LaTiM: Longitudinal representation learning in continuous-time models to predict disease progression

This work proposes a novel framework for analyzing disease progression using time-aware neural ordinary differential equations (NODE). We introduce a "time-aware head" in a framework trained through self-supervised learning (SSL) to leverage temporal information in latent space for data augmentation. This approach effectively integrates NODEs with SSL, offering significant performance improvements compared to traditional methods that lack explicit temporal integration. We demonstrate the effectiveness of our strategy for diabetic retinopathy progression prediction using the OPHDIAT database. Compared to the baseline, all NODE architectures achieve statistically significant improvements in area under the ROC curve (AUC) and Kappa metrics, highlighting the efficacy of pre-training with SSL-inspired approaches. Additionally, our framework promotes stable training for NODEs, a commonly encountered challenge in time-aware modeling.

L-MAE: Longitudinal masked auto-encoder with time and severity-aware encoding for diabetic retinopathy progression prediction

Pre-training strategies based on self-supervised learning (SSL) have proven to be effective pretext tasks for many downstream tasks in computer vision. Due to the significant disparity between medical and natural images, the application of typical SSL is not straightforward in medical imaging. Additionally, those pretext tasks often lack context, which is critical for computer-aided clinical decision support. In this paper, we developed a longitudinal masked auto-encoder (MAE) based on the well-known Transformer-based MAE. In particular, we explored the importance of time-aware position embedding as well as disease progression-aware masking. Taking into account the time between examinations instead of just scheduling them offers the benefit of capturing temporal changes and trends. The masking strategy, for its part, evolves during follow-up to better capture pathological changes, ensuring a more accurate assessment of disease progression. Using OPHDIAT, a large follow-up screening dataset targeting diabetic retinopathy (DR), we evaluated the pre-trained weights on a longitudinal task, which is to predict the severity label of the next visit within 3 years based on the past time series examinations. Our results demonstrated the relevancy of both time-aware position embedding and masking strategies based on disease progression knowledge. Compared to popular baseline models and standard longitudinal Transformers, these simple yet effective extensions significantly enhance the predictive ability of deep classification models.

An Enhanced Prompt-Based LLM Reasoning Scheme via Knowledge Graph-Integrated Collaboration

While Large Language Models (LLMs) demonstrate exceptional performance in a multitude of Natural Language Processing (NLP) tasks, they encounter challenges in practical applications, including issues with hallucinations, inadequate knowledge updating, and limited transparency in the reasoning process. To overcome these limitations, this study innovatively proposes a collaborative training-free reasoning scheme involving tight cooperation between Knowledge Graph (KG) and LLMs. This scheme first involves using LLMs to iteratively explore KG, selectively retrieving a task-relevant knowledge subgraph to support reasoning. The LLMs are then guided to further combine inherent implicit knowledge to reason on the subgraph while explicitly elucidating the reasoning process. Through such a cooperative approach, our scheme achieves more reliable knowledge-based reasoning and facilitates the tracing of the reasoning results. Experimental results show that our scheme significantly progressed across multiple datasets, notably achieving over a 10% improvement on the QALD10 dataset compared to the best baseline and the fine-tuned state-of-the-art (SOTA) work. Building on this success, this study hopes to offer a valuable reference for future research in the fusion of KG and LLMs, thereby enhancing LLMs' proficiency in solving complex issues.

DISCOVER: 2-D Multiview Summarization of Optical Coherence Tomography Angiography for Automatic Diabetic Retinopathy Diagnosis

Diabetic Retinopathy (DR), an ocular complication of diabetes, is a leading cause of blindness worldwide. Traditionally, DR is monitored using Color Fundus Photography (CFP), a widespread 2-D imaging modality. However, DR classifications based on CFP have poor predictive power, resulting in suboptimal DR management. Optical Coherence Tomography Angiography (OCTA) is a recent 3-D imaging modality offering enhanced structural and functional information (blood flow) with a wider field of view. This paper investigates automatic DR severity assessment using 3-D OCTA. A straightforward solution to this task is a 3-D neural network classifier. However, 3-D architectures have numerous parameters and typically require many training samples. A lighter solution consists in using 2-D neural network classifiers processing 2-D en-face (or frontal) projections and/or 2-D cross-sectional slices. Such an approach mimics the way ophthalmologists analyze OCTA acquisitions: 1) en-face flow maps are often used to detect avascular zones and neovascularization, and 2) cross-sectional slices are commonly analyzed to detect macular edemas, for instance. However, arbitrary data reduction or selection might result in information loss. Two complementary strategies are thus proposed to optimally summarize OCTA volumes with 2-D images: 1) a parametric en-face projection optimized through deep learning and 2) a cross-sectional slice selection process controlled through gradient-based attribution. The full summarization and DR classification pipeline is trained from end to end. The automatic 2-D summary can be displayed in a viewer or printed in a report to support the decision. We show that the proposed 2-D summarization and classification pipeline outperforms direct 3-D classification with the advantage of improved interpretability.

Automated Detection of Myopic Maculopathy in MMAC 2023: Achievements in Classification, Segmentation, and Spherical Equivalent Prediction

Myopic macular degeneration is the most common complication of myopia and the primary cause of vision loss in individuals with pathological myopia. Early detection and prompt treatment are crucial in preventing vision impairment due to myopic maculopathy. This was the focus of the Myopic Maculopathy Analysis Challenge (MMAC), in which we participated. In task 1, classification of myopic maculopathy, we employed the contrastive learning framework, specifically SimCLR, to enhance classification accuracy by effectively capturing enriched features from unlabeled data. This approach not only improved the intrinsic understanding of the data but also elevated the performance of our classification model. For Task 2 (segmentation of myopic maculopathy plus lesions), we have developed independent segmentation models tailored for different lesion segmentation tasks and implemented a test-time augmentation strategy to further enhance the model's performance. As for Task 3 (prediction of spherical equivalent), we have designed a deep regression model based on the data distribution of the dataset and employed an integration strategy to enhance the model's prediction accuracy. The results we obtained are promising and have allowed us to position ourselves in the Top 6 of the classification task, the Top 2 of the segmentation task, and the Top 1 of the prediction task. The code is available at \url{https://github.com/liyihao76/MMAC_LaTIM_Solution}.

Tokenized Model: A Blockchain-Empowered Decentralized Model Ownership Verification Platform

With the development of practical deep learning models like generative AI, their excellent performance has brought huge economic value. For instance, ChatGPT has attracted more than 100 million users in three months. Since the model training requires a lot of data and computing power, a well-performing deep learning model is behind a huge effort and cost. Facing various model attacks, unauthorized use and abuse from the network that threaten the interests of model owners, in addition to considering legal and other administrative measures, it is equally important to protect the model's copyright from the technical means. By using the model watermarking technology, we point out the possibility of building a unified platform for model ownership verification. Given the application history of blockchain in copyright verification and the drawbacks of a centralized third-party, this paper considers combining model watermarking technology and blockchain to build a unified model copyright protection platform. By a new solution we called Tokenized Model, it protects the model's copyright by reliable ownership record and verification mechanism. It also promotes the financial value of model by constructing the model's transaction process and contribution shares of a model. In the typical case study, we also study the various performance under usual scenario to verify the effectiveness of this platform.

VeryFL: A Verify Federated Learning Framework Embedded with Blockchain

Blockchain-empowered federated learning (FL) has provoked extensive research recently. Various blockchain-based federated learning algorithm, architecture and mechanism have been designed to solve issues like single point failure and data falsification brought by centralized FL paradigm. Moreover, it is easier to allocate incentives to nodes with the help of the blockchain. Various centralized federated learning frameworks like FedML, have emerged in the community to help boost the research on FL. However, decentralized blockchain-based federated learning framework is still missing, which cause inconvenience for researcher to reproduce or verify the algorithm performance based on blockchain. Inspired by the above issues, we have designed and developed a blockchain-based federated learning framework by embedding Ethereum network. This report will present the overall structure of this framework, which proposes a code practice paradigm for the combination of FL with blockchain and, at the same time, compatible with normal FL training task. In addition to implement some blockchain federated learning algorithms on smart contract to help execute a FL training, we also propose a model ownership authentication architecture based on blockchain and model watermarking to protect the intellectual property rights of models. These mechanism on blockchain shows an underlying support of blockchain for federated learning to provide a verifiable training, aggregation and incentive distribution procedure and thus we named this framework VeryFL (A Verify Federated Learninig Framework Embedded with Blockchain). The source code is avaliable on https://github.com/GTMLLab/VeryFL.

FIRST: A Million-Entry Dataset for Text-Driven Fashion Synthesis and Design

Text-driven fashion synthesis and design is an extremely valuable part of artificial intelligence generative content(AIGC), which has the potential to propel a tremendous revolution in the traditional fashion industry. To advance the research on text-driven fashion synthesis and design, we introduce a new dataset comprising a million high-resolution fashion images with rich structured textual(FIRST) descriptions. In the FIRST, there is a wide range of attire categories and each image-paired textual description is organized at multiple hierarchical levels. Experiments on prevalent generative models trained over FISRT show the necessity of FIRST. We invite the community to further develop more intelligent fashion synthesis and design systems that make fashion design more creative and imaginative based on our dataset. The dataset will be released soon.

Longitudinal Self-supervised Learning Using Neural Ordinary Differential Equation

Longitudinal analysis in medical imaging is crucial to investigate the progressive changes in anatomical structures or disease progression over time. In recent years, a novel class of algorithms has emerged with the goal of learning disease progression in a self-supervised manner, using either pairs of consecutive images or time series of images. By capturing temporal patterns without external labels or supervision, longitudinal self-supervised learning (LSSL) has become a promising avenue. To better understand this core method, we explore in this paper the LSSL algorithm under different scenarios. The original LSSL is embedded in an auto-encoder (AE) structure. However, conventional self-supervised strategies are usually implemented in a Siamese-like manner. Therefore, (as a first novelty) in this study, we explore the use of Siamese-like LSSL. Another new core framework named neural ordinary differential equation (NODE). NODE is a neural network architecture that learns the dynamics of ordinary differential equations (ODE) through the use of neural networks. Many temporal systems can be described by ODE, including modeling disease progression. We believe that there is an interesting connection to make between LSSL and NODE. This paper aims at providing a better understanding of those core algorithms for learning the disease progression with the mentioned change. In our different experiments, we employ a longitudinal dataset, named OPHDIAT, targeting diabetic retinopathy (DR) follow-up. Our results demonstrate the application of LSSL without including a reconstruction term, as well as the potential of incorporating NODE in conjunction with LSSL.

LMT: Longitudinal Mixing Training, a Framework to Predict Disease Progression from a Single Image

Longitudinal imaging is able to capture both static anatomical structures and dynamic changes in disease progression toward earlier and better patient-specific pathology management. However, conventional approaches rarely take advantage of longitudinal information for detection and prediction purposes, especially for Diabetic Retinopathy (DR). In the past years, Mix-up training and pretext tasks with longitudinal context have effectively enhanced DR classification results and captured disease progression. In the meantime, a novel type of neural network named Neural Ordinary Differential Equation (NODE) has been proposed for solving ordinary differential equations, with a neural network treated as a black box. By definition, NODE is well suited for solving time-related problems. In this paper, we propose to combine these three aspects to detect and predict DR progression. Our framework, Longitudinal Mixing Training (LMT), can be considered both as a regularizer and as a pretext task that encodes the disease progression in the latent space. Additionally, we evaluate the trained model weights on a downstream task with a longitudinal context using standard and longitudinal pretext tasks. We introduce a new way to train time-aware models using $t_{mix}$, a weighted average time between two consecutive examinations. We compare our approach to standard mixing training on DR classification using OPHDIAT a longitudinal retinal Color Fundus Photographs (CFP) dataset. We were able to predict whether an eye would develop a severe DR in the following visit using a single image, with an AUC of 0.798 compared to baseline results of 0.641. Our results indicate that our longitudinal pretext task can learn the progression of DR disease and that introducing $t_{mix}$ augmentation is beneficial for time-aware models.