Towards Generalizable Tumor Synthesis

Tumor synthesis enables the creation of artificial tumors in medical images, facilitating the training of AI models for tumor detection and segmentation. However, success in tumor synthesis hinges on creating visually realistic tumors that are generalizable across multiple organs and, furthermore, the resulting AI models being capable of detecting real tumors in images sourced from different domains (e.g., hospitals). This paper made a progressive stride toward generalizable tumor synthesis by leveraging a critical observation: early-stage tumors (< 2cm) tend to have similar imaging characteristics in computed tomography (CT), whether they originate in the liver, pancreas, or kidneys. We have ascertained that generative AI models, e.g., Diffusion Models, can create realistic tumors generalized to a range of organs even when trained on a limited number of tumor examples from only one organ. Moreover, we have shown that AI models trained on these synthetic tumors can be generalized to detect and segment real tumors from CT volumes, encompassing a broad spectrum of patient demographics, imaging protocols, and healthcare facilities.

Editing Out-of-domain GAN Inversion via Differential Activations

Despite the demonstrated editing capacity in the latent space of a pretrained GAN model, inverting real-world images is stuck in a dilemma that the reconstruction cannot be faithful to the original input. The main reason for this is that the distributions between training and real-world data are misaligned, and because of that, it is unstable of GAN inversion for real image editing. In this paper, we propose a novel GAN prior based editing framework to tackle the out-of-domain inversion problem with a composition-decomposition paradigm. In particular, during the phase of composition, we introduce a differential activation module for detecting semantic changes from a global perspective, \ie, the relative gap between the features of edited and unedited images. With the aid of the generated Diff-CAM mask, a coarse reconstruction can intuitively be composited by the paired original and edited images. In this way, the attribute-irrelevant regions can be survived in almost whole, while the quality of such an intermediate result is still limited by an unavoidable ghosting effect. Consequently, in the decomposition phase, we further present a GAN prior based deghosting network for separating the final fine edited image from the coarse reconstruction. Extensive experiments exhibit superiorities over the state-of-the-art methods, in terms of qualitative and quantitative evaluations. The robustness and flexibility of our method is also validated on both scenarios of single attribute and multi-attribute manipulations.