Abstract:Spatial understanding is crucial for foundation models (FMs), and maps have long helped humans organize and reason about geographic information. This study examines whether choropleth maps remain useful for machine spatial understanding when models can directly process structured geodata. We introduce ChoroplethMap-Bench, a controlled benchmark containing 2,400 synthetic choropleth maps, corresponding GeoJSON data, and 12,000 questions across five cognitive dimensions: Identify, Spatial Recognition, Compare, Rank, and Delineate. We evaluate 22 open-source and proprietary models under three input conditions: Data Only, Map Only, and Data + Map. The results show that maps substantially improve spatial reasoning, especially when combined with symbolic data and for tasks requiring higher-level understanding of spatial patterns. We further analyze the effects of map type, color hue, and spatial structure, as well as prompting strategies, language, geographic context, decoding settings, classification methods, and response stability. Overall, the Data + Map condition achieves the strongest performance, demonstrating that maps remain valuable external representations for foundation model spatial reasoning.
Abstract:Foundation models are reshaping computational pathology, yet their capabilities remain shaped by pretraining objectives, data sources, and spatial scales, fragmenting complementary expertise across separate backbones. Here we present ALICE, a unified foundation model trained through multi-stage agglomerative distillation that sequentially distills eight vision-only, vision-language, and slide-level teacher models into dedicated modules of a single backbone. ALICE is pretrained on 24,985,184 tile-level pathology images and 155,604 high-resolution images, and evaluated across 21 task scenarios, 96 downstream tasks, and 48 data sources, spanning region-of-interest tissue analysis, vision-language multimodal evaluation, and whole-slide clinical assessment. In all three evaluation settings, ALICE achieved the best average rank among task-matched pathology foundation models. These results demonstrate that agglomerative distillation can consolidate complementary capabilities from specialized models into a unified backbone for broad computational pathology applications. The model is available at https://github.com/WonderLandxD/ALICE.
Abstract:In recent years, with the emergence of Temporal Knowledge Graphs (TKGs), research on learning entity and relation representations in TKGs has attracted increasing attention, giving rise to a large number of TKG embedding methods. TeRo is a simple and efficient temporal knowledge graph embedding approach. However, TeRo does not do well in modeling the mapping properties of various relations, such as one-to-many, many-to-one, and many-to-many. Meanwhile, it also has limitations in the expression of temporal information. To address these issues, we propose a novel TKG embedding method named TeRoR. This method divides the temporal evolution of entity embeddings, and conducts independent rotation transformations on head and tail entities in the complex vector space to strengthen temporal information modeling capacity. In terms of relational characteristics, we train a radius to constrain the rotated and translated head entities within a circular region centered on the tail entity, which effectively captures the diverse mapping properties of relations. Experimental results demonstrate that TeRoR achieves competitive performance against state-of-the-art models on four distinct TKG datasets.
Abstract:Real-world knowledge graphs are often incomplete, lacking many valid facts. Knowledge Graph Completion (KGC) aims to predict missing links using known triples, thereby enhancing graph coverage. A key challenge is modeling diverse relational patterns such as symmetry, antisymmetry, inversion, composition and semantic hierarchy. Existing models such as RotatE can capture symmetric, antisymmetric, inverse, and commutative composition patterns, yet struggle with non-commutative composition. Rotate3D addresses this by introducing non-commutativity via three-dimensional rotations, but still fails to capture the semantic hierarchies prevalent in knowledge graphs. Moreover, both models cannot effectively model one-to-many relations. To overcome these limitations, we propose RelBall, which extends Rotate3D with two innovations. First, our model introduces modulus transformation to model hierarchies, driving abstract concepts toward smaller moduli and concrete instances toward larger ones. Second, it introduces a tail-centric relation ball to model one-to-one, one-to-many, many-to-one, and many-to-many relations. RelBall offers the following advantages: (1) coverage of all relational patterns, including the ones mentioned above; (2) an interpretable hierarchical representation where the modulus directly reflect semantic levels; (3) support for one-to-one, one-to-many, many-to-one, and many-to-many relations. Experiments on multiple datasets demonstrate RelBall's competitive link prediction performance against various baselines.
Abstract:Recent years have witnessed the rapid evolution of AI agents toward handling increasingly complex, real-world tasks. However, existing benchmarks rarely evaluate whether agents can operate graphical user interfaces to complete long-horizon, high-value professional workflows across diverse domains. Current GUI benchmarks still predominantly focus on general-purpose software, relatively simple applications, and short-horizon tasks, leaving it largely unknown whether modern agents can follow user instructions to autonomously operate domain-specific professional software and accomplish economically valuable work in an end-to-end manner. To bridge this gap, we introduce Workflow-GYM, a benchmark for long-horizon GUI tasks centered on professional domains and specialized software environments. Through extensive experiments on state-of-the-art models, we find that even the strongest models achieve only slightly above 30% success rates, highlighting that professional long-horizon GUI workflows remain highly challenging for current GUI agents. Further analysis reveals that current agents struggle to maintain long-horizon workflow consistency, frequently exhibiting workflow stage omission, error propagation, objective drift, and insufficient understanding of professional software environments. Our findings provide important insights into the limitations of current agent systems and suggest key directions for the next generation of GUI-agent research.
Abstract:Glomerular pathology is central to the diagnosis and prognosis of renal diseases, yet the heterogeneity of glomerular morphology and fine-grained lesion patterns remain challenging for current AI approaches. We present GloPath, an entity-centric foundation model trained on over one million glomeruli extracted from 14,049 renal biopsy specimens using multi-scale and multi-view self-supervised learning. GloPath addresses two major challenges in nephropathology: glomerular lesion assessment and clinicopathological insights discovery. For lesion assessment, GloPath was benchmarked across three independent cohorts on 52 tasks, including lesion recognition, grading, few-shot classification, and cross-modality diagnosis-outperforming state-of-the-art methods in 42 tasks (80.8%). In the large-scale real-world study, it achieved an ROC-AUC of 91.51% for lesion recognition, demonstrating strong robustness in routine clinical settings. For clinicopathological insights, GloPath systematically revealed statistically significant associations between glomerular morphological parameters and clinical indicators across 224 morphology-clinical variable pairs, demonstrating its capacity to connect tissue-level pathology with patient-level outcomes. Together, these results position GloPath as a scalable and interpretable platform for glomerular lesion assessment and clinicopathological discovery, representing a step toward clinically translatable AI in renal pathology.
Abstract:Immunohistochemical (IHC) staining provides crucial molecular characterization of tissue samples and plays an indispensable role in the clinical examination and diagnosis of cancers. However, compared with the commonly used Hematoxylin and Eosin (H&E) staining, IHC staining involves complex procedures and is both time-consuming and expensive, which limits its widespread clinical use. Virtual staining converts H&E images to IHC images, offering a cost-effective alternative to clinical IHC staining. Nevertheless, using adjacent slides as ground truth often results in weakly-paired data with spatial misalignment and local deformations, hindering effective supervised learning. To address these challenges, we propose a novel topology-aware framework for H&E-to-IHC virtual staining. Specifically, we introduce a Topology-aware Consistency Matching (TACM) mechanism that employs graph contrastive learning and topological perturbations to learn robust matching patterns despite spatial misalignments, ensuring structural consistency. Furthermore, we propose a Topology-constrained Pathological Matching (TCPM) mechanism that aligns pathological positive regions based on node importance to enhance pathological consistency. Extensive experiments on two benchmarks across four staining tasks demonstrate that our method outperforms state-of-the-art approaches, achieving superior generation quality with higher clinical relevance.
Abstract:Recent advances in coding agents suggest rapid progress toward autonomous software development, yet existing benchmarks fail to rigorously evaluate the long-horizon capabilities required to build complete software systems. Most prior evaluations focus on localized code generation, scaffolded completion, or short-term repair tasks, leaving open the question of whether agents can sustain coherent reasoning, planning, and execution over the extended horizons demanded by real-world repository construction. To address this gap, we present NL2Repo Bench, a benchmark explicitly designed to evaluate the long-horizon repository generation ability of coding agents. Given only a single natural-language requirements document and an empty workspace, agents must autonomously design the architecture, manage dependencies, implement multi-module logic, and produce a fully installable Python library. Our experiments across state-of-the-art open- and closed-source models reveal that long-horizon repository generation remains largely unsolved: even the strongest agents achieve below 40% average test pass rates and rarely complete an entire repository correctly. Detailed analysis uncovers fundamental long-horizon failure modes, including premature termination, loss of global coherence, fragile cross-file dependencies, and inadequate planning over hundreds of interaction steps. NL2Repo Bench establishes a rigorous, verifiable testbed for measuring sustained agentic competence and highlights long-horizon reasoning as a central bottleneck for the next generation of autonomous coding agents.
Abstract:Audio classification plays an essential role in sentiment analysis and emotion recognition, especially for analyzing customer attitudes in marketing phone calls. Efficiently categorizing customer purchasing propensity from large volumes of audio data remains challenging. In this work, we propose a novel Multi-Segment Multi-Task Fusion Network (MSMT-FN) that is uniquely designed for addressing this business demand. Evaluations conducted on our proprietary MarketCalls dataset, as well as established benchmarks (CMU-MOSI, CMU-MOSEI, and MELD), show MSMT-FN consistently outperforms or matches state-of-the-art methods. Additionally, our newly curated MarketCalls dataset will be available upon request, and the code base is made accessible at GitHub Repository MSMT-FN, to facilitate further research and advancements in audio classification domain.
Abstract:With the rapid advancement of large foundation models, AIGC, cloud rendering, and real-time motion capture technologies, digital humans are now capable of achieving synchronized facial expressions and body movements, engaging in intelligent dialogues driven by natural language, and enabling the fast creation of personalized avatars. While current mainstream approaches to digital humans primarily focus on 3D models and 2D video-based representations, interactive 2D cartoon-style digital humans have received relatively less attention. Compared to 3D digital humans that require complex modeling and high rendering costs, and 2D video-based solutions that lack flexibility and real-time interactivity, 2D cartoon-style Live2D models offer a more efficient and expressive alternative. By simulating 3D-like motion through layered segmentation without the need for traditional 3D modeling, Live2D enables dynamic and real-time manipulation. In this technical report, we present CartoonAlive, an innovative method for generating high-quality Live2D digital humans from a single input portrait image. CartoonAlive leverages the shape basis concept commonly used in 3D face modeling to construct facial blendshapes suitable for Live2D. It then infers the corresponding blendshape weights based on facial keypoints detected from the input image. This approach allows for the rapid generation of a highly expressive and visually accurate Live2D model that closely resembles the input portrait, within less than half a minute. Our work provides a practical and scalable solution for creating interactive 2D cartoon characters, opening new possibilities in digital content creation and virtual character animation. The project homepage is https://human3daigc.github.io/CartoonAlive_webpage/.