MOOSE-Chem: Large Language Models for Rediscovering Unseen Chemistry Scientific Hypotheses

Scientific discovery contributes largely to human society's prosperity, and recent progress shows that LLMs could potentially catalyze this process. However, it is still unclear whether LLMs can discover novel and valid hypotheses in chemistry. In this work, we investigate this central research question: Can LLMs automatically discover novel and valid chemistry research hypotheses given only a chemistry research background (consisting of a research question and/or a background survey), without limitation on the domain of the research question? After extensive discussions with chemistry experts, we propose an assumption that a majority of chemistry hypotheses can be resulted from a research background and several inspirations. With this key insight, we break the central question into three smaller fundamental questions. In brief, they are: (1) given a background question, whether LLMs can retrieve good inspirations; (2) with background and inspirations, whether LLMs can lead to hypothesis; and (3) whether LLMs can identify good hypotheses to rank them higher. To investigate these questions, we construct a benchmark consisting of 51 chemistry papers published in Nature, Science, or a similar level in 2024 (all papers are only available online since 2024). Every paper is divided by chemistry PhD students into three components: background, inspirations, and hypothesis. The goal is to rediscover the hypothesis, given only the background and a large randomly selected chemistry literature corpus consisting the ground truth inspiration papers, with LLMs trained with data up to 2023. We also develop an LLM-based multi-agent framework that leverages the assumption, consisting of three stages reflecting the three smaller questions. The proposed method can rediscover many hypotheses with very high similarity with the ground truth ones, covering the main innovations.

Negation Blindness in Large Language Models: Unveiling the NO Syndrome in Image Generation

Foundational Large Language Models (LLMs) have changed the way we perceive technology. They have been shown to excel in tasks ranging from poem writing and coding to essay generation and puzzle solving. With the incorporation of image generation capability, they have become more comprehensive and versatile AI tools. At the same time, researchers are striving to identify the limitations of these tools to improve them further. Currently identified flaws include hallucination, biases, and bypassing restricted commands to generate harmful content. In the present work, we have identified a fundamental limitation related to the image generation ability of LLMs, and termed it The NO Syndrome. This negation blindness refers to LLMs inability to correctly comprehend NO related natural language prompts to generate the desired images. Interestingly, all tested LLMs including GPT-4, Gemini, and Copilot were found to be suffering from this syndrome. To demonstrate the generalization of this limitation, we carried out simulation experiments and conducted entropy-based and benchmark statistical analysis tests on various LLMs in multiple languages, including English, Hindi, and French. We conclude that the NO syndrome is a significant flaw in current LLMs that needs to be addressed. A related finding of this study showed a consistent discrepancy between image and textual responses as a result of this NO syndrome. We posit that the introduction of a negation context-aware reinforcement learning based feedback loop between the LLMs textual response and generated image could help ensure the generated text is based on both the LLMs correct contextual understanding of the negation query and the generated visual output.

Has Multimodal Learning Delivered Universal Intelligence in Healthcare? A Comprehensive Survey

The rapid development of artificial intelligence has constantly reshaped the field of intelligent healthcare and medicine. As a vital technology, multimodal learning has increasingly garnered interest due to data complementarity, comprehensive modeling form, and great application potential. Currently, numerous researchers are dedicating their attention to this field, conducting extensive studies and constructing abundant intelligent systems. Naturally, an open question arises that has multimodal learning delivered universal intelligence in healthcare? To answer the question, we adopt three unique viewpoints for a holistic analysis. Firstly, we conduct a comprehensive survey of the current progress of medical multimodal learning from the perspectives of datasets, task-oriented methods, and universal foundation models. Based on them, we further discuss the proposed question from five issues to explore the real impacts of advanced techniques in healthcare, from data and technologies to performance and ethics. The answer is that current technologies have NOT achieved universal intelligence and there remains a significant journey to undertake. Finally, in light of the above reviews and discussions, we point out ten potential directions for exploration towards the goal of universal intelligence in healthcare.

PanoSent: A Panoptic Sextuple Extraction Benchmark for Multimodal Conversational Aspect-based Sentiment Analysis

While existing Aspect-based Sentiment Analysis (ABSA) has received extensive effort and advancement, there are still gaps in defining a more holistic research target seamlessly integrating multimodality, conversation context, fine-granularity, and also covering the changing sentiment dynamics as well as cognitive causal rationales. This paper bridges the gaps by introducing a multimodal conversational ABSA, where two novel subtasks are proposed: 1) Panoptic Sentiment Sextuple Extraction, panoramically recognizing holder, target, aspect, opinion, sentiment, rationale from multi-turn multi-party multimodal dialogue. 2) Sentiment Flipping Analysis, detecting the dynamic sentiment transformation throughout the conversation with the causal reasons. To benchmark the tasks, we construct PanoSent, a dataset annotated both manually and automatically, featuring high quality, large scale, multimodality, multilingualism, multi-scenarios, and covering both implicit and explicit sentiment elements. To effectively address the tasks, we devise a novel Chain-of-Sentiment reasoning framework, together with a novel multimodal large language model (namely Sentica) and a paraphrase-based verification mechanism. Extensive evaluations demonstrate the superiority of our methods over strong baselines, validating the efficacy of all our proposed methods. The work is expected to open up a new era for the ABSA community, and thus all our codes and data are open at https://PanoSent.github.io/

XAI meets LLMs: A Survey of the Relation between Explainable AI and Large Language Models

In this survey, we address the key challenges in Large Language Models (LLM) research, focusing on the importance of interpretability. Driven by increasing interest from AI and business sectors, we highlight the need for transparency in LLMs. We examine the dual paths in current LLM research and eXplainable Artificial Intelligence (XAI): enhancing performance through XAI and the emerging focus on model interpretability. Our paper advocates for a balanced approach that values interpretability equally with functional advancements. Recognizing the rapid development in LLM research, our survey includes both peer-reviewed and preprint (arXiv) papers, offering a comprehensive overview of XAI's role in LLM research. We conclude by urging the research community to advance both LLM and XAI fields together.

Prompted Aspect Key Point Analysis for Quantitative Review Summarization

Key Point Analysis (KPA) aims for quantitative summarization that provides key points (KPs) as succinct textual summaries and quantities measuring their prevalence. KPA studies for arguments and reviews have been reported in the literature. A majority of KPA studies for reviews adopt supervised learning to extract short sentences as KPs before matching KPs to review comments for quantification of KP prevalence. Recent abstractive approaches still generate KPs based on sentences, often leading to KPs with overlapping and hallucinated opinions, and inaccurate quantification. In this paper, we propose Prompted Aspect Key Point Analysis (PAKPA) for quantitative review summarization. PAKPA employs aspect sentiment analysis and prompted in-context learning with Large Language Models (LLMs) to generate and quantify KPs grounded in aspects for business entities, which achieves faithful KPs with accurate quantification, and removes the need for large amounts of annotated data for supervised training. Experiments on the popular review dataset Yelp and the aspect-oriented review summarization dataset SPACE show that our framework achieves state-of-the-art performance. Source code and data are available at: https://github.com/antangrocket1312/PAKPA

Self-training Large Language Models through Knowledge Detection

Large language models (LLMs) often necessitate extensive labeled datasets and training compute to achieve impressive performance across downstream tasks. This paper explores a self-training paradigm, where the LLM autonomously curates its own labels and selectively trains on unknown data samples identified through a reference-free consistency method. Empirical evaluations demonstrate significant improvements in reducing hallucination in generation across multiple subjects. Furthermore, the selective training framework mitigates catastrophic forgetting in out-of-distribution benchmarks, addressing a critical limitation in training LLMs. Our findings suggest that such an approach can substantially reduce the dependency on large labeled datasets, paving the way for more scalable and cost-effective language model training.

The MuSe 2024 Multimodal Sentiment Analysis Challenge: Social Perception and Humor Recognition

The Multimodal Sentiment Analysis Challenge (MuSe) 2024 addresses two contemporary multimodal affect and sentiment analysis problems: In the Social Perception Sub-Challenge (MuSe-Perception), participants will predict 16 different social attributes of individuals such as assertiveness, dominance, likability, and sincerity based on the provided audio-visual data. The Cross-Cultural Humor Detection Sub-Challenge (MuSe-Humor) dataset expands upon the Passau Spontaneous Football Coach Humor (Passau-SFCH) dataset, focusing on the detection of spontaneous humor in a cross-lingual and cross-cultural setting. The main objective of MuSe 2024 is to unite a broad audience from various research domains, including multimodal sentiment analysis, audio-visual affective computing, continuous signal processing, and natural language processing. By fostering collaboration and exchange among experts in these fields, the MuSe 2024 endeavors to advance the understanding and application of sentiment analysis and affective computing across multiple modalities. This baseline paper provides details on each sub-challenge and its corresponding dataset, extracted features from each data modality, and discusses challenge baselines. For our baseline system, we make use of a range of Transformers and expert-designed features and train Gated Recurrent Unit (GRU)-Recurrent Neural Network (RNN) models on them, resulting in a competitive baseline system. On the unseen test datasets of the respective sub-challenges, it achieves a mean Pearson's Correlation Coefficient ($\rho$) of 0.3573 for MuSe-Perception and an Area Under the Curve (AUC) value of 0.8682 for MuSe-Humor.

SemEval-2024 Task 3: Multimodal Emotion Cause Analysis in Conversations

The ability to understand emotions is an essential component of human-like artificial intelligence, as emotions greatly influence human cognition, decision making, and social interactions. In addition to emotion recognition in conversations, the task of identifying the potential causes behind an individual's emotional state in conversations, is of great importance in many application scenarios. We organize SemEval-2024 Task 3, named Multimodal Emotion Cause Analysis in Conversations, which aims at extracting all pairs of emotions and their corresponding causes from conversations. Under different modality settings, it consists of two subtasks: Textual Emotion-Cause Pair Extraction in Conversations (TECPE) and Multimodal Emotion-Cause Pair Extraction in Conversations (MECPE). The shared task has attracted 143 registrations and 216 successful submissions. In this paper, we introduce the task, dataset and evaluation settings, summarize the systems of the top teams, and discuss the findings of the participants.

MER 2024: Semi-Supervised Learning, Noise Robustness, and Open-Vocabulary Multimodal Emotion Recognition

Multimodal emotion recognition is an important research topic in artificial intelligence. Over the past few decades, researchers have made remarkable progress by increasing dataset size and building more effective architectures. However, due to various reasons (such as complex environments and inaccurate labels), current systems still cannot meet the demands of practical applications. Therefore, we plan to organize a series of challenges around emotion recognition to further promote the development of this field. Last year, we launched MER2023, focusing on three topics: multi-label learning, noise robustness, and semi-supervised learning. This year, we continue to organize MER2024. In addition to expanding the dataset size, we introduce a new track around open-vocabulary emotion recognition. The main consideration for this track is that existing datasets often fix the label space and use majority voting to enhance annotator consistency, but this process may limit the model's ability to describe subtle emotions. In this track, we encourage participants to generate any number of labels in any category, aiming to describe the emotional state as accurately as possible. Our baseline is based on MERTools and the code is available at: https://github.com/zeroQiaoba/MERTools/tree/master/MER2024.