts, where the marginal distribution of voxel intensities $P(\mathbf{x})$ varies non-linearly across acquisition protocols while the conditional anatomy $P(\mathbf{y}|\mathbf{x})$ remains constant. This is particularly detrimental to radiomic reproducibility, where acquisition variance often exceeds biological pathology variance. Existing statistical harmonization methods (e.g., ComBat) operate in feature space, precluding spatial downstream tasks, while standard deep learning approaches are theoretically bounded by local effective receptive fields (ERF), failing to model the global intensity correlations characteristic of field-strength bias. We propose SA-CycleGAN-2.5D, a domain adaptation framework motivated by the $HΔH$-divergence bound of Ben-David et al., integrating three architectural innovations: (1) A 2.5D tri-planar manifold injection preserving through-plane gradients $\nabla_z$ at $O(HW)$ complexity; (2) A U-ResNet generator with dense voxel-to-voxel self-attention, surpassing the $O(\sqrt{L})$ receptive field limit of CNNs to model global scanner field biases; and (3) A spectrally-normalized discriminator constraining the Lipschitz constant ($K_D \le 1$) for stable adversarial optimization. Evaluated on 654 glioma patients across two institutional domains (BraTS and UPenn-GBM), our method reduces Maximum Mean Discrepancy (MMD) by 99.1% ($1.729 \to 0.015$) and degrades domain classifier accuracy to near-chance (59.7%). Ablation confirms that global attention is statistically essential (Cohen's $d = 1.32$, $p < 0.001$) for the harder heterogeneous-to-homogeneous translation direction. By bridging 2D efficiency and 3D consistency, our framework yields voxel-level harmonized images that preserve tumor pathophysiology, enabling reproducible multi-center radiomic analysis.