RAVEL: Reasoning Agents for Validating and Evaluating LLM Text Synthesis

Large Language Models have evolved from single-round generators into long-horizon agents, capable of complex text synthesis scenarios. However, current evaluation frameworks lack the ability to assess the actual synthesis operations, such as outlining, drafting, and editing. Consequently, they fail to evaluate the actual and detailed capabilities of LLMs. To bridge this gap, we introduce RAVEL, an agentic framework that enables the LLM testers to autonomously plan and execute typical synthesis operations, including outlining, drafting, reviewing, and refining. Complementing this framework, we present C3EBench, a comprehensive benchmark comprising 1,258 samples derived from professional human writings. We utilize a "reverse-engineering" pipeline to isolate specific capabilities across four tasks: Cloze, Edit, Expand, and End-to-End. Through our analysis of 14 LLMs, we uncover that most LLMs struggle with tasks that demand contextual understanding under limited or under-specified instructions. By augmenting RAVEL with SOTA LLMs as operators, we find that such agentic text synthesis is dominated by the LLM's reasoning capability rather than raw generative capacity. Furthermore, we find that a strong reasoner can guide a weaker generator to yield higher-quality results, whereas the inverse does not hold. Our code and data are available at this link: https://github.com/ZhuoerFeng/RAVEL-Reasoning-Agents-Text-Eval.

GLM-5: from Vibe Coding to Agentic Engineering

We present GLM-5, a next-generation foundation model designed to transition the paradigm of vibe coding to agentic engineering. Building upon the agentic, reasoning, and coding (ARC) capabilities of its predecessor, GLM-5 adopts DSA to significantly reduce training and inference costs while maintaining long-context fidelity. To advance model alignment and autonomy, we implement a new asynchronous reinforcement learning infrastructure that drastically improves post-training efficiency by decoupling generation from training. Furthermore, we propose novel asynchronous agent RL algorithms that further improve RL quality, enabling the model to learn from complex, long-horizon interactions more effectively. Through these innovations, GLM-5 achieves state-of-the-art performance on major open benchmarks. Most critically, GLM-5 demonstrates unprecedented capability in real-world coding tasks, surpassing previous baselines in handling end-to-end software engineering challenges. Code, models, and more information are available at https://github.com/zai-org/GLM-5.

Video-o3: Native Interleaved Clue Seeking for Long Video Multi-Hop Reasoning

Existing multimodal large language models for long-video understanding predominantly rely on uniform sampling and single-turn inference, limiting their ability to identify sparse yet critical evidence amid extensive redundancy. We introduce Video-o3, a novel framework that supports iterative discovery of salient visual clues, fine-grained inspection of key segments, and adaptive termination once sufficient evidence is acquired. Technically, we address two core challenges in interleaved tool invocation. First, to mitigate attention dispersion induced by the heterogeneity of reasoning and tool-calling, we propose Task-Decoupled Attention Masking, which isolates per-step concentration while preserving shared global context. Second, to control context length growth in multi-turn interactions, we introduce a Verifiable Trajectory-Guided Reward that balances exploration coverage with reasoning efficiency. To support training at scale, we further develop a data synthesis pipeline and construct Seeker-173K, comprising 173K high-quality tool-interaction trajectories for effective supervised and reinforcement learning. Extensive experiments show that Video-o3 substantially outperforms state-of-the-art methods, achieving 72.1% accuracy on MLVU and 46.5% on Video-Holmes. These results demonstrate Video-o3's strong multi-hop evidence-seeking and reasoning capabilities, and validate the effectiveness of native tool invocation in long-video scenarios.

GLM-4.5: Agentic, Reasoning, and Coding (ARC) Foundation Models

We present GLM-4.5, an open-source Mixture-of-Experts (MoE) large language model with 355B total parameters and 32B activated parameters, featuring a hybrid reasoning method that supports both thinking and direct response modes. Through multi-stage training on 23T tokens and comprehensive post-training with expert model iteration and reinforcement learning, GLM-4.5 achieves strong performance across agentic, reasoning, and coding (ARC) tasks, scoring 70.1% on TAU-Bench, 91.0% on AIME 24, and 64.2% on SWE-bench Verified. With much fewer parameters than several competitors, GLM-4.5 ranks 3rd overall among all evaluated models and 2nd on agentic benchmarks. We release both GLM-4.5 (355B parameters) and a compact version, GLM-4.5-Air (106B parameters), to advance research in reasoning and agentic AI systems. Code, models, and more information are available at https://github.com/zai-org/GLM-4.5.

VideoChat-A1: Thinking with Long Videos by Chain-of-Shot Reasoning

The recent advance in video understanding has been driven by multimodal large language models (MLLMs). But these MLLMs are good at analyzing short videos, while suffering from difficulties in understanding videos with a longer context. To address this difficulty, several agent paradigms have recently been proposed, using MLLMs as agents for retrieving extra contextual knowledge in a long video. However, most existing agents ignore the key fact that a long video is composed with multiple shots, i.e., to answer the user question from a long video, it is critical to deeply understand its relevant shots like human. Without such insight, these agents often mistakenly find redundant even noisy temporal context, restricting their capacity for long video understanding. To fill this gap, we propose VideoChat-A1, a novel long video agent paradigm. Different from the previous works, our VideoChat-A1 can deeply think with long videos, via a distinct chain-of-shot reasoning paradigm. More specifically, it can progressively select the relevant shots of user question, and look into these shots in a coarse-to-fine partition. By multi-modal reasoning along the shot chain, VideoChat-A1 can effectively mimic step-by-step human thinking process, allowing to interactively discover preferable temporal context for thoughtful understanding in long videos. Extensive experiments show that, our VideoChat-A1 achieves the state-of-the-art performance on the mainstream long video QA benchmarks, e.g., it achieves 77.0 on VideoMME and 70.1 on EgoSchema, outperforming its strong baselines (e.g., Intern2.5VL-8B and InternVideo2.5-8B), by up to 10.8\% and 6.2\%. Compared to leading close-source GPT-4o and Gemini 1.5 Pro, VideoChat-A1 offers competitive accuracy, but with 7\% input frames and 12\% inference time on average.

DS-ProGen: A Dual-Structure Deep Language Model for Functional Protein Design

Inverse Protein Folding (IPF) is a critical subtask in the field of protein design, aiming to engineer amino acid sequences capable of folding correctly into a specified three-dimensional (3D) conformation. Although substantial progress has been achieved in recent years, existing methods generally rely on either backbone coordinates or molecular surface features alone, which restricts their ability to fully capture the complex chemical and geometric constraints necessary for precise sequence prediction. To address this limitation, we present DS-ProGen, a dual-structure deep language model for functional protein design, which integrates both backbone geometry and surface-level representations. By incorporating backbone coordinates as well as surface chemical and geometric descriptors into a next-amino-acid prediction paradigm, DS-ProGen is able to generate functionally relevant and structurally stable sequences while satisfying both global and local conformational constraints. On the PRIDE dataset, DS-ProGen attains the current state-of-the-art recovery rate of 61.47%, demonstrating the synergistic advantage of multi-modal structural encoding in protein design. Furthermore, DS-ProGen excels in predicting interactions with a variety of biological partners, including ligands, ions, and RNA, confirming its robust functional retention capabilities.

LVAgent: Long Video Understanding by Multi-Round Dynamical Collaboration of MLLM Agents

Existing Multimodal Large Language Models (MLLMs) encounter significant challenges in modeling the temporal context within long videos. Currently, mainstream Agent-based methods use external tools (e.g., search engine, memory banks, OCR, retrieval models) to assist a single MLLM in answering long video questions. Despite such tool-based support, a solitary MLLM still offers only a partial understanding of long videos, resulting in limited performance. In order to better address long video tasks, we introduce LVAgent, the first framework enabling multi-round dynamic collaboration of MLLM agents in long video understanding. Our methodology consists of four key steps: 1. Selection: We pre-select appropriate agents from the model library to form optimal agent teams based on different tasks. 2. Perception: We design an effective retrieval scheme for long videos, improving the coverage of critical temporal segments while maintaining computational efficiency. 3. Action: Agents answer long video-related questions and exchange reasons. 4. Reflection: We evaluate the performance of each agent in each round of discussion and optimize the agent team for dynamic collaboration. The agents iteratively refine their answers by multi-round dynamical collaboration of MLLM agents. LVAgent is the first agent system method that outperforms all closed-source models (including GPT-4o) and open-source models (including InternVL-2.5 and Qwen2-VL) in the long video understanding tasks. Our LVAgent achieves an accuracy of 80% on four mainstream long video understanding tasks. Notably, on the LongVideoBench dataset, LVAgent improves accuracy by up to 14.3% compared with SOTA.

Large Language Models in Bioinformatics: A Survey

Large Language Models (LLMs) are revolutionizing bioinformatics, enabling advanced analysis of DNA, RNA, proteins, and single-cell data. This survey provides a systematic review of recent advancements, focusing on genomic sequence modeling, RNA structure prediction, protein function inference, and single-cell transcriptomics. Meanwhile, we also discuss several key challenges, including data scarcity, computational complexity, and cross-omics integration, and explore future directions such as multimodal learning, hybrid AI models, and clinical applications. By offering a comprehensive perspective, this paper underscores the transformative potential of LLMs in driving innovations in bioinformatics and precision medicine.

Biological Sequence with Language Model Prompting: A Survey

Large Language models (LLMs) have emerged as powerful tools for addressing challenges across diverse domains. Notably, recent studies have demonstrated that large language models significantly enhance the efficiency of biomolecular analysis and synthesis, attracting widespread attention from academics and medicine. In this paper, we systematically investigate the application of prompt-based methods with LLMs to biological sequences, including DNA, RNA, proteins, and drug discovery tasks. Specifically, we focus on how prompt engineering enables LLMs to tackle domain-specific problems, such as promoter sequence prediction, protein structure modeling, and drug-target binding affinity prediction, often with limited labeled data. Furthermore, our discussion highlights the transformative potential of prompting in bioinformatics while addressing key challenges such as data scarcity, multimodal fusion, and computational resource limitations. Our aim is for this paper to function both as a foundational primer for newcomers and a catalyst for continued innovation within this dynamic field of study.