Knowledge-augmented Agentic AI for Mental Health Medication Information Seeking

Patients increasingly seek medication information online, yet safety knowledge for psychiatric drugs is split between regulatory adverse-event records, which are authoritative but abstract, and patient narratives, which are experience-near but unvalidated. Integrating them without conflating evidence and anecdote is especially consequential in psychiatry, where poorly contextualised information can amplify fear, nocebo responses, and non-adherence. Here we develop a provenance-aware, knowledge-graph-based multi-agent framework unifying 466,525 Reddit posts, 60,782 WebMD reviews, and twenty years of U.S. FDA Adverse Event Reporting System records for nine antidepressants. A large-language-model entity-recognition pipeline benchmarked against physician annotations reached highest F1 scores of 0.969 for medications and 0.973 for conditions. The two community platforms were far more concordant with each other (overlap up to a Jaccard similarity of 0.905) than with regulatory reports, indicating that patient-generated data form a partly independent safety signal. For sertraline, many adverse events appeared in community sources hundreds of days before the corresponding FDA date. A Neo4j knowledge graph grounded in ATC-N, ICD-10, and MedDRA vocabularies preserves provenance, keeping every claim traceable and regulatory facts distinct from patient experience. These results establish source-aware integration as a route to more auditable psychiatric medication information, with usefulness and patient benefit to be tested prospectively.

AIPatient Arena: EHR-grounded evaluation of large language models in end-to-end clinical consultation workflows

Large language models (LLMs) are increasingly considered for use in clinical consultation tasks, yet most medical evaluations remain static, single-turn, or narrowly outcome-based, limiting their ability to reflect the sequential, uncertain, and interactive nature of real-world care. Here, we propose AIPatient Arena, an EHRs-grounded evaluation framework for assessing the clinical utility of LLMs across eight dimensions of clinical competence. The framework integrates EHR data into patient-specific knowledge graphs, enabling multi-turn physician-patient interactions. We applied AIPatient Arena on a primary cohort of 437 patients and two out-of-distribution validation cohorts of 119 and 67 patients. We observe that LLMs performed well in medical interview questioning skills (QS; mean scores, 4.43-4.99/5), ethical and professional conduct (ET; 4.38-4.93/5), and clarity and transparency of clinical explanations (EX; 3.80-4.72/5). Performance was moderate in information integration (II; 3.19-4.21/5) and medication safety and justification (MS; 3.13-3.78/5), but persistent weaknesses were observed in handling of ambiguous patient responses (HR; 2.57-3.32/5), information coverage (IC; 2.08-3.02/5), and diagnostic accuracy and reasoning (Dx; 2.63-3.55/5). Process-based evaluation revealed recurrent interaction failures, including repetitive questioning, omission of past medical history, and inadequate handling of uncertainty. Richer conversational context improved diagnostic reasoning but yielded limited gains in treatment planning. These findings indicate that final-answer accuracy alone is insufficient for evaluating clinical readiness and highlight the importance of assessing how models gather, interpret, and communicate information throughout a consultation. AIPatient Arena provides an EHR-grounded framework for workflow-oriented pre-deployment evaluation of medical LLMs.

UniLab: A Heterogeneous Architecture for Robot RL Beyond GPU-Dominant Paradigms

Simulation-based RL for contemporary robot control is increasingly organized around GPU-resident simulation: physics, rollout collection, and learning are placed on a single GPU-centric execution path. This paradigm has greatly improved training speed, but it has also encouraged a default assumption that efficient training requires physics to reside on the GPU. We revisit this assumption. Our view is that, in simulation-dominated robot control, the essential question is not which processor runs physics, but whether simulation throughput, policy learning, and runtime synchronization form an efficient end-to-end loop. We present UniLab, a heterogeneous CPU-simulation / GPU-learning architecture that decouples CPU-parallel simulation from GPU policy updates through a unified runtime for data movement, buffering, and synchronization. UniLab is implemented as a complete and extensible training system using MuJoCoUni and MotrixSim CPU-batched physics backends, supporting PPO, FastSAC, FlashSAC, and APPO. On representative simulation-based robot control tasks, UniLab improves end-to-end training efficiency by 3--10$\times$ under the same hardware configuration, while reducing dependence on the NVIDIA CUDA-based software stack and supporting cross-platform execution on the Apple macOS platform and the AMD ROCm and Intel XPU accelerator backends. These results show that GPU simulation is an effective path to efficient training, but not a necessary one, broadening the practical system choices available for robot RL training. Project page: https://unilabsim.github.io.

A Heterogeneous Architecture for Robot RL Beyond GPU-Dominant Paradigms

Simulation-based RL for contemporary robot control is increasingly organized around GPU-resident simulation: physics, rollout collection, and learning are placed on a single GPU-centric execution path. This paradigm has greatly improved training speed, but it has also encouraged a default assumption that efficient training requires physics to reside on the GPU. We revisit this assumption. Our view is that, in simulation-dominated robot control, the essential question is not which processor runs physics, but whether simulation throughput, policy learning, and runtime synchronization form an efficient end-to-end loop. We present UniLab, a heterogeneous CPU-simulation / GPU-learning architecture that decouples CPU-parallel simulation from GPU policy updates through a unified runtime for data movement, buffering, and synchronization. UniLab is implemented as a complete and extensible training system using MuJoCoUni and MotrixSim CPU-batched physics backends, supporting PPO, SAC, FlashSAC, TD3, and APPO. On representative simulation-based robot control tasks, UniLab improves end-to-end training efficiency by 3--10$\times$ under the same hardware configuration, while reducing dependence on the NVIDIA CUDA-based software stack and supporting cross-platform execution on the Apple macOS platform and the AMD ROCm and Intel XPU accelerator backends. These results show that GPU simulation is an effective path to efficient training, but not a necessary one, broadening the practical system choices available for robot RL training. Project page: https://github.com/unilabsim/UniLab.

More Edits, More Stable: Understanding the Lifelong Normalization in Sequential Model Editing

Lifelong Model Editing aims to continuously update evolving facts in Large Language Models while preserving unrelated knowledge and general capabilities, yet it remains plagued by catastrophic forgetting and model collapse. Empirically, we find that recent editors resilient over long horizons share the same core strategy: Lifelong Normalization (LN), which normalizes value gradients using running statistics. Removing LN causes immediate performance collapse, and we observe a counter-intuitive positive cumulative effect where early edits can promote the success of future edits. Yet the mechanism of LN remains a "black box", leaving its precise role in lifelong stability poorly understood. In this work, we provide the first theoretical account of LN in the lifelong regime. Our analysis reveals a self-reinforcing stability loop and proves that, when combined with ridge-regularized regression, LN yields parameter updates with asymptotic orthogonality and bounded norms, directly mitigating forgetting and systemic collapse. Based on these insights, we derive StableEdit, which strengthens this stability loop via an explicit warm-up stage and full whitening, improving long-horizon stability at minimal overhead. Extensive experiments validate our theory and demonstrate competitive performance. Our code is available at https://github.com/MINE-USTC/StableEdit.

Fine-Grained Action Segmentation for Renorrhaphy in Robot-Assisted Partial Nephrectomy

Fine-grained action segmentation during renorrhaphy in robot-assisted partial nephrectomy requires frame-level recognition of visually similar suturing gestures with variable duration and substantial class imbalance. The SIA-RAPN benchmark defines this problem on 50 clinical videos acquired with the da Vinci Xi system and annotated with 12 frame-level labels. The benchmark compares four temporal models built on I3D features: MS-TCN++, AsFormer, TUT, and DiffAct. Evaluation uses balanced accuracy, edit score, segmental F1 at overlap thresholds of 10, 25, and 50, frame-wise accuracy, and frame-wise mean average precision. In addition to the primary evaluation across five released split configurations on SIA-RAPN, the benchmark reports cross-domain results on a separate single-port RAPN dataset. Across the strongest reported values over those five runs on the primary dataset, DiffAct achieves the highest F1, frame-wise accuracy, edit score, and frame mAP, while MS-TCN++ attains the highest balanced accuracy.

Evaluating an evidence-guided reinforcement learning framework in aligning light-parameter large language models with decision-making cognition in psychiatric clinical reasoning

Large language models (LLMs) hold transformative potential for medical decision support yet their application in psychiatry remains constrained by hallucinations and superficial reasoning. This limitation is particularly acute in light-parameter LLMs which are essential for privacy-preserving and efficient clinical deployment. Existing training paradigms prioritize linguistic fluency over structured clinical logic and result in a fundamental misalignment with professional diagnostic cognition. Here we introduce ClinMPO, a reinforcement learning framework designed to align the internal reasoning of LLMs with professional psychiatric practice. The framework employs a specialized reward model trained independently on a dataset derived from 4,474 psychiatry journal articles and structured according to evidence-based medicine principles. We evaluated ClinMPO on a unseen subset of the benchmark designed to isolate reasoning capabilities from rote memorization. This test set comprises items where leading large-parameter LLMs consistently fail. We compared the ClinMPO-aligned light LLM performance against a cohort of 300 medical students. The ClinMPO-tuned Qwen3-8B model achieved a diagnostic accuracy of 31.4% and surpassed the human benchmark of 30.8% on these complex cases. These results demonstrate that medical evidence-guided optimization enables light-parameter LLMs to master complex reasoning tasks. Our findings suggest that explicit cognitive alignment offers a scalable pathway to reliable and safe psychiatric decision support.

A Unified Complementarity-based Approach for Rigid-Body Manipulation and Motion Prediction

Robotic manipulation in unstructured environments requires planners to reason jointly about free-space motion and sustained, frictional contact with the environment. Existing (local) planning and simulation frameworks typically separate these regimes or rely on simplified contact representations, particularly when modeling non-convex or distributed contact patches. Such approximations limit the fidelity of contact-mode transitions and hinder the robust execution of contact-rich behaviors in real time. This paper presents a unified discrete-time modeling framework for robotic manipulation that consistently captures both free motion and frictional contact within a single mathematical formalism (Unicomp). Building on complementarity-based rigid-body dynamics, we formulate free-space motion and contact interactions as coupled linear and nonlinear complementarity problems, enabling principled transitions between contact modes without enforcing fixed-contact assumptions. For planar patch contact, we derive a frictional contact model from the maximum power dissipation principle in which the set of admissible contact wrenches is represented by an ellipsoidal limit surface. This representation captures coupled force-moment effects, including torsional friction, while remaining agnostic to the underlying pressure distribution across the contact patch. The resulting formulation yields a discrete-time predictive model that relates generalized velocities and contact wrenches through quadratic constraints and is suitable for real-time optimization-based planning. Experimental results show that the proposed approach enables stable, physically consistent behavior at interactive speeds across tasks, from planar pushing to contact-rich whole-body maneuvers.

Dynamic Facial Expressions Analysis Based Parkinson's Disease Auxiliary Diagnosis

Parkinson's disease (PD), a prevalent neurodegenerative disorder, significantly affects patients' daily functioning and social interactions. To facilitate a more efficient and accessible diagnostic approach for PD, we propose a dynamic facial expression analysis-based PD auxiliary diagnosis method. This method targets hypomimia, a characteristic clinical symptom of PD, by analyzing two manifestations: reduced facial expressivity and facial rigidity, thereby facilitating the diagnosis process. We develop a multimodal facial expression analysis network to extract expression intensity features during patients' performance of various facial expressions. This network leverages the CLIP architecture to integrate visual and textual features while preserving the temporal dynamics of facial expressions. Subsequently, the expression intensity features are processed and input into an LSTM-based classification network for PD diagnosis. Our method achieves an accuracy of 93.1%, outperforming other in-vitro PD diagnostic approaches. This technique offers a more convenient detection method for potential PD patients, improving their diagnostic experience.

Everything-Grasping (EG) Gripper: A Universal Gripper with Synergistic Suction-Grasping Capabilities for Cross-Scale and Cross-State Manipulation

Grasping objects across vastly different sizes and physical states-including both solids and liquids-with a single robotic gripper remains a fundamental challenge in soft robotics. We present the Everything-Grasping (EG) Gripper, a soft end-effector that synergistically integrates distributed surface suction with internal granular jamming, enabling cross-scale and cross-state manipulation without requiring airtight sealing at the contact interface with target objects. The EG Gripper can handle objects with surface areas ranging from sub-millimeter scale 0.2 mm2 (glass bead) to over 62,000 mm2 (A4 sized paper and woven bag), enabling manipulation of objects nearly 3,500X smaller and 88X larger than its own contact area (approximated at 707 mm2 for a 30 mm-diameter base). We further introduce a tactile sensing framework that combines liquid detection and pressure-based suction feedback, enabling real-time differentiation between solid and liquid targets. Guided by the actile-Inferred Grasping Mode Selection (TIGMS) algorithm, the gripper autonomously selects grasping modes based on distributed pressure and voltage signals. Experiments across diverse tasks-including underwater grasping, fragile object handling, and liquid capture-demonstrate robust and repeatable performance. To our knowledge, this is the first soft gripper to reliably grasp both solid and liquid objects across scales using a unified compliant architecture.