CDEMapper: Enhancing NIH Common Data Element Normalization using Large Language Models

Common Data Elements (CDEs) standardize data collection and sharing across studies, enhancing data interoperability and improving research reproducibility. However, implementing CDEs presents challenges due to the broad range and variety of data elements. This study aims to develop an effective and efficient mapping tool to bridge the gap between local data elements and National Institutes of Health (NIH) CDEs. We propose CDEMapper, a large language model (LLM) powered mapping tool designed to assist in mapping local data elements to NIH CDEs. CDEMapper has three core modules: (1) CDE indexing and embeddings. NIH CDEs were indexed and embedded to support semantic search; (2) CDE recommendations. The tool combines Elasticsearch (BM25 similarity methods) with state of the art GPT services to recommend candidate CDEs and their permissible values; and (3) Human review. Users review and select the NIH CDEs and values that best match their data elements and value sets. We evaluate the tool recommendation accuracy against manually annotated mapping results. CDEMapper offers a publicly available, LLM-powered, and intuitive user interface that consolidates essential and advanced mapping services into a streamlined pipeline. It provides a step by step, quality assured mapping workflow designed with a user-centered approach. The evaluation results demonstrated that augmenting BM25 with GPT embeddings and a ranker consistently enhances CDEMapper mapping accuracy in three different mapping settings across four evaluation datasets. This work opens up the potential of using LLMs to assist with CDE recommendation and human curation when aligning local data elements with NIH CDEs. Additionally, this effort enhances clinical research data interoperability and helps researchers better understand the gaps between local data elements and NIH CDEs.

Information Extraction from Clinical Notes: Are We Ready to Switch to Large Language Models?

Backgrounds: Information extraction (IE) is critical in clinical natural language processing (NLP). While large language models (LLMs) excel on generative tasks, their performance on extractive tasks remains debated. Methods: We investigated Named Entity Recognition (NER) and Relation Extraction (RE) using 1,588 clinical notes from four sources (UT Physicians, MTSamples, MIMIC-III, and i2b2). We developed an annotated corpus covering 4 clinical entities and 16 modifiers, and compared instruction-tuned LLaMA-2 and LLaMA-3 against BiomedBERT in terms of performance, generalizability, computational resources, and throughput to BiomedBERT. Results: LLaMA models outperformed BiomedBERT across datasets. With sufficient training data, LLaMA showed modest improvements (1% on NER, 1.5-3.7% on RE); improvements were larger with limited training data. On unseen i2b2 data, LLaMA-3-70B outperformed BiomedBERT by 7% (F1) on NER and 4% on RE. However, LLaMA models required more computing resources and ran up to 28 times slower. We implemented "Kiwi," a clinical IE package featuring both models, available at https://kiwi.clinicalnlp.org/. Conclusion: This study is among the first to develop and evaluate a comprehensive clinical IE system using open-source LLMs. Results indicate that LLaMA models outperform BiomedBERT for clinical NER and RE but with higher computational costs and lower throughputs. These findings highlight that choosing between LLMs and traditional deep learning methods for clinical IE applications should remain task-specific, taking into account both performance metrics and practical considerations such as available computing resources and the intended use case scenarios.

UCFE: A User-Centric Financial Expertise Benchmark for Large Language Models

This paper introduces the UCFE: User-Centric Financial Expertise benchmark, an innovative framework designed to evaluate the ability of large language models (LLMs) to handle complex real-world financial tasks. UCFE benchmark adopts a hybrid approach that combines human expert evaluations with dynamic, task-specific interactions to simulate the complexities of evolving financial scenarios. Firstly, we conducted a user study involving 804 participants, collecting their feedback on financial tasks. Secondly, based on this feedback, we created our dataset that encompasses a wide range of user intents and interactions. This dataset serves as the foundation for benchmarking 12 LLM services using the LLM-as-Judge methodology. Our results show a significant alignment between benchmark scores and human preferences, with a Pearson correlation coefficient of 0.78, confirming the effectiveness of the UCFE dataset and our evaluation approach. UCFE benchmark not only reveals the potential of LLMs in the financial sector but also provides a robust framework for assessing their performance and user satisfaction. The benchmark dataset and evaluation code are available.

AuditWen:An Open-Source Large Language Model for Audit

Intelligent auditing represents a crucial advancement in modern audit practices, enhancing both the quality and efficiency of audits within the realm of artificial intelligence. With the rise of large language model (LLM), there is enormous potential for intelligent models to contribute to audit domain. However, general LLMs applied in audit domain face the challenges of lacking specialized knowledge and the presence of data biases. To overcome these challenges, this study introduces AuditWen, an open-source audit LLM by fine-tuning Qwen with constructing instruction data from audit domain. We first outline the application scenarios for LLMs in the audit and extract requirements that shape the development of LLMs tailored for audit purposes. We then propose an audit LLM, called AuditWen, by fine-tuning Qwen with constructing 28k instruction dataset from 15 audit tasks and 3 layers. In evaluation stage, we proposed a benchmark with 3k instructions that covers a set of critical audit tasks derived from the application scenarios. With the benchmark, we compare AuditWen with other existing LLMs from information extraction, question answering and document generation. The experimental results demonstrate superior performance of AuditWen both in question understanding and answer generation, making it an immediately valuable tool for audit.

FMDLlama: Financial Misinformation Detection based on Large Language Models

The emergence of social media has made the spread of misinformation easier. In the financial domain, the accuracy of information is crucial for various aspects of financial market, which has made financial misinformation detection (FMD) an urgent problem that needs to be addressed. Large language models (LLMs) have demonstrated outstanding performance in various fields. However, current studies mostly rely on traditional methods and have not explored the application of LLMs in the field of FMD. The main reason is the lack of FMD instruction tuning datasets and evaluation benchmarks. In this paper, we propose FMDLlama, the first open-sourced instruction-following LLMs for FMD task based on fine-tuning Llama3.1 with instruction data, the first multi-task FMD instruction dataset (FMDID) to support LLM instruction tuning, and a comprehensive FMD evaluation benchmark (FMD-B) with classification and explanation generation tasks to test the FMD ability of LLMs. We compare our models with a variety of LLMs on FMD-B, where our model outperforms all other open-sourced LLMs as well as ChatGPT.

Selective Preference Optimization via Token-Level Reward Function Estimation

Recent advancements in large language model alignment leverage token-level supervisions to perform fine-grained preference optimization. However, existing token-level alignment methods either optimize on all available tokens, which can be noisy and inefficient, or perform selective training with complex and expensive key token selection strategies. In this work, we propose Selective Preference Optimization (SePO), a novel selective alignment strategy that centers on efficient key token selection. SePO proposes the first token selection method based on Direct Preference Optimization (DPO), which trains an oracle model to estimate a token-level reward function on the target data. This method applies to any existing alignment datasets with response-level annotations and enables cost-efficient token selection with small-scale oracle models and training data. The estimated reward function is then utilized to score all tokens within the target dataset, where only the key tokens are selected to supervise the target policy model with a reference model-free contrastive objective function. Extensive experiments on three public evaluation benchmarks show that SePO significantly outperforms competitive baseline methods by only optimizing 30% key tokens on the target dataset. SePO applications on weak-to-strong generalization show that weak oracle models effectively supervise strong policy models with up to 16.8x more parameters. SePO also effectively selects key tokens from out-of-distribution data to enhance strong policy models and alleviate the over-optimization problem.

Open-FinLLMs: Open Multimodal Large Language Models for Financial Applications

Large language models (LLMs) have advanced financial applications, yet they often lack sufficient financial knowledge and struggle with tasks involving multi-modal inputs like tables and time series data. To address these limitations, we introduce \textit{Open-FinLLMs}, a series of Financial LLMs. We begin with FinLLaMA, pre-trained on a 52 billion token financial corpus, incorporating text, tables, and time-series data to embed comprehensive financial knowledge. FinLLaMA is then instruction fine-tuned with 573K financial instructions, resulting in FinLLaMA-instruct, which enhances task performance. Finally, we present FinLLaVA, a multimodal LLM trained with 1.43M image-text instructions to handle complex financial data types. Extensive evaluations demonstrate FinLLaMA's superior performance over LLaMA3-8B, LLaMA3.1-8B, and BloombergGPT in both zero-shot and few-shot settings across 19 and 4 datasets, respectively. FinLLaMA-instruct outperforms GPT-4 and other Financial LLMs on 15 datasets. FinLLaVA excels in understanding tables and charts across 4 multimodal tasks. Additionally, FinLLaMA achieves impressive Sharpe Ratios in trading simulations, highlighting its robust financial application capabilities. We will continually maintain and improve our models and benchmarks to support ongoing innovation in academia and industry.

HARMONIC: Harnessing LLMs for Tabular Data Synthesis and Privacy Protection

Data serves as the fundamental foundation for advancing deep learning, particularly tabular data presented in a structured format, which is highly conducive to modeling. However, even in the era of LLM, obtaining tabular data from sensitive domains remains a challenge due to privacy or copyright concerns. Hence, exploring how to effectively use models like LLMs to generate realistic and privacy-preserving synthetic tabular data is urgent. In this paper, we take a step forward to explore LLMs for tabular data synthesis and privacy protection, by introducing a new framework HARMONIC for tabular data generation and evaluation. In the tabular data generation of our framework, unlike previous small-scale LLM-based methods that rely on continued pre-training, we explore the larger-scale LLMs with fine-tuning to generate tabular data and enhance privacy. Based on idea of the k-nearest neighbors algorithm, an instruction fine-tuning dataset is constructed to inspire LLMs to discover inter-row relationships. Then, with fine-tuning, LLMs are trained to remember the format and connections of the data rather than the data itself, which reduces the risk of privacy leakage. In the evaluation part of our framework, we develop specific privacy risk metrics DLT for LLM synthetic data generation, as well as performance evaluation metrics LLE for downstream LLM tasks. Our experiments find that this tabular data generation framework achieves equivalent performance to existing methods with better privacy, which also demonstrates our evaluation framework for the effectiveness of synthetic data and privacy risks in LLM scenarios.

FinCon: A Synthesized LLM Multi-Agent System with Conceptual Verbal Reinforcement for Enhanced Financial Decision Making

Large language models (LLMs) have demonstrated notable potential in conducting complex tasks and are increasingly utilized in various financial applications. However, high-quality sequential financial investment decision-making remains challenging. These tasks require multiple interactions with a volatile environment for every decision, demanding sufficient intelligence to maximize returns and manage risks. Although LLMs have been used to develop agent systems that surpass human teams and yield impressive investment returns, opportunities to enhance multi-sourced information synthesis and optimize decision-making outcomes through timely experience refinement remain unexplored. Here, we introduce the FinCon, an LLM-based multi-agent framework with CONceptual verbal reinforcement tailored for diverse FINancial tasks. Inspired by effective real-world investment firm organizational structures, FinCon utilizes a manager-analyst communication hierarchy. This structure allows for synchronized cross-functional agent collaboration towards unified goals through natural language interactions and equips each agent with greater memory capacity than humans. Additionally, a risk-control component in FinCon enhances decision quality by episodically initiating a self-critiquing mechanism to update systematic investment beliefs. The conceptualized beliefs serve as verbal reinforcement for the future agent's behavior and can be selectively propagated to the appropriate node that requires knowledge updates. This feature significantly improves performance while reducing unnecessary peer-to-peer communication costs. Moreover, FinCon demonstrates strong generalization capabilities in various financial tasks, including single stock trading and portfolio management.

MetaAligner: Conditional Weak-to-Strong Correction for Generalizable Multi-Objective Alignment of Language Models

Recent advancements in large language models (LLMs) aim to tackle heterogeneous human expectations and values via multi-objective preference alignment. However, existing methods are parameter-adherent to the policy model, leading to two key limitations: (1) the high-cost repetition of their alignment algorithms for each new target model; (2) they cannot expand to unseen objectives due to their static alignment objectives. In this work, we propose Meta-Objective Aligner (MetaAligner), a model that performs conditional weak-to-strong correction for weak responses to approach strong responses. MetaAligner is the first policy-agnostic and generalizable method for multi-objective preference alignment, which enables plug-and-play alignment by decoupling parameter updates from the policy models and facilitates zero-shot preference alignment for unseen objectives via in-context learning. Experimental results show that MetaAligner achieves significant and balanced improvements in multi-objective alignments on 11 policy models with up to 63x more parameters, and outperforms previous alignment methods with down to 22.27x less computational resources. The model also accurately aligns with unseen objectives, marking the first step towards generalizable multi-objective preference alignment.