Large Language Models in Biomedical and Health Informatics: A Bibliometric Review

Large Language Models (LLMs) have rapidly become important tools in Biomedical and Health Informatics (BHI), enabling new ways to analyze data, treat patients, and conduct research. This bibliometric review aims to provide a panoramic view of how LLMs have been used in BHI by examining research articles and collaboration networks from 2022 to 2023. It further explores how LLMs can improve Natural Language Processing (NLP) applications in various BHI areas like medical diagnosis, patient engagement, electronic health record management, and personalized medicine. To do this, our bibliometric review identifies key trends, maps out research networks, and highlights major developments in this fast-moving field. Lastly, it discusses the ethical concerns and practical challenges of using LLMs in BHI, such as data privacy and reliable medical recommendations. Looking ahead, we consider how LLMs could further transform biomedical research as well as healthcare delivery and patient outcomes. This bibliometric review serves as a resource for stakeholders in healthcare, including researchers, clinicians, and policymakers, to understand the current state and future potential of LLMs in BHI.

NPHardEval4V: A Dynamic Reasoning Benchmark of Multimodal Large Language Models

Understanding the reasoning capabilities of Multimodal Large Language Models (MLLMs) is an important area of research. In this study, we introduce a dynamic benchmark, NPHardEval4V, aimed at addressing the existing gaps in evaluating the pure reasoning abilities of MLLMs. Our benchmark aims to provide a venue to disentangle the effect of various factors such as image recognition and instruction following, from the overall performance of the models, allowing us to focus solely on evaluating their reasoning abilities. It is built by converting textual description of questions from NPHardEval to image representations. Our findings reveal significant discrepancies in reasoning abilities across different models and highlight the relatively weak performance of MLLMs compared to LLMs in terms of reasoning. We also investigate the impact of different prompting styles, including visual, text, and combined visual and text prompts, on the reasoning abilities of MLLMs, demonstrating the different impacts of multimodal inputs in model performance. Unlike traditional benchmarks, which focus primarily on static evaluations, our benchmark will be updated monthly to prevent overfitting and ensure a more authentic and fine-grained evaluation of the models. We believe that this benchmark can aid in understanding and guide the further development of reasoning abilities in MLLMs. The benchmark dataset and code are available at https://github.com/lizhouf/NPHardEval4V

NPHardEval: Dynamic Benchmark on Reasoning Ability of Large Language Models via Complexity Classes

Complex reasoning ability is one of the most important features of current LLMs, which has also been leveraged to play an integral role in complex decision-making tasks. Therefore, the investigation into the reasoning capabilities of Large Language Models (LLMs) is critical: numerous benchmarks have been established to assess the reasoning abilities of LLMs. However, current benchmarks are inadequate in offering a rigorous evaluation of the full extent of reasoning abilities that LLMs are capable of achieving. They are also prone to the risk of overfitting, as these benchmarks, being publicly accessible and static, allow models to potentially tailor their responses to specific benchmark metrics, thereby inflating their performance. Addressing these limitations, our research introduces a new benchmark, named NPHardEval. This benchmark is designed to evaluate the reasoning abilities of LLMs across a broad spectrum of 900 algorithmic questions, extending up to the NP-Hard complexity class. These questions are meticulously chosen to represent a wide range of complexity class below the NP-hard complexity class, offering a rigorous measure of the reasoning ability of LLMs. Through this study, we shed light on the current state of reasoning in LLMs, providing an objective and rigorous perspective through the comparison of LLMs' performance across complex classes. Moreover, this benchmark is designed with a dynamic update mechanism, where the datapoints are refreshed on a monthly basis. Such regular updates play a crucial role in mitigating the risk of LLMs overfitting to the benchmark, promoting a more accurate and reliable assessment of their reasoning capabilities. The benchmark dataset and code of NPHardEval are available at https://github.com/casmlab/NPHardEval.

War and Peace (WarAgent): Large Language Model-based Multi-Agent Simulation of World Wars

Can we avoid wars at the crossroads of history? This question has been pursued by individuals, scholars, policymakers, and organizations throughout human history. In this research, we attempt to answer the question based on the recent advances of Artificial Intelligence (AI) and Large Language Models (LLMs). We propose \textbf{WarAgent}, an LLM-powered multi-agent AI system, to simulate the participating countries, their decisions, and the consequences, in historical international conflicts, including the World War I (WWI), the World War II (WWII), and the Warring States Period (WSP) in Ancient China. By evaluating the simulation effectiveness, we examine the advancements and limitations of cutting-edge AI systems' abilities in studying complex collective human behaviors such as international conflicts under diverse settings. In these simulations, the emergent interactions among agents also offer a novel perspective for examining the triggers and conditions that lead to war. Our findings offer data-driven and AI-augmented insights that can redefine how we approach conflict resolution and peacekeeping strategies. The implications stretch beyond historical analysis, offering a blueprint for using AI to understand human history and possibly prevent future international conflicts. Code and data are available at \url{https://github.com/agiresearch/WarAgent}.

DataChat: Prototyping a Conversational Agent for Dataset Search and Visualization

Data users need relevant context and research expertise to effectively search for and identify relevant datasets. Leading data providers, such as the Inter-university Consortium for Political and Social Research (ICPSR), offer standardized metadata and search tools to support data search. Metadata standards emphasize the machine-readability of data and its documentation. There are opportunities to enhance dataset search by improving users' ability to learn about, and make sense of, information about data. Prior research has shown that context and expertise are two main barriers users face in effectively searching for, evaluating, and deciding whether to reuse data. In this paper, we propose a novel chatbot-based search system, DataChat, that leverages a graph database and a large language model to provide novel ways for users to interact with and search for research data. DataChat complements data archives' and institutional repositories' ongoing efforts to curate, preserve, and share research data for reuse by making it easier for users to explore and learn about available research data.

"HOT" ChatGPT: The promise of ChatGPT in detecting and discriminating hateful, offensive, and toxic comments on social media

Harmful content is pervasive on social media, poisoning online communities and negatively impacting participation. A common approach to address this issue is to develop detection models that rely on human annotations. However, the tasks required to build such models expose annotators to harmful and offensive content and may require significant time and cost to complete. Generative AI models have the potential to understand and detect harmful content. To investigate this potential, we used ChatGPT and compared its performance with MTurker annotations for three frequently discussed concepts related to harmful content: Hateful, Offensive, and Toxic (HOT). We designed five prompts to interact with ChatGPT and conducted four experiments eliciting HOT classifications. Our results show that ChatGPT can achieve an accuracy of approximately 80% when compared to MTurker annotations. Specifically, the model displays a more consistent classification for non-HOT comments than HOT comments compared to human annotations. Our findings also suggest that ChatGPT classifications align with provided HOT definitions, but ChatGPT classifies "hateful" and "offensive" as subsets of "toxic." Moreover, the choice of prompts used to interact with ChatGPT impacts its performance. Based on these in-sights, our study provides several meaningful implications for employing ChatGPT to detect HOT content, particularly regarding the reliability and consistency of its performance, its understand-ing and reasoning of the HOT concept, and the impact of prompts on its performance. Overall, our study provides guidance about the potential of using generative AI models to moderate large volumes of user-generated content on social media.

A Bibliometric Review of Large Language Models Research from 2017 to 2023

Large language models (LLMs) are a class of language models that have demonstrated outstanding performance across a range of natural language processing (NLP) tasks and have become a highly sought-after research area, because of their ability to generate human-like language and their potential to revolutionize science and technology. In this study, we conduct bibliometric and discourse analyses of scholarly literature on LLMs. Synthesizing over 5,000 publications, this paper serves as a roadmap for researchers, practitioners, and policymakers to navigate the current landscape of LLMs research. We present the research trends from 2017 to early 2023, identifying patterns in research paradigms and collaborations. We start with analyzing the core algorithm developments and NLP tasks that are fundamental in LLMs research. We then investigate the applications of LLMs in various fields and domains including medicine, engineering, social science, and humanities. Our review also reveals the dynamic, fast-paced evolution of LLMs research. Overall, this paper offers valuable insights into the current state, impact, and potential of LLMs research and its applications.

A Natural Language Processing Pipeline for Detecting Informal Data References in Academic Literature

Discovering authoritative links between publications and the datasets that they use can be a labor-intensive process. We introduce a natural language processing pipeline that retrieves and reviews publications for informal references to research datasets, which complements the work of data librarians. We first describe the components of the pipeline and then apply it to expand an authoritative bibliography linking thousands of social science studies to the data-related publications in which they are used. The pipeline increases recall for literature to review for inclusion in data-related collections of publications and makes it possible to detect informal data references at scale. We contribute (1) a novel Named Entity Recognition (NER) model that reliably detects informal data references and (2) a dataset connecting items from social science literature with datasets they reference. Together, these contributions enable future work on data reference, data citation networks, and data reuse.

Librarian-in-the-Loop: A Natural Language Processing Paradigm for Detecting Informal Mentions of Research Data in Academic Literature

Data citations provide a foundation for studying research data impact. Collecting and managing data citations is a new frontier in archival science and scholarly communication. However, the discovery and curation of research data citations is labor intensive. Data citations that reference unique identifiers (i.e. DOIs) are readily findable; however, informal mentions made to research data are more challenging to infer. We propose a natural language processing (NLP) paradigm to support the human task of identifying informal mentions made to research datasets. The work of discovering informal data mentions is currently performed by librarians and their staff in the Inter-university Consortium for Political and Social Research (ICPSR), a large social science data archive that maintains a large bibliography of data-related literature. The NLP model is bootstrapped from data citations actively collected by librarians at ICPSR. The model combines pattern matching with multiple iterations of human annotations to learn additional rules for detecting informal data mentions. These examples are then used to train an NLP pipeline. The librarian-in-the-loop paradigm is centered in the data work performed by ICPSR librarians, supporting broader efforts to build a more comprehensive bibliography of data-related literature that reflects the scholarly communities of research data users.