A Generalist Foundation Model for Total-body PET/CT Enables Diagnostic Reporting and System-wide Metabolic Profiling

Total-body PET/CT enables system-wide molecular imaging, but heterogeneous anatomical and metabolic signals, approximately 2 m axial coverage, and structured radiology semantics challenge existing medical AI models that assume single-modality inputs, localized fields of view, and coarse image-text alignment. We introduce SDF-HOLO (Systemic Dual-stream Fusion Holo Model), a multimodal foundation model for holistic total-body PET/CT, pre-trained on more than 10,000 patients. SDF-HOLO decouples CT and PET representation learning with dual-stream encoders and couples them through a cross-modal interaction module, allowing anatomical context to refine PET aggregation while metabolic saliency guides subtle morphological reasoning. To model long-range dependencies across the body, hierarchical context modeling combines efficient local windows with global attention. To bridge voxels and clinical language, we use anatomical segmentation masks as explicit semantic anchors and perform voxel-mask-text alignment during pre-training. Across tumor segmentation, low-dose lesion detection, and multilingual diagnostic report generation, SDF-HOLO outperforms strong task-specific and clinical-reference baselines while reducing localization errors and hallucinated findings. Beyond focal interpretation, the model enables system-wide metabolic profiling and reveals tumor-associated fingerprints of inter-organ metabolic network interactions, providing a scalable computational foundation for total-body PET/CT diagnostics and system-level precision oncology.

OpenAI GPT-5 System Card

This is the system card published alongside the OpenAI GPT-5 launch, August 2025. GPT-5 is a unified system with a smart and fast model that answers most questions, a deeper reasoning model for harder problems, and a real-time router that quickly decides which model to use based on conversation type, complexity, tool needs, and explicit intent (for example, if you say 'think hard about this' in the prompt). The router is continuously trained on real signals, including when users switch models, preference rates for responses, and measured correctness, improving over time. Once usage limits are reached, a mini version of each model handles remaining queries. This system card focuses primarily on gpt-5-thinking and gpt-5-main, while evaluations for other models are available in the appendix. The GPT-5 system not only outperforms previous models on benchmarks and answers questions more quickly, but -- more importantly -- is more useful for real-world queries. We've made significant advances in reducing hallucinations, improving instruction following, and minimizing sycophancy, and have leveled up GPT-5's performance in three of ChatGPT's most common uses: writing, coding, and health. All of the GPT-5 models additionally feature safe-completions, our latest approach to safety training to prevent disallowed content. Similarly to ChatGPT agent, we have decided to treat gpt-5-thinking as High capability in the Biological and Chemical domain under our Preparedness Framework, activating the associated safeguards. While we do not have definitive evidence that this model could meaningfully help a novice to create severe biological harm -- our defined threshold for High capability -- we have chosen to take a precautionary approach.

Enhanced Whole Page Optimization via Mixed-Grained Reward Mechanism-Adapted Language Models

Optimizing the presentation of search and recommendation results is crucial to enhancing user experience and engagement. Whole Page Optimization (WPO) plays a pivotal role in this process, as it directly influences how information is surfaced to users. While Pre-trained Large Language Models (LLMs) have demonstrated remarkable capabilities in generating coherent and contextually relevant content, fine-tuning these models for complex tasks like WPO presents challenges. Specifically, the need for extensive human-annotated data to mitigate issues such as hallucinations and model instability can be prohibitively expensive, especially in large-scale systems that interact with millions of items daily. In this work, we address the challenge of fine-tuning LLMs for WPO by using user feedback as the supervision. Unlike manually labeled datasets, user feedback is inherently noisy and less precise. To overcome this, we propose a reward-based fine-tuning approach, PageLLM, which employs a mixed-grained reward mechanism that combines page-level and item-level rewards. The page-level reward evaluates the overall quality and coherence, while the item-level reward focuses on the accuracy and relevance of key recommendations. This dual-reward structure ensures that both the holistic presentation and the critical individual components are optimized. We validate PageLLM on both public and industrial datasets. PageLLM outperforms baselines and achieves a 0.44\% GMV increase in an online A/B test with over 10 million users, demonstrating its real-world impact.

Stability-based Generalization Analysis of Randomized Coordinate Descent for Pairwise Learning

Pairwise learning includes various machine learning tasks, with ranking and metric learning serving as the primary representatives. While randomized coordinate descent (RCD) is popular in various learning problems, there is much less theoretical analysis on the generalization behavior of models trained by RCD, especially under the pairwise learning framework. In this paper, we consider the generalization of RCD for pairwise learning. We measure the on-average argument stability for both convex and strongly convex objective functions, based on which we develop generalization bounds in expectation. The early-stopping strategy is adopted to quantify the balance between estimation and optimization. Our analysis further incorporates the low-noise setting into the excess risk bound to achieve the optimistic bound as $O(1/n)$, where $n$ is the sample size.

R-CoT: Reverse Chain-of-Thought Problem Generation for Geometric Reasoning in Large Multimodal Models

Existing Large Multimodal Models (LMMs) struggle with mathematical geometric reasoning due to a lack of high-quality image-text paired data. Current geometric data generation approaches, which apply preset templates to generate geometric data or use Large Language Models (LLMs) to rephrase questions and answers (Q&A), unavoidably limit data accuracy and diversity. To synthesize higher-quality data, we propose a two-stage Reverse Chain-of-Thought (R-CoT) geometry problem generation pipeline. First, we introduce GeoChain to produce high-fidelity geometric images and corresponding descriptions highlighting relations among geometric elements. We then design a Reverse A&Q method that reasons step-by-step based on the descriptions and generates questions in reverse from the reasoning results. Experiments demonstrate that the proposed method brings significant and consistent improvements on multiple LMM baselines, achieving new performance records in the 2B, 7B, and 8B settings. Notably, R-CoT-8B significantly outperforms previous state-of-the-art open-source mathematical models by 16.6% on MathVista and 9.2% on GeoQA, while also surpassing the closed-source model GPT-4o by an average of 13% across both datasets. The code is available at https://github.com/dle666/R-CoT.

Merging Multiple Datasets for Improved Appearance-Based Gaze Estimation

Multiple datasets have been created for training and testing appearance-based gaze estimators. Intuitively, more data should lead to better performance. However, combining datasets to train a single esti-mator rarely improves gaze estimation performance. One reason may be differences in the experimental protocols used to obtain the gaze sam-ples, resulting in differences in the distributions of head poses, gaze an-gles, illumination, etc. Another reason may be the inconsistency between methods used to define gaze angles (label mismatch). We propose two innovations to improve the performance of gaze estimation by leveraging multiple datasets, a change in the estimator architecture and the intro-duction of a gaze adaptation module. Most state-of-the-art estimators merge information extracted from images of the two eyes and the entire face either in parallel or combine information from the eyes first then with the face. Our proposed Two-stage Transformer-based Gaze-feature Fusion (TTGF) method uses transformers to merge information from each eye and the face separately and then merge across the two eyes. We argue that this improves head pose invariance since changes in head pose affect left and right eye images in different ways. Our proposed Gaze Adaptation Module (GAM) method handles annotation inconsis-tency by applying a Gaze Adaption Module for each dataset to correct gaze estimates from a single shared estimator. This enables us to combine information across datasets despite differences in labeling. Our experi-ments show that these innovations improve gaze estimation performance over the SOTA both individually and collectively (by 10% - 20%). Our code is available at https://github.com/HKUST-NISL/GazeSetMerge.

Understanding and Modeling Job Marketplace with Pretrained Language Models

Job marketplace is a heterogeneous graph composed of interactions among members (job-seekers), companies, and jobs. Understanding and modeling job marketplace can benefit both job seekers and employers, ultimately contributing to the greater good of the society. However, existing graph neural network (GNN)-based methods have shallow understandings of the associated textual features and heterogeneous relations. To address the above challenges, we propose PLM4Job, a job marketplace foundation model that tightly couples pretrained language models (PLM) with job market graph, aiming to fully utilize the pretrained knowledge and reasoning ability to model member/job textual features as well as various member-job relations simultaneously. In the pretraining phase, we propose a heterogeneous ego-graph-based prompting strategy to model and aggregate member/job textual features based on the topological structure around the target member/job node, where entity type embeddings and graph positional embeddings are introduced accordingly to model different entities and their heterogeneous relations. Meanwhile, a proximity-aware attention alignment strategy is designed to dynamically adjust the attention of the PLM on ego-graph node tokens in the prompt, such that the attention can be better aligned with job marketplace semantics. Extensive experiments at LinkedIn demonstrate the effectiveness of PLM4Job.

Generalized Low-Rank Matrix Completion Model with Overlapping Group Error Representation

The low-rank matrix completion (LRMC) technology has achieved remarkable results in low-level visual tasks. There is an underlying assumption that the real-world matrix data is low-rank in LRMC. However, the real matrix data does not satisfy the strict low-rank property, which undoubtedly present serious challenges for the above-mentioned matrix recovery methods. Fortunately, there are feasible schemes that devise appropriate and effective priori representations for describing the intrinsic information of real data. In this paper, we firstly model the matrix data ${\bf{Y}}$ as the sum of a low-rank approximation component $\bf{X}$ and an approximation error component $\cal{E}$. This finer-grained data decomposition architecture enables each component of information to be portrayed more precisely. Further, we design an overlapping group error representation (OGER) function to characterize the above error structure and propose a generalized low-rank matrix completion model based on OGER. Specifically, the low-rank component describes the global structure information of matrix data, while the OGER component not only compensates for the approximation error between the low-rank component and the real data but also better captures the local block sparsity information of matrix data. Finally, we develop an alternating direction method of multipliers (ADMM) that integrates the majorization-minimization (MM) algorithm, which enables the efficient solution of the proposed model. And we analyze the convergence of the algorithm in detail both theoretically and experimentally. In addition, the results of numerical experiments demonstrate that the proposed model outperforms existing competing models in performance.

ERD: Exponential Retinex decomposition based on weak space and hybrid nonconvex regularization and its denoising application

The Retinex theory models the image as a product of illumination and reflection components, which has received extensive attention and is widely used in image enhancement, segmentation and color restoration. However, it has been rarely used in additive noise removal due to the inclusion of both multiplication and addition operations in the Retinex noisy image modeling. In this paper, we propose an exponential Retinex decomposition model based on hybrid non-convex regularization and weak space oscillation-modeling for image denoising. The proposed model utilizes non-convex first-order total variation (TV) and non-convex second-order TV to regularize the reflection component and the illumination component, respectively, and employs weak $H^{-1}$ norm to measure the residual component. By utilizing different regularizers, the proposed model effectively decomposes the image into reflection, illumination, and noise components. An alternating direction multipliers method (ADMM) combined with the Majorize-Minimization (MM) algorithm is developed to solve the proposed model. Furthermore, we provide a detailed proof of the convergence property of the algorithm. Numerical experiments validate both the proposed model and algorithm. Compared with several state-of-the-art denoising models, the proposed model exhibits superior performance in terms of peak signal-to-noise ratio (PSNR) and mean structural similarity (MSSIM).

StrucTexTv3: An Efficient Vision-Language Model for Text-rich Image Perception, Comprehension, and Beyond

Text-rich images have significant and extensive value, deeply integrated into various aspects of human life. Notably, both visual cues and linguistic symbols in text-rich images play crucial roles in information transmission but are accompanied by diverse challenges. Therefore, the efficient and effective understanding of text-rich images is a crucial litmus test for the capability of Vision-Language Models. We have crafted an efficient vision-language model, StrucTexTv3, tailored to tackle various intelligent tasks for text-rich images. The significant design of StrucTexTv3 is presented in the following aspects: Firstly, we adopt a combination of an effective multi-scale reduced visual transformer and a multi-granularity token sampler (MG-Sampler) as a visual token generator, successfully solving the challenges of high-resolution input and complex representation learning for text-rich images. Secondly, we enhance the perception and comprehension abilities of StrucTexTv3 through instruction learning, seamlessly integrating various text-oriented tasks into a unified framework. Thirdly, we have curated a comprehensive collection of high-quality text-rich images, abbreviated as TIM-30M, encompassing diverse scenarios like incidental scenes, office documents, web pages, and screenshots, thereby improving the robustness of our model. Our method achieved SOTA results in text-rich image perception tasks, and significantly improved performance in comprehension tasks. Among multimodal models with LLM decoder of approximately 1.8B parameters, it stands out as a leader, which also makes the deployment of edge devices feasible. In summary, the StrucTexTv3 model, featuring efficient structural design, outstanding performance, and broad adaptability, offers robust support for diverse intelligent application tasks involving text-rich images, thus exhibiting immense potential for widespread application.