PokeMQA: Programmable knowledge editing for Multi-hop Question Answering

Multi-hop question answering (MQA) is one of the challenging tasks to evaluate machine's comprehension and reasoning abilities, where large language models (LLMs) have widely achieved the human-comparable performance. Due to the dynamics of knowledge facts in real world, knowledge editing has been explored to update model with the up-to-date facts while avoiding expensive re-training or fine-tuning. Starting from the edited fact, the updated model needs to provide cascading changes in the chain of MQA. The previous art simply adopts a mix-up prompt to instruct LLMs conducting multiple reasoning tasks sequentially, including question decomposition, answer generation, and conflict checking via comparing with edited facts. However, the coupling of these functionally-diverse reasoning tasks inhibits LLMs' advantages in comprehending and answering questions while disturbing them with the unskilled task of conflict checking. We thus propose a framework, Programmable knowledge editing for Multi-hop Question Answering (PokeMQA), to decouple the jobs. Specifically, we prompt LLMs to decompose knowledge-augmented multi-hop question, while interacting with a detached trainable scope detector to modulate LLMs behavior depending on external conflict signal. The experiments on three LLM backbones and two benchmark datasets validate our superiority in knowledge editing of MQA, outperforming all competitors by a large margin in almost all settings and consistently producing reliable reasoning process.

SVAM: Saliency-guided Visual Attention Modeling by Autonomous Underwater Robots

This paper presents a holistic approach to saliency-guided visual attention modeling (SVAM) for use by autonomous underwater robots. Our proposed model, named SVAM-Net, integrates deep visual features at various scales and semantics for effective salient object detection (SOD) in natural underwater images. The SVAM-Net architecture is configured in a unique way to jointly accommodate bottom-up and top-down learning within two separate branches of the network while sharing the same encoding layers. We design dedicated spatial attention modules (SAMs) along these learning pathways to exploit the coarse-level and fine-level semantic features for SOD at four stages of abstractions. The bottom-up branch performs a rough yet reasonably accurate saliency estimation at a fast rate, whereas the deeper top-down branch incorporates a residual refinement module (RRM) that provides fine-grained localization of the salient objects. Extensive performance evaluation of SVAM-Net on benchmark datasets clearly demonstrates its effectiveness for underwater SOD. We also validate its generalization performance by several ocean trials' data that include test images of diverse underwater scenes and waterbodies, and also images with unseen natural objects. Moreover, we analyze its computational feasibility for robotic deployments and demonstrate its utility in several important use cases of visual attention modeling.

Estimate the Warfarin Dose by Ensemble of Machine Learning Algorithms

Warfarin dosing remains challenging due to narrow therapeutic index and highly individual variability. Incorrect warfarin dosing is associated with devastating adverse events. Remarkable efforts have been made to develop the machine learning based warfarin dosing algorithms incorporating clinical factors and genetic variants such as polymorphisms in CYP2C9 and VKORC1. The most widely validated pharmacogenetic algorithm is the IWPC algorithm based on multivariate linear regression (MLR). However, with only a single algorithm, the prediction performance may reach an upper limit even with optimal parameters. Here, we present novel algorithms using stacked generalization frameworks to estimate the warfarin dose, within which different types of machine learning algorithms function together through a meta-machine learning model to maximize the prediction accuracy. Compared to the IWPC-derived MLR algorithm, Stack 1 and 2 based on stacked generalization frameworks performed significantly better overall. Subgroup analysis revealed that the mean of the percentage of patients whose predicted dose of warfarin within 20% of the actual stable therapeutic dose (mean percentage within 20%) for Stack 1 was improved by 12.7% (from 42.47% to 47.86%) in Asians and by 13.5% (from 22.08% to 25.05%) in the low-dose group compared to that for MLR, respectively. These data suggest that our algorithms would especially benefit patients required low warfarin maintenance dose, as subtle changes in warfarin dose could lead to adverse clinical events (thrombosis or bleeding) in patients with low dose. Our study offers novel pharmacogenetic algorithms for clinical trials and practice.