UFDA: Universal Federated Domain Adaptation with Practical Assumptions

Conventional Federated Domain Adaptation (FDA) approaches usually demand an abundance of assumptions, such as label set consistency, which makes them significantly less feasible for real-world situations and introduces security hazards. In this work, we propose a more practical scenario named Universal Federated Domain Adaptation (UFDA). It only requires the black-box model and the label set information of each source domain, while the label sets of different source domains could be inconsistent and the target-domain label set is totally blind. This relaxes the assumptions made by FDA, which are often challenging to meet in real-world cases and diminish model security. To address the UFDA scenario, we propose a corresponding framework called Hot-Learning with Contrastive Label Disambiguation (HCLD), which tackles UFDA's domain shifts and category gaps problem by using one-hot outputs from the black-box models of various source domains. Moreover, to better distinguish the shared and unknown classes, we further present a cluster-level strategy named Mutual-Voting Decision (MVD) to extract robust consensus knowledge across peer classes from both source and target domains. The extensive experiments on three benchmarks demonstrate that our HCLD achieves comparable performance for our UFDA scenario with much fewer assumptions, compared to the previous methodologies with many additional assumptions.

LATTE: Label-efficient Incident Phenotyping from Longitudinal Electronic Health Records

Electronic health record (EHR) data are increasingly used to support real-world evidence (RWE) studies. Yet its ability to generate reliable RWE is limited by the lack of readily available precise information on the timing of clinical events such as the onset time of heart failure. We propose a LAbel-efficienT incidenT phEnotyping (LATTE) algorithm to accurately annotate the timing of clinical events from longitudinal EHR data. By leveraging the pre-trained semantic embedding vectors from large-scale EHR data as prior knowledge, LATTE selects predictive EHR features in a concept re-weighting module by mining their relationship to the target event and compresses their information into longitudinal visit embeddings through a visit attention learning network. LATTE employs a recurrent neural network to capture the sequential dependency between the target event and visit embeddings before/after it. To improve label efficiency, LATTE constructs highly informative longitudinal silver-standard labels from large-scale unlabeled patients to perform unsupervised pre-training and semi-supervised joint training. Finally, LATTE enhances cross-site portability via contrastive representation learning. LATTE is evaluated on three analyses: the onset of type-2 diabetes, heart failure, and the onset and relapses of multiple sclerosis. We use various evaluation metrics present in the literature including the $ABC_{gain}$, the proportion of reduction in the area between the observed event indicator and the predicted cumulative incidences in reference to the prediction per incident prevalence. LATTE consistently achieves substantial improvement over benchmark methods such as SAMGEP and RETAIN in all settings.