6D Robotic OCT Scanning of Curved Tissue Surfaces

Optical coherence tomography (OCT) is a non-invasive volumetric imaging modality with high spatial and temporal resolution. For imaging larger tissue structures, OCT probes need to be moved to scan the respective area. For handheld scanning, stitching of the acquired OCT volumes requires overlap to register the images. For robotic scanning and stitching, a typical approach is to restrict the motion to translations, as this avoids a full hand-eye calibration, which is complicated by the small field of view of most OCT probes. However, stitching by registration or by translational scanning are limited when curved tissue surfaces need to be scanned. We propose a marker for full six-dimensional hand-eye calibration of a robot mounted OCT probe. We show that the calibration results in highly repeatable estimates of the transformation. Moreover, we evaluate robotic scanning of two phantom surfaces to demonstrate that the proposed calibration allows for consistent scanning of large, curved tissue surfaces. As the proposed approach is not relying on image registration, it does not suffer from a potential accumulation of errors along a scan path. We also illustrate the improvement compared to conventional 3D-translational robotic scanning.

Designing Any Imaging System from Natural Language: Agent-Constrained Composition over a Finite Primitive Basis

Designing a computational imaging system -- selecting operators, setting parameters, validating consistency -- requires weeks of specialist effort per modality, creating an expertise bottleneck that excludes the broader scientific community from prototyping imaging instruments. We introduce spec.md, a structured specification format, and three autonomous agents -- Plan, Judge, and Execute -- that translate a one-sentence natural-language description into a validated forward model with bounded reconstruction error. A design-to-real error theorem decomposes total reconstruction error into five independently bounded terms, each linked to a corrective action. On 6 real-data modalities spanning all 5 carrier families, the automated pipeline matches expert-library quality (98.1 +/- 4.2%). Ten novel designs -- composing primitives into chains from 3D to 5D -- demonstrate compositional reach beyond any single-modality tool.

A Reasoning-Enabled Vision-Language Foundation Model for Chest X-ray Interpretation

Chest X-rays (CXRs) are among the most frequently performed imaging examinations worldwide, yet rising imaging volumes increase radiologist workload and the risk of diagnostic errors. Although artificial intelligence (AI) systems have shown promise for CXR interpretation, most generate only final predictions, without making explicit how visual evidence is translated into radiographic findings and diagnostic predictions. We present CheXOne, a reasoning-enabled vision-language model for CXR interpretation. CheXOne jointly generates diagnostic predictions and explicit, clinically grounded reasoning traces that connect visual evidence, radiographic findings, and these predictions. The model is trained on 14.7 million instruction and reasoning samples curated from 30 public datasets spanning 36 CXR interpretation tasks, using a two-stage framework that combines instruction tuning with reinforcement learning to improve reasoning quality. We evaluate CheXOne in zero-shot settings across visual question answering, report generation, visual grounding and reasoning assessment, covering 17 evaluation settings. CheXOne outperforms existing medical and general-domain foundation models and achieves strong performance on independent public benchmarks. A clinical reader study demonstrates that CheXOne-drafted reports are comparable to or better than resident-written reports in 55% of cases, while effectively addressing clinical indications and enhancing both report writing and CXR interpretation efficiency. Further analyses involving radiologists reveal that the generated reasoning traces show high clinical factuality and provide causal support for the final predictions, offering a plausible explanation for the performance gains. These results suggest that explicit reasoning can improve model performance, interpretability and clinical utility in AI-assisted CXR interpretation.

Enhancing behavioral nudges with large language model-based iterative personalization: A field experiment on electricity and hot-water conservation

Nudging is widely used to promote behavioral change, but its effectiveness is often limited when recipients must repeatedly translate feedback into workable next steps under changing circumstances. Large language models (LLMs) may help reduce part of this cognitive work by generating personalized guidance and updating it iteratively across intervention rounds. We developed an LLM agent for iterative personalization and tested it in a three-arm randomized experiment among 233 university residents in China, using daily electricity and shower hot-water conservation as objectively measured cases differing in friction. LLM-personalized nudges (T2) produced the largest conservation effects, while image-enhanced conventional nudges (T1) and text-based conventional nudges (C) showed similar outcomes (omnibus p = 0.009). Relative to C, T2 reduced electricity consumption by 0.56 kWh per room-day (p = 0.014), corresponding to an 18.3 percentage-point higher adjusted saving rate. This advantage emerged within the first two intervention rounds, alongside iterative updating of personalized guidance, and persisted thereafter. Hot-water outcomes followed the same direction but were smaller, less precisely estimated, and attenuated over time, consistent with stronger friction in this domain. LLM-personalized nudges emphasized prospective and context-specific guidance and were associated with higher participant engagement. This study provides field evidence that LLM-based iterative personalization can enhance behavioral nudging, with behavioral friction as a potential boundary condition. Larger trials and extension to more behaviors are warranted.

Big2Small: A Unifying Neural Network Framework for Model Compression

With the development of foundational models, model compression has become a critical requirement. Various model compression approaches have been proposed such as low-rank decomposition, pruning, quantization, ergodic dynamic systems, and knowledge distillation, which are based on different heuristics. To elevate the field from fragmentation to a principled discipline, we construct a unifying mathematical framework for model compression grounded in measure theory. We further demonstrate that each model compression technique is mathematically equivalent to a neural network subject to a regularization. Building upon this mathematical and structural equivalence, we propose an experimentally-verified data-free model compression framework, termed \textit{Big2Small}, which translates Implicit Neural Representations (INRs) from data domain to the domain of network parameters. \textit{Big2Small} trains compact INRs to encode the weights of larger models and reconstruct the weights during inference. To enhance reconstruction fidelity, we introduce Outlier-Aware Preprocessing to handle extreme weight values and a Frequency-Aware Loss function to preserve high-frequency details. Experiments on image classification and segmentation demonstrate that \textit{Big2Small} achieves competitive accuracy and compression ratios compared to state-of-the-art baselines.

Multiscale Structure-Guided Latent Diffusion for Multimodal MRI Translation

Although diffusion models have achieved remarkable progress in multi-modal magnetic resonance imaging (MRI) translation tasks, existing methods still tend to suffer from anatomical inconsistencies or degraded texture details when handling arbitrary missing-modality scenarios. To address these issues, we propose a latent diffusion-based multi-modal MRI translation framework, termed MSG-LDM. By leveraging the available modalities, the proposed method infers complete structural information, which preserves reliable boundary details. Specifically, we introduce a style--structure disentanglement mechanism in the latent space, which explicitly separates modality-specific style features from shared structural representations, and jointly models low-frequency anatomical layouts and high-frequency boundary details in a multi-scale feature space. During the structure disentanglement stage, high-frequency structural information is explicitly incorporated to enhance feature representations, guiding the model to focus on fine-grained structural cues while learning modality-invariant low-frequency anatomical representations. Furthermore, to reduce interference from modality-specific styles and improve the stability of structure representations, we design a style consistency loss and a structure-aware loss. Extensive experiments on the BraTS2020 and WMH datasets demonstrate that the proposed method outperforms existing MRI synthesis approaches, particularly in reconstructing complete structures. The source code is publicly available at https://github.com/ziyi-start/MSG-LDM.

PSDesigner: Automated Graphic Design with a Human-Like Creative Workflow

Graphic design is a creative and innovative process that plays a crucial role in applications such as e-commerce and advertising. However, developing an automated design system that can faithfully translate user intentions into editable design files remains an open challenge. Although recent studies have leveraged powerful text-to-image models and MLLMs to assist graphic design, they typically simplify professional workflows, resulting in limited flexibility and intuitiveness. To address these limitations, we propose PSDesigner, an automated graphic design system that emulates the creative workflow of human designers. Building upon multiple specialized components, PSDesigner collects theme-related assets based on user instructions, and autonomously infers and executes tool calls to manipulate design files, such as integrating new assets or refining inferior elements. To endow the system with strong tool-use capabilities, we construct a design dataset, CreativePSD, which contains a large amount of high-quality PSD design files annotated with operation traces across a wide range of design scenarios and artistic styles, enabling models to learn expert design procedures. Extensive experiments demonstrate that PSDesigner outperforms existing methods across diverse graphic design tasks, empowering non-specialists to conveniently create production-quality designs.

Oscillating Dispersion for Maximal Light-throughput Spectral Imaging

Existing computational spectral imaging systems typically rely on coded aperture and beam splitters that block a substantial fraction of incident light, degrading reconstruction quality under light-starved conditions. To address this limitation, we develop the Oscillating Dispersion Imaging Spectrometer (ODIS), which for the first time achieves near-full light throughput by axially translating a disperser between the conjugate image plane and a defocused position, sequentially capturing a panchromatic (PAN) image and a dispersed measurement along a single optical path. We further propose a PAN-guided Dispersion-Aware Deep Unfolding Network (PDAUN) that recovers high-fidelity spectral information from maskless dispersion under PAN structural guidance. Its data-fidelity step derives an FFT-Woodbury preconditioned solver by exploiting the cyclic-convolution property of the ODIS forward model, while a Dispersion-Aware Deformable Convolution module (DADC) corrects sub-pixel spectral misalignment using PAN features. Experiments show state-of-the-art performance on standard benchmarks, and cross-system comparisons confirm that ODIS yields decisive gains under low illumination. High-fidelity reconstruction is validated on a physical prototype.

A Unified Platform and Quality Assurance Framework for 3D Ultrasound Reconstruction with Robotic, Optical, and Electromagnetic Tracking

Three-dimensional (3D) Ultrasound (US) can facilitate diagnosis, treatment planning, and image-guided therapy. However, current studies rarely provide a comprehensive evaluation of volumetric accuracy and reproducibility, highlighting the need for robust Quality Assurance (QA) frameworks, particularly for tracked 3D US reconstruction using freehand or robotic acquisition. This study presents a QA framework for 3D US reconstruction and a flexible open source platform for tracked US research. A custom phantom containing geometric inclusions with varying symmetry properties enables straightforward evaluation of optical, electromagnetic, and robotic kinematic tracking for 3D US at different scanning speeds and insonation angles. A standardised pipeline performs real-time segmentation and 3D reconstruction of geometric targets (DSC = 0.97, FPS = 46) without GPU acceleration, followed by automated registration and comparison with ground-truth geometries. Applying this framework showed that our robotic 3D US achieves state-of-the-art reconstruction performance (DSC-3D = 0.94 +- 0.01, HD95 = 1.17 +- 0.12), approaching the spatial resolution limit imposed by the transducer. This work establishes a flexible experimental platform and a reproducible validation methodology for 3D US reconstruction. The proposed framework enables robust cross-platform comparisons and improved reporting practices, supporting the safe and effective clinical translation of 3D ultrasound in diagnostic and image-guided therapy applications.

ViBA: Implicit Bundle Adjustment with Geometric and Temporal Consistency for Robust Visual Matching

Most existing image keypoint detection and description methods rely on datasets with accurate pose and depth annotations, limiting scalability and generalization, and often degrading navigation and localization performance. We propose ViBA, a sustainable learning framework that integrates geometric optimization with feature learning for continuous online training on unconstrained video streams. Embedded in a standard visual odometry pipeline, it consists of an implicitly differentiable geometric residual framework: (i) an initial tracking network for inter-frame correspondences, (ii) depth-based outlier filtering, and (iii) differentiable global bundle adjustment that jointly refines camera poses and feature positions by minimizing reprojection errors. By combining geometric consistency from BA with long-term temporal consistency across frames, ViBA enforces stable and accurate feature representations. We evaluate ViBA on EuRoC and UMA datasets. Compared with state-of-the-art methods such as SuperPoint+SuperGlue, ALIKED, and LightGlue, ViBA reduces mean absolute translation error (ATE) by 12-18% and absolute rotation error (ARE) by 5-10% across sequences, while maintaining real-time inference speeds (FPS 36-91). When evaluated on unseen sequences, it retains over 90% localization accuracy, demonstrating robust generalization. These results show that ViBA supports continuous online learning with geometric and temporal consistency, consistently improving navigation and localization in real-world scenarios.