Natural Language Generation in Healthcare: A Review of Methods and Applications

Natural language generation (NLG) is the key technology to achieve generative artificial intelligence (AI). With the breakthroughs in large language models (LLMs), NLG has been widely used in various medical applications, demonstrating the potential to enhance clinical workflows, support clinical decision-making, and improve clinical documentation. Heterogeneous and diverse medical data modalities, such as medical text, images, and knowledge bases, are utilized in NLG. Researchers have proposed many generative models and applied them in a number of healthcare applications. There is a need for a comprehensive review of NLG methods and applications in the medical domain. In this study, we systematically reviewed 113 scientific publications from a total of 3,988 NLG-related articles identified using a literature search, focusing on data modality, model architecture, clinical applications, and evaluation methods. Following PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines, we categorize key methods, identify clinical applications, and assess their capabilities, limitations, and emerging challenges. This timely review covers the key NLG technologies and medical applications and provides valuable insights for future studies to leverage NLG to transform medical discovery and healthcare.

Bayesian Reasoning Enabled by Spin-Orbit Torque Magnetic Tunnel Junctions

Bayesian networks play an increasingly important role in data mining, inference, and reasoning with the rapid development of artificial intelligence. In this paper, we present proof-of-concept experiments demonstrating the use of spin-orbit torque magnetic tunnel junctions (SOT-MTJs) in Bayesian network reasoning. Not only can the target probability distribution function (PDF) of a Bayesian network be precisely formulated by a conditional probability table as usual but also quantitatively parameterized by a probabilistic forward propagating neuron network. Moreover, the parameters of the network can also approach the optimum through a simple point-by point training algorithm, by leveraging which we do not need to memorize all historical data nor statistically summarize conditional probabilities behind them, significantly improving storage efficiency and economizing data pretreatment. Furthermore, we developed a simple medical diagnostic system using the SOT-MTJ as a random number generator and sampler, showcasing the application of SOT-MTJ-based Bayesian reasoning. This SOT-MTJ-based Bayesian reasoning shows great promise in the field of artificial probabilistic neural network, broadening the scope of spintronic device applications and providing an efficient and low-storage solution for complex reasoning tasks.

DR-Encoder: Encode Low-rank Gradients with Random Prior for Large Language Models Differentially Privately

The emergence of the Large Language Model (LLM) has shown their superiority in a wide range of disciplines, including language understanding and translation, relational logic reasoning, and even partial differential equations solving. The transformer is the pervasive backbone architecture for the foundation model construction. It is vital to research how to adjust the Transformer architecture to achieve an end-to-end privacy guarantee in LLM fine-tuning. In this paper, we investigate three potential information leakage during a federated fine-tuning procedure for LLM (FedLLM). Based on the potential information leakage, we provide an end-to-end privacy guarantee solution for FedLLM by inserting two-stage randomness. The first stage is to train a gradient auto-encoder with a Gaussian random prior based on the statistical information of the gradients generated by local clients. The second stage is to fine-tune the overall LLM with a differential privacy guarantee by adopting appropriate Gaussian noises. We show the efficiency and accuracy gains of our proposed method with several foundation models and two popular evaluation benchmarks. Furthermore, we present a comprehensive privacy analysis with Gaussian Differential Privacy (GDP) and Renyi Differential Privacy (RDP).

Improving Sequential Recommender Systems with Online and In-store User Behavior

Online e-commerce platforms have been extending in-store shopping, which allows users to keep the canonical online browsing and checkout experience while exploring in-store shopping. However, the growing transition between online and in-store becomes a challenge to sequential recommender systems for future online interaction prediction due to the lack of holistic modeling of hybrid user behaviors (online and in-store). The challenges are twofold. First, combining online and in-store user behavior data into a single data schema and supporting multiple stages in the model life cycle (pre-training, training, inference, etc.) organically needs a new data pipeline design. Second, online recommender systems, which solely rely on online user behavior sequences, must be redesigned to support online and in-store user data as input under the sequential modeling setting. To overcome the first challenge, we propose a hybrid, omnichannel data pipeline to compile online and in-store user behavior data by caching information from diverse data sources. Later, we introduce a model-agnostic encoder module to the sequential recommender system to interpret the user in-store transaction and augment the modeling capacity for better online interaction prediction given the hybrid user behavior.

RiTeK: A Dataset for Large Language Models Complex Reasoning over Textual Knowledge Graphs

Answering complex real-world questions often requires accurate retrieval from textual knowledge graphs (TKGs). The scarcity of annotated data, along with intricate topological structures, makes this task particularly challenging. As the nature of relational path information could enhance the inference ability of Large Language Models (LLMs), efficiently retrieving more complex relational path information from TKGs presents another key challenge. To tackle these challenges, we first develop a Dataset for LLMs Complex Reasoning over Textual Knowledge Graphs (RiTeK) with a broad topological structure coverage.We synthesize realistic user queries that integrate diverse topological structures, relational information, and complex textual descriptions. We conduct rigorous expert evaluation to validate the quality of our synthesized queries. And then, we introduce an enhanced Monte Carlo Tree Search (MCTS) method, Relational MCTS, to automatically extract relational path information from textual graphs for specific queries. Our dataset mainly covers the medical domain as the relation types and entity are complex and publicly available. Experimental results indicate that RiTeK poses significant challenges for current retrieval and LLM systems, while the proposed Relational MCTS method enhances LLM inference ability and achieves state-of-the-art performance on RiTeK.

Iter-AHMCL: Alleviate Hallucination for Large Language Model via Iterative Model-level Contrastive Learning

The development of Large Language Models (LLMs) has significantly advanced various AI applications in commercial and scientific research fields, such as scientific literature summarization, writing assistance, and knowledge graph construction. However, a significant challenge is the high risk of hallucination during LLM inference, which can lead to security concerns like factual inaccuracies, inconsistent information, and fabricated content. To tackle this issue, it is essential to develop effective methods for reducing hallucination while maintaining the original capabilities of the LLM. This paper introduces a novel approach called Iterative Model-level Contrastive Learning (Iter-AHMCL) to address hallucination. This method modifies the representation layers of pre-trained LLMs by using contrastive `positive' and `negative' models, trained on data with and without hallucinations. By leveraging the differences between these two models, we create a more straightforward pathway to eliminate hallucinations, and the iterative nature of contrastive learning further enhances performance. Experimental validation on four pre-trained foundation LLMs (LLaMA2, Alpaca, LLaMA3, and Qwen) finetuning with a specially designed dataset shows that our approach achieves an average improvement of 10.1 points on the TruthfulQA benchmark. Comprehensive experiments demonstrate the effectiveness of Iter-AHMCL in reducing hallucination while maintaining the general capabilities of LLMs.

Triple Modality Fusion: Aligning Visual, Textual, and Graph Data with Large Language Models for Multi-Behavior Recommendations

Integrating diverse data modalities is crucial for enhancing the performance of personalized recommendation systems. Traditional models, which often rely on singular data sources, lack the depth needed to accurately capture the multifaceted nature of item features and user behaviors. This paper introduces a novel framework for multi-behavior recommendations, leveraging the fusion of triple-modality, which is visual, textual, and graph data through alignment with large language models (LLMs). By incorporating visual information, we capture contextual and aesthetic item characteristics; textual data provides insights into user interests and item features in detail; and graph data elucidates relationships within the item-behavior heterogeneous graphs. Our proposed model called Triple Modality Fusion (TMF) utilizes the power of LLMs to align and integrate these three modalities, achieving a comprehensive representation of user behaviors. The LLM models the user's interactions including behaviors and item features in natural languages. Initially, the LLM is warmed up using only natural language-based prompts. We then devise the modality fusion module based on cross-attention and self-attention mechanisms to integrate different modalities from other models into the same embedding space and incorporate them into an LLM. Extensive experiments demonstrate the effectiveness of our approach in improving recommendation accuracy. Further ablation studies validate the effectiveness of our model design and benefits of the TMF.

CG-FedLLM: How to Compress Gradients in Federated Fune-tuning for Large Language Models

The success of current Large-Language Models (LLMs) hinges on extensive training data that is collected and stored centrally, called Centralized Learning (CL). However, such a collection manner poses a privacy threat, and one potential solution is Federated Learning (FL), which transfers gradients, not raw data, among clients. Unlike traditional networks, FL for LLMs incurs significant communication costs due to their tremendous parameters. This study introduces an innovative approach to compress gradients to improve communication efficiency during LLM FL, formulating the new FL pipeline named CG-FedLLM. This approach integrates an encoder on the client side to acquire the compressed gradient features and a decoder on the server side to reconstruct the gradients. We also developed a novel training strategy that comprises Temporal-ensemble Gradient-Aware Pre-training (TGAP) to identify characteristic gradients of the target model and Federated AutoEncoder-Involved Fine-tuning (FAF) to compress gradients adaptively. Extensive experiments confirm that our approach reduces communication costs and improves performance (e.g., average 3 points increment compared with traditional CL- and FL-based fine-tuning with LlaMA on a well-recognized benchmark, C-Eval). This improvement is because our encoder-decoder, trained via TGAP and FAF, can filter gradients while selectively preserving critical features. Furthermore, we present a series of experimental analyses focusing on the signal-to-noise ratio, compression rate, and robustness within this privacy-centric framework, providing insight into developing more efficient and secure LLMs.

Prompt Optimizer of Text-to-Image Diffusion Models for Abstract Concept Understanding

The rapid evolution of text-to-image diffusion models has opened the door of generative AI, enabling the translation of textual descriptions into visually compelling images with remarkable quality. However, a persistent challenge within this domain is the optimization of prompts to effectively convey abstract concepts into concrete objects. For example, text encoders can hardly express "peace", while can easily illustrate olive branches and white doves. This paper introduces a novel approach named Prompt Optimizer for Abstract Concepts (POAC) specifically designed to enhance the performance of text-to-image diffusion models in interpreting and generating images from abstract concepts. We propose a Prompt Language Model (PLM), which is initialized from a pre-trained language model, and then fine-tuned with a curated dataset of abstract concept prompts. The dataset is created with GPT-4 to extend the abstract concept to a scene and concrete objects. Our framework employs a Reinforcement Learning (RL)-based optimization strategy, focusing on the alignment between the generated images by a stable diffusion model and optimized prompts. Through extensive experiments, we demonstrate that our proposed POAC significantly improves the accuracy and aesthetic quality of generated images, particularly in the description of abstract concepts and alignment with optimized prompts. We also present a comprehensive analysis of our model's performance across diffusion models under different settings, showcasing its versatility and effectiveness in enhancing abstract concept representation.

Automatic Summarization of Doctor-Patient Encounter Dialogues Using Large Language Model through Prompt Tuning

Automatic text summarization (ATS) is an emerging technology to assist clinicians in providing continuous and coordinated care. This study presents an approach to summarize doctor-patient dialogues using generative large language models (LLMs). We developed prompt-tuning algorithms to instruct generative LLMs to summarize clinical text. We examined the prompt-tuning strategies, the size of soft prompts, and the few-short learning ability of GatorTronGPT, a generative clinical LLM developed using 277 billion clinical and general English words with up to 20 billion parameters. We compared GatorTronGPT with a previous solution based on fine-tuning of a widely used T5 model, using a clinical benchmark dataset MTS-DIALOG. The experimental results show that the GatorTronGPT- 20B model achieved the best performance on all evaluation metrics. The proposed solution has a low computing cost as the LLM parameters are not updated during prompt-tuning. This study demonstrates the efficiency of generative clinical LLMs for clinical ATS through prompt tuning.