Divide-and-Conquer: Cold-Start Bundle Recommendation via Mixture of Diffusion Experts

Cold-start bundle recommendation focuses on modeling new bundles with insufficient information to provide recommendations. Advanced bundle recommendation models usually learn bundle representations from multiple views (e.g., interaction view) at both the bundle and item levels. Consequently, the cold-start problem for bundles is more challenging than that for traditional items due to the dual-level multi-view complexity. In this paper, we propose a novel Mixture of Diffusion Experts (MoDiffE) framework, which employs a divide-and-conquer strategy for cold-start bundle recommendation and follows three steps:(1) Divide: The bundle cold-start problem is divided into independent but similar sub-problems sequentially by level and view, which can be summarized as the poor representation of feature-missing bundles in prior-embedding models. (2) Conquer: Beyond prior-embedding models that fundamentally provide the embedded representations, we introduce a diffusion-based method to solve all sub-problems in a unified way, which directly generates diffusion representations using diffusion models without depending on specific features. (3) Combine: A cold-aware hierarchical Mixture of Experts (MoE) is employed to combine results of the sub-problems for final recommendations, where the two models for each view serve as experts and are adaptively fused for different bundles in a multi-layer manner. Additionally, MoDiffE adopts a multi-stage decoupled training pipeline and introduces a cold-start gating augmentation method to enable the training of gating for cold bundles. Through extensive experiments on three real-world datasets, we demonstrate that MoDiffE significantly outperforms existing solutions in handling cold-start bundle recommendation. It achieves up to a 0.1027 absolute gain in Recall@20 in cold-start scenarios and up to a 47.43\% relative improvement in all-bundle scenarios.

Pangu Ultra MoE: How to Train Your Big MoE on Ascend NPUs

Sparse large language models (LLMs) with Mixture of Experts (MoE) and close to a trillion parameters are dominating the realm of most capable language models. However, the massive model scale poses significant challenges for the underlying software and hardware systems. In this paper, we aim to uncover a recipe to harness such scale on Ascend NPUs. The key goals are better usage of the computing resources under the dynamic sparse model structures and materializing the expected performance gain on the actual hardware. To select model configurations suitable for Ascend NPUs without repeatedly running the expensive experiments, we leverage simulation to compare the trade-off of various model hyperparameters. This study led to Pangu Ultra MoE, a sparse LLM with 718 billion parameters, and we conducted experiments on the model to verify the simulation results. On the system side, we dig into Expert Parallelism to optimize the communication between NPU devices to reduce the synchronization overhead. We also optimize the memory efficiency within the devices to further reduce the parameter and activation management overhead. In the end, we achieve an MFU of 30.0% when training Pangu Ultra MoE, with performance comparable to that of DeepSeek R1, on 6K Ascend NPUs, and demonstrate that the Ascend system is capable of harnessing all the training stages of the state-of-the-art language models. Extensive experiments indicate that our recipe can lead to efficient training of large-scale sparse language models with MoE. We also study the behaviors of such models for future reference.

Breast density in MRI: an AI-based quantification and relationship to assessment in mammography

Mammographic breast density is a well-established risk factor for breast cancer. Recently there has been interest in breast MRI as an adjunct to mammography, as this modality provides an orthogonal and highly quantitative assessment of breast tissue. However, its 3D nature poses analytic challenges related to delineating and aggregating complex structures across slices. Here, we applied an in-house machine-learning algorithm to assess breast density on normal breasts in three MRI datasets. Breast density was consistent across different datasets (0.104 - 0.114). Analysis across different age groups also demonstrated strong consistency across datasets and confirmed a trend of decreasing density with age as reported in previous studies. MR breast density was correlated with mammographic breast density, although some notable differences suggest that certain breast density components are captured only on MRI. Future work will determine how to integrate MR breast density with current tools to improve future breast cancer risk prediction.

Relation-R1: Cognitive Chain-of-Thought Guided Reinforcement Learning for Unified Relational Comprehension

Recent advances in multi-modal large language models (MLLMs) have significantly improved object-level grounding and region captioning, but remain limited in visual relation understanding (\eg, scene graph generation), particularly in modeling \textit{N}-ary relationships that identify multiple semantic roles among an action event. Such a lack of \textit{semantic dependencies} modeling among multi-entities leads to unreliable outputs, intensifying MLLMs' hallucinations and over-reliance on language priors. To this end, we propose Relation-R1, the first unified relational comprehension framework that explicitly integrates cognitive chain-of-thought (CoT)-guided Supervised Fine-Tuning (SFT) and Group Relative Policy Optimization (GRPO) within a reinforcement learning (RL) paradigm. Specifically, we first establish foundational reasoning capabilities via SFT, enforcing structured outputs with thinking processes. Then, GRPO is utilized to refine these outputs via multi-reward optimization, prioritizing visual-semantic grounding over language-induced biases, thereby improving generalization capability. Extensive experiments on widely-used PSG and SWiG datasets demonstrate that Relation-R1 achieves state-of-the-art performance in both binary and \textit{N}-ary relation understanding.

Knowledge Acquisition on Mass-shooting Events via LLMs for AI-Driven Justice

Mass-shooting events pose a significant challenge to public safety, generating large volumes of unstructured textual data that hinder effective investigations and the formulation of public policy. Despite the urgency, few prior studies have effectively automated the extraction of key information from these events to support legal and investigative efforts. This paper presented the first dataset designed for knowledge acquisition on mass-shooting events through the application of named entity recognition (NER) techniques. It focuses on identifying key entities such as offenders, victims, locations, and criminal instruments, that are vital for legal and investigative purposes. The NER process is powered by Large Language Models (LLMs) using few-shot prompting, facilitating the efficient extraction and organization of critical information from diverse sources, including news articles, police reports, and social media. Experimental results on real-world mass-shooting corpora demonstrate that GPT-4o is the most effective model for mass-shooting NER, achieving the highest Micro Precision, Micro Recall, and Micro F1-scores. Meanwhile, o1-mini delivers competitive performance, making it a resource-efficient alternative for less complex NER tasks. It is also observed that increasing the shot count enhances the performance of all models, but the gains are more substantial for GPT-4o and o1-mini, highlighting their superior adaptability to few-shot learning scenarios.

Predicting ulcer in H&E images of inflammatory bowel disease using domain-knowledge-driven graph neural network

Inflammatory bowel disease (IBD) involves chronic inflammation of the digestive tract, with treatment options often burdened by adverse effects. Identifying biomarkers for personalized treatment is crucial. While immune cells play a key role in IBD, accurately identifying ulcer regions in whole slide images (WSIs) is essential for characterizing these cells and exploring potential therapeutics. Multiple instance learning (MIL) approaches have advanced WSI analysis but they lack spatial context awareness. In this work, we propose a weakly-supervised model called DomainGCN that employs a graph convolution neural network (GCN) and incorporates domain-specific knowledge of ulcer features, specifically, the presence of epithelium, lymphocytes, and debris for WSI-level ulcer prediction in IBD. We demonstrate that DomainGCN outperforms various state-of-the-art (SOTA) MIL methods and show the added value of domain knowledge.

Pangu Ultra: Pushing the Limits of Dense Large Language Models on Ascend NPUs

We present Pangu Ultra, a Large Language Model (LLM) with 135 billion parameters and dense Transformer modules trained on Ascend Neural Processing Units (NPUs). Although the field of LLM has been witnessing unprecedented advances in pushing the scale and capability of LLM in recent years, training such a large-scale model still involves significant optimization and system challenges. To stabilize the training process, we propose depth-scaled sandwich normalization, which effectively eliminates loss spikes during the training process of deep models. We pre-train our model on 13.2 trillion diverse and high-quality tokens and further enhance its reasoning capabilities during post-training. To perform such large-scale training efficiently, we utilize 8,192 Ascend NPUs with a series of system optimizations. Evaluations on multiple diverse benchmarks indicate that Pangu Ultra significantly advances the state-of-the-art capabilities of dense LLMs such as Llama 405B and Mistral Large 2, and even achieves competitive results with DeepSeek-R1, whose sparse model structure contains much more parameters. Our exploration demonstrates that Ascend NPUs are capable of efficiently and effectively training dense models with more than 100 billion parameters. Our model and system will be available for our commercial customers.

SlimSpeech: Lightweight and Efficient Text-to-Speech with Slim Rectified Flow

Recently, flow matching based speech synthesis has significantly enhanced the quality of synthesized speech while reducing the number of inference steps. In this paper, we introduce SlimSpeech, a lightweight and efficient speech synthesis system based on rectified flow. We have built upon the existing speech synthesis method utilizing the rectified flow model, modifying its structure to reduce parameters and serve as a teacher model. By refining the reflow operation, we directly derive a smaller model with a more straight sampling trajectory from the larger model, while utilizing distillation techniques to further enhance the model performance. Experimental results demonstrate that our proposed method, with significantly reduced model parameters, achieves comparable performance to larger models through one-step sampling.

Personalize Anything for Free with Diffusion Transformer

Personalized image generation aims to produce images of user-specified concepts while enabling flexible editing. Recent training-free approaches, while exhibit higher computational efficiency than training-based methods, struggle with identity preservation, applicability, and compatibility with diffusion transformers (DiTs). In this paper, we uncover the untapped potential of DiT, where simply replacing denoising tokens with those of a reference subject achieves zero-shot subject reconstruction. This simple yet effective feature injection technique unlocks diverse scenarios, from personalization to image editing. Building upon this observation, we propose \textbf{Personalize Anything}, a training-free framework that achieves personalized image generation in DiT through: 1) timestep-adaptive token replacement that enforces subject consistency via early-stage injection and enhances flexibility through late-stage regularization, and 2) patch perturbation strategies to boost structural diversity. Our method seamlessly supports layout-guided generation, multi-subject personalization, and mask-controlled editing. Evaluations demonstrate state-of-the-art performance in identity preservation and versatility. Our work establishes new insights into DiTs while delivering a practical paradigm for efficient personalization.

A Novel Ophthalmic Benchmark for Evaluating Multimodal Large Language Models with Fundus Photographs and OCT Images

In recent years, large language models (LLMs) have demonstrated remarkable potential across various medical applications. Building on this foundation, multimodal large language models (MLLMs) integrate LLMs with visual models to process diverse inputs, including clinical data and medical images. In ophthalmology, LLMs have been explored for analyzing optical coherence tomography (OCT) reports, assisting in disease classification, and even predicting treatment outcomes. However, existing MLLM benchmarks often fail to capture the complexities of real-world clinical practice, particularly in the analysis of OCT images. Many suffer from limitations such as small sample sizes, a lack of diverse OCT datasets, and insufficient expert validation. These shortcomings hinder the accurate assessment of MLLMs' ability to interpret OCT scans and their broader applicability in ophthalmology. Our dataset, curated through rigorous quality control and expert annotation, consists of 439 fundus images and 75 OCT images. Using a standardized API-based framework, we assessed seven mainstream MLLMs and observed significant variability in diagnostic accuracy across different diseases. While some models performed well in diagnosing conditions such as diabetic retinopathy and age-related macular degeneration, they struggled with others, including choroidal neovascularization and myopia, highlighting inconsistencies in performance and the need for further refinement. Our findings emphasize the importance of developing clinically relevant benchmarks to provide a more accurate assessment of MLLMs' capabilities. By refining these models and expanding their scope, we can enhance their potential to transform ophthalmic diagnosis and treatment.