RefineAnything: Multimodal Region-Specific Refinement for Perfect Local Details

We introduce region-specific image refinement as a dedicated problem setting: given an input image and a user-specified region (e.g., a scribble mask or a bounding box), the goal is to restore fine-grained details while keeping all non-edited pixels strictly unchanged. Despite rapid progress in image generation, modern models still frequently suffer from local detail collapse (e.g., distorted text, logos, and thin structures). Existing instruction-driven editing models emphasize coarse-grained semantic edits and often either overlook subtle local defects or inadvertently change the background, especially when the region of interest occupies only a small portion of a fixed-resolution input. We present RefineAnything, a multimodal diffusion-based refinement model that supports both reference-based and reference-free refinement. Building on a counter-intuitive observation that crop-and-resize can substantially improve local reconstruction under a fixed VAE input resolution, we propose Focus-and-Refine, a region-focused refinement-and-paste-back strategy that improves refinement effectiveness and efficiency by reallocating the resolution budget to the target region, while a blended-mask paste-back guarantees strict background preservation. We further introduce a boundary-aware Boundary Consistency Loss to reduce seam artifacts and improve paste-back naturalness. To support this new setting, we construct Refine-30K (20K reference-based and 10K reference-free samples) and introduce RefineEval, a benchmark that evaluates both edited-region fidelity and background consistency. On RefineEval, RefineAnything achieves strong improvements over competitive baselines and near-perfect background preservation, establishing a practical solution for high-precision local refinement. Project Page: https://limuloo.github.io/RefineAnything/.

Scaling Video Pretraining for Surgical Foundation Models

Surgical video understanding is essential for computer-assisted interventions, yet existing surgical foundation models remain constrained by limited data scale, procedural diversity, and inconsistent evaluation, often lacking a reproducible training pipeline. We propose SurgRec, a scalable and reproducible pretraining recipe for surgical video understanding, instantiated with two variants: SurgRec-MAE and SurgRec-JEPA. We curate a large multi-source corpus of 10,535 videos and 214.5M frames spanning endoscopy, laparoscopy, cataract, and robotic surgery. Building on this corpus, we develop a unified pretraining pipeline with balanced sampling and standardize a reproducible benchmark across 16 downstream datasets and four clinical domains with consistent data splits. Across extensive comparisons against SSL baselines and vision-language models, SurgRec consistently achieves superior performance across downstream datasets. In contrast, VLMs prove unreliable for fine-grained temporal recognition, exhibiting both performance gaps and sensitivity to prompt phrasing. Our work provides a reproducible, scalable foundation for the community to build more general surgical video models. All code, models, and data will be publicly released.

TRACE: High-Fidelity 3D Scene Editing via Tangible Reconstruction and Geometry-Aligned Contextual Video Masking

We present TRACE, a mesh-guided 3DGS editing framework that achieves automated, high-fidelity scene transformation. By anchoring video diffusion with explicit 3D geometry, TRACE uniquely enables fine-grained, part-level manipulatio--such as local pose shifting or component replacemen--while preserving the structural integrity of the central subject, a capability largely absent in existing editing methods. Our approach comprises three key stages: (1) Multi-view 3D-Anchor Synthesis, which leverages a sparse-view editor trained on our MV-TRACE datase--the first multi-view consistent dataset dedicated to scene-coherent object addition and modificatio--to generate spatially consistent 3D-anchors; (2) Tangible Geometry Anchoring (TGA), which ensures precise spatial synchronization between inserted meshes and the 3DGS scene via two-phase registration; and (3) Contextual Video Masking (CVM), which integrates 3D projections into an autoregressive video pipeline to achieve temporally stable, physically-grounded rendering. Extensive experiments demonstrate that TRACE consistently outperforms existing methods especially in editing versatility and structural integrity.

Stroke3D: Lifting 2D strokes into rigged 3D model via latent diffusion models

Rigged 3D assets are fundamental to 3D deformation and animation. However, existing 3D generation methods face challenges in generating animatable geometry, while rigging techniques lack fine-grained structural control over skeleton creation. To address these limitations, we introduce Stroke3D, a novel framework that directly generates rigged meshes from user inputs: 2D drawn strokes and a descriptive text prompt. Our approach pioneers a two-stage pipeline that separates the generation into: 1) Controllable Skeleton Generation, we employ the Skeletal Graph VAE (Sk-VAE) to encode the skeleton's graph structure into a latent space, where the Skeletal Graph DiT (Sk-DiT) generates a skeletal embedding. The generation process is conditioned on both the text for semantics and the 2D strokes for explicit structural control, with the VAE's decoder reconstructing the final high-quality 3D skeleton; and 2) Enhanced Mesh Synthesis via TextuRig and SKA-DPO, where we then synthesize a textured mesh conditioned on the generated skeleton. For this stage, we first enhance an existing skeleton-to-mesh model by augmenting its training data with TextuRig: a dataset of textured and rigged meshes with captions, curated from Objaverse-XL. Additionally, we employ a preference optimization strategy, SKA-DPO, guided by a skeleton-mesh alignment score, to further improve geometric fidelity. Together, our framework enables a more intuitive workflow for creating ready to animate 3D content. To the best of our knowledge, our work is the first to generate rigged 3D meshes conditioned on user-drawn 2D strokes. Extensive experiments demonstrate that Stroke3D produces plausible skeletons and high-quality meshes.

Beyond Independent Genes: Learning Module-Inductive Representations for Gene Perturbation Prediction

Predicting transcriptional responses to genetic perturbations is a central problem in functional genomics. In practice, perturbation responses are rarely gene-independent but instead manifest as coordinated, program-level transcriptional changes among functionally related genes. However, most existing methods do not explicitly model such coordination, due to gene-wise modeling paradigms and reliance on static biological priors that cannot capture dynamic program reorganization. To address these limitations, we propose scBIG, a module-inductive perturbation prediction framework that explicitly models coordinated gene programs. scBIG induces coherent gene programs from data via Gene-Relation Clustering, captures inter-program interactions through a Gene-Cluster-Aware Encoder, and preserves modular coordination using structure-aware alignment objectives. These structured representations are then modeled using conditional flow matching to enable flexible and generalizable perturbation prediction. Extensive experiments on multiple single-cell perturbation benchmarks show that scBIG consistently outperforms state-of-the-art methods, particularly on unseen and combinatorial perturbation settings, achieving an average improvement of 6.7% over the strongest baselines.

TraceFlow: Dynamic 3D Reconstruction of Specular Scenes Driven by Ray Tracing

We present TraceFlow, a novel framework for high-fidelity rendering of dynamic specular scenes by addressing two key challenges: precise reflection direction estimation and physically accurate reflection modeling. To achieve this, we propose a Residual Material-Augmented 2D Gaussian Splatting representation that models dynamic geometry and material properties, allowing accurate reflection ray computation. Furthermore, we introduce a Dynamic Environment Gaussian and a hybrid rendering pipeline that decomposes rendering into diffuse and specular components, enabling physically grounded specular synthesis via rasterization and ray tracing. Finally, we devise a coarse-to-fine training strategy to improve optimization stability and promote physically meaningful decomposition. Extensive experiments on dynamic scene benchmarks demonstrate that TraceFlow outperforms prior methods both quantitatively and qualitatively, producing sharper and more realistic specular reflections in complex dynamic environments.

SurgBench: A Unified Large-Scale Benchmark for Surgical Video Analysis

Surgical video understanding is pivotal for enabling automated intraoperative decision-making, skill assessment, and postoperative quality improvement. However, progress in developing surgical video foundation models (FMs) remains hindered by the scarcity of large-scale, diverse datasets for pretraining and systematic evaluation. In this paper, we introduce \textbf{SurgBench}, a unified surgical video benchmarking framework comprising a pretraining dataset, \textbf{SurgBench-P}, and an evaluation benchmark, \textbf{SurgBench-E}. SurgBench offers extensive coverage of diverse surgical scenarios, with SurgBench-P encompassing 53 million frames across 22 surgical procedures and 11 specialties, and SurgBench-E providing robust evaluation across six categories (phase classification, camera motion, tool recognition, disease diagnosis, action classification, and organ detection) spanning 72 fine-grained tasks. Extensive experiments reveal that existing video FMs struggle to generalize across varied surgical video analysis tasks, whereas pretraining on SurgBench-P yields substantial performance improvements and superior cross-domain generalization to unseen procedures and modalities. Our dataset and code are available upon request.

In-Context Edit: Enabling Instructional Image Editing with In-Context Generation in Large Scale Diffusion Transformer

Instruction-based image editing enables robust image modification via natural language prompts, yet current methods face a precision-efficiency tradeoff. Fine-tuning methods demand significant computational resources and large datasets, while training-free techniques struggle with instruction comprehension and edit quality. We resolve this dilemma by leveraging large-scale Diffusion Transformer (DiT)' enhanced generation capacity and native contextual awareness. Our solution introduces three contributions: (1) an in-context editing framework for zero-shot instruction compliance using in-context prompting, avoiding structural changes; (2) a LoRA-MoE hybrid tuning strategy that enhances flexibility with efficient adaptation and dynamic expert routing, without extensive retraining; and (3) an early filter inference-time scaling method using vision-language models (VLMs) to select better initial noise early, improving edit quality. Extensive evaluations demonstrate our method's superiority: it outperforms state-of-the-art approaches while requiring only 0.5% training data and 1% trainable parameters compared to conventional baselines. This work establishes a new paradigm that enables high-precision yet efficient instruction-guided editing. Codes and demos can be found in https://river-zhang.github.io/ICEdit-gh-pages/.

MedSAM2: Segment Anything in 3D Medical Images and Videos

Medical image and video segmentation is a critical task for precision medicine, which has witnessed considerable progress in developing task or modality-specific and generalist models for 2D images. However, there have been limited studies on building general-purpose models for 3D images and videos with comprehensive user studies. Here, we present MedSAM2, a promptable segmentation foundation model for 3D image and video segmentation. The model is developed by fine-tuning the Segment Anything Model 2 on a large medical dataset with over 455,000 3D image-mask pairs and 76,000 frames, outperforming previous models across a wide range of organs, lesions, and imaging modalities. Furthermore, we implement a human-in-the-loop pipeline to facilitate the creation of large-scale datasets resulting in, to the best of our knowledge, the most extensive user study to date, involving the annotation of 5,000 CT lesions, 3,984 liver MRI lesions, and 251,550 echocardiogram video frames, demonstrating that MedSAM2 can reduce manual costs by more than 85%. MedSAM2 is also integrated into widely used platforms with user-friendly interfaces for local and cloud deployment, making it a practical tool for supporting efficient, scalable, and high-quality segmentation in both research and healthcare environments.

DreamRenderer: Taming Multi-Instance Attribute Control in Large-Scale Text-to-Image Models

Image-conditioned generation methods, such as depth- and canny-conditioned approaches, have demonstrated remarkable abilities for precise image synthesis. However, existing models still struggle to accurately control the content of multiple instances (or regions). Even state-of-the-art models like FLUX and 3DIS face challenges, such as attribute leakage between instances, which limits user control. To address these issues, we introduce DreamRenderer, a training-free approach built upon the FLUX model. DreamRenderer enables users to control the content of each instance via bounding boxes or masks, while ensuring overall visual harmony. We propose two key innovations: 1) Bridge Image Tokens for Hard Text Attribute Binding, which uses replicated image tokens as bridge tokens to ensure that T5 text embeddings, pre-trained solely on text data, bind the correct visual attributes for each instance during Joint Attention; 2) Hard Image Attribute Binding applied only to vital layers. Through our analysis of FLUX, we identify the critical layers responsible for instance attribute rendering and apply Hard Image Attribute Binding only in these layers, using soft binding in the others. This approach ensures precise control while preserving image quality. Evaluations on the COCO-POS and COCO-MIG benchmarks demonstrate that DreamRenderer improves the Image Success Ratio by 17.7% over FLUX and enhances the performance of layout-to-image models like GLIGEN and 3DIS by up to 26.8%. Project Page: https://limuloo.github.io/DreamRenderer/.