PADReg: Physics-Aware Deformable Registration Guided by Contact Force for Ultrasound Sequences

Ultrasound deformable registration estimates spatial transformations between pairs of deformed ultrasound images, which is crucial for capturing biomechanical properties and enhancing diagnostic accuracy in diseases such as thyroid nodules and breast cancer. However, ultrasound deformable registration remains highly challenging, especially under large deformation. The inherently low contrast, heavy noise and ambiguous tissue boundaries in ultrasound images severely hinder reliable feature extraction and correspondence matching. Existing methods often suffer from poor anatomical alignment and lack physical interpretability. To address the problem, we propose PADReg, a physics-aware deformable registration framework guided by contact force. PADReg leverages synchronized contact force measured by robotic ultrasound systems as a physical prior to constrain the registration. Specifically, instead of directly predicting deformation fields, we first construct a pixel-wise stiffness map utilizing the multi-modal information from contact force and ultrasound images. The stiffness map is then combined with force data to estimate a dense deformation field, through a lightweight physics-aware module inspired by Hooke's law. This design enables PADReg to achieve physically plausible registration with better anatomical alignment than previous methods relying solely on image similarity. Experiments on in-vivo datasets demonstrate that it attains a HD95 of 12.90, which is 21.34\% better than state-of-the-art methods. The source code is available at https://github.com/evelynskip/PADReg.

Selection and Exploitation of High-Quality Knowledge from Large Language Models for Recommendation

In recent years, there has been growing interest in leveraging the impressive generalization capabilities and reasoning ability of large language models (LLMs) to improve the performance of recommenders. With this operation, recommenders can access and learn the additional world knowledge and reasoning information via LLMs. However, in general, for different users and items, the world knowledge derived from LLMs suffers from issues of hallucination, content redundant, and information homogenization. Directly feeding the generated response embeddings into the recommendation model can lead to unavoidable performance deterioration. To address these challenges, we propose a Knowledge Selection \& Exploitation Recommendation (KSER) framework, which effectively select and extracts the high-quality knowledge from LLMs. The framework consists of two key components: a knowledge filtering module and a embedding spaces alignment module. In the knowledge filtering module, a Embedding Selection Filter Network (ESFNet) is designed to assign adaptive weights to different knowledge chunks in different knowledge fields. In the space alignment module, an attention-based architecture is proposed to align the semantic embeddings from LLMs with the feature space used to train the recommendation models. In addition, two training strategies--\textbf{all-parameters training} and \textbf{extractor-only training}--are proposed to flexibly adapt to different downstream tasks and application scenarios, where the extractor-only training strategy offers a novel perspective on knowledge-augmented recommendation. Experimental results validate the necessity and effectiveness of both the knowledge filtering and alignment modules, and further demonstrate the efficiency and effectiveness of the extractor-only training strategy.

Shape Completion and Real-Time Visualization in Robotic Ultrasound Spine Acquisitions

Ultrasound (US) imaging is increasingly used in spinal procedures due to its real-time, radiation-free capabilities; however, its effectiveness is hindered by shadowing artifacts that obscure deeper tissue structures. Traditional approaches, such as CT-to-US registration, incorporate anatomical information from preoperative CT scans to guide interventions, but they are limited by complex registration requirements, differences in spine curvature, and the need for recent CT imaging. Recent shape completion methods can offer an alternative by reconstructing spinal structures in US data, while being pretrained on large set of publicly available CT scans. However, these approaches are typically offline and have limited reproducibility. In this work, we introduce a novel integrated system that combines robotic ultrasound with real-time shape completion to enhance spinal visualization. Our robotic platform autonomously acquires US sweeps of the lumbar spine, extracts vertebral surfaces from ultrasound, and reconstructs the complete anatomy using a deep learning-based shape completion network. This framework provides interactive, real-time visualization with the capability to autonomously repeat scans and can enable navigation to target locations. This can contribute to better consistency, reproducibility, and understanding of the underlying anatomy. We validate our approach through quantitative experiments assessing shape completion accuracy and evaluations of multiple spine acquisition protocols on a phantom setup. Additionally, we present qualitative results of the visualization on a volunteer scan.

P-CAFE: Personalized Cost-Aware Incremental Feature Selection For Electronic Health Records

Electronic Health Records (EHR) have revolutionized healthcare by digitizing patient data, improving accessibility, and streamlining clinical workflows. However, extracting meaningful insights from these complex and multimodal datasets remains a significant challenge for researchers. Traditional feature selection methods often struggle with the inherent sparsity and heterogeneity of EHR data, especially when accounting for patient-specific variations and feature costs in clinical applications. To address these challenges, we propose a novel personalized, online and cost-aware feature selection framework tailored specifically for EHR datasets. The features are aquired in an online fashion for individual patients, incorporating budgetary constraints and feature variability costs. The framework is designed to effectively manage sparse and multimodal data, ensuring robust and scalable performance in diverse healthcare contexts. A primary application of our proposed method is to support physicians' decision making in patient screening scenarios. By guiding physicians toward incremental acquisition of the most informative features within budget constraints, our approach aims to increase diagnostic confidence while optimizing resource utilization.

Landmark Guided Visual Feature Extractor for Visual Speech Recognition with Limited Resource

Visual speech recognition is a technique to identify spoken content in silent speech videos, which has raised significant attention in recent years. Advancements in data-driven deep learning methods have significantly improved both the speed and accuracy of recognition. However, these deep learning methods can be effected by visual disturbances, such as lightning conditions, skin texture and other user-specific features. Data-driven approaches could reduce the performance degradation caused by these visual disturbances using models pretrained on large-scale datasets. But these methods often require large amounts of training data and computational resources, making them costly. To reduce the influence of user-specific features and enhance performance with limited data, this paper proposed a landmark guided visual feature extractor. Facial landmarks are used as auxiliary information to aid in training the visual feature extractor. A spatio-temporal multi-graph convolutional network is designed to fully exploit the spatial locations and spatio-temporal features of facial landmarks. Additionally, a multi-level lip dynamic fusion framework is introduced to combine the spatio-temporal features of the landmarks with the visual features extracted from the raw video frames. Experimental results show that this approach performs well with limited data and also improves the model's accuracy on unseen speakers.

Fine-Tuning Large Language Models Using EEG Microstate Features for Mental Workload Assessment

This study explores the intersection of electroencephalography (EEG) microstates and Large Language Models (LLMs) to enhance the assessment of cognitive load states. By utilizing EEG microstate features, the research aims to fine-tune LLMs for improved predictions of distinct cognitive states, specifically 'Rest' and 'Load'. The experimental design is delineated in four comprehensive stages: dataset collection and preprocessing, microstate segmentation and EEG backfitting, feature extraction paired with prompt engineering, and meticulous LLM model selection and refinement. Employing a supervised learning paradigm, the LLM is trained to identify cognitive load states based on EEG microstate features integrated into prompts, producing accurate discrimination of cognitive load. A curated dataset, linking EEG features to specified cognitive load conditions, underpins the experimental framework. The results indicate a significant improvement in model performance following the proposed fine-tuning, showcasing the potential of EEG-informed LLMs in cognitive neuroscience and cognitive AI applications. This approach not only contributes to the understanding of brain dynamics but also paves the way for advancements in machine learning techniques applicable to cognitive load and cognitive AI research.

Exploring the Challenges and Opportunities of AI-assisted Codebase Generation

Recent AI code assistants have significantly improved their ability to process more complex contexts and generate entire codebases based on a textual description, compared to the popular snippet-level generation. These codebase AI assistants (CBAs) can also extend or adapt codebases, allowing users to focus on higher-level design and deployment decisions. While prior work has extensively studied the impact of snippet-level code generation, this new class of codebase generation models is relatively unexplored. Despite initial anecdotal reports of excitement about these agents, they remain less frequently adopted compared to snippet-level code assistants. To utilize CBAs better, we need to understand how developers interact with CBAs, and how and why CBAs fall short of developers' needs. In this paper, we explored these gaps through a counterbalanced user study and interview with (n = 16) students and developers working on coding tasks with CBAs. We found that participants varied the information in their prompts, like problem description (48% of prompts), required functionality (98% of prompts), code structure (48% of prompts), and their prompt writing process. Despite various strategies, the overall satisfaction score with generated codebases remained low (mean = 2.8, median = 3, on a scale of one to five). Participants mentioned functionality as the most common factor for dissatisfaction (77% of instances), alongside poor code quality (42% of instances) and communication issues (25% of instances). We delve deeper into participants' dissatisfaction to identify six underlying challenges that participants faced when using CBAs, and extracted five barriers to incorporating CBAs into their workflows. Finally, we surveyed 21 commercial CBAs to compare their capabilities with participant challenges and present design opportunities for more efficient and useful CBAs.

Automated Creation of the Legal Knowledge Graph Addressing Legislation on Violence Against Women: Resource, Methodology and Lessons Learned

Legal decision-making process requires the availability of comprehensive and detailed legislative background knowledge and up-to-date information on legal cases and related sentences/decisions. Legal Knowledge Graphs (KGs) would be a valuable tool to facilitate access to legal information, to be queried and exploited for the purpose, and to enable advanced reasoning and machine learning applications. Indeed, legal KGs may act as knowledge intensive component to be used by pre-dictive machine learning solutions supporting the decision process of the legal expert. Nevertheless, a few KGs can be found in the legal domain. To fill this gap, we developed a legal KG targeting legal cases of violence against women, along with clear adopted methodologies. Specifically, the paper introduces two complementary approaches for automated legal KG construction; a systematic bottom-up approach, customized for the legal domain, and a new solution leveraging Large Language Models. Starting from legal sentences publicly available from the European Court of Justice, the solutions integrate structured data extraction, ontology development, and semantic enrichment to produce KGs tailored for legal cases involving violence against women. After analyzing and comparing the results of the two approaches, the developed KGs are validated via suitable competency questions. The obtained KG may be impactful for multiple purposes: can improve the accessibility to legal information both to humans and machine, can enable complex queries and may constitute an important knowledge component to be possibly exploited by machine learning tools tailored for predictive justice.

How Effectively Can Large Language Models Connect SNP Variants and ECG Phenotypes for Cardiovascular Risk Prediction?

Cardiovascular disease (CVD) prediction remains a tremendous challenge due to its multifactorial etiology and global burden of morbidity and mortality. Despite the growing availability of genomic and electrophysiological data, extracting biologically meaningful insights from such high-dimensional, noisy, and sparsely annotated datasets remains a non-trivial task. Recently, LLMs has been applied effectively to predict structural variations in biological sequences. In this work, we explore the potential of fine-tuned LLMs to predict cardiac diseases and SNPs potentially leading to CVD risk using genetic markers derived from high-throughput genomic profiling. We investigate the effect of genetic patterns associated with cardiac conditions and evaluate how LLMs can learn latent biological relationships from structured and semi-structured genomic data obtained by mapping genetic aspects that are inherited from the family tree. By framing the problem as a Chain of Thought (CoT) reasoning task, the models are prompted to generate disease labels and articulate informed clinical deductions across diverse patient profiles and phenotypes. The findings highlight the promise of LLMs in contributing to early detection, risk assessment, and ultimately, the advancement of personalized medicine in cardiac care.

Semantic Item Graph Enhancement for Multimodal Recommendation

Multimodal recommendation systems have attracted increasing attention for their improved performance by leveraging items' multimodal information. Prior methods often build modality-specific item-item semantic graphs from raw modality features and use them as supplementary structures alongside the user-item interaction graph to enhance user preference learning. However, these semantic graphs suffer from semantic deficiencies, including (1) insufficient modeling of collaborative signals among items and (2) structural distortions introduced by noise in raw modality features, ultimately compromising performance. To address these issues, we first extract collaborative signals from the interaction graph and infuse them into each modality-specific item semantic graph to enhance semantic modeling. Then, we design a modulus-based personalized embedding perturbation mechanism that injects perturbations with modulus-guided personalized intensity into embeddings to generate contrastive views. This enables the model to learn noise-robust representations through contrastive learning, thereby reducing the effect of structural noise in semantic graphs. Besides, we propose a dual representation alignment mechanism that first aligns multiple semantic representations via a designed Anchor-based InfoNCE loss using behavior representations as anchors, and then aligns behavior representations with the fused semantics by standard InfoNCE, to ensure representation consistency. Extensive experiments on four benchmark datasets validate the effectiveness of our framework.