Artificial General Intelligence for Medical Imaging

In this review, we explore the potential applications of Artificial General Intelligence (AGI) models in healthcare, focusing on foundational Large Language Models (LLMs), Large Vision Models, and Large Multimodal Models. We emphasize the importance of integrating clinical expertise, domain knowledge, and multimodal capabilities into AGI models. In addition, we lay out key roadmaps that guide the development and deployment of healthcare AGI models. Throughout the review, we provide critical perspectives on the potential challenges and pitfalls associated with deploying large-scale AGI models in the medical field. This comprehensive review aims to offer insights into the future implications of AGI in medical imaging, healthcare and beyond.

EfficientViT: Memory Efficient Vision Transformer with Cascaded Group Attention

Vision transformers have shown great success due to their high model capabilities. However, their remarkable performance is accompanied by heavy computation costs, which makes them unsuitable for real-time applications. In this paper, we propose a family of high-speed vision transformers named EfficientViT. We find that the speed of existing transformer models is commonly bounded by memory inefficient operations, especially the tensor reshaping and element-wise functions in MHSA. Therefore, we design a new building block with a sandwich layout, i.e., using a single memory-bound MHSA between efficient FFN layers, which improves memory efficiency while enhancing channel communication. Moreover, we discover that the attention maps share high similarities across heads, leading to computational redundancy. To address this, we present a cascaded group attention module feeding attention heads with different splits of the full feature, which not only saves computation cost but also improves attention diversity. Comprehensive experiments demonstrate EfficientViT outperforms existing efficient models, striking a good trade-off between speed and accuracy. For instance, our EfficientViT-M5 surpasses MobileNetV3-Large by 1.9% in accuracy, while getting 40.4% and 45.2% higher throughput on Nvidia V100 GPU and Intel Xeon CPU, respectively. Compared to the recent efficient model MobileViT-XXS, EfficientViT-M2 achieves 1.8% superior accuracy, while running 5.8x/3.7x faster on the GPU/CPU, and 7.4x faster when converted to ONNX format. Code and models are available at https://github.com/microsoft/Cream/tree/main/EfficientViT.

Instruction-ViT: Multi-Modal Prompts for Instruction Learning in ViT

Prompts have been proven to play a crucial role in large language models, and in recent years, vision models have also been using prompts to improve scalability for multiple downstream tasks. In this paper, we focus on adapting prompt design based on instruction tuning into a visual transformer model for image classification which we called Instruction-ViT. The key idea is to implement multi-modal prompts (text or image prompt) related to category information to guide the fine-tuning of the model. Based on the experiments of several image captionining tasks, the performance and domain adaptability were improved. Our work provided an innovative strategy to fuse multi-modal prompts with better performance and faster adaptability for visual classification models.

Prompt Engineering for Healthcare: Methodologies and Applications

This review will introduce the latest advances in prompt engineering in the field of natural language processing (NLP) for the medical domain. First, we will provide a brief overview of the development of prompt engineering and emphasize its significant contributions to healthcare NLP applications such as question-answering systems, text summarization, and machine translation. With the continuous improvement of general large language models, the importance of prompt engineering in the healthcare domain is becoming increasingly prominent. The aim of this article is to provide useful resources and bridges for healthcare NLP researchers to better explore the application of prompt engineering in this field. We hope that this review can provide new ideas and inspire ample possibilities for research and application in medical NLP.

Bidirectional Propagation for Cross-Modal 3D Object Detection

Recent works have revealed the superiority of feature-level fusion for cross-modal 3D object detection, where fine-grained feature propagation from 2D image pixels to 3D LiDAR points has been widely adopted for performance improvement. Still, the potential of heterogeneous feature propagation between 2D and 3D domains has not been fully explored. In this paper, in contrast to existing pixel-to-point feature propagation, we investigate an opposite point-to-pixel direction, allowing point-wise features to flow inversely into the 2D image branch. Thus, when jointly optimizing the 2D and 3D streams, the gradients back-propagated from the 2D image branch can boost the representation ability of the 3D backbone network working on LiDAR point clouds. Then, combining pixel-to-point and point-to-pixel information flow mechanisms, we construct an bidirectional feature propagation framework, dubbed BiProDet. In addition to the architectural design, we also propose normalized local coordinates map estimation, a new 2D auxiliary task for the training of the 2D image branch, which facilitates learning local spatial-aware features from the image modality and implicitly enhances the overall 3D detection performance. Extensive experiments and ablation studies validate the effectiveness of our method. Notably, we rank $\mathbf{1^{\mathrm{st}}}$ on the highly competitive KITTI benchmark on the cyclist class by the time of submission. The source code is available at https://github.com/Eaphan/BiProDet.

CLIP-Driven Universal Model for Organ Segmentation and Tumor Detection

An increasing number of public datasets have shown a marked clinical impact on assessing anatomical structures. However, each of the datasets is small, partially labeled, and rarely investigates severe tumor subjects. Moreover, current models are limited to segmenting specific organs/tumors, which can not be extended to novel domains and classes. To tackle these limitations, we introduce embedding learned from Contrastive Language-Image Pre-training (CLIP) to segmentation models, dubbed the CLIP-Driven Universal Model. The Universal Model can better segment 25 organs and 6 types of tumors by exploiting the semantic relationship between abdominal structures. The model is developed from an assembly of 14 datasets with 3,410 CT scans and evaluated on 6,162 external CT scans from 3 datasets. We achieve the state-of-the-art results on Beyond The Cranial Vault (BTCV). Compared with dataset-specific models, the Universal Model is computationally more efficient (6x faster), generalizes better to CT scans from varying sites, and shows stronger transfer learning performance on novel tasks. The design of CLIP embedding enables the Universal Model to be easily extended to new classes without catastrophically forgetting the previously learned classes.

A Comprehensive Study and Comparison of the Robustness of 3D Object Detectors Against Adversarial Attacks

Deep learning-based 3D object detectors have made significant progress in recent years and have been deployed in a wide range of applications. It is crucial to understand the robustness of detectors against adversarial attacks when employing detectors in security-critical applications. In this paper, we make the first attempt to conduct a thorough evaluation and analysis of the robustness of 3D detectors under adversarial attacks. Specifically, we first extend three kinds of adversarial attacks to the 3D object detection task to benchmark the robustness of state-of-the-art 3D object detectors against attacks on KITTI and Waymo datasets, subsequently followed by the analysis of the relationship between robustness and properties of detectors. Then, we explore the transferability of cross-model, cross-task, and cross-data attacks. We finally conduct comprehensive experiments of defense for 3D detectors, demonstrating that simple transformations like flipping are of little help in improving robustness when the strategy of transformation imposed on input point cloud data is exposed to attackers. Our findings will facilitate investigations in understanding and defending the adversarial attacks against 3D object detectors to advance this field.

Biomedical image analysis competitions: The state of current participation practice

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

A heterogeneous group CNN for image super-resolution

Convolutional neural networks (CNNs) have obtained remarkable performance via deep architectures. However, these CNNs often achieve poor robustness for image super-resolution (SR) under complex scenes. In this paper, we present a heterogeneous group SR CNN (HGSRCNN) via leveraging structure information of different types to obtain a high-quality image. Specifically, each heterogeneous group block (HGB) of HGSRCNN uses a heterogeneous architecture containing a symmetric group convolutional block and a complementary convolutional block in a parallel way to enhance internal and external relations of different channels for facilitating richer low-frequency structure information of different types. To prevent appearance of obtained redundant features, a refinement block with signal enhancements in a serial way is designed to filter useless information. To prevent loss of original information, a multi-level enhancement mechanism guides a CNN to achieve a symmetric architecture for promoting expressive ability of HGSRCNN. Besides, a parallel up-sampling mechanism is developed to train a blind SR model. Extensive experiments illustrate that the proposed HGSRCNN has obtained excellent SR performance in terms of both quantitative and qualitative analysis. Codes can be accessed at https://github.com/hellloxiaotian/HGSRCNN.

GLENet: Boosting 3D Object Detectors with Generative Label Uncertainty Estimation

The inherent ambiguity in ground-truth annotations of 3D bounding boxes caused by occlusions, signal missing, or manual annotation errors can confuse deep 3D object detectors during training, thus deteriorating the detection accuracy. However, existing methods overlook such issues to some extent and treat the labels as deterministic. In this paper, we propose GLENet, a generative label uncertainty estimation framework adapted from conditional variational autoencoders, to model the one-to-many relationship between a typical 3D object and its potential ground-truth bounding boxes with latent variables. The label uncertainty generated by GLENet is a plug-and-play module and can be conveniently integrated into existing deep 3D detectors to build probabilistic detectors and supervise the learning of the localization uncertainty. Besides, we propose an uncertainty-aware quality estimator architecture in probabilistic detectors to guide the training of IoU-branch with predicted localization uncertainty. We incorporate the proposed methods into various popular base 3D detectors and observe that their performance is significantly boosted to the current state-of-the-art over the Waymo Open dataset and KITTI dataset.