EXGnet: a single-lead explainable-AI guided multiresolution network with train-only quantitative features for trustworthy ECG arrhythmia classification

Background: Deep learning has significantly advanced ECG arrhythmia classification, enabling high accuracy in detecting various cardiac conditions. The use of single-lead ECG systems is crucial for portable devices, as they offer convenience and accessibility for continuous monitoring in diverse settings. However, the interpretability and reliability of deep learning models in clinical applications poses challenges due to their black-box nature. Methods: To address these challenges, we propose EXGnet, a single-lead, trustworthy ECG arrhythmia classification network that integrates multiresolution feature extraction with Explainable Artificial Intelligence (XAI) guidance and train only quantitative features. Results: Trained on two public datasets, including Chapman and Ningbo, EXGnet demonstrates superior performance through key metrics such as Accuracy, F1-score, Sensitivity, and Specificity. The proposed method achieved average five fold accuracy of 98.762%, and 96.932% and average F1-score of 97.910%, and 95.527% on the Chapman and Ningbo datasets, respectively. Conclusions: By employing XAI techniques, specifically Grad-CAM, the model provides visual insights into the relevant ECG segments it analyzes, thereby enhancing clinician trust in its predictions. While quantitative features further improve classification performance, they are not required during testing, making the model suitable for real-world applications. Overall, EXGnet not only achieves better classification accuracy but also addresses the critical need for interpretability in deep learning, facilitating broader adoption in portable ECG monitoring.

CardioPatternFormer: Pattern-Guided Attention for Interpretable ECG Classification with Transformer Architecture

Accurate ECG interpretation is vital, yet complex cardiac data and "black-box" AI models limit clinical utility. Inspired by Transformer architectures' success in NLP for understanding sequential data, we frame ECG as the heart's unique "language" of temporal patterns. We present CardioPatternFormer, a novel Transformer-based model for interpretable ECG classification. It employs a sophisticated attention mechanism to precisely identify and classify diverse cardiac patterns, excelling at discerning subtle anomalies and distinguishing multiple co-occurring conditions. This pattern-guided attention provides clear insights by highlighting influential signal regions, effectively allowing the "heart to talk" through transparent interpretations. CardioPatternFormer demonstrates robust performance on challenging ECGs, including complex multi-pathology cases. Its interpretability via attention maps enables clinicians to understand the model's rationale, fostering trust and aiding informed diagnostic decisions. This work offers a powerful, transparent solution for advanced ECG analysis, paving the way for more reliable and clinically actionable AI in cardiology.

Signal, Image, or Symbolic: Exploring the Best Input Representation for Electrocardiogram-Language Models Through a Unified Framework

Recent advances have increasingly applied large language models (LLMs) to electrocardiogram (ECG) interpretation, giving rise to Electrocardiogram-Language Models (ELMs). Conditioned on an ECG and a textual query, an ELM autoregressively generates a free-form textual response. Unlike traditional classification-based systems, ELMs emulate expert cardiac electrophysiologists by issuing diagnoses, analyzing waveform morphology, identifying contributing factors, and proposing patient-specific action plans. To realize this potential, researchers are curating instruction-tuning datasets that pair ECGs with textual dialogues and are training ELMs on these resources. Yet before scaling ELMs further, there is a fundamental question yet to be explored: What is the most effective ECG input representation? In recent works, three candidate representations have emerged-raw time-series signals, rendered images, and discretized symbolic sequences. We present the first comprehensive benchmark of these modalities across 6 public datasets and 5 evaluation metrics. We find symbolic representations achieve the greatest number of statistically significant wins over both signal and image inputs. We further ablate the LLM backbone, ECG duration, and token budget, and we evaluate robustness to signal perturbations. We hope that our findings offer clear guidance for selecting input representations when developing the next generation of ELMs.

Cardioformer: Advancing AI in ECG Analysis with Multi-Granularity Patching and ResNet

Electrocardiogram (ECG) classification is crucial for automated cardiac disease diagnosis, yet existing methods often struggle to capture local morphological details and long-range temporal dependencies simultaneously. To address these challenges, we propose Cardioformer, a novel multi-granularity hybrid model that integrates cross-channel patching, hierarchical residual learning, and a two-stage self-attention mechanism. Cardioformer first encodes multi-scale token embeddings to capture fine-grained local features and global contextual information and then selectively fuses these representations through intra- and inter-granularity self-attention. Extensive evaluations on three benchmark ECG datasets under subject-independent settings demonstrate that model consistently outperforms four state-of-the-art baselines. Our Cardioformer model achieves the AUROC of 96.34$\pm$0.11, 89.99$\pm$0.12, and 95.59$\pm$1.66 in MIMIC-IV, PTB-XL and PTB dataset respectively outperforming PatchTST, Reformer, Transformer, and Medformer models. It also demonstrates strong cross-dataset generalization, achieving 49.18% AUROC on PTB and 68.41% on PTB-XL when trained on MIMIC-IV. These findings underscore the potential of Cardioformer to advance automated ECG analysis, paving the way for more accurate and robust cardiovascular disease diagnosis. We release the source code at https://github.com/KMobin555/Cardioformer.

ArrhythmiaVision: Resource-Conscious Deep Learning Models with Visual Explanations for ECG Arrhythmia Classification

Cardiac arrhythmias are a leading cause of life-threatening cardiac events, highlighting the urgent need for accurate and timely detection. Electrocardiography (ECG) remains the clinical gold standard for arrhythmia diagnosis; however, manual interpretation is time-consuming, dependent on clinical expertise, and prone to human error. Although deep learning has advanced automated ECG analysis, many existing models abstract away the signal's intrinsic temporal and morphological features, lack interpretability, and are computationally intensive-hindering their deployment on resource-constrained platforms. In this work, we propose two novel lightweight 1D convolutional neural networks, ArrhythmiNet V1 and V2, optimized for efficient, real-time arrhythmia classification on edge devices. Inspired by MobileNet's depthwise separable convolutional design, these models maintain memory footprints of just 302.18 KB and 157.76 KB, respectively, while achieving classification accuracies of 0.99 (V1) and 0.98 (V2) on the MIT-BIH Arrhythmia Dataset across five classes: Normal Sinus Rhythm, Left Bundle Branch Block, Right Bundle Branch Block, Atrial Premature Contraction, and Premature Ventricular Contraction. In order to ensure clinical transparency and relevance, we integrate Shapley Additive Explanations and Gradient-weighted Class Activation Mapping, enabling both local and global interpretability. These techniques highlight physiologically meaningful patterns such as the QRS complex and T-wave that contribute to the model's predictions. We also discuss performance-efficiency trade-offs and address current limitations related to dataset diversity and generalizability. Overall, our findings demonstrate the feasibility of combining interpretability, predictive accuracy, and computational efficiency in practical, wearable, and embedded ECG monitoring systems.

xLSTM-ECG: Multi-label ECG Classification via Feature Fusion with xLSTM

Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, highlighting the critical need for efficient and accurate diagnostic tools. Electrocardiograms (ECGs) are indispensable in diagnosing various heart conditions; however, their manual interpretation is time-consuming and error-prone. In this paper, we propose xLSTM-ECG, a novel approach that leverages an extended Long Short-Term Memory (xLSTM) network for multi-label classification of ECG signals, using the PTB-XL dataset. To the best of our knowledge, this work represents the first design and application of xLSTM modules specifically adapted for multi-label ECG classification. Our method employs a Short-Time Fourier Transform (STFT) to convert time-series ECG waveforms into the frequency domain, thereby enhancing feature extraction. The xLSTM architecture is specifically tailored to address the complexities of 12-lead ECG recordings by capturing both local and global signal features. Comprehensive experiments on the PTB-XL dataset reveal that our model achieves strong multi-label classification performance, while additional tests on the Georgia 12-Lead dataset underscore its robustness and efficiency. This approach significantly improves ECG classification accuracy, thereby advancing clinical diagnostics and patient care. The code will be publicly available upon acceptance.

ProtoECGNet: Case-Based Interpretable Deep Learning for Multi-Label ECG Classification with Contrastive Learning

Deep learning-based electrocardiogram (ECG) classification has shown impressive performance but clinical adoption has been slowed by the lack of transparent and faithful explanations. Post hoc methods such as saliency maps may fail to reflect a model's true decision process. Prototype-based reasoning offers a more transparent alternative by grounding decisions in similarity to learned representations of real ECG segments, enabling faithful, case-based explanations. We introduce ProtoECGNet, a prototype-based deep learning model for interpretable, multi-label ECG classification. ProtoECGNet employs a structured, multi-branch architecture that reflects clinical interpretation workflows: it integrates a 1D CNN with global prototypes for rhythm classification, a 2D CNN with time-localized prototypes for morphology-based reasoning, and a 2D CNN with global prototypes for diffuse abnormalities. Each branch is trained with a prototype loss designed for multi-label learning, combining clustering, separation, diversity, and a novel contrastive loss that encourages appropriate separation between prototypes of unrelated classes while allowing clustering for frequently co-occurring diagnoses. We evaluate ProtoECGNet on all 71 diagnostic labels from the PTB-XL dataset, demonstrating competitive performance relative to state-of-the-art black-box models while providing structured, case-based explanations. To assess prototype quality, we conduct a structured clinician review of the final model's projected prototypes, finding that they are rated as representative and clear. ProtoECGNet shows that prototype learning can be effectively scaled to complex, multi-label time-series classification, offering a practical path toward transparent and trustworthy deep learning models for clinical decision support.

Time-Series Analysis on Edge-AI Hardware for Healthcare Monitoring

This project addresses the need for efficient, real-time analysis of biomedical signals such as electrocardiograms (ECG) and electroencephalograms (EEG) for continuous health monitoring. Traditional methods rely on long-duration data recording followed by offline analysis, which is power-intensive and delays responses to critical symptoms such as arrhythmia. To overcome these limitations, a time-domain ECG analysis model based on a novel dynamically-biased Long Short-Term Memory (DB-LSTM) neural network is proposed. This model supports simultaneous ECG forecasting and classification with high performance-achieving over 98% accuracy and a normalized mean square error below 1e-3 for forecasting, and over 97% accuracy with faster convergence and fewer training parameters for classification. To enable edge deployment, the model is hardware-optimized by quantizing weights to INT4 or INT3 formats, resulting in only a 2% and 6% drop in classification accuracy during training and inference, respectively, while maintaining full accuracy for forecasting. Extensive simulations using multiple ECG datasets confirm the model's robustness. Future work includes implementing the algorithm on FPGA and CMOS circuits for practical cardiac monitoring, as well as developing a digital hardware platform that supports flexible neural network configurations and on-chip online training for personalized healthcare applications.

Application of Contrastive Learning on ECG Data: Evaluating Performance in Japanese and Classification with Around 100 Labels

The electrocardiogram (ECG) is a fundamental tool in cardiovascular diagnostics due to its powerful and non-invasive nature. One of the most critical usages is to determine whether more detailed examinations are necessary, with users ranging across various levels of expertise. Given this diversity in expertise, it is essential to assist users to avoid critical errors. Recent studies in machine learning have addressed this challenge by extracting valuable information from ECG data. Utilizing language models, these studies have implemented multimodal models aimed at classifying ECGs according to labeled terms. However, the number of classes was reduced, and it remains uncertain whether the technique is effective for languages other than English. To move towards practical application, we utilized ECG data from regular patients visiting hospitals in Japan, maintaining a large number of Japanese labels obtained from actual ECG readings. Using a contrastive learning framework, we found that even with 98 labels for classification, our Japanese-based language model achieves accuracy comparable to previous research. This study extends the applicability of multimodal machine learning frameworks to broader clinical studies and non-English languages.

Towards Robust Multimodal Physiological Foundation Models: Handling Arbitrary Missing Modalities

Multimodal physiological signals, such as EEG, ECG, EOG, and EMG, are crucial for healthcare and brain-computer interfaces. While existing methods rely on specialized architectures and dataset-specific fusion strategies, they struggle to learn universal representations that generalize across datasets and handle missing modalities at inference time. To address these issues, we propose PhysioOmni, a foundation model for multimodal physiological signal analysis that models both homogeneous and heterogeneous features to decouple multimodal signals and extract generic representations while maintaining compatibility with arbitrary missing modalities. PhysioOmni trains a decoupled multimodal tokenizer, enabling masked signal pre-training via modality-invariant and modality-specific objectives. To ensure adaptability to diverse and incomplete modality combinations, the pre-trained encoders undergo resilient fine-tuning with prototype alignment on downstream datasets. Extensive experiments on four downstream tasks, emotion recognition, sleep stage classification, motor prediction, and mental workload detection, demonstrate that PhysioOmni achieves state-of-the-art performance while maintaining strong robustness to missing modalities. Our code and model weights will be released.