A Narrative Review on Large AI Models in Lung Cancer Screening, Diagnosis, and Treatment Planning

Lung cancer remains one of the most prevalent and fatal diseases worldwide, demanding accurate and timely diagnosis and treatment. Recent advancements in large AI models have significantly enhanced medical image understanding and clinical decision-making. This review systematically surveys the state-of-the-art in applying large AI models to lung cancer screening, diagnosis, prognosis, and treatment. We categorize existing models into modality-specific encoders, encoder-decoder frameworks, and joint encoder architectures, highlighting key examples such as CLIP, BLIP, Flamingo, BioViL-T, and GLoRIA. We further examine their performance in multimodal learning tasks using benchmark datasets like LIDC-IDRI, NLST, and MIMIC-CXR. Applications span pulmonary nodule detection, gene mutation prediction, multi-omics integration, and personalized treatment planning, with emerging evidence of clinical deployment and validation. Finally, we discuss current limitations in generalizability, interpretability, and regulatory compliance, proposing future directions for building scalable, explainable, and clinically integrated AI systems. Our review underscores the transformative potential of large AI models to personalize and optimize lung cancer care.

CoIn: Counting the Invisible Reasoning Tokens in Commercial Opaque LLM APIs

As post-training techniques evolve, large language models (LLMs) are increasingly augmented with structured multi-step reasoning abilities, often optimized through reinforcement learning. These reasoning-enhanced models outperform standard LLMs on complex tasks and now underpin many commercial LLM APIs. However, to protect proprietary behavior and reduce verbosity, providers typically conceal the reasoning traces while returning only the final answer. This opacity introduces a critical transparency gap: users are billed for invisible reasoning tokens, which often account for the majority of the cost, yet have no means to verify their authenticity. This opens the door to token count inflation, where providers may overreport token usage or inject synthetic, low-effort tokens to inflate charges. To address this issue, we propose CoIn, a verification framework that audits both the quantity and semantic validity of hidden tokens. CoIn constructs a verifiable hash tree from token embedding fingerprints to check token counts, and uses embedding-based relevance matching to detect fabricated reasoning content. Experiments demonstrate that CoIn, when deployed as a trusted third-party auditor, can effectively detect token count inflation with a success rate reaching up to 94.7%, showing the strong ability to restore billing transparency in opaque LLM services. The dataset and code are available at https://github.com/CASE-Lab-UMD/LLM-Auditing-CoIn.

VeriReason: Reinforcement Learning with Testbench Feedback for Reasoning-Enhanced Verilog Generation

Automating Register Transfer Level (RTL) code generation using Large Language Models (LLMs) offers substantial promise for streamlining digital circuit design and reducing human effort. However, current LLM-based approaches face significant challenges with training data scarcity, poor specification-code alignment, lack of verification mechanisms, and balancing generalization with specialization. Inspired by DeepSeek-R1, we introduce VeriReason, a framework integrating supervised fine-tuning with Guided Reward Proximal Optimization (GRPO) reinforcement learning for RTL generation. Using curated training examples and a feedback-driven reward model, VeriReason combines testbench evaluations with structural heuristics while embedding self-checking capabilities for autonomous error correction. On the VerilogEval Benchmark, VeriReason delivers significant improvements: achieving 83.1% functional correctness on the VerilogEval Machine benchmark, substantially outperforming both comparable-sized models and much larger commercial systems like GPT-4 Turbo. Additionally, our approach demonstrates up to a 2.8X increase in first-attempt functional correctness compared to baseline methods and exhibits robust generalization to unseen designs. To our knowledge, VeriReason represents the first system to successfully integrate explicit reasoning capabilities with reinforcement learning for Verilog generation, establishing a new state-of-the-art for automated RTL synthesis. The models and datasets are available at: https://huggingface.co/collections/AI4EDA-CASE Code is Available at: https://github.com/NellyW8/VeriReason

SymRTLO: Enhancing RTL Code Optimization with LLMs and Neuron-Inspired Symbolic Reasoning

Optimizing Register Transfer Level (RTL) code is crucial for improving the power, performance, and area (PPA) of digital circuits in the early stages of synthesis. Manual rewriting, guided by synthesis feedback, can yield high-quality results but is time-consuming and error-prone. Most existing compiler-based approaches have difficulty handling complex design constraints. Large Language Model (LLM)-based methods have emerged as a promising alternative to address these challenges. However, LLM-based approaches often face difficulties in ensuring alignment between the generated code and the provided prompts. This paper presents SymRTLO, a novel neuron-symbolic RTL optimization framework that seamlessly integrates LLM-based code rewriting with symbolic reasoning techniques. Our method incorporates a retrieval-augmented generation (RAG) system of optimization rules and Abstract Syntax Tree (AST)-based templates, enabling LLM-based rewriting that maintains syntactic correctness while minimizing undesired circuit behaviors. A symbolic module is proposed for analyzing and optimizing finite state machine (FSM) logic, allowing fine-grained state merging and partial specification handling beyond the scope of pattern-based compilers. Furthermore, a fast verification pipeline, combining formal equivalence checks with test-driven validation, further reduces the complexity of verification. Experiments on the RTL-Rewriter benchmark with Synopsys Design Compiler and Yosys show that SymRTLO improves power, performance, and area (PPA) by up to 43.9%, 62.5%, and 51.1%, respectively, compared to the state-of-the-art methods.

Probabilistic Task Parameterization of Tool-Tissue Interaction via Sparse Landmarks Tracking in Robotic Surgery

Accurate modeling of tool-tissue interactions in robotic surgery requires precise tracking of deformable tissues and integration of surgical domain knowledge. Traditional methods rely on labor-intensive annotations or rigid assumptions, limiting flexibility. We propose a framework combining sparse keypoint tracking and probabilistic modeling that propagates expert-annotated landmarks across endoscopic frames, even with large tissue deformations. Clustered tissue keypoints enable dynamic local transformation construction via PCA, and tool poses, tracked similarly, are expressed relative to these frames. Embedding these into a Task-Parameterized Gaussian Mixture Model (TP-GMM) integrates data-driven observations with labeled clinical expertise, effectively predicting relative tool-tissue poses and enhancing visual understanding of robotic surgical motions directly from video data.

Caution for the Environment: Multimodal Agents are Susceptible to Environmental Distractions

This paper investigates the faithfulness of multimodal large language model (MLLM) agents in the graphical user interface (GUI) environment, aiming to address the research question of whether multimodal GUI agents can be distracted by environmental context. A general setting is proposed where both the user and the agent are benign, and the environment, while not malicious, contains unrelated content. A wide range of MLLMs are evaluated as GUI agents using our simulated dataset, following three working patterns with different levels of perception. Experimental results reveal that even the most powerful models, whether generalist agents or specialist GUI agents, are susceptible to distractions. While recent studies predominantly focus on the helpfulness (i.e., action accuracy) of multimodal agents, our findings indicate that these agents are prone to environmental distractions, resulting in unfaithful behaviors. Furthermore, we switch to the adversarial perspective and implement environment injection, demonstrating that such unfaithfulness can be exploited, leading to unexpected risks.

Flooding Spread of Manipulated Knowledge in LLM-Based Multi-Agent Communities

The rapid adoption of large language models (LLMs) in multi-agent systems has highlighted their impressive capabilities in various applications, such as collaborative problem-solving and autonomous negotiation. However, the security implications of these LLM-based multi-agent systems have not been thoroughly investigated, particularly concerning the spread of manipulated knowledge. In this paper, we investigate this critical issue by constructing a detailed threat model and a comprehensive simulation environment that mirrors real-world multi-agent deployments in a trusted platform. Subsequently, we propose a novel two-stage attack method involving Persuasiveness Injection and Manipulated Knowledge Injection to systematically explore the potential for manipulated knowledge (i.e., counterfactual and toxic knowledge) spread without explicit prompt manipulation. Our method leverages the inherent vulnerabilities of LLMs in handling world knowledge, which can be exploited by attackers to unconsciously spread fabricated information. Through extensive experiments, we demonstrate that our attack method can successfully induce LLM-based agents to spread both counterfactual and toxic knowledge without degrading their foundational capabilities during agent communication. Furthermore, we show that these manipulations can persist through popular retrieval-augmented generation frameworks, where several benign agents store and retrieve manipulated chat histories for future interactions. This persistence indicates that even after the interaction has ended, the benign agents may continue to be influenced by manipulated knowledge. Our findings reveal significant security risks in LLM-based multi-agent systems, emphasizing the imperative need for robust defenses against manipulated knowledge spread, such as introducing ``guardian'' agents and advanced fact-checking tools.

Exploring Generative AI for Sim2Real in Driving Data Synthesis

Datasets are essential for training and testing vehicle perception algorithms. However, the collection and annotation of real-world images is time-consuming and expensive. Driving simulators offer a solution by automatically generating various driving scenarios with corresponding annotations, but the simulation-to-reality (Sim2Real) domain gap remains a challenge. While most of the Generative Artificial Intelligence (AI) follows the de facto Generative Adversarial Nets (GANs)-based methods, the recent emerging diffusion probabilistic models have not been fully explored in mitigating Sim2Real challenges for driving data synthesis. To explore the performance, this paper applied three different generative AI methods to leverage semantic label maps from a driving simulator as a bridge for the creation of realistic datasets. A comparative analysis of these methods is presented from the perspective of image quality and perception. New synthetic datasets, which include driving images and auto-generated high-quality annotations, are produced with low costs and high scene variability. The experimental results show that although GAN-based methods are adept at generating high-quality images when provided with manually annotated labels, ControlNet produces synthetic datasets with fewer artefacts and more structural fidelity when using simulator-generated labels. This suggests that the diffusion-based approach may provide improved stability and an alternative method for addressing Sim2Real challenges.

Benchmarking the Robustness of Panoptic Segmentation for Automated Driving

Precise situational awareness is required for the safe decision-making of assisted and automated driving (AAD) functions. Panoptic segmentation is a promising perception technique to identify and categorise objects, impending hazards, and driveable space at a pixel level. While segmentation quality is generally associated with the quality of the camera data, a comprehensive understanding and modelling of this relationship are paramount for AAD system designers. Motivated by such a need, this work proposes a unifying pipeline to assess the robustness of panoptic segmentation models for AAD, correlating it with traditional image quality. The first step of the proposed pipeline involves generating degraded camera data that reflects real-world noise factors. To this end, 19 noise factors have been identified and implemented with 3 severity levels. Of these factors, this work proposes novel models for unfavourable light and snow. After applying the degradation models, three state-of-the-art CNN- and vision transformers (ViT)-based panoptic segmentation networks are used to analyse their robustness. The variations of the segmentation performance are then correlated to 8 selected image quality metrics. This research reveals that: 1) certain specific noise factors produce the highest impact on panoptic segmentation, i.e. droplets on lens and Gaussian noise; 2) the ViT-based panoptic segmentation backbones show better robustness to the considered noise factors; 3) some image quality metrics (i.e. LPIPS and CW-SSIM) correlate strongly with panoptic segmentation performance and therefore they can be used as predictive metrics for network performance.

ClassLIE: Structure- and Illumination-Adaptive Classification for Low-Light Image Enhancement

Low-light images often suffer from limited visibility and multiple types of degradation, rendering low-light image enhancement (LIE) a non-trivial task. Some endeavors have been recently made to enhance low-light images using convolutional neural networks (CNNs). However, they have low efficiency in learning the structural information and diverse illumination levels at the local regions of an image. Consequently, the enhanced results are affected by unexpected artifacts, such as unbalanced exposure, blur, and color bias. To this end, this paper proposes a novel framework, called ClassLIE, that combines the potential of CNNs and transformers. It classifies and adaptively learns the structural and illumination information from the low-light images in a holistic and regional manner, thus showing better enhancement performance. Our framework first employs a structure and illumination classification (SIC) module to learn the degradation information adaptively. In SIC, we decompose an input image into an illumination map and a reflectance map. A class prediction block is then designed to classify the degradation information by calculating the structure similarity scores on the reflectance map and mean square error on the illumination map. As such, each input image can be divided into patches with three enhancement difficulty levels. Then, a feature learning and fusion (FLF) module is proposed to adaptively learn the feature information with CNNs for different enhancement difficulty levels while learning the long-range dependencies for the patches in a holistic manner. Experiments on five benchmark datasets consistently show our ClassLIE achieves new state-of-the-art performance, with 25.74 PSNR and 0.92 SSIM on the LOL dataset.