NeuroLoRA: Context-Aware Neuromodulation for Parameter-Efficient Multi-Task Adaptation

Parameter-Efficient Fine-Tuning (PEFT) techniques, particularly Low-Rank Adaptation (LoRA), have become essential for adapting Large Language Models (LLMs) to downstream tasks. While the recent FlyLoRA framework successfully leverages bio-inspired sparse random projections to mitigate parameter interference, it relies on a static, magnitude-based routing mechanism that is agnostic to input context. In this paper, we propose NeuroLoRA, a novel Mixture-of-Experts (MoE) based LoRA framework inspired by biological neuromodulation -- the dynamic regulation of neuronal excitability based on context. NeuroLoRA retains the computational efficiency of frozen random projections while introducing a lightweight, learnable neuromodulation gate that contextually rescales the projection space prior to expert selection. We further propose a Contrastive Orthogonality Loss to explicitly enforce separation between expert subspaces, enhancing both task decoupling and continual learning capacity. Extensive experiments on MMLU, GSM8K, and ScienceQA demonstrate that NeuroLoRA consistently outperforms FlyLoRA and other strong baselines across single-task adaptation, multi-task model merging, and sequential continual learning scenarios, while maintaining comparable parameter efficiency.

MERRY: Semantically Decoupled Evaluation of Multimodal Emotional and Role Consistencies of Role-Playing Agents

Multimodal Role-Playing Agents (MRPAs) are attracting increasing attention due to their ability to deliver more immersive multimodal emotional interactions. However, existing studies still rely on pure textual benchmarks to evaluate the text responses of MRPAs, while delegating the assessment of their multimodal expressions solely to modality-synthesis metrics. This evaluation paradigm, on the one hand, entangles semantic assessment with modality generation, leading to ambiguous error attribution, and on the other hand remains constrained by the heavy reliance on human judgment. To this end, we propose MERRY, a semantically decoupled evaluation framework for assessing Multimodal Emotional and Role consistencies of Role-playing agents. This framework introduce five refined metrics for EC and three for RC. Notably, we transform the traditional subjective scoring approach into a novel bidirectional-evidence-finding task, significantly improving the human agreement of LLM-as-Judge evaluations. Based on MERRY, we conduct extensive evaluations. Our empirical results primarily reveal that: (1) Training on synthetic datasets tends to reduce emotional consistency, whereas training on real-world datasets improves it; (2) Existing models suffer from emotional templatization and simplification, exhibiting positive-bias and performance bottleneck in fine-grained negative emotions; (3) Simple prompting method strengthens the weak models but constrains the strong ones, while simple fine-tuning method suffers from poor role generalization. Codes and dataset are available.

MUSE: A Multi-agent Framework for Unconstrained Story Envisioning via Closed-Loop Cognitive Orchestration

Generating long-form audio-visual stories from a short user prompt remains challenging due to an intent-execution gap, where high-level narrative intent must be preserved across coherent, shot-level multimodal generation over long horizons. Existing approaches typically rely on feed-forward pipelines or prompt-only refinement, which often leads to semantic drift and identity inconsistency as sequences grow longer. We address this challenge by formulating storytelling as a closed-loop constraint enforcement problem and propose MUSE, a multi-agent framework that coordinates generation through an iterative plan-execute-verify-revise loop. MUSE translates narrative intent into explicit, machine-executable controls over identity, spatial composition, and temporal continuity, and applies targeted multimodal feedback to correct violations during generation. To evaluate open-ended storytelling without ground-truth references, we introduce MUSEBench, a reference-free evaluation protocol validated by human judgments. Experiments demonstrate that MUSE substantially improves long-horizon narrative coherence, cross-modal identity consistency, and cinematic quality compared with representative baselines.

Continuous-Flow Data-Rate-Aware CNN Inference on FPGA

Among hardware accelerators for deep-learning inference, data flow implementations offer low latency and high throughput capabilities. In these architectures, each neuron is mapped to a dedicated hardware unit, making them well-suited for field-programmable gate array (FPGA) implementation. Previous unrolled implementations mostly focus on fully connected networks because of their simplicity, although it is well known that convolutional neural networks (CNNs) require fewer computations for the same accuracy. When observing the data flow in CNNs, pooling layers and convolutional layers with a stride larger than one, the number of data at their output is reduced with respect to their input. This data reduction strongly affects the data rate in a fully parallel implementation, making hardware units heavily underutilized unless it is handled properly. This work addresses this issue by analyzing the data flow of CNNs and presents a novel approach to designing data-rate-aware, continuous-flow CNN architectures. The proposed approach ensures a high hardware utilization close to 100% by interleaving low data rate signals and sharing hardware units, as well as using the right parallelization to achieve the throughput of a fully parallel implementation. The results show that a significant amount of the arithmetic logic can be saved, which allows implementing complex CNNs like MobileNet on a single FPGA with high throughput.

MDAgent2: Large Language Model for Code Generation and Knowledge Q&A in Molecular Dynamics

Molecular dynamics (MD) simulations are essential for understanding atomic-scale behaviors in materials science, yet writing LAMMPS scripts remains highly specialized and time-consuming tasks. Although LLMs show promise in code generation and domain-specific question answering, their performance in MD scenarios is limited by scarce domain data, the high deployment cost of state-of-the-art LLMs, and low code executability. Building upon our prior MDAgent, we present MDAgent2, the first end-to-end framework capable of performing both knowledge Q&A and code generation within the MD domain. We construct a domain-specific data-construction pipeline that yields three high-quality datasets spanning MD knowledge, question answering, and code generation. Based on these datasets, we adopt a three stage post-training strategy--continued pre-training (CPT), supervised fine-tuning (SFT), and reinforcement learning (RL)--to train two domain-adapted models, MD-Instruct and MD-Code. Furthermore, we introduce MD-GRPO, a closed-loop RL method that leverages simulation outcomes as reward signals and recycles low-reward trajectories for continual refinement. We further build MDAgent2-RUNTIME, a deployable multi-agent system that integrates code generation, execution, evaluation, and self-correction. Together with MD-EvalBench proposed in this work, the first benchmark for LAMMPS code generation and question answering, our models and system achieve performance surpassing several strong baselines.This work systematically demonstrates the adaptability and generalization capability of large language models in industrial simulation tasks, laying a methodological foundation for automatic code generation in AI for Science and industrial-scale simulations. URL: https://github.com/FredericVAN/PKU_MDAgent2

Generating Novel and Realistic Speakers for Voice Conversion

Voice conversion models modify timbre while preserving paralinguistic features, enabling applications like dubbing and identity protection. However, most VC systems require access to target utterances, limiting their use when target data is unavailable or when users desire conversion to entirely novel, unseen voices. To address this, we introduce a lightweight method SpeakerVAE to generate novel speakers for VC. Our approach uses a deep hierarchical variational autoencoder to model the speaker timbre space. By sampling from the trained model, we generate novel speaker representations for voice synthesis in a VC pipeline. The proposed method is a flexible plug-in module compatible with various VC models, without co-training or fine-tuning of the base VC system. We evaluated our approach with state-of-the-art VC models: FACodec and CosyVoice2. The results demonstrate that our method successfully generates novel, unseen speakers with quality comparable to that of the training speakers.

LoopExpose: An Unsupervised Framework for Arbitrary-Length Exposure Correction

Exposure correction is essential for enhancing image quality under challenging lighting conditions. While supervised learning has achieved significant progress in this area, it relies heavily on large-scale labeled datasets, which are difficult to obtain in practical scenarios. To address this limitation, we propose a pseudo label-based unsupervised method called LoopExpose for arbitrary-length exposure correction. A nested loop optimization strategy is proposed to address the exposure correction problem, where the correction model and pseudo-supervised information are jointly optimized in a two-level framework. Specifically, the upper-level trains a correction model using pseudo-labels generated through multi-exposure fusion at the lower level. A feedback mechanism is introduced where corrected images are fed back into the fusion process to refine the pseudo-labels, creating a self-reinforcing learning loop. Considering the dominant role of luminance calibration in exposure correction, a Luminance Ranking Loss is introduced to leverage the relative luminance ordering across the input sequence as a self-supervised constraint. Extensive experiments on different benchmark datasets demonstrate that LoopExpose achieves superior exposure correction and fusion performance, outperforming existing state-of-the-art unsupervised methods. Code is available at https://github.com/FALALAS/LoopExpose.

Bridging BCI and Communications: A MIMO Framework for EEG-to-ECoG Wireless Channel Modeling

As a method to connect human brain and external devices, Brain-computer interfaces (BCIs) are receiving extensive research attention. Recently, the integration of communication theory with BCI has emerged as a popular trend, offering potential to enhance system performance and shape next-generation communications. A key challenge in this field is modeling the brain wireless communication channel between intracranial electrocorticography (ECoG) emitting neurons and extracranial electroencephalography (EEG) receiving electrodes. However, the complex physiology of brain challenges the application of traditional channel modeling methods, leaving relevant research in its infancy. To address this gap, we propose a frequency-division multiple-input multiple-output (MIMO) estimation framework leveraging simultaneous macaque EEG and ECoG recordings, while employing neurophysiology-informed regularization to suppress noise interference. This approach reveals profound similarities between neural signal propagation and multi-antenna communication systems. Experimental results show improved estimation accuracy over conventional methods while highlighting a trade-off between frequency resolution and temporal stability determined by signal duration. This work establish a conceptual bridge between neural interfacing and communication theory, accelerating synergistic developments in both fields.

StablePCA: Learning Shared Representations across Multiple Sources via Minimax Optimization

When synthesizing multisource high-dimensional data, a key objective is to extract low-dimensional feature representations that effectively approximate the original features across different sources. Such general feature extraction facilitates the discovery of transferable knowledge, mitigates systematic biases such as batch effects, and promotes fairness. In this paper, we propose Stable Principal Component Analysis (StablePCA), a novel method for group distributionally robust learning of latent representations from high-dimensional multi-source data. A primary challenge in generalizing PCA to the multi-source regime lies in the nonconvexity of the fixed rank constraint, rendering the minimax optimization nonconvex. To address this challenge, we employ the Fantope relaxation, reformulating the problem as a convex minimax optimization, with the objective defined as the maximum loss across sources. To solve the relaxed formulation, we devise an optimistic-gradient Mirror Prox algorithm with explicit closed-form updates. Theoretically, we establish the global convergence of the Mirror Prox algorithm, with the convergence rate provided from the optimization perspective. Furthermore, we offer practical criteria to assess how closely the solution approximates the original nonconvex formulation. Through extensive numerical experiments, we demonstrate StablePCA's high accuracy and efficiency in extracting robust low-dimensional representations across various finite-sample scenarios.

Large Language Models in Bioinformatics: A Survey

Large Language Models (LLMs) are revolutionizing bioinformatics, enabling advanced analysis of DNA, RNA, proteins, and single-cell data. This survey provides a systematic review of recent advancements, focusing on genomic sequence modeling, RNA structure prediction, protein function inference, and single-cell transcriptomics. Meanwhile, we also discuss several key challenges, including data scarcity, computational complexity, and cross-omics integration, and explore future directions such as multimodal learning, hybrid AI models, and clinical applications. By offering a comprehensive perspective, this paper underscores the transformative potential of LLMs in driving innovations in bioinformatics and precision medicine.