APTOS-2024 challenge report: Generation of synthetic 3D OCT images from fundus photographs

Optical Coherence Tomography (OCT) provides high-resolution, 3D, and non-invasive visualization of retinal layers in vivo, serving as a critical tool for lesion localization and disease diagnosis. However, its widespread adoption is limited by equipment costs and the need for specialized operators. In comparison, 2D color fundus photography offers faster acquisition and greater accessibility with less dependence on expensive devices. Although generative artificial intelligence has demonstrated promising results in medical image synthesis, translating 2D fundus images into 3D OCT images presents unique challenges due to inherent differences in data dimensionality and biological information between modalities. To advance generative models in the fundus-to-3D-OCT setting, the Asia Pacific Tele-Ophthalmology Society (APTOS-2024) organized a challenge titled Artificial Intelligence-based OCT Generation from Fundus Images. This paper details the challenge framework (referred to as APTOS-2024 Challenge), including: the benchmark dataset, evaluation methodology featuring two fidelity metrics-image-based distance (pixel-level OCT B-scan similarity) and video-based distance (semantic-level volumetric consistency), and analysis of top-performing solutions. The challenge attracted 342 participating teams, with 42 preliminary submissions and 9 finalists. Leading methodologies incorporated innovations in hybrid data preprocessing or augmentation (cross-modality collaborative paradigms), pre-training on external ophthalmic imaging datasets, integration of vision foundation models, and model architecture improvement. The APTOS-2024 Challenge is the first benchmark demonstrating the feasibility of fundus-to-3D-OCT synthesis as a potential solution for improving ophthalmic care accessibility in under-resourced healthcare settings, while helping to expedite medical research and clinical applications.

SAR2Struct: Extracting 3D Semantic Structural Representation of Aircraft Targets from Single-View SAR Image

To translate synthetic aperture radar (SAR) image into interpretable forms for human understanding is the ultimate goal of SAR advanced information retrieval. Existing methods mainly focus on 3D surface reconstruction or local geometric feature extraction of targets, neglecting the role of structural modeling in capturing semantic information. This paper proposes a novel task: SAR target structure recovery, which aims to infer the components of a target and the structural relationships between its components, specifically symmetry and adjacency, from a single-view SAR image. Through learning the structural consistency and geometric diversity across the same type of targets as observed in different SAR images, it aims to derive the semantic representation of target directly from its 2D SAR image. To solve this challenging task, a two-step algorithmic framework based on structural descriptors is developed. Specifically, in the training phase, it first detects 2D keypoints from real SAR images, and then learns the mapping from these keypoints to 3D hierarchical structures using simulated data. During the testing phase, these two steps are integrated to infer the 3D structure from real SAR images. Experimental results validated the effectiveness of each step and demonstrated, for the first time, that 3D semantic structural representation of aircraft targets can be directly derived from a single-view SAR image.

Normalized Radon Cumulative Distribution Transforms for Invariance and Robustness in Optimal Transport Based Image Classification

The Radon cumulative distribution transform (R-CDT), is an easy-to-compute feature extractor that facilitates image classification tasks especially in the small data regime. It is closely related to the sliced Wasserstein distance and provably guaranties the linear separability of image classes that emerge from translations or scalings. In many real-world applications, like the recognition of watermarks in filigranology, however, the data is subject to general affine transformations originating from the measurement process. To overcome this issue, we recently introduced the so-called max-normalized R-CDT that only requires elementary operations and guaranties the separability under arbitrary affine transformations. The aim of this paper is to continue our study of the max-normalized R-CDT especially with respect to its robustness against non-affine image deformations. Our sensitivity analysis shows that its separability properties are stable provided the Wasserstein-infinity distance between the samples can be controlled. Since the Wasserstein-infinity distance only allows small local image deformations, we moreover introduce a mean-normalized version of the R-CDT. In this case, robustness relates to the Wasserstein-2 distance and also covers image deformations caused by impulsive noise for instance. Our theoretical results are supported by numerical experiments showing the effectiveness of our novel feature extractors as well as their robustness against local non-affine deformations and impulsive noise.

Unsupervised risk factor identification across cancer types and data modalities via explainable artificial intelligence

Risk stratification is a key tool in clinical decision-making, yet current approaches often fail to translate sophisticated survival analysis into actionable clinical criteria. We present a novel method for unsupervised machine learning that directly optimizes for survival heterogeneity across patient clusters through a differentiable adaptation of the multivariate logrank statistic. Unlike most existing methods that rely on proxy metrics, our approach represents novel methodology for training any neural network architecture on any data modality to identify prognostically distinct patient groups. We thoroughly evaluate the method in simulation experiments and demonstrate its utility in practice by applying it to two distinct cancer types: analyzing laboratory parameters from multiple myeloma patients and computed tomography images from non-small cell lung cancer patients, identifying prognostically distinct patient subgroups with significantly different survival outcomes in both cases. Post-hoc explainability analyses uncover clinically meaningful features determining the group assignments which align well with established risk factors and thus lend strong weight to the methods utility. This pan-cancer, model-agnostic approach represents a valuable advancement in clinical risk stratification, enabling the discovery of novel prognostic signatures across diverse data types while providing interpretable results that promise to complement treatment personalization and clinical decision-making in oncology and beyond.

SPC to 3D: Novel View Synthesis from Binary SPC via I2I translation

Single Photon Avalanche Diodes (SPADs) represent a cutting-edge imaging technology, capable of detecting individual photons with remarkable timing precision. Building on this sensitivity, Single Photon Cameras (SPCs) enable image capture at exceptionally high speeds under both low and high illumination. Enabling 3D reconstruction and radiance field recovery from such SPC data holds significant promise. However, the binary nature of SPC images leads to severe information loss, particularly in texture and color, making traditional 3D synthesis techniques ineffective. To address this challenge, we propose a modular two-stage framework that converts binary SPC images into high-quality colorized novel views. The first stage performs image-to-image (I2I) translation using generative models such as Pix2PixHD, converting binary SPC inputs into plausible RGB representations. The second stage employs 3D scene reconstruction techniques like Neural Radiance Fields (NeRF) or Gaussian Splatting (3DGS) to generate novel views. We validate our two-stage pipeline (Pix2PixHD + Nerf/3DGS) through extensive qualitative and quantitative experiments, demonstrating significant improvements in perceptual quality and geometric consistency over the alternative baseline.

Deep learning image burst stacking to reconstruct high-resolution ground-based solar observations

Large aperture ground based solar telescopes allow the solar atmosphere to be resolved in unprecedented detail. However, observations are limited by Earths turbulent atmosphere, requiring post image corrections. Current reconstruction methods using short exposure bursts face challenges with strong turbulence and high computational costs. We introduce a deep learning approach that reconstructs 100 short exposure images into one high quality image in real time. Using unpaired image to image translation, our model is trained on degraded bursts with speckle reconstructions as references, improving robustness and generalization. Our method shows an improved robustness in terms of perceptual quality, especially when speckle reconstructions show artifacts. An evaluation with a varying number of images per burst demonstrates that our method makes efficient use of the combined image information and achieves the best reconstructions when provided with the full image burst.

LoopDB: A Loop Closure Dataset for Large Scale Simultaneous Localization and Mapping

In this study, we introduce LoopDB, which is a challenging loop closure dataset comprising over 1000 images captured across diverse environments, including parks, indoor scenes, parking spaces, as well as centered around individual objects. Each scene is represented by a sequence of five consecutive images. The dataset was collected using a high resolution camera, providing suitable imagery for benchmarking the accuracy of loop closure algorithms, typically used in simultaneous localization and mapping. As ground truth information, we provide computed rotations and translations between each consecutive images. Additional to its benchmarking goal, the dataset can be used to train and fine-tune loop closure methods based on deep neural networks. LoopDB is publicly available at https://github.com/RovisLab/LoopDB.

Synthetic multi-inversion time magnetic resonance images for visualization of subcortical structures

Purpose: Visualization of subcortical gray matter is essential in neuroscience and clinical practice, particularly for disease understanding and surgical planning.While multi-inversion time (multi-TI) T$_1$-weighted (T$_1$-w) magnetic resonance (MR) imaging improves visualization, it is rarely acquired in clinical settings. Approach: We present SyMTIC (Synthetic Multi-TI Contrasts), a deep learning method that generates synthetic multi-TI images using routinely acquired T$_1$-w, T$_2$-weighted (T$_2$-w), and FLAIR images. Our approach combines image translation via deep neural networks with imaging physics to estimate longitudinal relaxation time (T$_1$) and proton density (PD) maps. These maps are then used to compute multi-TI images with arbitrary inversion times. Results: SyMTIC was trained using paired MPRAGE and FGATIR images along with T$_2$-w and FLAIR images. It accurately synthesized multi-TI images from standard clinical inputs, achieving image quality comparable to that from explicitly acquired multi-TI data.The synthetic images, especially for TI values between 400-800 ms, enhanced visualization of subcortical structures and improved segmentation of thalamic nuclei. Conclusion: SyMTIC enables robust generation of high-quality multi-TI images from routine MR contrasts. It generalizes well to varied clinical datasets, including those with missing FLAIR images or unknown parameters, offering a practical solution for improving brain MR image visualization and analysis.

SocialCredit+

SocialCredit+ is AI powered credit scoring system that leverages publicly available social media data to augment traditional credit evaluation. It uses a conversational banking assistant to gather user consent and fetch public profiles. Multimodal feature extractors analyze posts, bios, images, and friend networks to generate a rich behavioral profile. A specialized Sharia-compliance layer flags any non-halal indicators and prohibited financial behavior based on Islamic ethics. The platform employs a retrieval-augmented generation module: an LLM accesses a domain specific knowledge base to generate clear, text-based explanations for each decision. We describe the end-to-end architecture and data flow, the models used, and system infrastructure. Synthetic scenarios illustrate how social signals translate into credit-score factors. This paper emphasizes conceptual novelty, compliance mechanisms, and practical impact, targeting AI researchers, fintech practitioners, ethical banking jurists, and investors.

ConECT Dataset: Overcoming Data Scarcity in Context-Aware E-Commerce MT

Neural Machine Translation (NMT) has improved translation by using Transformer-based models, but it still struggles with word ambiguity and context. This problem is especially important in domain-specific applications, which often have problems with unclear sentences or poor data quality. Our research explores how adding information to models can improve translations in the context of e-commerce data. To this end we create ConECT -- a new Czech-to-Polish e-commerce product translation dataset coupled with images and product metadata consisting of 11,400 sentence pairs. We then investigate and compare different methods that are applicable to context-aware translation. We test a vision-language model (VLM), finding that visual context aids translation quality. Additionally, we explore the incorporation of contextual information into text-to-text models, such as the product's category path or image descriptions. The results of our study demonstrate that the incorporation of contextual information leads to an improvement in the quality of machine translation. We make the new dataset publicly available.