Deep Learning-Based Airway Segmentation in Systemic Lupus Erythematosus Patients with Interstitial Lung Disease (SLE-ILD): A Comparative High-Resolution CT Analysis

To characterize lobar and segmental airway volume differences between systemic lupus erythematosus (SLE) patients with interstitial lung disease (ILD) and those without ILD (non-ILD) using a deep learning-based approach on non-contrast chest high-resolution CT (HRCT). Methods: A retrospective analysis was conducted on 106 SLE patients (27 SLE-ILD, 79 SLE-non-ILD) who underwent HRCT. A customized deep learning framework based on the U-Net architecture was developed to automatically segment airway structures at the lobar and segmental levels via HRCT. Volumetric measurements of lung lobes and segments derived from the segmentations were statistically compared between the two groups using two-sample t-tests (significance threshold: p < 0.05). Results: At lobar level, significant airway volume enlargement in SLE-ILD patients was observed in the right upper lobe (p=0.009) and left upper lobe (p=0.039) compared to SLE-non-ILD. At the segmental level, significant differences were found in segments including R1 (p=0.016), R3 (p<0.001), and L3 (p=0.038), with the most marked changes in the upper lung zones, while lower zones showed non-significant trends. Conclusion: Our study demonstrates that an automated deep learning-based approach can effectively quantify airway volumes on HRCT scans and reveal significant, region-specific airway dilation in patients with SLE-ILD compared to those without ILD. The pattern of involvement, predominantly affecting the upper lobes and specific segments, highlights a distinct topographic phenotype of SLE-ILD and implicates airway structural alterations as a potential biomarker for disease presence. This AI-powered quantitative imaging biomarker holds promise for enhancing the early detection and monitoring of ILD in the SLE population, ultimately contributing to more personalized patient management.

FlowComposer: Composable Flows for Compositional Zero-Shot Learning

Compositional zero-shot learning (CZSL) aims to recognize unseen attribute-object compositions by recombining primitives learned from seen pairs. Recent CZSL methods built on vision-language models (VLMs) typically adopt parameter-efficient fine-tuning (PEFT). They apply visual disentanglers for decomposition and manipulate token-level prompts or prefixes to encode compositions. However, such PEFT-based designs suffer from two fundamental limitations: (1) Implicit Composition Construction, where composition is realized only via token concatenation or branch-wise prompt tuning rather than an explicit operation in the embedding space; (2) Remained Feature Entanglement, where imperfect disentanglement leaves attribute, object, and composition features mutually contaminated. Together, these issues limit the generalization ability of current CZSL models. In this paper, we are the first to systematically study flow matching for CZSL and introduce FlowComposer, a model-agnostic framework that learns two primitive flows to transport visual features toward attribute and object text embeddings, and a learnable Composer that explicitly fuses their velocity fields into a composition flow. To exploit the inevitable residual entanglement, we further devise a leakage-guided augmentation scheme that reuses leaked features as auxiliary signals. We thoroughly evaluate FlowComposer on three public CZSL benchmarks by integrating it as a plug-and-play component into various baselines, consistently achieving significant improvements.

SegviGen: Repurposing 3D Generative Model for Part Segmentation

We introduce SegviGen, a framework that repurposes native 3D generative models for 3D part segmentation. Existing pipelines either lift strong 2D priors into 3D via distillation or multi-view mask aggregation, often suffering from cross-view inconsistency and blurred boundaries, or explore native 3D discriminative segmentation, which typically requires large-scale annotated 3D data and substantial training resources. In contrast, SegviGen leverages the structured priors encoded in pretrained 3D generative model to induce segmentation through distinctive part colorization, establishing a novel and efficient framework for part segmentation. Specifically, SegviGen encodes a 3D asset and predicts part-indicative colors on active voxels of a geometry-aligned reconstruction. It supports interactive part segmentation, full segmentation, and full segmentation with 2D guidance in a unified framework. Extensive experiments show that SegviGen improves over the prior state of the art by 40% on interactive part segmentation and by 15% on full segmentation, while using only 0.32% of the labeled training data. It demonstrates that pretrained 3D generative priors transfer effectively to 3D part segmentation, enabling strong performance with limited supervision. See our project page at https://fenghora.github.io/SegviGen-Page/.

Intrinsic Tolerance in C-Arm Imaging: How Extrinsic Re-optimization Preserves 3D Reconstruction Accuracy

\textbf{Purpose:} C-arm fluoroscopy's 3D reconstruction relies on accurate intrinsic calibration, which is often challenging in clinical practice. This study ensures high-precision reconstruction accuracy by re-optimizing the extrinsic parameters to compensate for intrinsic calibration errors. \noindent\textbf{Methods:} We conducted both simulation and real-world experiments using five commercial C-arm systems. Intrinsic parameters were perturbed in controlled increments. Focal length was increased by 100 to 700 pixels ($\approx$20 mm to 140 mm) and principal point by 20 to 200 pixels. For each perturbation, we (1) reconstructed 3D points from known phantom geometries, (2) re-estimated extrinsic poses using standard optimization, and (3) measured reconstruction and reprojection errors relative to ground truth. \noindent\textbf{Results:} Even with focal length errors up to 500 pixels ($\approx$100 mm, assuming a nominal focal length of $\sim$1000 mm), mean 3D reconstruction error remained under 0.2 mm. Larger focal length deviations (700 pixels) elevated error to only $\approx$0.3 mm. Principal point shifts up to 200 pixels introduced negligible reconstruction error once extrinsic parameters were re-optimized, with reprojection error increases below 0.5 pixels. \noindent\textbf{Conclusion:} Moderate errors in intrinsic calibration can be effectively mitigated by extrinsic re-optimization, preserving submillimeter 3D reconstruction accuracy. This intrinsic tolerance suggests a practical pathway to relax calibration precision requirements, thereby simplifying C-arm system setup and reducing clinical workflow burden without compromising performance.

AlphaFlowTSE: One-Step Generative Target Speaker Extraction via Conditional AlphaFlow

In target speaker extraction (TSE), we aim to recover target speech from a multi-talker mixture using a short enrollment utterance as reference. Recent studies on diffusion and flow-matching generators have improved target-speech fidelity. However, multi-step sampling increases latency, and one-step solutions often rely on a mixture-dependent time coordinate that can be unreliable for real-world conversations. We present AlphaFlowTSE, a one-step conditional generative model trained with a Jacobian-vector product (JVP)-free AlphaFlow objective. AlphaFlowTSE learns mean-velocity transport along a mixture-to-target trajectory starting from the observed mixture, eliminating auxiliary mixing-ratio prediction, and stabilizes training by combining flow matching with an interval-consistency teacher-student target. Experiments on Libri2Mix and REAL-T confirm that AlphaFlowTSE improves target-speaker similarity and real-mixture generalization for downstream automatic speech recognition (ASR).

StyleVLA: Driving Style-Aware Vision Language Action Model for Autonomous Driving

Vision Language Models (VLMs) bridge visual perception and linguistic reasoning. In Autonomous Driving (AD), this synergy has enabled Vision Language Action (VLA) models, which translate high-level multimodal understanding into driving behaviors, typically represented as future trajectories. However, existing VLA models mainly generate generic collision-free trajectories. Beyond collision avoidance, adapting to diverse driving styles (e.g., sporty, comfortable) is essential for personalized driving. Moreover, many methods treat trajectory generation as naive token prediction, which can produce kinematically infeasible actions. To address these limitations, we present StyleVLA, a physics-informed VLA framework for generating diverse and physically plausible driving behaviors. We introduce a hybrid loss that combines a kinematic consistency constraint with a continuous regression head to improve trajectory feasibility. To train StyleVLA, built on Qwen3-VL-4B, we construct a large-scale instruction dataset with over 1.2k scenarios, 76k Bird's Eye View (BEV) samples, and 42k First Person View (FPV) samples, with ground-truth trajectories for five driving styles and natural-language instructions. Experiments show that our 4B-parameter StyleVLA significantly outperforms proprietary models (e.g., Gemini-3-Pro) and state-of-the-art VLA models. Using a composite driving score measuring success rate, physical feasibility, and style adherence, StyleVLA achieves 0.55 on BEV and 0.51 on FPV, versus 0.32 and 0.35 for Gemini-3-Pro. These results show that a specialized, physics-informed, lightweight model can surpass closed-source models on domain-specific tasks.

MEDSYN: Benchmarking Multi-EviDence SYNthesis in Complex Clinical Cases for Multimodal Large Language Models

Multimodal large language models (MLLMs) have shown great potential in medical applications, yet existing benchmarks inadequately capture real-world clinical complexity. We introduce MEDSYN, a multilingual, multimodal benchmark of highly complex clinical cases with up to 7 distinct visual clinical evidence (CE) types per case. Mirroring clinical workflow, we evaluate 18 MLLMs on differential diagnosis (DDx) generation and final diagnosis (FDx) selection. While top models often match or even outperform human experts on DDx generation, all MLLMs exhibit a much larger DDx--FDx performance gap compared to expert clinicians, indicating a failure mode in synthesis of heterogeneous CE types. Ablations attribute this failure to (i) overreliance on less discriminative textual CE ($\it{e.g.}$, medical history) and (ii) a cross-modal CE utilization gap. We introduce Evidence Sensitivity to quantify the latter and show that a smaller gap correlates with higher diagnostic accuracy. Finally, we demonstrate how it can be used to guide interventions to improve model performance. We will open-source our benchmark and code.

Path-Decoupled Hyperbolic Flow Matching for Few-Shot Adaptation

Recent advances in cross-modal few-shot adaptation treat visual-semantic alignment as a continuous feature transport problem via Flow Matching (FM). However, we argue that Euclidean-based FM overlooks fundamental limitations of flat geometry, where polynomial volume growth fails to accommodate diverse feature distributions, leading to severe path entanglement. To this end, we propose path-decoupled Hyperbolic Flow Matching (HFM), leveraging the Lorentz manifold's exponential expansion for trajectory decoupling. HFM structures the transport via two key designs: 1) Centripetal hyperbolic alignment: It constructs a centripetal hierarchy by anchoring textual roots, which pushes visual leaves to the boundary to initialize orderly flows. 2) Path-decoupled objective: It acts as a ``semantic guardrail'' rigidly confining trajectories within isolated class-specific geodesic corridors via step-wise supervision. Furthermore, we devise an adaptive diameter-based stopping to prevent over-transportation into the crowded origin based on the intrinsic semantic scale. Extensive ablations on 11 benchmarks have shown that HFM establishes a new state-of-the-art, consistently outperforming its Euclidean counterparts. Our codes and models will be released.

How Foundational Skills Influence VLM-based Embodied Agents:A Native Perspective

Recent advances in vision-language models (VLMs) have shown promise for human-level embodied intelligence. However, existing benchmarks for VLM-driven embodied agents often rely on high-level commands or discretized action spaces, which are non-native settings that differ markedly from real-world control. In addition, current benchmarks focus primarily on high-level tasks and lack joint evaluation and analysis at both low and high levels. To address these limitations, we present NativeEmbodied, a challenging benchmark for VLM-driven embodied agents that uses a unified, native low-level action space. Built on diverse simulated scenes, NativeEmbodied includes three representative high-level tasks in complex scenarios to evaluate overall performance. For more detailed analysis, we further decouple the skills required by complex tasks and construct four types of low-level tasks, each targeting a fundamental embodied skill. This joint evaluation across task and skill granularities enables fine-grained assessment of embodied agents. Experiments with state-of-the-art VLMs reveal clear deficiencies in several fundamental embodied skills, and further analysis shows that these bottlenecks significantly limit performance on high-level tasks. NativeEmbodied highlights key challenges for current VLM-driven embodied agents and provides insights to guide future research.

Time Series Reasoning via Process-Verifiable Thinking Data Synthesis and Scheduling for Tailored LLM Reasoning

Time series is a pervasive data type across various application domains, rendering the reasonable solving of diverse time series tasks a long-standing goal. Recent advances in large language models (LLMs), especially their reasoning abilities unlocked through reinforcement learning (RL), have opened new opportunities for tackling tasks with long Chain-of-Thought (CoT) reasoning. However, leveraging LLM reasoning for time series remains in its infancy, hindered by the absence of carefully curated time series CoT data for training, limited data efficiency caused by underexplored data scheduling, and the lack of RL algorithms tailored for exploiting such time series CoT data. In this paper, we introduce VeriTime, a framework that tailors LLMs for time series reasoning through data synthesis, data scheduling, and RL training. First, we propose a data synthesis pipeline that constructs a TS-text multimodal dataset with process-verifiable annotations. Second, we design a data scheduling mechanism that arranges training samples according to a principled hierarchy of difficulty and task taxonomy. Third, we develop a two-stage reinforcement finetuning featuring fine-grained, multi-objective rewards that leverage verifiable process-level CoT data. Extensive experiments show that VeriTime substantially boosts LLM performance across diverse time series reasoning tasks. Notably, it enables compact 3B, 4B models to achieve reasoning capabilities on par with or exceeding those of larger proprietary LLMs.